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The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease
Open accessAbstract
Background & aims Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population and signifies increased risk of liver fibrosis and cirrhosis, type 2 diabetes, and cardiovascular disease. Therapies are limited. Weight loss is of benefit but is difficult to maintain. We aimed at examining the effect of the Mediterranean diet (MD), a diet high in monounsaturated fatty acids, on steatosis and insulin sensitivity, using gold standard techniques.Methods Twelve non-diabetic subjects (6 Females/6 Males) with biopsy-proven NAFLD were recruited for a randomised, cross-over 6-week dietary intervention study. All subjects undertook both the MD and a control diet, a low fat-high carbohydrate diet (LF/HCD), in random order with a 6-week wash-out period in- between. Insulin sensitivity was determined with a 3-h hyperinsulinemic-euglycemic clamp study and hepatic steatosis was assessed with localized magnetic resonance (1)H spectroscopy ((1)H-MRS).Results At baseline, subjects were abdominally obese with elevated fasting concentrations of glucose, insulin, triglycerides, ALT, and GGT. Insulin sensitivity at baseline was low (M=2.7 ± 1.0 mg/kg/min(-1)). Mean weight loss was not different between the two diets (p=0.22). There was a significant relative reduction in hepatic steatosis after the MD compared with the LF/HCD: 39 ± 4% versus 7 ± 3%, as measured by (1)H-MRS (p=0.012). Insulin sensitivity improved with the MD, whereas after the LF/HCD there was no change (p=0.03 between diets).Conclusions Even without weight loss, MD reduces liver steatosis and improves insulin sensitivity in an insulin-resistant population with NAFLD, compared to current dietary advice. This diet should be further investigated in subjects with NAFLD.
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“In total, seven studies reported data revealed that the MD significantly reduced BMI [56–60, 62, 64](WMD = − 0.70 kg/m2, 95% CI = − 1.03 to − 0.36, P < 0.001)”
From Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials (2025) · cites this paper as [57]
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“The overall results showed that the MD significantly reduced weight [weighted mean difference (WMD = − 2.38 kg, 95% CI − 4.11 to − 0.66, P = 0.01) in comparison to standard care or control diet.”
From Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials (2025) · cites this paper as [57]
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“and WC [56–60, 62, 64] (WMD = − 1.56 cm, 95% CI = − 3.02 to − 0.09, P = 0.04) in comparison to standard care or control diet”
From Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials (2025) · cites this paper as [57]
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“while two others reported significantly lower liver fat percentages in the MD group compared to either a low-fat–high-carbohydrate diet [57] or a standard control group [64].”
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“the overall results of six RCTs [56, 57, 59, 60, 62, 63] showed a significant effect of the MD on ALT levels (WMD = − 3.96 IU/L, 95% CI = − 6.54 to − 1.38, P < 0.001).”
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“Notably, the findings demonstrated that, even in the absence of weight loss, adherence to the Mediterranean diet led to a reduction in hepatic steatosis and an improvement in insulin sensitivity (102).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [102]
In the citing paper
“Cross-sectional and longitudinal reports evidenced a lower likelihood of NASH in patients who were adherent to the MedDiet [75,76], whereas randomized controlled crossover trials defined the superiority of this diet in the improvement of insulin sensitivity, metabolic parameters and steatosis over low-fat ones [77,78].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [77]
