Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Open accessAbstract
Irisin seems to play an important role in several chronic diseases, however, the interactions between chronic training and irisin are still unclear. The purpose of this systematic review and meta-analysis was to examine the effect of chronic resistance training on circulating irisin in adults. Literature search was conducted in PubMed, Web of Science and EBSCOhost (Academic Search Complete) until December 2020. Randomized controlled trials researching irisin levels after a resistance training program for at least 8 weeks among an adult population were eligible. Other inclusion criteria comprised recruiting a control group and reporting circulating irisin through ELISA kits. Cohen’s d effect size and subgroup analyses (95% confidence level) were calculated using a random effects analysis model. Data of the seven included studies comprising 282 individuals showed an increasing and non-significant tendency after a resistance training program (d = 0.58, 95% CI: −0.25 to 1.40, p = 0.17). Subgroup analyses showed significant increases for the older adults group (p < 0.001) and when training is demanding and progressive in terms of intensity (p = 0.03). Data suggest that resistance training programs seem to increase circulating irisin, especially in older adults and in demanding and progressive training programs. However, more studies should be conducted using robust measurement methods, such as mass spectrometry, to better understand the interaction between chronic resistance exercise and irisin.
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Age may influence responses; some studies suggest that older adults show blunted irisin responses to training compared with younger populations.
“Age may also influence responses; some studies suggest that older adults show blunted irisin responses to training compared with younger populations [40,77].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [40]
The Results (§3.4; page not provided) report a significant increase in circulating irisin among older adults after resistance training, versus a nonsignificant increase in the younger adult group. The Discussion (§4.1) explicitly says older adults showed greater increases than adults of other ages—the opposite of a blunted response. (LLM, conf=0.90)
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Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
RoB 2: a revised tool for assessing risk of bias in randomised trials
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., Cates, C. J., Cheng, H.-Y., Corbett, M. S., Eldridge, S. M., et al. (2019) · BMJ · doi:10.1136/bmj.l4898 · Cited by 33,583 · see citing works
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955 · see citing works
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099 · see citing works
Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388 · see citing works
Estimating effect sizes from pretest-posttest-control group designs
Morris, S. B. (2008) · Organizational Research Methods · doi:10.1177/1094428106291059 · Cited by 2,133 · see citing works
Exercise and the immune system: regulation, integration, and adaptation
Pedersen, B. K., & Hoffman-Goetz, L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1055 · Cited by 1,710 · see citing works
The role of exercise and PGC1α in inflammation and chronic disease
Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083 · see citing works
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Gonçalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0275-4 · Cited by 935 · see citing works
An overview of sarcopenia: facts and numbers on prevalence and clinical impact
von Haehling, S., Morley, J. E., & Anker, S. D. (2010) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-010-0014-2 · Cited by 888 · see citing works
Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882 · see citing works
Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V.-J. A., Novick, S. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.025 · Cited by 638 · see citing works
Physiology and role of irisin in glucose homeostasis
Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.221 · Cited by 621 · see citing works
Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry
Jedrychowski, M. P., Wrann, C. D., Paulo, J. A., Gerber, K. K., Szpyt, J., Robinson, M. M., Nair, K. S., Gygi, S. P., & Spiegelman, B. M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.001 · Cited by 568 · see citing works
Influence of Resistance Exercise on Lean Body Mass in Aging Adults: A Meta-Analysis
PETERSON, M. D., SEN, A., & GORDON, P. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181eb6265 · Cited by 558 · cited 1× · see citing works
“On the other hand, resistance training programs ranged from 10 to 52 weeks at an average intensity of 75% 1RM similarly increase lean body mass in older adults [53].”
BackgroundIrisin – a myth rather than an exercise-inducible myokine
Albrecht, E., Norheim, F., Thiede, B., Holen, T., Ohashi, T., Schering, L., Lee-Ødegård, S., Brenmoehl, J., Thomas, S., Drevon, C. A., et al. (2015) · Scientific Reports · doi:10.1038/srep08889 · Cited by 346 · see citing works
Evidence against a Beneficial Effect of Irisin in Humans
Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 322 · see citing works
Is There Any Practical Application of Meta-Analytical Results in Strength Training?
