Cited by 412Liver physiology and pathologyHippo pathway signaling and YAP/TAZLiver Disease Diagnosis and Treatment

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

Mannaerts, Inge, Leite, Sofia Batista, Verhulst, Stefaan, Claerhout, Sofie, Eysackers, Nathalie, Thoen, Lien F.R., Hoorens, Anne, Reynaert, Hendrik, Halder, Georg, van Grunsven, Leo A.·2015·Journal of Hepatology

DOI 10.1016/j.jhep.2015.04.011

Open this paper in CoChat — free account

Abstract

Background & aims Hepatic stellate cell activation is a wound-healing response to liver injury. However, continued activation of stellate cells during chronic liver damage causes excessive matrix deposition and the formation of pathological scar tissue leading to fibrosis and ultimately cirrhosis. The importance of sustained stellate cell activation for this pathological process is well recognized, and several signalling pathways that can promote stellate cell activation have been identified, such as the TGFβ-, PDGF-, and LPS-dependent pathways. However, the mechanisms that trigger and drive the early steps in activation are not well understood. Methods and results We identified the Hippo pathway and its effector YAP as a key pathway that controls stellate cell activation. YAP is a transcriptional co-activator and we found that it drives the earliest changes in gene expression during stellate cell activation. Activation of stellate cells in vivo by CCl4 administration to mice or activation in vitro caused rapid activation of YAP as revealed by its nuclear translocation and by the induction of YAP target genes. YAP was also activated in stellate cells of human fibrotic livers as evidenced by its nuclear localization. Importantly, knockdown of YAP expression or pharmacological inhibition of YAP prevented hepatic stellate cell activation in vitro and pharmacological inhibition of YAP impeded fibrogenesis in mice. Conclusions YAP activation is a critical driver of hepatic stellat…

Integrity signals

Registry

Crossref · 10.1016/j.jhep.2015.04.011

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
Taking Cell-Matrix Adhesions to the Third Dimension
Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842
Elucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370
Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP
Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S.-J., Anders, R. A., Liu, J. O., & Pan, D. (2012) · Genes & Development · doi:10.1101/gad.192856.112 · Cited by 1,452
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252
The emerging roles of YAP and TAZ in cancer
Moroishi, T., Hansen, C. G., & Guan, K. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3876 · Cited by 1,181
Hippo signaling: growth control and beyond
Halder, G. A., & Johnson, R. L. (2010) · Development · doi:10.1242/dev.045500 · Cited by 1,091
Self-citation
Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
Zhou, D., Conrad, C. H., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W. E., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 937

