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Cited by 184Nutrition and Health in AgingMuscle metabolism and nutritionMuscle Physiology and Disorders

A High Whey Protein, Vitamin D and E Supplement Preserves Muscle Mass, Strength, and Quality of Life in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial

Bo, Yacong, Liu, Changfeng, Ji, Zhe, Yang, Ruihong, An, Qianqian, Zhang, Xueyuan, You, Jie, Duan, Dandan +4 more·2019·Clinical Nutrition
DOI 10.1016/j.clnu.2017.12.020
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Abstract

Objective Sarcopenia, an age-related decline of muscle mass, strength, and physical function, was associated with falls, frailty, and poor quality of life. The aim of the current study is to examine the effect of nutritional supplement containing whey protein, vitamin D and E on measures of sarcopenia.Methods A total of 60 sarcopenic older adult subjects participated in the current randomized, double-blind, placebo-controlled (iso-caloric control product) trial for 6 months. Muscle mass [Relative skeletal mass index (RSMI) measured by bioimpedance analysis (BIA)], muscle strength (handgrip strength), physical function (6-m gait speed, chair stand test, and timed-up-and-go test, TUG), quality of life (measured by Short-Form 36-Item Health Survey, SF-36), and blood biochemical indexes were measured before and after the 6-month intervention.Results Compared to placebo group, nutritional supplementation improves RSMI (mean difference: 0.18 kg/m 2, 95%CI: 0.01-0.35, P = 0.040), handgrip strength (mean difference: 2.68 kg, 95%CI: 0.71-4.65, P = 0.009), SF-36 mental component summary (SF-36 MCS) (mean difference: 11.26, 95%CI: 3.86-18.65, P = 0.004), SF-36 physical component summary (SF-36 PCS) (mean difference: 20.21, 95%CI: 11.30-29.12, P < 0.001), serum IGF-1 (mean difference: 14.34 ng/mL, 95%CI: 2.06-26.73), IL-2 (mean difference: -575.32 pg/mL, 95%CI: -1116.94 ∼ -33.70, P = 0.038), serum vitamin D 3 (mean difference: 11.01 ng/mL, 95%CI: 6.44-15,58, P < 0.001), and serum vitamin E (mean difference: 4.17 ng/L, 95%CI: 1.89-6.45, P = 0.001).Conclusion The current study demonstrated that the combined supplementation of whey protein, vitamin D and E can significantly improve RSMI, muscle strength, and anabolic markers such as IGF-I and IL-2 in older adults with sarcopenia. Further larger well-designed studies are warranted to evaluate whether long-term whey protein supplementation can blunt the declines of muscle function and mass in older adults with sarcopenia.

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  • Oral vitamin D and E supplement preserves muscle mass and strength and enhances quality of life in sarcopenic older adults.

    “A double-blind randomized controlled trial reported that oral vitamin D and E supplement preserves muscle mass and strength and enhances quality of life in sarcopenic older adults [63].”

    From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [63]

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Authors
Bo, Y., Liu, C., Ji, Z., Yang, R., An, Q., Zhang, X., You, J., Duan, D., Sun, Y., Zhu, Y., Cui, H., & Lu, Q.
Affiliations
  • Zhengzhou University (CN)
  • First Affiliated Hospital of Zhengzhou University (CN)
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2019-02
Volume
38
Issue
1
Pages
159-164
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2017.12.020
OpenAlex
W2783113045
Cited by
184
References
38
Citations by year
2026: 14 · 2025: 35 · 2024: 26 · 2023: 29 · 2022: 23 · 2021: 27 · 2020: 11 · 2019: 10 · 2018: 8 · 2017: 1
FWCI
9.60
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Danone Institute of Canada
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
sarcopenia, older adults, whey protein, vitamin D, vitamin E, dietary supplementation, muscle mass, muscle strength, grip strength, physical function, quality of life, insulin-like growth factor I, interleukin-2, walking speed, Timed Up and Go test, frailty, falls, bioimpedance
MeSH terms
Whey Proteins, Aged, Aged, 80 and over, Double-Blind Method, Female, Humans, Male, Middle Aged, Quality of Life, Vitamin D, Vitamin E, Vitamins, Muscle, Skeletal, Dietary Supplements, Muscle Strength, Sarcopenia

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