Gentil, P., Arruda, A. C. P., Souza, D., Gießing, J., Paoli, A., Fisher, J. P., & Steele, J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00001 · Cited by 309 · see citing works
Chronic Inflammation as an Immunological Abnormality and Effectiveness of Exercise
Suzuki, K. (2019) · Biomolecules · doi:10.3390/biom9060223 · Cited by 301 · see citing works
Polyzos, S. A., Anastasilakis, A. D., Efstathiadou, Z. A., Makras, P., Perakakis, N., Kountouras, J., & Mantzoros, C. S. (2018) · Endocrine · doi:10.1007/s12020-017-1476-1 · Cited by 262 · see citing works
Irisin and exercise training in humans – Results from a randomized controlled training trial
Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A., Ruppenthal, S., Kaestner, L., & Meyer, T. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-235 · Cited by 250 · see citing works
Resistance exercise induces a greater irisin response than endurance exercise
Tsuchiya, Y., Ando, D., Takamatsu, K., & Goto, K. (2015) · Metabolism · doi:10.1016/j.metabol.2015.05.010 · Cited by 207 · see citing works
Suzuki, K., Tominaga, T., Ruhee, R. T., & Ma, S. (2020) · Antioxidants · doi:10.3390/antiox9050401 · Cited by 190 · see citing works
Askari, H., Rajani, S. F., Poorebrahim, M., Haghi‐Aminjan, H., Raeis-Abdollahi, E., & Abdollahi, M. R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.012 · Cited by 188 · see citing works
Gannon, N. P., Vaughan, R. A., Garcia‐Smith, R., Bisoffi, M., & Trujillo, K. A. (2014) · International Journal of Cancer · doi:10.1002/ijc.29142 · Cited by 187 · see citing works
Irisin exerts dual effects on browning and adipogenesis of human white adipocytes.
Zhang, Y., Xie, C., Wang, H., Foss, R. M., Clare, M., George, E., Li, S.-W., Katz, A. J., Cheng, H., Ding, Y.-S., et al. (2016) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00094.2016 · Cited by 187 · see citing works
Anastasilakis, A. D., Pοlyzos, S. A., Saridakis, Z. G., Kynigopoulos, G., Skouvaklidou, E. C., Molyvas, D., Vasiloglou, M. F., Apostolou, A., Karagiozoglou‐Lampoudi, Τ., Siopi, A., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1367 · Cited by 186 · see citing works
Kim, H.-J., So, B., Choi, M., Kang, D., & Song, W. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.07.006 · Cited by 181 · see citing works
New role of irisin in hepatocytes: the protective effect of hepatic steatosis in vitro
Park, M.-J., Kim, D.-I., Choi, J.-H., Heo, Y.-R., & Park, S.-H. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.04.010 · Cited by 168 · see citing works
Chang, J. S., Kim, T. H., Nguyen, T. T., Park, K., Kim, N., & Kong, I. D. (2017) · Geriatrics & Gerontology International · doi:10.1111/ggi.13030 · Cited by 166 · see citing works
Nygaard, H., Slettaløkken, G., Vegge, G., Hollan, I., Whist, J. E., Strand, T. A., Rønnestad, B. R., & Ellefsen, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121367 · Cited by 141 · see citing works
KIM, H.-J., LEE, H.-J., SO, B., SON, J. S., YOON, D., & SONG, W. (2016) · Physiological Research · doi:10.33549/physiolres.932997 · Cited by 141 · see citing works
Chronic Exercise Training and Circulating Irisin in Adults: A Meta-Analysis
Qiu, S., Cai, X., Sun, Z., Schumann, U., Zügel, M., & Steinacker, J. M. (2015) · Sports Medicine · doi:10.1007/s40279-014-0293-4 · Cited by 129 · see citing works
Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway
Han, F., Zhang, S., Hou, N., Wang, D., & Sun, X. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00443.2015 · Cited by 123 · see citing works
Wang, Z., Chen, K., Han, Y., Zhu, H., Zhou, X.-Y., Tan, T., Zeng, J., Zhang, J., Liu, Y., Li, Y., et al. (2018) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000608 · Cited by 116 · see citing works
Influence of Supervision Ratio on Muscle Adaptations to Resistance Training in Nontrained Subjects
Gentil, P., & Bottaro, M. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181ad3373 · Cited by 107 · see citing works
Albrecht, E., Schering, L., Buck, F., Vlach, K., Schober, H., Drevon, C. A., & Maak, S. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.01.016 · Cited by 92 · see citing works
