Release of dipeptidyl peptidase IV, α-amylase and α-glucosidase inhibitory peptides from quinoa (Chenopodium quinoa Willd.) during in vitro simulated gastrointestinal digestion

A standardised static in vitro digestion method suitable for food – an international consensus

Minekus, M., Alminger, M., Alvito, P., Ballance, S., Bohn, T., Bourlieu, C., Carrière, F., Boutrou, R., Corredig, M., Dupont, D., et al. (2014) · Food Funct. · doi:10.1039/c3fo60702j · Cited by 5,824

Pharmacologic Therapy for Type 2 Diabetes Mellitus

DeFronzo, R. A. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-4-199908170-00008 · Cited by 1,173

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

Nauck, M. A., Kleine, N., �rskov, C., Holst, J. J., Willms, B., & Creutzfeldt, W. (1993) · Diabetologia · doi:10.1007/bf00401145 · Cited by 1,092

Nutritional Value and Use of the Andean Crops Quinoa (Chenopodium quinoa) and Kañiwa (Chenopodium pallidicaule)

Repo-Carrasco, R., Espinoza, C., & Jacobsen, S. E. (2003) · Food Reviews International · doi:10.1081/fri-120018884 · Cited by 633

Degradation of Endogenous and Exogenous Gastric Inhibitory Polypeptide in Healthy and in Type 2 Diabetic Subjects as Revealed Using a New Assay for the Intact Peptide1

Deacon, C. F., Nauck, M. A., Meier, J., Hücking, K., & Holst, J. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6855 · Cited by 401

Nutritional and Biological Value of Quinoa (Chenopodium quinoa Willd.)

Vilcacundo, R., & Hernández-Ledesma, B. (2017) · Current Opinion in Food Science · doi:10.1016/j.cofs.2016.11.007 · Cited by 334

Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

Deacon, C. F., Hughes, T. E., & Holst, J. J. (1998) · Diabetes · doi:10.2337/diabetes.47.5.764 · Cited by 321

Study of Some Physicochemical and Functional Properties of Quinoa (Chenopodium Quinoa Willd) Protein Isolates

Abugoch, L. E., Romero, N., Tapia, C. A., Silva, J., & Rivera, M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf703689u · Cited by 302

Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM

Nauck, M. A., Wollschläger, D., Werner, J., Holst, J. J., Ørskov, C., Creutzfeldt, W., & Willms, B. (1996) · Diabetologia · doi:10.1007/s001250050613 · Cited by 285

Functional and Bioactive Properties of Quinoa Seed Protein Hydrolysates

Aluko, R. E., & Monu, E. (2003) · Journal of Food Science · doi:10.1111/j.1365-2621.2003.tb09635.x · Cited by 282

Enzyme-assisted extraction and identification of antioxidative and α-amylase inhibitory peptides from Pinto beans ( Phaseolus vulgaris cv. Pinto)

Ngoh, Y.-Y., & Gan, C.-Y. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2015.05.120 · Cited by 262

Identification of antioxidant and ACE‐inhibitory peptides in fermented milk

Hernández‐Ledesma, B., Miralles, B., Amigo, L., Ramos, M., & Recio, I. (2005) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2063 · Cited by 246

Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in β-lactoglobulin

Silveira, S. T., Martínez-Maqueda, D., Recio, I., & Hernández-Ledesma, B. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.056 · Cited by 240

Food protein-derived bioactive peptides in management of type 2 diabetes

Patil, P., Mandal, S., Tomar, S. K., & Anand, S. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0974-2 · Cited by 231

In Vitro Survey of α-Glucosidase Inhibitory Food Components

Matsui, T., Yoshimoto, C., Osajima, K., Oki, T., & Osajima, Y. (1996) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.60.2019 · Cited by 229

Novel peptides derived from egg white protein inhibiting alpha-glucosidase

Yu, Z., Yin, Y., Zhao, W., Yu, Y., Liu, B., Liu, J., & Chen, F. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.05.067 · Cited by 211

In vitro inhibition of dipeptidyl peptidase IV by peptides derived from the hydrolysis of amaranth (Amaranthus hypochondriacus L.) proteins

Velarde-Salcedo, A. J., Barrera-Pacheco, A., Lara-González, S., Montero-Morán, G. M., Díaz-Gois, A., González de Mejia, E., & Barba de la Rosa, A. P. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2012.08.032 · Cited by 210

Inhibitory Effect of α-Glucosidase Inhibitors Varies According to Its Origin

Oki, T., Matsui, T., & Osajima, Y. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980788t · Cited by 209

Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats

Uenishi, H., Kabuki, T., Seto, Y., Serizawa, A., & Nakajima, H. (2012) · International Dairy Journal · doi:10.1016/j.idairyj.2011.08.002 · Cited by 201

Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?

