Design, fabrication and evaluation of a conforming circumpolar peripheral nerve cuff electrode for acute experimental use
Open accessAbstract
Nerve cuff electrodes are a principle tool of basic and applied electro-neurophysiology studies and are championed for their ability to achieve good nerve recruitment with low thresholds. We describe the design and method of fabrication for a novel circumpolar peripheral nerve electrode for acute experimental use. This cylindrical cuff-style electrode provides approximately 270° of radial electrode contact with a nerve for each of an arbitrary number of contacts, has a profile that allows for simple placement and removal in an acute nerve preparation, and is designed for adjustment of the cylindrical diameter to ensure a close fit on the nerve. For each electrode, the electrical contacts were cut from 25 μm platinum foil as an array so as to maintain their positions relative to each other within the cuff. Lead wires were welded to each intended contact. The structure was then molded in silicone elastomer, after which the individual contacts were electrically isolated. The final electrode was curved into a cylindrical shape with an inner diameter corresponding to that of the intended target nerve. The positions of these contacts were well maintained during the molding and shaping process and failure rates during fabrication due to contact displacements were very low. Established electrochemical measurements were made on one electrode to confirm expected behavior for a platinum electrode and to measure the electrode impedance to applied voltages at different frequencies. These electrodes have been successfully used for nerve stimulation, recording, and conduction block in a number of different acute animal experiments by several investigators.
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Existing extraneural electrodes have at least one of the following drawbacks: large mechanical and geometrical mismatches and complicated surgical implantation procedures.
“Although promising, existing extraneural electrodes have at least one of the following drawbacks: large mechanical and geometrical mismatches and complicated surgical implantation procedures.”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [8]
Large mechanical and geometrical mismatches still exist at the neural interfaces of first-generation extraneural electrodes.
“Large mechanical and geometrical mismatches still exist at the neural interfaces.”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [8]
First-generation extraneural electrodes, including traditional 3D cuff electrodes, helical electrodes, and flat interface nerve electrodes, are made of silicone rubber and platinum.
“the first-generation extraneural electrodes, including traditional 3D cuff electrodes, helical electrodes, and flat interface nerve electrodes, are made of silicone rubber (thickness, ~0.5 mm; modulus, ~2 MPa) and platinum (thickness, ~25 μm; modulus, ~200 GPa) (5–8).”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [8]
The EI value of the twining electrodes is ~1.0 × 10−10 N·m2, while traditional silicone rubber- and PI-based extraneural electrodes have EI values of ~2.1 × 10−7 N·m2 and ~4.6 × 10−10 N·m2, respectively.
“The EI values of traditional silicone rubber– and PI-based extraneural electrodes are usually ~2.1 × 10−7 N·m2 and ~4.6 × 10−10 N·m2, respectively (5, 8, 9, 43), while the EI value of the twining electrodes is ~1.0 × 10−10 N·m2 (note S2).”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [8]
Current peripheral nerve interfaces have electrodes that vary in number of contacts, separated by hundreds of micrometers or several millimeters.
“Current peripheral nerve interfaces have electrodes that vary in their number of contacts, which can be separated by hundreds of micrometers [2,4,5,[11][12][13] or several millimeters [3,7,14].”
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Cites
Neural Stimulation and Recording Electrodes
Cogan, S. F. (2008) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.10.061807.160518 · Cited by 2,243 · see citing works
Electrical stimulation of excitable tissue: design of efficacious and safe protocols
Merrill, D. R., Bikson, M., & Jefferys, J. G. R. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.020 · Cited by 2,078 · see citing works
Navarro, X., Krueger, T. B., Lago, N., Micera, S., Stieglitz, T., & Dario, P. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10303.x · Cited by 845 · cited 2× · see citing works
“This positions the electrical interface close to the neural tissue, resulting in lower stimulus threshold currents and a subsequent decrease in the power demands on a stimulator system relative to other types of electrodes, such as epimysial or intramuscular electrodes (Navarro et al, 2005).”