Show all 46 references

Sorted by citations

Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909
Hepatic stellate cells as key target in liver fibrosis
Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485
Mechanobiology of YAP and TAZ in physiology and disease
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981
Self-citation
Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
Dey, A., Varelas, X., & Guan, K.-L. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0070-z · Cited by 860
Wound healing, fibroblast heterogeneity, and fibrosis
desJardins-Park, H. E., Mascharak, S., Griffin, M., Wan, D. C., & Longaker, M. T. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.006 · Cited by 835
The Hippo signalling pathway and its implications in human health and diseases
Fu, M., Hu, Y., Lan, T., Guan, K., Luo, T., & Luo, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01191-9 · Cited by 823
Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis
Schwabe, R. F., Tabas, I., & Pajvani, U. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.311 · Cited by 671
Extracellular matrix as a driver of progressive fibrosis
Herrera, J., Henke, C. A., & Bitterman, P. B. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93557 · Cited by 639
Targeting extracellular matrix stiffness to attenuate disease: from molecular mechanisms to clinical trials
Lampi, M. C., & Reinhart-King, C. A. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0475 · Cited by 551
YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis
Szeto, S. G., Narimatsu, M., Lu, M., He, X., Sidiqi, A. M., Tolosa, M. F., Chan, L., Freitas, K. D., Bialik, J. F., Majumder, S., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050499 · Cited by 478
Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge
Piersma, B., Bank, R. A., & Boersema, M. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00059 · Cited by 465
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
Dupont, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.034 · Cited by 449
Metabolic reprogramming in liver fibrosis
Horn, P., & Tacke, F. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.05.003 · Cited by 432
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
Fan, F., He, Z., Kong, L., Chen, Q., Yuan, Q., Zhang, S., Ye, J., Liu, H., Sun, X., Geng, J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2304 · Cited by 395
YAP/TAZ functions and their regulation at a glance
Pocaterra, A., Romani, P., & Dupont, S. (2020) · Journal of Cell Science · doi:10.1242/jcs.230425 · Cited by 389
Mechanosensing and fibrosis
Tschumperlin, D. J., Ligresti, G., Hilscher, M. B., & Shah, V. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93561 · Cited by 359
Connective tissue growth factor (CTGF) from basics to clinics
Ramazani, Y., Knops, N., Elmonem, M. A., Nguyen, T. Q., Arcolino, F. O., van den Heuvel, L., Levtchenko, E. N., Kuypers, D. R. J., & Goldschmeding, R. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.007 · Cited by 333
The Hippo pathway in intestinal regeneration and disease
Hong, A. W., Meng, Z., & Guan, K. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.59 · Cited by 330
Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis
Patel, S. H., Camargo, F. D., & Yimlamai, D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.047 · Cited by 303
Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury
Liu, Y., Lu, T., Zhang, C., Xu, J., Xue, Z., Busuttil, R. W., Xu, N., Xia, Q., Kupiec‐Weglinski, J. W., & Ji, H. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.05.029 · Cited by 279
YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer
Noguchi, S. F., Saito, A., & Nagase, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113674 · Cited by 295
Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour
Brusatin, G., Panciera, T., Gandin, A., Citron, A., & Piccolo, S. (2018) · Nature Materials · doi:10.1038/s41563-018-0180-8 · Cited by 274
Single-cell transcriptomic analysis reveals a hepatic stellate cell-activation roadmap and myofibroblast origin during liver fibrosis in mice
Yang, W., He, H., Wang, T., Su, N., Zhang, F., Jiang, K., Zhu, J., Zhang, C., Niu, K., Wang, L., et al. (2021) · Hepatology · doi:10.1002/hep.31987 · Cited by 250
The Hippo Pathway in Liver Homeostasis and Pathophysiology
Driskill, J. H., & Pan, D. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-030420-105050 · Cited by 234
Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis
Khomich, O. A., Ivanov, A. V., & Bartosch, B. (2019) · Cells · doi:10.3390/cells9010024 · Cited by 239
Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation
Caliari, S. R., Perepelyuk, M., Cosgrove, B. D., Tsai, S. J., Lee, G. Y., Mauck, R. L., Wells, R. G., & Burdick, J. A. (2016) · Scientific Reports · doi:10.1038/srep21387 · Cited by 220
PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
Martin, K., Pritchett, J. P., Llewellyn, J., Mullan, A. F., Athwal, V. S., Dobie, R., Harvey, E., Zeef, L. A. H., Farrow, S. N., Streuli, C. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12502 · Cited by 223
The balancing act of the liver: tissue regeneration versus fibrosis
