Effect of an acute exercise bout on immediate post‐exercise irisin concentration in adults: A meta‐analysis
Abstract
Irisin is a recently discovered myokine that increases adipocyte metabolism, induces further “browning” of white adipose tissue, and enhances glucose metabolism. No study has ever determined how an acute bout of exercise impacts immediate post‐exercise irisin concentration using a meta‐analytic approach. The purpose of this study is to determine the impact of an acute bout of exercise on the magnitude of post‐exercise irisin concentration in adults using meta‐analytic procedures. Searches were performed on PubMed, EMBASE, CINAHL, PEDro, SCOPUS, and SPORTDiscus databases. Effect summaries were obtained using random‐effects models. Random‐effects single and multiple meta‐regressions were performed to determine relationships between, and potential confounding effects of, variables of interest. Ten articles were retained for the final meta‐analysis, producing 21 study estimates. An acute bout of exercise was accompanied by a post‐exercise average increase in irisin concentration of 15.0 (95% CI: 10.8%‐19.3%). There was no significant relationship between post‐exercise irisin concentration and age, intensity of aerobic exercise, or type of exercise training session (resistance vs aerobic training). Fitness level and body mass index were identified as significant predictive variables for post‐exercise irisin concentration. However, a multiple meta‐regression model identified fitness level as the single best predictor, with being fit (21.1%±2.2%) associated with a nearly twofold increase in post‐exercise irisin concentration, compared with being unfit (11.8%±2.1%). Immediately following an acute bout of exercise, irisin concentration increases substantially in adults, with fitness level as an important modifier for the effect.
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Although still controversial, it is generally agreed that irisin levels increase transiently following acute bouts of aerobic and resistance exercise, which could contribute to loss of fat mass.
“Although still controversial [56], it is generally agreed that irisin levels increase transiently following acute bouts of aerobic and resistance exercise [40], which could contribute to loss of fat mass.”
The decrease in irisin with chronic training could be attributed to decreased metabolic stress and inflammation following exercise-associated fat loss rather than exercise per se, and to inclusion of studies that did not measure irisin immediately following exercise bouts.
“These results could be attributed to decreased metabolic stress and inflammation that follows exercise-associated fat loss, rather than as a consequence of exercise per se, and to the inclusion of studies that did not measure irisin levels immediately following exercise bouts, considering its proposed short life in circulation [40].”
Acute exercise in humans generally increases plasma irisin, but the effect of chronic exercise training remains highly variable.
“Although acute exercise in humans generally increases plasma levels of irisin87, the effect of chronic exercise training remains highly variable.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [87]
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“These results could be attributed to decreased metabolic stress and inflammation that follows exercise-associated fat loss, rather than as a consequence of exercise per se, and to the inclusion of studies that did not measure irisin levels immediately following exercise bouts, considering its proposed short life in ci…”
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- Authors
- Fox, J., Rioux, B. V., Goulet, E. D. B., Johanssen, N. M., Swift, D. L., Bouchard, D. R., Loewen, H., & Sénéchal, M.
- Affiliations
- University of New Brunswick (CA)
- Université de Sherbrooke (CA)
- School of Kinesiology Louisiana State University Baton Rouge LA USA
- East Carolina University (US)
- Faculty of Kinesiology University of New Brunswick Fredericton NB Canada
- University of Manitoba (CA)
- Corresponding author
- Sénéchal, M.
- Venue
- Scandinavian Journal of Medicine & Science in Sports
- Publisher
- Wiley
- Published
- 2017-05-24
- Volume
- 28
- Issue
- 1
- Pages
- 16-28
- ISSN
- 0905-7188 (ISSN-L)
- 1600-0838
- OpenAlex
- W2609559846
- Cited by
- 161
- References
- 56
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 26 · 2023: 16 · 2022: 29 · 2021: 22 · 2020: 16 · 2019: 11 · 2018: 8 · 2017: 6
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of New Brunswick
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- irisin, acute exercise, myokines, aerobic exercise, resistance training, physical fitness, body mass index, adipose tissue browning, glucose metabolism
- MeSH terms
- Age Factors, Fibronectins, Humans, Physical Fitness, Regression Analysis, Exercise, Body Mass Index, Resistance Training
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