BackgroundImpedance Characterization and Modeling of Electrodes for Biomedical Applications
Franks, W., Schenker, I., Schmutz, P., & Hierlemann, A. R. (2005) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2005.847523 · Cited by 660 · see citing works
A spiral nerve cuff electrode for peripheral nerve stimulation
Naples, G. G., Mortimer, J. T., Scheiner, A., & Sweeney, J. D. (1988) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.8670 · Cited by 415 · see citing works
Functionally selective peripheral nerve stimulation with a flat interface nerve electrode
Tyler, D. J., & Durand, D. M. (2002) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2002.806840 · Cited by 398 · cited 1× · see citing works
“…have contributed important innovations such as a low activation threshold (Navarro et al, 2005), chronic safety (Naples et al, 1988; Agnew et al, 1989), fascicular selectivity (Veraart et al, 1993; Tyler and Durand, 2002) and manipulation of longitudinal current flow (Sweeney and Mortimer, 1968).”
BackgroundSelective control of muscle activation with a multipolar nerve cuff electrode
Veraart, C., Grill, W. M., & Mortimer, J. T. (1993) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.237694 · Cited by 320 · see citing works
Selective Electrical Interfaces with the Nervous System
Rutten, W. L. C. (2002) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.4.020702.153427 · Cited by 276 · see citing works
High‐frequency electrical conduction block of mammalian peripheral motor nerve
Bhadra, N., & Kilgore, K. L. (2005) · Muscle & Nerve · doi:10.1002/mus.20428 · Cited by 239 · see citing works
Self-citationCuff electrodes for chronic stimulation and recording of peripheral nerve activity
Loeb, G. E., & Peck, R. A. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00123-9 · Cited by 215 · see citing works
Agnew, W. F., McCreery, D. B., Yuen, T. G. H., & Bullara, L. A. (1989) · Annals of Biomedical Engineering · doi:10.1007/bf02364272 · Cited by 185 · see citing works
Optimum electrode geometry for spinal cord stimulation: The narrow bipole and tripole
Holsheimer, J., & Wesselink, W. A. (1997) · Medical & Biological Engineering & Computing · doi:10.1007/bf02525529 · Cited by 125 · see citing works
High frequency electrical conduction block of the pudendal nerve
Bhadra, N., Bhadra, N., Kilgore, K. L., & Gustafson, K. J. (2006) · Journal of Neural Engineering · doi:10.1088/1741-2560/3/2/012 · Cited by 118 · see citing works
Self-citationElectrical properties of platinum electrodes: Impedance measurements and time-domain analysis
de Boer, R. W., & van Oosterom, A. (1978) · Medical & Biological Engineering & Computing · doi:10.1007/bf02442925 · Cited by 108 · see citing works
Functional electrical stimulation
Rushton, D. N. (1997) · Physiological Measurement · doi:10.1088/0967-3334/18/4/001 · Cited by 102 · see citing works
An Asymmetric Two Electrode Cuf for Generation of Unidirectionally Propagated Action Potentials
Sweeney, J., & Mortimer, J. T. (1986) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1986.325818 · Cited by 80 · see citing works
A flexible method for fabrication of nerve cuff electrodes
Haugland, M. K. (2002) · Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/iembs.1996.656992 · Cited by 79 · see citing works
Böger, A., Bhadra, N., & Gustafson, K. J. (2007) · Neurourology and Urodynamics · doi:10.1002/nau.20538 · Cited by 77 · see citing works
Self-citationEffects of ramped amplitude waveforms on the onset response of high-frequency mammalian nerve block
Miles, J. D., Kilgore, K. L., Bhadra, N., et al. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/4/005 · Cited by 70 · see citing works
Self-citationAckermann, D. M., Bhadra, N., Foldes, E. L., Wang, X.-F., & Kilgore, K. L. (2010) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2010.2071882 · Cited by 52 · see citing works
Self-citationAckermann, D. M., Foldes, E. L., Bhadra, N., & Kilgore, K. L. (2009) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2009.2034069 · Cited by 52 · see citing works
Self-citationAckermann, D. M., Foldes, E. L., Bhadra, N., & Kilgore, K. L. (2009) · Muscle & Nerve · doi:10.1002/mus.21496 · Cited by 47 · see citing works
Self-citationSchuettler, M. (2007) · Conference proceedings · doi:10.1109/iembs.2007.4352254 · Cited by 37 · see citing works
Variable Patterned Pudendal Nerve Stimuli Improves Reflex Bladder Activation