McIntosh, C. H. S., Demuth, H.-U., Pospisilik, J. A., & Pederson, R. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.06.001 · Cited by 192

Dipeptidyl peptidase-IV inhibitory activity of dairy protein hydrolysates

Lacroix, I. M. E., & Li-Chan, E. C. Y. (2012) · International Dairy Journal · doi:10.1016/j.idairyj.2012.01.003 · Cited by 191

Food protein hydrolysates as a source of dipeptidyl peptidase IV inhibitory peptides for the management of type 2 diabetes

Power, O., Nongonierma, A. B., Jakeman, P., & FitzGerald, R. J. (2014) · Proceedings of the Nutrition Society · doi:10.1017/s0029665113003601 · Cited by 180

Anti-diabetic activities of phenolic compounds in muscadine against alpha-glucosidase and pancreatic lipase

You, Q., Chen, F., Wang, X., Jiang, Y., & Lin, S. (2012) · LWT - Food Science and Technology · doi:10.1016/j.lwt.2011.10.011 · Cited by 171

An in silico model to predict the potential of dietary proteins as sources of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides

Nongonierma, A. B., & FitzGerald, R. J. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.05.090 · Cited by 167

Cultivar Evaluation and Effect of Fermentation on Antioxidant Capacity and in Vitro Inhibition of α-Amylase and α-Glucosidase by Highbush Blueberry (Vaccinium corombosum)

Johnson, M. H., Lucius, A., Meyer, T., & Gonzalez de Mejia, E. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201720z · Cited by 164

Identification and characterization of two novel α-glucosidase inhibitory oligopeptides from hemp ( Cannabis sativa L.) seed protein

Ren, Y., Liang, K. F., Jin, Y., Zhang, M., Yu, C., Wu, H., & Lai, F. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.07.024 · Cited by 164

Quinoa (Chenopodium quinoa Willd.) protein hydrolysates with in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory and antioxidant properties

Nongonierma, A. B., Le Maux, S., Dubrulle, C., Barre, C., & FitzGerald, R. J. (2015) · Journal of Cereal Science · doi:10.1016/j.jcs.2015.07.004 · Cited by 161

Dipeptidyl Peptidase IV Inhibitory Peptides Derived from Oat (Avena sativa L.), Buckwheat (Fagopyrum esculentum), and Highland Barley (Hordeum vulgare trifurcatum (L.) Trofim) Proteins

Wang, F., Yu, G., Zhang, Y., Zhang, B., & Fan, J. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b04016 · Cited by 159

Dipeptidyl-peptidase IV inhibitory activity of peptides derived from tuna cooking juice hydrolysates

Huang, S.-L., Jao, C., Ho, K.-P., & Hsu, K. (2012) · Peptides · doi:10.1016/j.peptides.2012.03.006 · Cited by 149

Isolation and characterization of chenopodin, the 11S seed storage protein of quinoa (Chenopodium quinoa)

Brinegar, C., & Goundan, S. (1993) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00026a006 · Cited by 149

Inhibition of α-amylase activity by condensed tannins

Gonçalves, R., Mateus, N. F. D. C. B., & de Freitas, V. A. P. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.09.061 · Cited by 141

The Evaluation of Dipeptidyl Peptidase (DPP)-IV, α-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities of Whey Proteins Hydrolyzed with Serine Protease Isolated from Asian Pumpkin (Cucurbita ficifolia)

Babij, K., Anna, D., Szołtysik, M., Pokora, M., Zambrowicz, A., & Chrzanowska, J. (2014) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-014-9413-0 · Cited by 128

Human insulinotropic response to oral ingestion of native and hydrolysed whey protein

Power, O., Hallihan, A., & Jakeman, P. (2009) · Amino Acids · doi:10.1007/s00726-008-0156-0 · Cited by 128

Extraction, identification, and structure–activity relationship of antioxidative and α-amylase inhibitory peptides from cumin seeds (Cuminum cyminum)

Siow, H.-L., & Gan, C. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.01.011 · Cited by 128

Inhibitory effect of black tea and its combination with acarbose on small intestinal α-glucosidase activity

Satoh, T. K., Igarashi, M., Yamada, S., Takahashi, N., & Watanabe, K. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.12.009 · Cited by 123

Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus

Holst, J. J., & Deacon, C. F. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.08.005 · Cited by 120

Rice bran protein hydrolysates exhibit strong in vitro α‐amylase, β‐glucosidase and ACE ‐inhibition activities

Uraipong, C., & Zhao, J. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7182 · Cited by 115

Binding mode analyses and pharmacophore model development for sulfonamide chalcone derivatives, a new class of α-glucosidase inhibitors

Bharatham, K., Bharatham, N., Park, K. H., & Lee, K. W. (2007) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2007.11.002 · Cited by 107

The Corn Protein, Zein Hydrolysate, Administered into the Ileum Attenuates Hyperglycemia via Its Dual Action on Glucagon-Like Peptide-1 Secretion and Dipeptidyl Peptidase-IV Activity in Rats

Mochida, T., Hira, T., & Hara, H. (2010) · Endocrinology · doi:10.1210/en.2009-1510 · Cited by 99

The development of bioactive peptides from dietary proteins as a dipeptidyl peptidase IV inhibitor for the management of type 2 diabetes

Jao, C., Hung, C.-C., Tung, Y.-S., Lin, P.-Y., Chen, M., & Hsu, K. (2015) · Biomedicine · doi:10.7603/s40681-015-0014-9 · Cited by 92

High-Cysteine 2S Seed Storage Proteins from Quinoa (Chenopodium quinoa)

Brinegar, C., Sine, B., & Nwokocha, L. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf950830+ · Cited by 91

Investigation of the Potential of Hemp, Pea, Rice and Soy Protein Hydrolysates as a Source of Dipeptidyl Peptidase IV (DPP-IV) Inhibitory Peptides

Nongonierma, A. B., & Fitzgerald, R. J. (2015) · Food Digestion · doi:10.1007/s13228-015-0039-2 · Cited by 79

Hypocholesterolemic Effect of Protein Isolated from Quinoa (Chenopodium quinoa Willd.) Seeds

TAKAO, T., Watanabe, N., YUHARA, K., Syoko, I. T. O. H., Suda, S., TSURUOKA, Y., Nakatsugawa, K., & Konishi, Y. (2005) · Food Science and Technology Research · doi:10.3136/fstr.11.161 · Cited by 78

Characterisation of the potential of β-lactoglobulin and α-lactalbumin as sources of bioactive peptides affecting incretin function: In silico and in vitro comparative studies

Tulipano, G., Faggi, L., Nardone, A., Cocchi, D., & Caroli, A. M. (2015) · International Dairy Journal · doi:10.1016/j.idairyj.2015.01.008 · Cited by 78

Dipeptidyl Peptidase IV Inhibition Improves Impaired Glucose Tolerance in High-Fat Diet-Fed Rats: Study Using a Fischer 344 Rat Substrain Deficient in Its Enzyme Activity

Mitani, H., Takimoto, M., Hughes, T. E., & Kimura, M. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.88.442 · Cited by 64

Therapeutic assessment of glucagon-like peptide-1 agonists compared with dipeptidyl peptidase IV inhibitors as potential antidiabetic drugs

Mentlein, R. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.1.57 · Cited by 52

Antagonist: diabetes and insulin resistance--philosophy, science, and the multiplier hypothesis.

Robertson, R. P. (1995) · PubMed · Cited by 51

Extraction optimization and in vitro and in vivo anti-postprandial hyperglycemia effects of inhibitor from Phoenix dactylifera L. parthenocarpic fruit

Abed, H. E., Chakroun, M., Fendri, I., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.129 · Cited by 43

Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?

Majumdar, S. K., & Inzucchi, S. E. (2013) · Endocrine · doi:10.1007/s12020-013-9884-3 · Cited by 33

Inhibitors of Dipeptidyl Peptidase IV - Recent Advances and Structural Views

Hunziker, D., Hennig, M., & Peters, J. (2005) · Current Topics in Medicinal Chemistry · doi:10.2174/156802605775009685 · Cited by 32

ANALYSIS OF PROTEIN ISOLATE FROM QUINOA (CHENOPODIUM QUINOA WILLD)

Carrillo, W., Carpio, C., Toapanta, A. B. P., & Vilcacundo, R. (2016) · Asian Journal of Pharmaceutical and Clinical Research · Cited by 32

Peptide modulators of alpha‐glucosidase

Roškar, I., Molek, P., Vodnik, M., Stempelj, M., Štrukelj, B., & Lunder, M. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12358 · Cited by 28

Optimization Study in Extracting Anti-Oxidative and Α-Amylase Inhibitor Peptides from Cumin Seeds (Cuminum Cyminum)

Siow, H.-L., & Gan, C. (2016) · Journal of Food Biochemistry · doi:10.1111/jfbc.12280 · Cited by 18

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Samtiya, M., Aluko, R. E., Dhewa, T., & Moreno-Rojas, J. M. (2021) · Foods · doi:10.3390/foods10040839 · Cited by 632

Pseudocereal grains: Nutritional value, health benefits and current applications for the development of gluten-free foods

Martínez-Villaluenga, C., Peñas, E., & Hernández-Ledesma, B. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111178 · Cited by 325

Impact of high-pressure homogenization on physico-chemical, structural, and rheological properties of quinoa protein isolates

Luo, L., Cheng, L., Zhang, R., & Yang, Z. (2022) · Food Structure · doi:10.1016/j.foostr.2022.100265 · Cited by 104

Functional Composition, Physiological Effect and Agronomy of Future Food Quinoa (Chenopodium quinoa Willd.): A Review

Chaudhary, N., Walia, S., & Kumar, R. (2023) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2023.105192 · Cited by 89

Functional properties of amaranth, quinoa and chia proteins and the biological activities of their hydrolyzates

López, D. N., Galante, M., Raimundo, G., Spelzini, D., & Boeris, V. (2019) · Food Research International · doi:10.1016/j.foodres.2018.08.056 · Cited by 77