Cited by 278Stress Responses and CortisolTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression

Michael D. De Bellis, Philip W. Gold, Thomas D. Geracioti, SAM J. LISTWAK, Mitchel A. Kling·1993·American Journal of Psychiatry

Abstract

The authors measured CSF concentrations of corticotropin-releasing hormone (CRH) and arginine vasopressin in nine depressed patients before and after fluoxetine treatment. They found significant decreases in CSF CRH, CSF arginine vasopressin, and Hamilton depression ratings. Thus, the therapeutic effect of this serotonin-uptake inhibitor may be related to diminution of these arousal-promoting neuropeptides.

Integrity signals

Registry

Crossref · 10.1176/ajp.150.4.656

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11 of 11 references verified0 citation errors · 0 not checkable

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Authors
Bellis, M. D. D., Gold, P. W., Geracioti, T. D., LISTWAK, S. J., & Kling, M. A.
Affiliations
National Institutes of Health (US)
Venue
American Journal of Psychiatry
Published
1993-04-01
Volume
150
Issue
4
Pages
656-657
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2397426560
Cited by
278
References
11
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 1 · 2014: 15 · 2013: 7 · 2012: 8
FWCI
3.18
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
fluoxetine, major depressive disorder, corticotropin-releasing factor, vasopressin, cerebrospinal fluid, serotonin reuptake inhibitors, neuropeptides, arousal, antidepressant mechanism
MeSH terms
Adult, Arginine Vasopressin, Corticotropin-Releasing Hormone, Depression, Chemical, Depressive Disorder, Female, Fluoxetine, Humans, Male, Psychiatric Status Rating Scales

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