Bruns, T. M., Bhadra, N., & Gustafson, K. J. (2008) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.914460 · Cited by 34 · see citing works
Self-citationMailley, S., Hyland, M., Mailley, P., McLaughlin, J. A., & McAdams, E. T. (2004) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2003.10.033 · Cited by 33 · see citing works
Lewandowski, B. E., Kilgore, K. L., & Gustafson, K. J. (2009) · Annals of Biomedical Engineering · doi:10.1007/s10439-009-9770-6 · Cited by 28 · see citing works
Self-citationThe Electrochemistry Of Electrical Stimulation
Robblee, L. S., & Rose, T. L. (2005) · doi:10.1109/iembs.1990.691848 · Cited by 21 · see citing works
Combined direct current and high frequency nerve block for elimination of the onset response
Kilgore, K. L., Foldes, E., Ackermann, D. M., et al. (2009) · doi:10.1109/iembs.2009.5333642 · Cited by 14 · see citing works
Self-citationMariano, T. Y., Bhadra, N., & Gustafson, K. J. (2009) · Neurourology and Urodynamics · doi:10.1002/nau.20717 · Cited by 10 · see citing works
Self-citationPlatinum stimulating electrodes in physiological media
Rozman, J., MilosIev, I., & Jenko, M. (2000) · Journal of Medical Engineering & Technology · doi:10.1080/03091900050135040 · Cited by 7 · see citing works
A stimulating electrode for nerves
McCarty, L. P. (1965) · Journal of Applied Physiology · doi:10.1152/jappl.1965.20.3.542 · Cited by 6 · see citing works
A constant-contact stimulating electrode for nerves
Dubkin, C. (1970) · Journal of Applied Physiology · doi:10.1152/jappl.1970.28.3.350 · Cited by 6 · see citing works
Peripheral nerve electrode applicator
GARDINER, A. S. (1967) · Anaesthesia · doi:10.1111/j.1365-2044.1967.tb02772.x · Cited by 2 · see citing works
REDUCTION OF THE ONSET RESPONSE IN HIGH FREQUENCY NERVE BLOCK
Ackermann, D. M. (2010) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Hoffer JA Kallesoe K Nerve cuff electrodes for prosthetic and research applications 1999 Conference Proceedings of the International FES Society Sendai, Japan
- Lahowetz EA Bhadra N Kilgore KL High Frequency Conduction Block of Sensory Nerves 2007 Conference Proceedings of the International FES Society Philadelphia, PA
Cited by
Sorted by citations
Zhang, Y., Zheng, N., Cao, Y., Wang, F., Wang, P., Ma, Y., Lu, B., Hou, G., Fang, Z., Liang, Z., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw1066 · Cited by 314 · see citing works
Role of the vagus nerve in the development and treatment of diet‐induced obesity
de Lartigue, G. (2016) · The Journal of Physiology · doi:10.1113/jp271538 · Cited by 238 · see citing works
Wark, H. A. C., Sharma, R., Mathews, K. S., Fernandez, E., Yoo, J., Christensen, B., Tresco, P., Rieth, L., Solzbacher, F., Normann, R. A., et al. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/4/045003 · Cited by 148 · see citing works
A review for the peripheral nerve interface designer
Larson, C. E., & Meng, E. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108523 · Cited by 133 · see citing works
Lee, Y. J., Kim, H.-J., Do, S. H., Kang, J. Y., & Lee, S. H. (2016) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2016.06.169 · Cited by 54 · see citing works
- Authors
- Foldes, E. L., Ackermann, D. M., Bhadra, N., Kilgore, K. L., & Bhadra, N.
- Affiliations
- Case Western Reserve University (US)
- MetroHealth Medical Center (US)
- Louis Stokes Cleveland VA Medical Center (US)
- Corresponding author
- Bhadra, Narendra
- Venue
- Journal of Neuroscience Methods
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 196
- Issue
- 1
- Pages
- 31-37
- ISSN
- 0165-0270 (ISSN-L)
- PMC
- PMC3042051
- OpenAlex
- W2063399457
- Cited by
- 61
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 6 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 3 · 2013: 7 · 2012: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Journal of Neuroscience Methods (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK077089, R01-EB-002091)
- National Institute of Biomedical Imaging and Bioengineering (R01-DK077089, R01-EB-002091)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
- Keywords
- cuff electrodes, peripheral nerve recording, peripheral nerve stimulation, electrode fabrication, electrode impedance, nerve conduction block
- MeSH terms
- Animals, Electric Stimulation, Electrodes, Implanted, Equipment Design, Humans, Peripheral Nerves, Platinum
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