The Role of Irisin in Alzheimer’s Disease
Kim, O. Y., & Song, J. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7110407 · Cited by 90 · see citing works
Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults
Zhao, J., Su, Z., Qu, C., & Dong, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00171 · Cited by 82 · see citing works
Ruan, Q., Huang, Y., Yang, L., Ruan, J., Gu, W., Zhang, X., Zhang, Y., Zhang, W., & Yu, Z. (2019) · Peptides · doi:10.1016/j.peptides.2019.01.004 · Cited by 76 · see citing works
Amanat, S., Sinaei, E., Panji, M., MohammadporHodki, R., Bagheri-Hosseinabadi, Z., Asadimehr, H., Fararouei, M., & Dianatinasab, A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.562895 · Cited by 70 · see citing works
Bang, H. S., Seo, D. Y., Chung, Y. M., Oh, K.-M., Park, J. J., Arturo, F., Jeong, S.-H., Kim, N., & Han, J. (2014) · The Korean Journal of Physiology & Pharmacology · doi:10.4196/kjpp.2014.18.5.441 · Cited by 69 · see citing works
Gao, S., Li, F., Li, H., Yi, H., Liu, Y., & Chen, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147480 · Cited by 63 · see citing works
Irisin Does Not Mediate Resistance Training–Induced Alterations in Resting Metabolic Rate
Scharhag‐Rosenberger, F., Meyer, T., Wegmann, M., Ruppenthal, S., Kaestner, L., Morsch, A., & Hecksteden, A. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000286 · Cited by 59 · see citing works
Role of Irisin on the bone–muscle functional unit
Colaianni, G., & Grano, M. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.134 · Cited by 57 · see citing works
Zhao, Y., Wang, J., Yano, N., Zhang, L. X., Wang, H., Zhang, S.-Y., Qin, G., Dubielecka, P., Zhuang, S., Liu, P., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27037 · Cited by 57 · see citing works
Dianatinasab, A., Koroni, R., Bahramian, M., Bagheri-Hosseinabadi, Z., Vaismoradi, M., Fararouei, M., & Amanat, S. (2020) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2020.06.004 · Cited by 56 · see citing works
Effects of Training Attendance on Muscle Strength of Young Men after 11 Weeks of Resistance Training
Gentil, P., & Bottaro, M. (2013) · Asian Journal of Sports Medicine · doi:10.5812/asjsm.34489 · Cited by 51 · see citing works
Buscemi, S., Corleo, D., Vasto, S., Buscemi, C., Massenti, M. F., Nuzzo, D., Lucisano, G., Barile, A. M., Rosafio, G., Maniaci, V., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.255 · Cited by 46 · see citing works
Effects of concurrent aerobic and resistance exercise in frail and pre-frail older adults
Meng, N., Li, C., Liu, C.-S., Lin, C., Chang, C.-K., Chang, H.-W., Yang, C., Li, T., & Lin, C. (2020) · Medicine · doi:10.1097/md.0000000000021187 · Cited by 41 · see citing works
Ghanbari–Niaki, A., Saeidi, A., Ahmadian, M., Gharahcholo, L., Naghavi, N., Fazelzadeh, M., Mahjoub, S., Myers, S., & Williams, A. D. (2018) · Integrative Medicine Research · doi:10.1016/j.imr.2018.01.007 · Cited by 36 · see citing works
Korkmaz, A., Venojärvi, M., Wasenius, N., Manderoos, S., DeRuisseau, K. C., Gidlund, E., Heinonen, O. J., Lindholm, H. J., Aunola, S., Eriksson, J. G., et al. (2018) · European Journal of Sport Science · doi:10.1080/17461391.2018.1506504 · Cited by 32 · see citing works
Liang, H. W., Xu, L.-L., Tian, X., Wang, S., Liu, X., Dai, Y., Li, K., Chen, L.-S., Jin, L., Li, Q., et al. (2020) · Medicine · doi:10.1097/md.0000000000019229 · Cited by 31 · see citing works
A fresh look at adult neurogenesis
Steiner, E., Tata, M., & Frisén, J. (2019) · Nature Medicine · doi:10.1038/s41591-019-0408-4 · Cited by 25 · see citing works
Bittar, S. T., Maeda, S. S., Marone, M. M. S., & Santili, C. (2015) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000542 · Cited by 23 · see citing works
Montes‐Nieto, R., Martínez-García, M. Á., Luque‐Ramírez, M., & Escobar-Morreale, H. F. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2015-1071 · Cited by 18 · see citing works
Rodrigues, A. C., Ferreira, E., Carneiro‐Júnior, M. A., Natali, A. J., & Bressan, J. (2016) · Science & Sports · doi:10.1016/j.scispo.2016.07.005 · Cited by 9 · see citing works
