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Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement
Abstract
Mental health problems frequently occur in chronic infection with the hepatitis C virus (HCV) and during antiviral treatment with pegylated interferon-alpha (PegIFNα) and ribavirin. Depression is one of the most important complications during antiviral treatment of chronic hepatitis C infection. However, an increased prevalence of depression, fatigue, and cognitive disturbances has also been reported in untreated HCV-positive patients. Patients with psychiatric disorders or drug addiction also have an increased risk of HCV infection. Furthermore, because of possible drug-drug interactions, new antivirals administered together with PegIFNα and ribavirin may complicate psychiatric side effect management, even if no specific psychiatric adverse events are known so far for these new drugs. The European liver patient's organization (ELPA) organised a European expert conference to review the literature and develop expert recommendations for the management of mental health problems in HCV infected patients. This paper results from the output of the 2011 EASL meeting and subsequent dialogue with patient groups and relevant experts in Europe. It summarises the current knowledge of HCV infection and the brain; prevalence, course, and neurobiology of IFN-α associated psychiatric side effects; possible risk factors for IFN-α associated depression and suicide attempts; psychiatric management of HCV infected patients before and during antiviral treatment; prevention of IFN- α associated psychiatric side effects; and psychiatric aspects of the new antivirals. The summarised current knowledge about mental health changes before and during antiviral treatment should improve interdisciplinary management of HCV infected patients.
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“Historical data have shown that interferon (INF)based antiviral therapy for patients with HCV is frequently associated with treatment-induced DEP and ANX.[22]”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [22]
In the citing paper
“Schaefer and colleagues reported the prevalence of DEP during INF treatment to be 30%-70% based on 10 studies, though prevalence rates varied by type of screening instrument.”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [22]
In the citing paper
“For example, it was estimated that MDD developed in 15%-45% of patients treated with INF, [22] as assessed by diagnostic interview.”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [22]
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Metadata
- Authors
- Schaefer, M., Capuron, L., Friebe, A., Diez-Quevedo, C., Robaeys, G., Neri, S., Foster, G. R., Kautz, A., Forton, D., & Pariante, C. M.
- Affiliations
- Kliniken Essen-Mitte (DE)
- Université de Bordeaux (FR)
- Ruhr University Bochum (DE)
- Ziekenhuis Oost-Limburg (BE)
- University of Catania (IT)
- Queen Mary University of London (GB)
- University of London (GB)
- King's College London (GB)
- Corresponding author
- Schaefer, Martin
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 57
- Issue
- 6
- Pages
- 1379-1390
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2153538902
- Cited by
- 225
- References
- 151
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 20 · 2017: 22 · 2016: 26 · 2015: 20 · 2014: 26 · 2013: 24 · 2012: 2
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- European Association for the Study of the Liver
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- hepatitis C, chronic hepatitis C, depression, psychiatric adverse effects, pegylated interferon-alpha, ribavirin, antiviral therapy, mental health, fatigue, cognitive disorders, drug addiction, suicide risk, drug-drug interactions, psychiatric management
- MeSH terms
- Antiviral Agents, Depression, Drug Interactions, Hepatitis C, Humans, Mental Health, Risk Factors, Suicide, Attempted, Interferon-alpha
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