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Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Adherence to a Mediterranean diet and survival in a Greek population
Trichopoulou, A., Costacou, T., Bamia, C., & Trichopoulos, D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025039 · Cited by 4,397
Angulo, P., Hui, J. M., Marchesini, G., Bugianesi, E., George, J., Farrell, G. C., Enders, F., Saksena, S., Burt, A. D., Bida, J. P., et al. (2007) · Hepatology · doi:10.1002/hep.21496 · Cited by 3,255
THE DIET AND 15-YEAR DEATH RATE IN THE SEVEN COUNTRIES STUDY
KEYS, A., MIENOTTI, A., KARVONEN, M. J., ARAVANIS, C., BLACKBURN, H., BUZINA, R., DJORDJEVIC, B. S., DONTAS, A. S., FIDANZA, F., KEYS, M. H., et al. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114480 · Cited by 1,790
Adherence to Mediterranean diet and health status: meta-analysis
Sofi, F., Cesari, F., Abbate, R., Gensini, G. F., & Casini, A. (2008) · BMJ · doi:10.1136/bmj.a1344 · Cited by 1,717
Sofi, F., Abbate, R., Gensini, G. F., & Casini, A. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29673 · Cited by 1,605
Szczepaniak, L. S., Nurenberg, P., Leonard, D. S., Browning, J. D., Reingold, J. S., Grundy, S. M., Hobbs, H. H., & Dobbins, R. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00064.2004 · Cited by 1,573
Research works printed but not linked: 1
- Elhayany, 2010, A low carbohydrate Mediterranean diet improves cardiovascular risk factors and diabetes control among overweight patients with type 2 diabetes mellitus: a 1-year prospective randomized intervention study, Diabetes Obes Metab, 12, 204, 10.1111/j.1463-1326.2009.01151.x · DOI · Paper page
Cited by
Sorted by citations
Items 101–200 of 777
Non-alcoholic fatty liver disease: a practical approach to treatment
Dyson, J. K., Anstee, Q. M., & McPherson, S. (2014) · Frontline Gastroenterology · doi:10.1136/flgastro-2013-100404 · Cited by 113
Alimentary regimen in non-alcoholic fatty liver disease: Mediterranean diet
Abenavoli, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i45.16831 · Cited by 105
Non-Alcoholic Fatty Liver Disease: From Pathogenesis to Clinical Impact
Caturano, A., Acierno, C., Nevola, R., Pafundi, P. C., Galiero, R., Rinaldi, L., Salvatore, T., Adinolfi, L. E., & Sasso, F. C. (2021) · Processes · doi:10.3390/pr9010135 · Cited by 109
Miller, D. M., McCauley, K. F., & Dunham‐Snary, K. J. (2025) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70132 · Cited by 131
Duseja, A. K., Singh, S. P., De, A., Madan, K., Rao, P. N., Shukla, A., Choudhuri, G., Saigal, S., Shalimar, S., Arora, A., et al. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.11.014 · Cited by 107
Pintó, X., Fanlo‐Maresma, M., Corbella, E., Corbella, X., Mitjavila, M. T., Moreno, J. J., Casas, R. M., Estruch, R., Corella, D., Bulló, M., et al. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz147 · Cited by 109
Roeb, E., Canbay, A. E., Tacke, F., Bantel, H., Bojunga, J., de Laffolie, J., Demir, M., Denzer, U. W., Geier, A., Hofmann, W. P., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2283 · Cited by 108
Non-Alcoholic Fatty Liver Disease in Lean and Non-Obese Individuals: Current and Future Challenges
Kuchay, M. S., Martínez‐Montoro, J. I., Choudhary, N. S., Fernández‐García, J. C., & Ramos‐Molina, B. (2021) · Biomedicines · doi:10.3390/biomedicines9101346 · Cited by 105
The Effect of the Traditional Mediterranean-Style Diet on Metabolic Risk Factors: A Meta-Analysis
Garcia, M., Bihuniak, J. D., Shook, J., Kenny, R. A., Kerstetter, J. E., & Huedo-Medina, T. B. (2016) · Nutrients · doi:10.3390/nu8030168 · Cited by 106
Mediterranean diet and NAFLD: what we know and questions that still need to be answered
Plaz Torres, M. C., Aghemo, A., Lleo, A., Bodini, G., Furnari, M., Marabotto, E., Miele, L., & Giannini, E. G. (2019) · Nutrients · doi:10.3390/nu11122971 · Cited by 97
Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study
Montemayor, S., Mascaró, C. M., Ugarriza, L., Casares, M., Llompart, I., Abete, I., Zulet, M. Á., Martínez, J. A., Tur, J. A., & Bouzas, C. (2022) · Nutrients · doi:10.3390/nu14153186 · Cited by 96
Aspirin for Metabolic Dysfunction–Associated Steatotic Liver Disease Without Cirrhosis
Simon, T. G., Wilechansky, R. M., Stoyanova, S., Grossman, A., Dichtel, L. E., Lauer, G. M., Miller, K. K., Hoshida, Y., Corey, K. E., Loomba, R. S., et al. (2024) · JAMA · doi:10.1001/jama.2024.1215 · Cited by 96
Houttu, V., Csader, S., Nieuwdorp, M., Holleboom, A. G., & Schwab, U. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.716783 · Cited by 104
The Geometric Framework for Nutrition as a tool in precision medicine
Simpson, S. J., Couteur, D. G. L., James, D. E., George, J., Gunton, J. E., Solon‐Biet, S. M., & Raubenheimer, D. (2017) · Nutrition and Healthy Aging · doi:10.3233/nha-170027 · Cited by 95
Suárez, M., Boqué, N., Bas-Prior, J. M. D., Mayneris‐Perxachs, J., Arola, L., & Caimari, A. (2017) · Nutrients · doi:10.3390/nu9101052 · Cited by 93
The influence of dietary fatty acids on liver fat content and metabolism
Hodson, L., Rosqvist, F., & Parry, S. A. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000569 · Cited by 98
Mediterranean diet and nonalcoholic fatty liver disease: molecular mechanisms of protection
Godos, J., Federico, A., Dallio, M., & Scazzina, F. (2016) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1214239 · Cited by 94
Management of Recurrent and De Novo NAFLD/NASH After Liver Transplantation
Germani, G., Laryea, M. A., Rubbia‐Brandt, L., Egawa, H., Burra, P., O’Grady, J., & Watt, K. D. S. (2018) · Transplantation · doi:10.1097/tp.0000000000002485 · Cited by 92
Corte, C. D., Mosca, A., Vania, A., Alterio, A., Iasevoli, S., & Nobili, V. (2017) · Nutrition · doi:10.1016/j.nut.2017.02.008 · Cited by 92
George, E. S., Forsyth, A. K., Itsiopoulos, C., Nicoll, A., Ryan, M. C., Sood, S. S., Roberts, S. K., & Tierney, A. C. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx007 · Cited by 96
Self-citationCowell, O. R., Mistry, N., Deighton, K., Matu, J., Griffiths, A., Minihane, A. M., Mathers, J. C., Shannon, O. M., & Siervo, M. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002667 · Cited by 96
Shively, C. A., Appt, S. E., Vitolins, M. Z., Uberseder, B., Michalson, K. T., Silverstein‐Metzler, M. G., & Register, T. C. (2019) · Obesity · doi:10.1002/oby.22436 · Cited by 99
Rajapakse, J., Khatiwada, S., Akon, A. C., Yu, K. L., Shen, S., & Zekry, A. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2240031 · Cited by 99
Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options
Milić, S., Mikolašević, I., Zrnić, I. K., Stanić, M., Poropat, G., Štimac, D., Vlahović-Palčevski, V., & Orlić, L. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s64877 · Cited by 97
Bambha, K. M., Wilson, L., Ünalp, A., Loomba, R. S., Neuschwander‐Tetri, B. A., Brunt, E. M., & Bass, N. M. (2013) · Liver International · doi:10.1111/liv.12379 · Cited by 90
A review of non‐alcoholic fatty liver disease in non‐obese and lean individuals
Ahadi, M., Molooghi, K., Masoudifar, N., Namdar, A. B., Vossoughinia, H., & Farzanehfar, M. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15353 · Cited by 94
Zhu, X., Cai, J., Wang, Y., Liu, X., Chen, X., Wang, H., Wu, Z., Bao, W., Fan, H., & Wu, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316733 · Cited by 96
Trouwborst, I., Gijbels, A., Jardon, K. M. C., Siebelink, E., Hul, G. B. J., Wanders, L., Erdõs, B., Péter, S., Singh‐Povel, C. M., den Bosch, J. D. V., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.002 · Cited by 90
Mediterranean diet and non-alcoholic fatty liver disease: New therapeutic option around the corner?
Sofi, F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7339 · Cited by 91
Abenavoli, L., Greco, M., Nazionale, I., Peta, V., Milić, N., Accattato, F., FOTI, D. P., Gulletta, E., & Luzza, F. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1004312 · Cited by 88
The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease
Jennison, E., & Byrne, C. D. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0129 · Cited by 91
Papamiltiadous, E. S., Roberts, S. K., Nicoll, A., Ryan, M. C., Itsiopoulos, C., Salim, A., & Tierney, A. C. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0426-3 · Cited by 86
Self-citationGnoni, A., Stanca, B. D. C., Giannotti, L., Gnoni, G. V., Siculella, L., & Damiano, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031044 · Cited by 89
Diagnosis and management of cardiovascular risk in nonalcoholic fatty liver disease
Lonardo, A., Ballestri, S., Targher, G., & Loria, P. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.965143 · Cited by 86
Mayr, H. L., Thomas, C. J., Tierney, A. C., Kucianski, T., George, E. S., Ruiz‐Canela, M., Hébert, J. R., Shivappa, N., & Itsiopoulos, C. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.04.006 · Cited by 87
Self-citationAliasghari, F., Izadi, A., Gargari, B. P., & Ebrahimi, S. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1339644 · Cited by 84
Hydes, T., Ravi, S., Loomba, R. S., & Gray, M. E. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0067 · Cited by 90
Olive oil antioxidants and non-alcoholic fatty liver disease
Abenavoli, L., Milanović, M., Milić, N., Luzza, F., & Giuffrè, A. M. (2019) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1634544 · Cited by 85
Depboylu, G. Y., Akbulut, G., Baran, M., & Yılmaz, C. (2021) · Pediatric Obesity · doi:10.1111/ijpo.12872 · Cited by 83
Barrea, L., Macchia, P. E., Tarantino, G., Somma, C. D., Pane, E., Balato, N., Napolitano, M., Colao, A., & Savastano, S. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0658-y · Cited by 83
Relationship between Diet and Non-alcoholic Fatty Liver Disease: A Review Article.
Mirmiran, P., Amirhamidi, Z., Ejtahed, H., Bahadoran, Z., & Azizi, F. (2017) · Europe PMC (PubMed Central) · Cited by 82
Perspectives on Treatment for Nonalcoholic Steatohepatitis
Lassailly, G., Caiazzo, R. J., Pattou, F. N., & Mathurin, P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.004 · Cited by 87
Ristic-Medic, D., Kovacic, M., Takic, M., Arsic, A., Petrovic, S., Paunovic, M., Jovicic, M., & Vucic, V. (2020) · Nutrients · doi:10.3390/nu13010015 · Cited by 81
Del Bo’, C., Perna, S., Allehdan, S., Rafique, A., Saad, S., AlGhareeb, F., Rondanelli, M., Tayyem, R. F., Marino, M., Martini, D., et al. (2023) · Nutrients · doi:10.3390/nu15102250 · Cited by 80
Ofosu, A. (2018) · Annals of Gastroenterology · doi:10.20524/aog.2018.0240 · Cited by 81
George, E. S., Kucianski, T., Mayr, H. L., Moschonis, G., Tierney, A. C., & Itsiopoulos, C. (2018) · Nutrients · doi:10.3390/nu10040465 · Cited by 81
Self-citationIvashkin, V. T., Maevskaya, M. V., Жаркова, М. С., Kotovskaya, Y. V., Ткачева, О. Н., Troshina, E. A., Shestakova, M. V., Maev, I. V., Breder, V. V., Geyvandova, N. I., et al. (2022) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2022-32-4-104-140 · Cited by 86
Modern approach to the clinical management of non-alcoholic fatty liver disease
Ben, M. D. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8341 · Cited by 78
Lama, A., Pirozzi, C., Mollica, M. P., Trinchese, G., Guida, F., Cavaliere, G., Calignano, A., Raso, G. M., Canani, R. B., & Meli, R. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600418 · Cited by 77
Randomized Controlled Trial of a MUFA or Fiber-Rich Diet on Hepatic Fat in Prediabetes
Errazuriz, I., Dube, S., Slama, M. Q., VISENTIN, R., Nayar, S., O'Connor, H. T., Cobelli, C., Das, S. K., Basu, A., Kremers, W. K., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3722 · Cited by 79
Kouvari, M., Boutari, C., Chrysohoou, C. A., Fragkopoulou, E., Antonopoulou, S., Tousoulis, D., Pitsavos, C. S., Panagiotakos, D. B., & Mantzoros, C. S. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.10.058 · Cited by 76
George, E. S., Reddy, A., Nicoll, A. J., Ryan, M. C., Itsiopoulos, C., Abbott, G., Johnson, N. A., Sood, S., Roberts, S. K., & Tierney, A. C. (2022) · Liver International · doi:10.1111/liv.15264 · Cited by 76
Self-citationNonalcoholic fatty liver disease: current concepts, epidemiology and management strategies
Tomic, D., Kemp, W. W., & Roberts, S. K. (2018) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001235 · Cited by 76
Consumption of processed red meat and its impact on human health: A review
Libera, J., Iłowiecka, K., & Stasiak, D. M. (2021) · International Journal of Food Science & Technology · doi:10.1111/ijfs.15270 · Cited by 80
Pataky, Z., Genton, L., Spahr, L., Lazarevic, V., Terraz, S., Gaïa, N., Rubbia-Brandt, L., Golay, A., Schrenzel, J., & Pichard, C. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4179-1 · Cited by 75
Haigh, L., Bremner, S., Houghton, D., Henderson, E., Avery, L., Hardy, T., Hallsworth, K., McPherson, S., & Anstee, Q. M. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.044 · Cited by 77
Zelber‐Sagi, S., Salomone, F., Yeshua, H., Lotan, R., Webb, M., Halpern, Z., Santo, E., Oren, R., & Shibolet, O. (2013) · Liver International · doi:10.1111/liv.12318 · Cited by 73
Biolato, M., Manca, F., Marrone, G., Cefalo, C., Racco, S., Miggiano, G. A. D., Valenza, V., Gasbarrini, A., Miele, L., & Grieco, A. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i4.509 · Cited by 78
Lambert, J. E., Parnell, J. A., Eksteen, B., Raman, M., Bomhof, M. R., Rioux, K. P., Madsen, K. L., & Reimer, R. A. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0400-5 · Cited by 73
Aller, R., Izaola, O., de la Fuente, B., & de Luis, D. A. (2015) · PubMed · doi:10.3305/nh.2015.32.6.10074 · Cited by 72
Maskarinec, G., Lim, U., Jacobs, S., Monroe, K. R., Ernst, T. M., Buchthal, S. D., Shepherd, J., Wilkens, L. R., Marchand, L. L., & Boushey, C. J. (2017) · Obesity · doi:10.1002/oby.21868 · Cited by 71
Microbiota, Fiber, and NAFLD: Is There Any Connection?
de, A. P.-M., Julián, M. T., Ramos, A., Puig‐Domingo, M., & Alonso, N. (2020) · Nutrients · doi:10.3390/nu12103100 · Cited by 69
Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease
Campos-Murguía, A., Ruiz‐Margáin, A., González-Regueiro, J. A., & Macías‐Rodríguez, R. U. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i39.5919 · Cited by 75
Franco, I., Bianco, A., Mirizzi, A., Campanella, A., Bonfiglio, C., Sorino, P., Notarnicola, M., Tutino, V., Cozzolongo, R., Giannuzzi, V., et al. (2020) · Nutrients · doi:10.3390/nu13010066 · Cited by 73
Chooi, Y. C., Zhang, Q. A., Magkos, F., Ng, M., Michael, N., Wu, X., Volchanskaya, V. S. B., Lai, X., Wanjaya, E. R., Elejalde, U., et al. (2024) · The American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.11.013 · Cited by 69
Exercise and diet in the management of nonalcoholic fatty liver disease
Mahady, S. E., & George, J. (2015) · Metabolism · doi:10.1016/j.metabol.2015.10.032 · Cited by 73
Mambrini, S. P., Grillo, A., Colosimo, S., Zarpellon, F., Pozzi, G., Furlan, D., Amodeo, G., & Bertoli, S. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1426551 · Cited by 70
Tsompanaki, E., Thanapirom, K., Papatheodoridi, Μ., Parikh, P. M., de Lima, Y. C., & Tsochatzis, E. A. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.11.026 · Cited by 76