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Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity
Vints, W. A. J., Levin, O., Fujiyama, H., Verbunt, J., & Masiulis, N. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100993 · Cited by 114 · see citing works
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Bao, J., She, Q.-Y., Hu, P., Jia, N., & Li, A. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.06.003 · Cited by 102 · see citing works
Adipose–Muscle Crosstalk in Age-Related Metabolic Disorders: The Emerging Roles of Adipo-Myokines
Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101829 · Cited by 62 · see citing works
Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis
Jandova, T., Buendía‐Romero, Á., Polanská, H., Hola, V., Říhova, M., Větrovský, T., Courel‐Ibáñez, J., & Šteffl, M. (2021) · Healthcare · doi:10.3390/healthcare9111438 · Cited by 61 · see citing works
Irisin, Exercise, and COVID-19
Alves, H. R., Lomba, G. S. B., Gonçalves-de-Albuquerque, C. F., & Burth, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.879066 · Cited by 39 · see citing works
Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review
Barros, D. G. M., Marques, E. A., Magalhães, J., & Carvalho, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101780 · Cited by 36 · see citing works
Ning, K., Wang, Z., & Zhang, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.934406 · Cited by 35 · see citing works
Vecchiato, M., Zanardo, E., Battista, F., Quinto, G., Bergia, C., Palermi, S., Duregon, F., Ermolao, A., & Neunhäeuserer, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010062 · Cited by 32 · see citing works
Makiel, K., Suder, A., Targosz, A., Maciejczyk, M., & Haim, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12010369 · Cited by 30 · see citing works
Rahimi, G. R. M., Hejazi, K., & Hofmeister, M. (2022) · EXCLI journal · doi:10.17179/excli2022-4703 · Cited by 36 · see citing works
Hola, V., Polanská, H., Jandova, T., Dytrtová, J. J., Weinerová, J., Šteffl, M., Kramperová, V., Daďová, K., Durkalec‐Michalski, K., & Bartoš, A. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s482479 · Cited by 27 · see citing works
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Yu, F., Zong, B., Tian, Z., Jia, D., & Wang, R. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102816 · Cited by 14 · see citing works
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Hekmatikar, A. A., Nelson, A., & Petersen, A. C. (2023) · BMC Cancer · doi:10.1186/s12885-023-11391-3 · Cited by 13 · see citing works
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Rodríguez-Pérez, M. D. C., Kontro, T. K., González, D. A., Álvarez, B. G., Marcelino-Rodríguez, I., & de León, Y. A. C. (2022) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2022.09.002 · Cited by 8 · see citing works
Picciotto, D., Macciò, L., Verzola, D., Baciga, F., Momentè, C., Russo, E., Viazzi, F. C., Battaglia, Y., & Esposito, P. B. (2024) · Kidney & Blood Pressure Research · doi:10.1159/000539489 · Cited by 8 · see citing works
Godinho, W. D. N., Vasconcelos-Filho, F. S. L., Pinto, D. V., Alves, J. O., Nascimento, T. D. S., de Aguiar, I. D., Almeida, G. N. S., Ceccatto, V. M., & Soares, P. M. (2022) · Current Alzheimer Research · doi:10.2174/1567205020666221207103109 · Cited by 7 · see citing works
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Aslam, M. A., Lee, J., Bowen, T. S., & Huh, J. Y. (2026) · Archives of Pharmacal Research · doi:10.1007/s12272-026-01624-x · Cited by 4 · see citing works
Chen, M., Zhang, Y. C., Yu, X., & Qun, Z. (2024) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003627 · Cited by 4 · see citing works
Li, Q., Li, C., & Zhang, X. (2024) · Cellular and molecular neurobiology · doi:10.1007/s10571-024-01497-y · Cited by 5 · see citing works
Zhang, Y., & Qiu, Y. (2026) · Sports · doi:10.3390/sports14050212 · Cited by 3 · see citing works
“Studies in elderly populations further suggest that higher-intensity resistance training produces more pronounced effects [40].”