Cordero-Espinoza, L., & Huch, M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93562 · Cited by 233
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis
Haak, A. J., Kostallari, E., Sicard, D., Ligresti, G., Choi, K. M., Caporarello, N., Jones, D. L., Tan, Q., Meridew, J. A., Espinosa, A. M. D., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau6296 · Cited by 227
Hippo signalling in the liver: role in development, regeneration and disease
Russell, J. O., & Camargo, F. D. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00571-w · Cited by 207
The Hippo signaling pathway in development and regeneration
Zhong, Z., Jiao, Z., & Yu, F. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113926 · Cited by 223
Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017) · Oncotarget · doi:10.18632/oncotarget.21234 · Cited by 211
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia
Morrow, M. R., Batchuluun, B., Wu, J., Ahmadi, E., Leroux, J. M., Mohammadi-Shemirani, P., Desjardins, E. M., Wang, Z., Tsakiridis, E. E., Lavoie, D. C. T., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.05.004 · Cited by 199
TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts
Vallée, A., & Lecarpentier, Y. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0362-3 · Cited by 205
The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart
Herum, K. M., Lunde, I. G., McCulloch, A. D., & Christensen, G. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6050053 · Cited by 193
Molecular and tissue alterations of collagens in fibrosis
Ricard‐Blum, S., Baffet, G., & Théret, N. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.004 · Cited by 179
The Hippo pathway in normal development and cancer
Maugeri‐Saccà, M., & Maria, R. D. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.12.011 · Cited by 169
Crosstalk between YAP/TAZ and Notch Signaling
Totaro, A., Castellan, M., Biagio, D. D., & Piccolo, S. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.03.001 · Cited by 165
3D in vitro models of liver fibrosis
van Grunsven, L. A. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.004 · Cited by 162
Cancer-associated fibroblasts: how do they contribute to metastasis?
Kwa, M. Q., Herum, K. M., & Brakebusch, C. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09959-0 · Cited by 150
Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
Speight, P., Kofler, M., Szászi, K., & Kapus, A. (2016) · Nature Communications · doi:10.1038/ncomms11642 · Cited by 144
Molecular networks underlying myofibroblast fate and fibrosis
Stempien‐Otero, A., Kim, D., & Davis, J. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.05.002 · Cited by 143
Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis
Li, S., Li, C. R., Zhang, Y., He, X., Chen, X., Zeng, X., Liu, F., Chen, Y., & Chen, J. (2019) · Theranostics · doi:10.7150/thno.35665 · Cited by 143
Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
Francisco, J., Zhang, Y., Jeong, J. I., Mizushima, W., Ikeda, S., Ivessa, A., Oka, S., Zhai, P., Tallquist, M. D., & Del Re, D. P. (2020) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2020.07.009 · Cited by 133
Liver-on-a-Chip models of fatty liver disease
Hassan, S., Sebastian, S., Maharjan, S., Lesha, A., Carpenter, A., Liu, X., Xie, X., Livermore, C., Zhang, Y. S., & Zarrinpar, A. (2020) · Hepatology · doi:10.1002/hep.31106 · Cited by 127
Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways
Heng, B. C., Zhang, X., Aubel, D., Bai, Y., Li, X., Yan, W., Fussenegger, M., & Deng, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00735 · Cited by 133
YAP Activation in Renal Proximal Tubule Cells Drives Diabetic Renal Interstitial Fibrogenesis
Chen, J., Wang, X., Qian, H., Bulus, N. M., Fogo, A. B., Zhang, M., & Harris, R. C. (2020) · Diabetes · doi:10.2337/db20-0579 · Cited by 127
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay8798 · Cited by 122
Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities
Pei, Q., Yi, Q., & Tang, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119671 · Cited by 121
Hedgehog regulates yes‐associated protein 1 in regenerating mouse liver
Swiderska‐Syn, M., Xie, G., Michelotti, G. A., Jewell, M. L., Premont, R. T., Syn, W., & Diehl, A. M. (2016) · Hepatology · doi:10.1002/hep.28542 · Cited by 121
Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling
Xiang, D., Zou, J., Zhu, X., Chen, X., Luo, J., Kong, L., & Zhang, H. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153294 · Cited by 123
Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin
Lefebvre, P., Lalloyer, F., Baugé, E., Pawlak, M., Gheeraert, C., Dehondt, H., Vanhoutte, J., Woitrain, E., Hennuyer, N., Mazuy, C., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92264 · Cited by 117
New Insights into Hippo/YAP Signaling in Fibrotic Diseases
Mia, M. M., & Singh, M. K. (2022) · Cells · doi:10.3390/cells11132065 · Cited by 120
NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling
Zhang, T., He, X., Caldwell, L., Goru, S. K., Severino, L. U., Tolosa, M. F., Misra, P. S., McEvoy, C. M., Christova, T. Y., Liu, Y., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz4028 · Cited by 116
Role of the Hippo Pathway in Fibrosis and Cancer
