Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression
Abstract
The authors measured CSF concentrations of corticotropin-releasing hormone (CRH) and arginine vasopressin in nine depressed patients before and after fluoxetine treatment. They found significant decreases in CSF CRH, CSF arginine vasopressin, and Hamilton depression ratings. Thus, the therapeutic effect of this serotonin-uptake inhibitor may be related to diminution of these arousal-promoting neuropeptides.
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CSF levels of CRF are reduced by successful antidepressant treatment of depression.
“Cerebrospinal fluid (CSF) levels of CRF are reduced by successful treatment of depression by antidepressants.54,55”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [54]
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- Authors
- Bellis, M. D. D., Gold, P. W., Geracioti, T. D., LISTWAK, S. J., & Kling, M. A.
- Affiliations
- National Institutes of Health (US)
- Venue
- American Journal of Psychiatry
- Published
- 1993-04-01
- Volume
- 150
- Issue
- 4
- Pages
- 656-657
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2397426560
- Cited by
- 278
- References
- 11
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 1 · 2014: 15 · 2013: 7 · 2012: 8
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fluoxetine, major depressive disorder, corticotropin-releasing factor, vasopressin, cerebrospinal fluid, serotonin reuptake inhibitors, neuropeptides, arousal, antidepressant mechanism
- MeSH terms
- Adult, Arginine Vasopressin, Corticotropin-Releasing Hormone, Depression, Chemical, Depressive Disorder, Female, Fluoxetine, Humans, Male, Psychiatric Status Rating Scales
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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