Aguirre, F. S., Valero‐Breton, M., Cabrera, D., Peñailillo, L., Otero, C., Fredes, C., & Cabello‐Verrugio, C. (2025) · European Journal of Translational Myology · doi:10.4081/ejtm.2025.13365 · Cited by 4 · see citing works
Die parakrine und endokrine Funktion der Muskulatur
Heitkamp, H. (2023) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-023-2493-z · Cited by 2 · see citing works
Sanchez‐Martinez, J., Solis‐Urra, P., Fernandez‐Gamez, B., Fernández‐Ortega, J., Sánchez‐Aranda, L., Erickson, K. I., Ortega, F. B., & Esteban‐Cornejo, I. (2026) · Age and Ageing · doi:10.1093/ageing/afag086 · Cited by 5 · see citing works
The Effect of Physical Activity on the Secretory Function of Muscles and Bone Tissue in Humans
Траверсе, Г., Горошко, В. І., & Danylchenko, S. I. (2023) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs08.01.050 · Cited by 2 · see citing works
Sertdemir, H. B., Dursun, S. B., Namulodı, S., Kaya, M. S., & Bayıroğlu, F. (2023) · Ahi Evran Medical Journal · doi:10.46332/aemj.1331280 · Cited by 2 · see citing works
Obesity, Myokines, and Metabolic Health
Malandrino, N., & Ahima, R. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-40116-9_56 · Cited by 2 · see citing works
Serum irisin concentration in patients with bladder cancer
Kawada, T. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03199-0 · Cited by 2 · see citing works
Dehkordi, E. S., & Jafari, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1766054/v1 · Cited by 2 · see citing works
Impact of blood flow restriction training timing: Does exercising at dusk or dawn enhance response?
Peskett, L. E., Thomson, A. M., Rioux, B. V., Nancekievill, D., Arnason, J. T., Paudel, Y., & Sénéchal, M. (2025) · Physiological Reports · doi:10.14814/phy2.70644 · Cited by 1 · see citing works
Poshtdar, S., Ataei-Goujani, H., & Ahrabi, A. (2026) · Journal of Diabetes Research · doi:10.1155/jdr/5552311 · Cited by 1 · see citing works
Zhang, F.-R., Kim, C.-B., Ahn, D., Sung, J., Oh, J. H., Heo, H. R., Jo, E., Kim, H.-S., & Park, J.-J. (2026) · Nutrients · doi:10.3390/nu18081272 · Cited by 1 · see citing works
Hejazi, K., Rahimi, G. R. M., Saeidi, A., Ayed, K., Laher, I., Coso, J. D., Hackney, A. C., Granacher, U., & Zouhal, H. (2026) · Sports Medicine · doi:10.1007/s40279-026-02446-z · Cited by 1 · see citing works
INFLUENCE OF SECRETORY FUNCTION OF SKELETAL MUSCLE ON REHABILITATION
Траверсе, Г. М., Горошко, В. І., & Hordiienko, O. V. (2023) · Реабілітаційні та фізкультурно-рекреаційні аспекти розвитку людини (Rehabilitation & recreation) · doi:10.32782/2522-1795.2023.14.12 · Cited by 1 · see citing works
Newman, J. E., Jenkins, D. G., Mielke, G. I., Askew, C. D., & Schaumberg, M. A. (2023) · Journal of Clinical Exercise Physiology · doi:10.31189/2165-6193-12.4.111 · Cited by 1 · see citing works
Berković, M. C., Cigrovski, V., & Ružić, L. (2025) · World Journal of Methodology · doi:10.5662/wjm.v15.i4.105462 · Cited by 1 · see citing works
"Metabolic Syndrome, Obesity and Irisin: State of the Art"
Finelli, C. (2022) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2022.46.007329
Obesity, Myokines, and Metabolic Health
Malandrino, N., & Ahima, R. S. (2023) · Springer eBooks · doi:10.1007/978-3-319-12125-3_56-1
Feter, N., Cunha, L. L., de Paula, D., Feter, J. S., Caputo, E. L., & Rombaldi, A. J. (2024) · Science & Sports · doi:10.1016/j.scispo.2023.10.005
Afshar, R. K., Rahmati, M., & Mirnasouri, R. (2025) · مجله دانشگاه علوم پزشکی اردبیل · doi:10.61186/jarums.24.4.397
Paz, C. R., de Araújo, J. P., Paz, N. H., Donato, M. F., Júnior, A. T. D. A., Dantas, P. A. M., de Lucena, P. H. M., Paz, M. D. T., França, C. L. M. D. P., França, A. M. D. P., et al. (2026) · Caderno Pedagógico · doi:10.54033/cadpedv23n1-125
Molecular and Physiological Adaptations to Seasonal Training in Elite U18 Ice Hockey Players
Czont, A., Bodor, Z., Koncsag, T., & Miklóssy, I. (2026) · Sports · doi:10.3390/sports14020057
Kamath, P. U., Golamari, U. R., Nair, A. S., & Kalra, P. (2026) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_631_25
Paz, C. R., de Araújo, J. P., Paz, N. H., Donato, M. F., Paz, M. D. T., Júnior, A. T. D. A., Dantas, P. A. M., de Lucena, P. H. M., França, C. L. M. D. P., França, A. M. D. P., et al. (2026) · Revista Multidisciplinar do Nordeste Mineiro · doi:10.66104/tjzd1a51
Predictive Factors for Changes in Serum Irisin Concentrations after Different Exercise Interventions
Chen, T., Gu, Z.-Z., & He, Z. (2026) · International Journal of Sports Medicine · doi:10.1055/a-2912-9831
The Effect of Progressive Resistance Training on Irisin and Cognition in Healthy Older Adults
Newman, J. E., King, I. N., Flemming, N., Buhmann, R., Rose, G. L., Broadhouse, K. M., Jenkins, D. G., Askew, C. D., & Schaumberg, M. A. (2026) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000005477
Ersever, E. M. (2026) · Muscles Ligaments and Tendons Journal · doi:10.32098/mltj_2026_6329
Ersever, E. M. (2026) · European Journal of Translational Myology · doi:10.4081/ejtm.2026.15846
Myokines and mitochondrial function in cardiometabolic diseases
Saavedra, J. E., Gallo-Villegas, J., & Calderón, J. C. (2026) · Journal of physiology and biochemistry · doi:10.1007/s13105-026-01233-8
- Authors
- Cosio, P. L., Crespo-Posadas, M., Velarde-Sotres, Á., & Pelaez, M.
- Affiliations
- Universidad Europea del Atlántico (ES)
- Faculty of Health Sciences, Universidad Europea del Atlántico, 39011 Santander, Spain
- Corresponding author
- Cosio, Pedro L.
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2021-03-03
- Volume
- 18
- Issue
- 5
- Pages
- 2476
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC7967601
- OpenAlex
- W3134859404
- Cited by
- 56
- References
- 63
- Citations by year
- 2026: 15 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 15 · 2021: 1
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- irisin, resistance training, exercise training, circulating biomarkers, older adults, exercise intensity, progressive training
- MeSH terms
- Aged, Fibronectins, Humans, Exercise, Randomized Controlled Trials as Topic, Resistance Training
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