Kim, C.-L., Choi, S.-H., & Mo, J. (2019) · Cells · doi:10.3390/cells8050468 · Cited by 114
Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis
Zhu, C., Tabas, I., Schwabe, R. F., & Pajvani, U. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00365-6 · Cited by 112
Yes-associated protein in kupffer cells enhances the production of proinflammatory cytokines and promotes the development of nonalcoholic steatohepatitis
Song, K., Kwon, H., Han, C., Chen, W., Zhang, J., Ma, W., Dash, S., Gandhi, C. R., & Wu, T. (2020) · Hepatology · doi:10.1002/hep.30990 · Cited by 110
Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis
He, X., Tolosa, M. F., Zhang, T., Goru, S. K., Ulloa Severino, L., Misra, P. S., McEvoy, C. M., Caldwell, L., Szeto, S. G., Gao, F., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.146243 · Cited by 106
Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?
Zisser, A., Ipsen, D. H., & Tveden‐Nyborg, P. (2021) · Biomedicines · doi:10.3390/biomedicines9040365 · Cited by 112
The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver
Mederacke, I., Filliol, A., Affo, S., Nair, A., Hernandez, C., Sun, Q., Hamberger, F., Brundu, F., Chen, Y., Ravichandra, A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abe5795 · Cited by 103
Targeting YAP-mediated HSC death susceptibility and senescence for treatment of liver fibrosis
Du, K., Maeso-Díaz, R., Oh, S. H., Wang, E., Chen, T., Pan, C., Xiang, K., Dutta, R. K., Wang, X.-F., Chi, J.-T., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000326 · Cited by 102
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH
Baboota, R. K., Rawshani, A., Bonnet, L., Li, X., Yang, H., Mardinoglu, A., Tchkonia, T., Kirkland, J. L., Hoffmann, A., Dietrich, A., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00620-x · Cited by 99
Inflammatory and fibrotic mechanisms in NAFLD—Implications for new treatment strategies
Lee, Y. A., & Friedman, S. L. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13380 · Cited by 104
Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression
Caliari, S. R., Perepelyuk, M., Soulas, E. M., Lee, G. Y., Wells, R. G., & Burdick, J. A. (2016) · Integrative Biology · doi:10.1039/c6ib00027d · Cited by 100
YAP1/Twist promotes fibroblast activation and lung fibrosis that conferred by miR-15a loss in IPF
Chen, Y., Zhao, X., Sun, J., Su, W., Zhang, L., Li, Y., Liu, Y., Zhang, L., Lu, Y., Shan, H., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-018-0250-0 · Cited by 98
Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation
Yan, Y., Zeng, J., Xing, L., & Li, C. (2021) · Biomedicines · doi:10.3390/biomedicines9081014 · Cited by 103
Transcriptional regulation of Hepatic Stellate Cell activation in NASH
Marcher, A.-B., Bendixen, S. M., Terkelsen, M. K., Hohmann, S. S., Hansen, M. H., Larsen, B. D., Mandrup, S., Dimke, H., Detlefsen, S., & Ravnskjaer, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-39112-6 · Cited by 95
p300 Acetyltransferase Is a Cytoplasm‐to‐Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in Transforming Growth Factor β–Stimulated Hepatic Stellate Cells
Wang, Y., Tu, K., Liu, D., Guo, L., Chen, Y., Li, Q., Maiers, J. L., Liu, Z., Shah, V. H., Dou, C., et al. (2019) · Hepatology · doi:10.1002/hep.30668 · Cited by 95
Framework to function: mechanosensitive regulators of gene transcription
Finch-Edmondson, M., & Sudol, M. (2016) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-016-0028-7 · Cited by 93
Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells
Yu, H., Yao, Y., Bu, F., Chen, Y., Wu, Y., Yang, Y., Chen, X., Zhu, Y., Wang, Q., Pan, X., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.01.004 · Cited by 92
Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer
Baroja, I., Kyriakidis, N. C., Halder, G. A., & Moya, I. M. (2024) · Nature Communications · doi:10.1038/s41467-024-46531-1 · Cited by 96
Self-citation
In vitro reversion of activated primary human hepatic stellate cells
Taghdouini, A. E., Najimi, M., Sancho‐Bru, P., Sokal, E. M., & van Grunsven, L. A. (2015) · Fibrogenesis & Tissue Repair · doi:10.1186/s13069-015-0031-z · Cited by 92
Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse diseases
Fu, M., Peng, D., Lan, T., Wei, Y., & Wei, X. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.007 · Cited by 93
Hippo signaling instructs ectopic but not normal organ growth
Kowalczyk, W., Romanelli, L., Atkins, M., Hillen, H., González‐Blas, C. B., Jacobs, J., Xie, J., Soheily, S., Verboven, E., Moya, I. M., et al. (2022) · Science · doi:10.1126/science.abg3679 · Cited by 87
Self-citation
Treatment of type 2 diabetes with the designer cytokine IC7Fc
Findeisen, M., Allen, T. L., Henstridge, D. C., Kammoun, H., Brandon, A. E., Baggio, L. L., Watt, K. I., Pal, M., Cron, L., Estevez, E., et al. (2019) · Nature · doi:10.1038/s41586-019-1601-9 · Cited by 86
Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling
Perumal, N., Perumal, M. K., Devaraj, H., & NiranjaliDevaraj, S. (2017) · Biochimie · doi:10.1016/j.biochi.2017.05.017 · Cited by 86
Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype
Anorga, S., Overstreet, J. M., Falke, L. L., Tang, J., Goldschmeding, R., Higgins, P. J., & Samarakoon, R. (2018) · The FASEB Journal · doi:10.1096/fj.201700722r · Cited by 85
YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer
Song, H., Lü, T., Han, D., Zhang, J., Gan, L., Xu, C., Liu, S., Li, P., Zhang, K., Hu, Z., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0932 · Cited by 83
YAP/TAZ Are Essential for TGF-β2–Mediated Conjunctival Fibrosis
Futakuchi, A., Inoue, T., Wei, F., Inoue-Mochita, M., Fujimoto, T., Tomizawa, K., & Tanihara, H. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24258 · Cited by 84
Mechanotransduction in the pathogenesis of non-alcoholic fatty liver disease
Mitten, E. K., & Baffy, G. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.08.028 · Cited by 85
TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression
Jorgenson, A. J., Choi, K. M., Sicard, D., Smith, K. M. J., Hiemer, S. E., Varelas, X., & Tschumperlin, D. J. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00205.2016 · Cited by 79
Hippo Signaling in the Liver – A Long and Ever-Expanding Story
Manmadhan, S., & Ehmer, U. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00033 · Cited by 79
Initiation of hepatic stellate cell activation extends into chronic liver disease
De Smet, V., Eysackers, N., Merens, V., Kazemzadeh Dastjerd, M., Halder, G., Verhulst, S., Mannaerts, I., & van Grunsven, L. A. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04377-1 · Cited by 78
Self-citation
Rejuvenation of tendon stem/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1
Lu, J., Yang, X., He, C., Chen, Y., Li, C., Li, C., Chen, Y., Wu, Y., Xiang, Z., Kang, J., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.02.018 · Cited by 77
Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis
Guo, Q., Furuta, K., Islam, S., Caporarello, N., Kostallari, E., Dielis, K., Tschumperlin, D. J., Hirsova, P., & Ibrahim, S. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.983255 · Cited by 73
3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway
Wang, N., Li, X., Zhong, Z., Qiu, Y., Liu, S., Wu, H., Tang, X., Chen, C., Fu, Y., Chen, Q., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01138-2 · Cited by 75
Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells
Taghdouini, A. E., Sørensen, A. L., Reiner, A. H., Coll, M., Verhulst, S., Mannaerts, I., Øie, C. I., Smedsrød, B. H., Najimi, M., Sokal, E. M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4925 · Cited by 72
Self-citation
Screening for YAP inhibitors identifies statins as modulators of fibrosis
Santos, D. M., Pantano, L., Pronzati, G., Grasberger, P., Probst, C. K., Black, K. E., Spinney, J. J., Hariri, L. P., Nichols, R., Lin, Y., et al. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0296oc · Cited by 72
Matrix Mechanics as Regulatory Factors and Therapeutic Targets in Hepatic Fibrosis
Chen, G., Xia, B., Fu, Q., Xiang, H., Wang, F., Chen, Z., & Lv, Y. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37500 · Cited by 75
The m6A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis
Li, Y., Kang, X., Zhou, Z., Pan, L., Chen, H., Liang, X., Chu, J., Dong, S., Liu, C., Yu, S., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.07.020 · Cited by 70
FAK, vinculin, and talin control mechanosensitive YAP nuclear localization
Holland, E. N., Fernández, M., Zhou, D. W., O’Neill, E. B., Woodfolk, A. U., Mora‐Boza, A., Fu, J., Schlaepfer, D. D., & García, A. J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122542 · Cited by 78
Mechanochemical control of epidermal stem cell divisions by B-plexins
Chen, J., Javed, A., Kaiser, L., Nava, M. M., Xu, R. C., Brandt, D. T., Zhao, D., Mayer, B., Fernández-Baldovinos, J., Zhou, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21513-9 · Cited by 73
Taurocholic acid promotes hepatic stellate cell activation via S1PR2/p38 MAPK/YAP signaling under cholestatic conditions
Yang, J., Tang, X., Zhu, L., Chen, M., & Sun, L. (2023) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0327 · Cited by 70
Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury
Konishi, T., Schuster, R. M., & Lentsch, A. B. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00153.2017 · Cited by 70
Liquiritigenin inhibits hepatic fibrogenesis and TGF-β1/Smad with Hippo/YAP signal
Lee, E. H., Park, K., Kim, K.-Y., Lee, J., Jang, E. J., Ku, S., Kim, S. C., Suk, H. Y., Park, J. Y., Baek, S. Y., et al. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.12.003 · Cited by 70
The anti‐hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes‐associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy
Ge, M., Liu, H., Zhang, Y., Li, N., Zhao, S., Zhao, W., Zhen, Y., Yu, J., He, H., & Shao, R. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13766 · Cited by 69
Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
Chakraborty, S., & Hong, W. (2018) · Cancers · doi:10.3390/cancers10020045 · Cited by 65
The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix
Matsuda, M., & Seki, E. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111556 · Cited by 65
Icariin attenuates bleomycin-induced pulmonary fibrosis by targeting Hippo/YAP pathway
Du, W., Tang, Z., Yang, F., Liu, X., & Dong, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112152 · Cited by 61