Pepa, G. D., Vetrani, C., Lombardi, G., Bozzetto, L., Annuzzi, G., & Rivellese, A. A. (2017) · Nutrients · doi:10.3390/nu9101065 · Cited by 71
Soleimani, D., Ranjbar, G., Rezvani, R., Goshayeshi, L., Razmpour, F., & Nematy, M. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s198744 · Cited by 67
Khalatbari‐Soltani, S., Imamura, F., Brage, S., Rolfe, E. D. L., Griffin, S. J., Wareham, N. J., Marques-Vidal, P. M., & Forouhi, N. G. (2019) · BMC Medicine · doi:10.1186/s12916-019-1251-7 · Cited by 72
Lipotoxicity as the Leading Cause of Non-Alcoholic Steatohepatitis
Branković, M., Jovanović, I., Dukić, M., Radonjić, T., Oprić, S., Klašnja, S., & Zdravkovic, M. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095146 · Cited by 72
Haghighatdoost, F., Salehi‐Abargouei, A., Surkan, P. J., & Azadbakht, L. (2016) · Journal of Research in Medical Sciences · doi:10.4103/1735-1995.187269 · Cited by 66
Saeed, N., Nadeau, B., Shannon, C., & Tincopa, M. (2019) · Nutrients · doi:10.3390/nu11123064 · Cited by 65
Dikariyanto, V., Smith, L., Francis, L., Robertson, M., Kusaslan, E., O’Callaghan-Latham, M., Palanche, C., D’Annibale, M., Christodoulou, D., Basty, N., et al. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa100 · Cited by 64
Exercising the hepatobiliary‐gut axis. The impact of physical activity performance
Molina‐Molina, E., Baccetto, R., Wang, D. Q. ‐., de Bari, O., Krawczyk, M. J., & Portincasa, P. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12958 · Cited by 66
Health benefits of Mediterranean diet in nonalcoholic fatty liver disease
Abenavoli, L., Di Renzo, L., Boccuto, L., Alwardat, N., Gratteri, S., & De Lorenzo, A. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1503947 · Cited by 62
Implementing a Mediterranean-Style Diet Outside the Mediterranean Region
Murphy, K. J., & Parletta, N. (2018) · Current Atherosclerosis Reports · doi:10.1007/s11883-018-0732-z · Cited by 66
Díaz, L. A., Arab, J. P., Idalsoaga, F. J., Perelli, J., Vega, J. A., Dirchwolf, M., Carreño, J., Samith, B., Valério, C. M., Moreira, R. O., et al. (2025) · Annals of Hepatology · doi:10.1016/j.aohep.2025.101903 · Cited by 72
Parra-Vargas, M., Rodriguez‐Echevarría, R., & Jiménez‐Chillarón, J. C. (2020) · Nutrients · doi:10.3390/nu12123860 · Cited by 64
Carrieri, P., Mourad, A., Marcellin, F., Trylesinski, A., Calleja, J. L., Protopopescu, C., & Lazarus, J. V. (2022) · Liver International · doi:10.1111/liv.15209 · Cited by 61
Maevskaya, M. V., Kotovskaya, Y. V., Ivashkin, V. T., Ткачева, О. Н., Troshina, E. A., Shestakova, M. V., Breder, V. V., Geyvandova, N. I., Doshchitsin, V. L., Dudinskaya, Е. N., et al. (2022) · Terapevticheskii arkhiv · doi:10.26442/00403660.2022.02.201363 · Cited by 66
Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease
de Oliveira, C. P. M. S., Sanches, P. D. L., de Abreu-Silva, E. O., & Marcadenti, A. (2015) · Journal of Diabetes Research · doi:10.1155/2016/4597246 · Cited by 64
Agosti, P., Sabbà, C., & Mazzocca, A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.11.026 · Cited by 59
He, Z., Li, X., Yang, H., Wu, P., Wang, S., Cao, D., Guo, X. C., Xu, Z., Gao, J., Zhang, W., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.745609 · Cited by 64
Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention
Otten, J., Mellberg, C., Ryberg, M., Sandberg, S., Kullberg, J., Lindahl, B., Larsson, C. L., Hauksson, J. B., & Olsson, T. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.4 · Cited by 60
Lifestyle interventions for non-alcoholic fatty liver disease
Ahmed, I. A., Mikail, M. A., Mustafa, M. R., Ibrahim, M., & Othman, R. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2018.12.016 · Cited by 63
Moore, J. B. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000570 · Cited by 60
Nutrition and Nonalcoholic Fatty Liver Disease
Chakravarthy, M. V., Waddell, T. K., Banerjee, R., & Guess, N. D. (2019) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2019.09.003 · Cited by 67
Shidfar, F., Bahrololumi, S. S., Doaei, S., Mohammadzadeh, A., Gholamalizadeh, M., & Mohammadimanesh, A. (2018) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2018/1053710 · Cited by 58
MANAGEMENT OF ENDOCRINE DISEASE: Polycystic ovary syndrome and nonalcoholic fatty liver disease
Μacut, D., Antić, I. B., Bjekić-Macut, J., & Τζιόμαλος, Κ. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-1063 · Cited by 58
Metabolic Syndrome—Role of Dietary Fat Type and Quantity
Clifton, P. M. (2019) · Nutrients · doi:10.3390/nu11071438 · Cited by 61
Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes
Jamwal, R., & Barlock, B. J. (2020) · Pharmaceuticals · doi:10.3390/ph13090222 · Cited by 59
Drugs for Non-alcoholic Steatohepatitis (NASH): Quest for the Holy Grail
Sharma, M., Premkumar, M., Kulkarni, A. V., Kumar, P., Reddy, D. N., & Rao, N. P. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00055 · Cited by 54
Lifestyle effects on aging and CVD: A spotlight on the nutrient-sensing network
Yang, K., Hou, R., Zhao, J., Wang, X., Wei, J., Pan, X., & Zhu, X. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102121 · Cited by 59
Vu, K., Gilbert, G., Chalut, M., Chagnon, M., Chartrand, G., & Tang, A. (2015) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25083 · Cited by 55
Healthy dietary pattern is inversely associated with non-alcoholic fatty liver disease in elderly
Adriano, L. S., Sampaio, H. A. D. C., Arruda, S. P. M., Portela, C. L. D. M., de Melo, M. L. P., Carioca, A. A. F., & Soares, N. T. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001410 · Cited by 55
Dietary patterns and non-alcoholic fatty liver disease in a Greek case–control study
Kalafati, I. P., Borsa, D., Dimitriou, M., Revenas, K., Kokkinos, A. D., & Dedoussis, G. V. (2018) · Nutrition · doi:10.1016/j.nut.2018.10.032 · Cited by 58
Moosavian, S. P., Arab, A., & Paknahad, Z. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.10.008 · Cited by 56
Alferink, L. J. M., Erler, N. S., de Knegt, R. J., Janssen, H. L. A., Metselaar, H. J., Murad, S. D., & Jong, J. C. K. (2020) · European Journal of Epidemiology · doi:10.1007/s10654-020-00627-2 · Cited by 56
Metadata
- Authors
- Ryan, M. C., Itsiopoulos, C., Thodis, T., Ward, G., Trost, N., Hofferberth, S., O’Dea, K., Desmond, P. V., Johnson, N. A., & Wilson, A. M.
- Affiliations
- St Vincent's Hospital Melbourne (AU)
- La Trobe University (AU)
- University of South Australia (AU)
- The University of Sydney (AU)
- Corresponding author
- Ryan, Marno C.
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 59
- Issue
- 1
- Pages
- 138-143
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2053985254
- Cited by
- 778
- References
- 46
- Citations by year
- 2026: 39 · 2025: 59 · 2024: 66 · 2023: 90 · 2022: 66 · 2021: 71 · 2020: 77 · 2019: 70 · 2018: 69 · 2017: 52 · 2016: 50 · 2015: 26 · 2014: 29 · 2013: 12
- FWCI
- 28.42
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- Mediterranean diet, non-alcoholic fatty liver disease, hepatic steatosis, insulin sensitivity, monounsaturated fatty acids, low-fat high-carbohydrate diet, dietary intervention, hyperinsulinemic-euglycemic clamp, 1H magnetic resonance spectroscopy, weight loss, insulin resistance
- MeSH terms
- Adult, Aged, Fatty Liver, Female, Humans, Insulin Resistance, Magnetic Resonance Imaging, Male, Middle Aged, Pilot Projects, Glucose Clamp Technique, Cross-Over Studies, Diet, Mediterranean, Lipid Metabolism, Obesity, Abdominal, Non-alcoholic Fatty Liver Disease
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