Cited by 225Hepatitis C virus researchTryptophan and brain disordersCOVID-19 and Mental Health

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Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement

Schaefer, Martin, Capuron, Lucile, Friebe, Astrid, Diez-Quevedo, Crisanto, Robaeys, Geert, Neri, Sergio, Foster, Graham R., Kautz, Achim, Forton, Daniel, Pariante, Carmine M.·2012·Journal of Hepatology

DOI 10.1016/j.jhep.2012.07.037

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Abstract

Mental health problems frequently occur in chronic infection with the hepatitis C virus (HCV) and during antiviral treatment with pegylated interferon-alpha (PegIFNα) and ribavirin. Depression is one of the most important complications during antiviral treatment of chronic hepatitis C infection. However, an increased prevalence of depression, fatigue, and cognitive disturbances has also been reported in untreated HCV-positive patients. Patients with psychiatric disorders or drug addiction also have an increased risk of HCV infection. Furthermore, because of possible drug-drug interactions, new antivirals administered together with PegIFNα and ribavirin may complicate psychiatric side effect management, even if no specific psychiatric adverse events are known so far for these new drugs. The European liver patient's organization (ELPA) organised a European expert conference to review the literature and develop expert recommendations for the management of mental health problems in HCV infected patients. This paper results from the output of the 2011 EASL meeting and subsequent dialogue with patient groups and relevant experts in Europe. It summarises the current knowledge of HCV infection and the brain; prevalence, course, and neurobiology of IFN-α associated psychiatric side effects; possible risk factors for IFN-α associated depression and suicide attempts; psychiatric management of HCV infected patients before and during antiviral treatment; prevention of IFN- α associated psychiatric side effects; and psychiatric aspects of the new antivirals. The summarised current knowledge about mental health changes before and during antiviral treatment should improve interdisciplinary management of HCV infected patients.

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Authors: Schaefer, M., Capuron, L., Friebe, A., Diez-Quevedo, C., Robaeys, G., Neri, S., Foster, G. R., Kautz, A., Forton, D., & Pariante, C. M.
Affiliations: Kliniken Essen-Mitte (DE)
Université de Bordeaux (FR)
Ruhr University Bochum (DE)
Ziekenhuis Oost-Limburg (BE)
University of Catania (IT)
Queen Mary University of London (GB)
University of London (GB)
King's College London (GB)
Corresponding author: Schaefer, Martin
ORCID: Schaefer, Martin
Capuron, Lucile
Friebe, Astrid
Robaeys, Geert
Neri, Sergio
Foster, Graham R.
Forton, Daniel
Pariante, Carmine M.
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2012-12
Volume: 57
Issue: 6
Pages: 1379-1390
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2012.07.037
OpenAlex: W2153538902
Cited by: 225
References: 151
Citations by year: 2026: 4 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 20 · 2017: 22 · 2016: 26 · 2015: 20 · 2014: 26 · 2013: 24 · 2012: 2
FWCI: 14.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: European Association for the Study of the Liver
Topics: Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
Keywords: hepatitis C, chronic hepatitis C, depression, psychiatric adverse effects, pegylated interferon-alpha, ribavirin, antiviral therapy, mental health, fatigue, cognitive disorders, drug addiction, suicide risk, drug-drug interactions, psychiatric management
MeSH terms: Antiviral Agents, Depression, Drug Interactions, Hepatitis C, Humans, Mental Health, Risk Factors, Suicide, Attempted, Interferon-alpha

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Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement

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