Authors: Mannaerts, I., Leite, S. B., Verhulst, S., Claerhout, S., Eysackers, N., Thoen, L. F. R., Hoorens, A., Reynaert, H., Halder, G., & van Grunsven, L. A.
Affiliations: Vrije Universiteit Brussel (BE)
KU Leuven (BE)
Universitair Ziekenhuis Brussel (BE)
Corresponding author: van Grunsven, Leo A.
ORCID: Mannaerts, Inge
Leite, Sofia Batista
Verhulst, Stefaan
Claerhout, Sofie
Hoorens, Anne
Reynaert, Hendrik
Halder, Georg
van Grunsven, Leo A.
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2015-09
Volume: 63
Issue: 3
Pages: 679-688
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2015.04.011
OpenAlex: W2154530183
Cited by: 410
References: 46
Citations by year: 2026: 37 · 2025: 44 · 2024: 43 · 2023: 29 · 2022: 60 · 2021: 49 · 2020: 35 · 2019: 38 · 2018: 29 · 2017: 23 · 2016: 19 · 2015: 4
FWCI: 14.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: YAP, Hippo signaling pathway, hepatic stellate cell activation, liver fibrosis, YAP inhibition, carbon tetrachloride-induced liver injury, nuclear translocation, transcriptional coactivator, liver cirrhosis, fibrogenesis
MeSH terms: Hippo Signaling Pathway, YAP-Signaling Proteins, Animals, Humans, Liver Cirrhosis, Mice, Inbred BALB C, Phosphoproteins, Transcription Factors, Signal Transduction, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Adaptor Proteins, Signal Transducing, Mice, Hepatic Stellate Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks