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Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change
Abstract
Health-related quality of life (HQOL) is poor in multiple sclerosis (MS) but the clinical precipitants of the problem are not well understood. Previous correlative studies demonstrated relationships between various clinical parameters and diminished HQOL in MS. Unfortunately, these studies failed to account for multiple predictors in the same analysis. We endeavored to determine what clinical parameters account for most variance in predicting HQOL, and employability, while accounting for disease course, physical disability, fatigue, cognition, mood disorder, personality, and behavior disorder. In 120 MS patients, we measured HQOL (MS Quality of Life-54) and vocational status (employed vs. disabled) and then conducted detailed clinical testing. Data were analyzed by linear and logistic regression methods. MS patients reported lower HQOL (p<0.001) and were more likely to be disabled (45% of patients vs. 0 controls). Physical HQOL was predicted by fatigue, depression, and physical disability. Mental HQOL was associated with only depression and fatigue. In contrast, vocational status was predicted by three cognitive tests, conscientiousness, and disease duration (p<0.05). Thus, for the first time, we predicted HQOL in MS while accounting for measures from these many clinical domains. We conclude that self-report HQOL indices are most strongly predicted by measures of depression, whereas vocational status is predicted primarily by objective measures of cognitive function. The findings highlight core clinical problems that merit early identification and further research regarding the development of effective treatment.
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“More specifically, the facet of conscientiousness, in conjunction with depression, accounted for 63% of the variance when predicting overall QOL.46”
From Quality of life and psychological well-being in the early stages of multiple sclerosis (MS): importance of adopting a biopsychosocial model (2018) · cites this paper as [46]
In the citing paper
“With regard to disease related factors, fatigue and cognitive impairment have been found to be the greatest culprits in reducing QOL in MS.”
From Quality of life and psychological well-being in the early stages of multiple sclerosis (MS): importance of adopting a biopsychosocial model (2018) · cites this paper as [25]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
(1992) · PubMed · Cited by 33,716
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · cited 1×
“Finally, behavior disorder was measured with the Neuropsychiatric Inventory [41] which assesses delusions, hallucinations, aggression, depression, anxiety, euphoria, apathy, disinhibition, lability, aberrant motor behaviors, and caregiver distress.”
MethodNew diagnostic criteria for multiple sclerosis: Guidelines for research protocols
Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969
Defining the clinical course of multiple sclerosis
LUBLIN, F. D., & Reingold, S. C. (1996) · Neurology · doi:10.1212/wnl.46.4.907 · Cited by 3,762
Paced Auditory Serial-Addition Task: A Measure of Recovery from Concussion
Gronwall, D. M. A. (1977) · Perceptual and Motor Skills · doi:10.2466/pms.1977.44.2.367 · Cited by 2,395 · cited 1×
“This battery included the Judgment of Line Orientation Test (JLO) [28], the Controlled Oral Word Association Test (COWAT) [28], Rao’s adaptations [29] of the Paced Auditory Serial Addition Test (PASAT) [30] and the Symbol Digit Modalities Test (SDMT) [31], the total learning, delayed recall, and recognition indices fr…”
Method
Cited by
Sorted by citations
Benedict, R. H. B., DeLuca, J., Phillips, G. A., LaRocca, N. G., Hudson, L. D., & Rudick, R. A. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458517690821 · Cited by 846
Self-citationValidity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)
Benedict, R. H. B., Cookfair, D. L., Gavett, R. A., Gunther, M. W., Munschauer, F. E., Garg, N., & Weinstock‐Guttman, B. (2006) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617706060723 · Cited by 800
Self-citationMitchell, A. J., Benito‐León, J., González, J.-M. M., & Navarro, J. R. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70166-6 · Cited by 546
Brain health: time matters in multiple sclerosis
Giovannoni, G., Butzkueven, H., Dhib-Jalbut, S. S., Hobart, J. C., Kobelt, G., Pepper, G., Sormani, M. P., Thalheim, C., Traboulsee, A. L., & Vollmer, T. L. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2016.07.003 · Cited by 480
Brief International Cognitive Assessment for MS (BICAMS): international standards for validation
Benedict, R., Amato, M., Boringa, J., Brochet, B., Foley, F., Fredrikson, S., Hämäläinen, P., Hartung, H., Krupp, L., Penner, I., et al. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-55 · Cited by 430
Self-citationThe benefits of exercise training in multiple sclerosis
Motl, R. W., & Pilutti, L. A. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.136 · Cited by 403
Motl, R. W., McAuley, E., Snook, E. M., & Gliottoni, R. C. (2008) · Psychology Health & Medicine · doi:10.1080/13548500802241902 · Cited by 391
Risk factors for and management of cognitive dysfunction in multiple sclerosis
Benedict, R., & Zivadinov, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.61 · Cited by 400
Self-citationNeocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis.
Benedict, R., Bruce, J. M., Dwyer, M., Abdelrahman, N., Hussein, S., Weinstock-Guttman, B., Garg, N., Munschauer, F., & Zivadinov, R. (2006) · Archives of Neurology · doi:10.1001/archneur.63.9.1301 · Cited by 323
Self-citationInternational Journal of Collaborative Research on Internal Medicine & Public Health
Valdivia, J. R. M. (2021) · Journal of Womens Health Issues and Care · Cited by 300
Cognitive and psychosocial features of childhood and juvenile MS
Amato, M. P., Goretti, B., Ghezzi, A., Lori, S., Zipoli, V., Portaccio, E., Moiola, L., Falautano, M., Caro, M. F. D., López, M. D. P. S., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000312276.23177.fa · Cited by 287
Bruce, J. M., Hancock, L. M., Arnett, P., & Lynch, S. (2010) · Journal of behavioral medicine · doi:10.1007/s10865-010-9247-y · Cited by 297
Drake, A. S., Weinstock‐Guttman, B., Morrow, S., Hojnacki, D. W., Munschauer, F. E., & Benedict, R. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509354552 · Cited by 264
Self-citationFurther validation of the Multidimensional Fatigue Inventory in a US adult population sample
Lin, J.-M. S., Brimmer, D. J., Maloney, E. M., Nyarko, E., BeLue, R., & Reeves, W. C. (2009) · Population Health Metrics · doi:10.1186/1478-7954-7-18 · Cited by 263
Morrow, S. A., Drake, A. S., Zivadinov, R., Munschauer, F. E., Weinstock‐Guttman, B., & Benedict, R. H. B. (2010) · The Clinical Neuropsychologist · doi:10.1080/13854046.2010.511272 · Cited by 251
Self-citationA prospective study of patterns of fatigue in multiple sclerosis
Lerdal, A., Celius, E. G., Krupp, L., & Dahl, A. A. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01974.x · Cited by 235
Contribution of impaired mobility and general symptoms to the burden of multiple sclerosis
Zwibel, H. (2009) · Advances in Therapy · doi:10.1007/s12325-009-0082-x · Cited by 225
Strober, L. B., Englert, J. J., Munschauer, F. E., Weinstock‐Guttman, B., Rao, S. M., & Benedict, R. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509106615 · Cited by 217
Self-citationCognitive and psychosocial features in childhood and juvenile MS
Amato, M. P., Goretti, B., Ghezzi, A., Lori, S., Zipoli, V., Moiola, L., Falautano, M., Caro, M. F. D., Viterbo, R. G., Patti, F., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f4d821 · Cited by 219
Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways
Sepulcre, J., Masdeu, J. C., Goñi, J., Arrondo, G., de Mendizábal, N. V., Bejarano, B., & Villoslada, P. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458508098373 · Cited by 212
Treatment Optimization in MS: Canadian MS Working Group Updated Recommendations
Freedman, M. S., Selchen, D. H., Arnold, D. L., Prat, A., Banwell, B., Yeung, M., Morgenthau, D., & Lapierre, Y. (2013) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100014244 · Cited by 199
Benedict, R., DUQUIN, J. A., Jurgensen, S., Rudick, R., Feitcher, J., Munschauer, F. E., Panzara, M. A., & Weinstock‐Guttman, B. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458508090923 · Cited by 182
Self-citationThe influence of cognitive impairment on health-related quality of life in neurological disease
Mitchell, A. J., Kemp, S., Benito‐León, J., & Reuber, M. (2010) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2009.00439.x · Cited by 185
The S ymbol D igit M odalities T est as sentinel test for cognitive impairment in multiple sclerosis
Schependom, J. V., D'hooghe, M. B., Cleynhens, K., D’hooge, M., Haelewyck, M.-C., Keyser, J. D., & Nagels, G. (2014) · European Journal of Neurology · doi:10.1111/ene.12463 · Cited by 169
Unemployment in multiple sclerosis: the contribution of personality and disease
Strober, L., Christodoulou, C., Benedict, R., Westervelt, H., Melville, P., Scherl, W., Weinstock-Guttman, B., Rizvi, S., Goodman, A., & Krupp, L. (2012) · Multiple Sclerosis · doi:10.1177/1352458511426735 · Cited by 177
Self-citationRuet, A., Deloire, M., Lamargue-Hamel, D., Ouallet, J., Petry, K. G., & Brochet, B. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6705-1 · Cited by 162
Kalmar, J. H., Gaudino, E. A., Moore, N. B., Halper, J., & DeLuca, J. (2008) · Neuropsychology · doi:10.1037/0894-4105.22.4.442 · Cited by 160
Fatigue in multiple sclerosis – Insights into evaluation and management
Ayache, S. S., & Chalah, M. A. (2017) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2017.02.004 · Cited by 163
Upper and Lower Extremity Motor Function and Cognitive Impairment in Multiple Sclerosis
Benedict, R. H. B., Holtzer, R., Motl, R. W., Foley, F. W., Kaur, S., Hojnacki, D. W., & Weinstock‐Guttman, B. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711000403 · Cited by 159
Self-citationBrain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options
Andravizou, A., Dardiotis, E., Artemiadis, A., Sokratous, M., Siokas, V., Tsouris, Z., Aloizou, A., Nikolaidis, I., Bakirtzis, C., Tsivgoulis, G. K., et al. (2019) · Autoimmunity Highlights · doi:10.1186/s13317-019-0117-5 · Cited by 167
Goretti, B., Portaccio, E., Zipoli, V., Hakiki, B., Siracusa, G., Sorbi, S., & Amato, M. P. (2009) · Neurological Sciences · doi:10.1007/s10072-008-0009-3 · Cited by 151
Campbell, J. L., Rashid, W., Cercignani, M., & Langdon, D. W. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2016-134071 · Cited by 144
Fatigue in Multiple Sclerosis: Neural Correlates and the Role of Non-Invasive Brain Stimulation
Chalah, M. A., Riachi, N. J., Ahdab, R., Créange, A., Lefaucheur, J., & Ayache, S. S. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00460 · Cited by 146
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Raggi, A., Covelli, V., Schiavolin, S., Scaratti, C., Leonardi, M., & Willems, M. (2015) · Disability and Rehabilitation · doi:10.3109/09638288.2015.1070295 · Cited by 145
Predictors of quality of life among multiple sclerosis patients: a comprehensive analysis
Yamout, B., Issa, Z. A., Herlopian, A., Bejjani, M. E., Khalifa, A., Ghadieh, A. S., & Habib, R. (2013) · European Journal of Neurology · doi:10.1111/ene.12046 · Cited by 135
How do I sound to me? Perceived changes in communication in Parkinson's disease
Miller, N., Noble, E. J., Jones, D. E., Allcock, L. M., & Burn, D. J. (2007) · Clinical Rehabilitation · doi:10.1177/0269215507079096 · Cited by 136
Patti, F., Pozzilli, C., Montanari, E., Pappalardo, A., Piazza, L., Levi, A., Onesti, E., Pesci, I., & the Italian Study Group on Quality of Life in MS (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506073511 · Cited by 135
Benedict, R. H. B., Smerbeck, A. M., Parikh, R. S., Rodgers, J. D., Cadavid, D., & Erlanger, D. M. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458511435717 · Cited by 130
Self-citationGlanz, B. I., Healy, B. C., Rintell, D. J., Jaffin, S. K., Bakshi, R., & Weiner, H. L. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.11.004 · Cited by 124
Self-citationHonarmand, K., Akbar, N., Kou, N., & Feinstein, A. (2010) · Journal of Neurology · doi:10.1007/s00415-010-5736-8 · Cited by 117
Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis
Stankiewicz, J. M., Glanz, B. I., Healy, B. C., Arora, A., Neema, M., Benedict, R. H. B., Guss, Z. D., Tauhid, S., Buckle, G. J., Houtchens, M. K., et al. (2009) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2009.00449.x · Cited by 119
Self-citationMorrow, S., O'Connor, P. W., Polman, C. H., Goodman, A. D., Kappos, L., Lublin, F., Rudick, R., Jurgensen, S., Paes, D., Forrestal, F., et al. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510378021 · Cited by 119
Self-citationCognitive Dysfunctions and Assessments in Multiple Sclerosis
Oreja-Guevara, C., Blanco, T. A., Ruiz, L. B., Pérez, M. Á. H., Meca-Lallana, V., & Ramió-Torrentá, L. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00581 · Cited by 102
Fernández, Ó., Baumstarck, K., Siméoni, M.-C., Auquier, P., & on behalf of the MusiQoL study group (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511407951 · Cited by 108
Pathways between physical activity and quality of life in adults with multiple sclerosis.
Motl, R. W., & McAuley, E. (2009) · Health Psychology · doi:10.1037/a0015985 · Cited by 106
Determinants of quality of life in relapsing-remitting and progressive multiple sclerosis
Yalachkov, Y., Soydaş, D., Bergmann, J., Frisch, S., Behrens, M., Foerch, C., & Gehrig, J. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.01.049 · Cited by 103
Validating Neuro-QoL short forms and targeted scales with people who have multiple sclerosis
Miller, D. M., Béthoux, F., Victorson, D. E., Nowinski, C. J., Buono, S. K., Lai, J., Wortman, K., Burns, J. L., Moy, C. S., & Cella, D. F. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515599450 · Cited by 103
Morrow, S., Weinstock‐Guttman, B., Munschauer, F. E., Hojnacki, D. W., & Benedict, R. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509106213 · Cited by 102
Self-citationHonan, C. A., Brown, R. F., & Batchelor, J. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715000053 · Cited by 107
Validity of the California Verbal Learning Test–II in Multiple Sclerosis
Stegen, S., Stepanov, I. I., Cookfair, D. L., Schwartz, E. S., Hojnacki, D. W., Weinstock‐Guttman, B., & Benedict, R. H. B. (2009) · The Clinical Neuropsychologist · doi:10.1080/13854040903266910 · Cited by 100
Self-citationSonder, J. M., Burggraaff, J., Knol, D. L., Polman, C. H., & Uitdehaag, B. M. J. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458513501570 · Cited by 99
Strober, L. B. (2018) · Disability and health journal · doi:10.1016/j.dhjo.2018.05.003 · Cited by 99
Illness perception and health-related quality of life in multiple sclerosis.
Spain, L. A., Tubridy, N., Kilpatrick, T. J., Adams, S. J., & Holmes, A. C. N. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00895.x · Cited by 97
Iaffaldano, P., Viterbo, R. G., Paolicelli, D., Lucchese, G., Portaccio, E., Goretti, B., Direnzo, V., D’Onghia, M., Zoccolella, S., Amato, M. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035843 · Cited by 98
Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis
Benedict, R. H. B., Bruce, J. M., Dwyer, M. G., Weinstock‐Guttman, B., Tjoa, C., Tavazzi, E., Munschauer, F. E., & Zivadinov, R. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458507075592 · Cited by 97
Self-citationSleep and Cognitive Function in Multiple Sclerosis
Braley, T. J., Kratz, A. L., Kaplish, N., & Chervin, R. D. (2016) · Sleep · doi:10.5665/sleep.6012 · Cited by 97
Progressive multiple sclerosis, cognitive function, and quality of life
Chow, H. H., Schreiber, K. I., Magyari, M., Ammitzbøll, C., Börnsen, L. S., Christensen, J. R., Ratzer, R. L., Sørensen, P. S., & Sellebjerg, F. T. (2018) · Brain and Behavior · doi:10.1002/brb3.875 · Cited by 97
Cognitive impairment in multiple sclerosis
Hoffmann, S., Tittgemeyer, M., & von Cramon, D. Y. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32810c8e87 · Cited by 93
Parmenter, B. A., Zivadinov, R., Kerenyi, L., Gavett, R. A., Weinstock‐Guttman, B., Dwyer, M. G., Garg, N., Munschauer, F. E., & Benedict, R. H. B. (2006) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390600672163 · Cited by 93
Self-citationDiagnosis and Treatment of Depression Comorbid with Neurologic Disorders
Raskind, M. A. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.09.011 · Cited by 89
Effects of acute relapses on neuropsychological status in multiple sclerosis patients
Morrow, S. A., Jurgensen, S., Forrestal, F., Munchauer, F. E., & Benedict, R. H. B. (2011) · Journal of Neurology · doi:10.1007/s00415-011-5975-3 · Cited by 88
Self-citationThe incremental value of neuropsychological assessment: A critical review
Donders, J. (2020) · The Clinical Neuropsychologist · doi:10.1080/13854046.2019.1575471 · Cited by 87
Being Kind to Your Future Self: Probability Discounting of Health Decision-Making
Bruce, J. M., Bruce, A. S., Catley, D., LYNCH, S. G., Goggin, K. J., Reed, D. D., Lim, S.-L., Strober, L. B., Glusman, M. B., Ness, A. R., et al. (2015) · Annals of Behavioral Medicine · doi:10.1007/s12160-015-9754-8 · Cited by 85
Simão, L. M., Lana–Peixoto, M. A., Araújo, C. R., Moreira, M. A., & Teixeira, A. L. (2008) · Arquivos Brasileiros de Oftalmologia · doi:10.1590/s0004-27492008000400014 · Cited by 85
da Silva, A. M., Vilhena, E., Lopes, A., Santos, E., Gonçalves, M. A., Pinto, C., Moreira, I., Mendonça, D., & Cavaco, S. (2011) · Journal of Neurological Sciences · doi:10.1016/j.jns.2011.03.042 · Cited by 86
Ghahari, S., Packer, T. L., & Passmore, A. E. (2010) · Clinical Rehabilitation · doi:10.1177/0269215509360648 · Cited by 83
Association Between Physical Fitness and Cognitive Function in Multiple Sclerosis
Sandroff, B. M., Pilutti, L. A., Benedict, R. H. B., & Motl, R. W. (2014) · Neurorehabilitation and neural repair · doi:10.1177/1545968314541331 · Cited by 85
Self-citationJohansson, S., Kottorp, A., Lee, K. A., Gay, C., & Lerdal, A. (2014) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-12-24 · Cited by 80
A biopsychosocial model of resilience for multiple sclerosis
Black, R., & Dorstyn, D. (2013) · Journal of Health Psychology · doi:10.1177/1359105313512879 · Cited by 84
Campbell, J. L., Langdon, D. W., Cercignani, M., & Rashid, W. (2016) · Neural Plasticity · doi:10.1155/2016/4292585 · Cited by 88
Cognitive function and quality of life in multiple sclerosis patients: a cross-sectional study
Baumstarck, K., Siméoni, M.-C., Françoise Reuter, A., Klemina, I., Aghababian, V., Pelletier, J., & Auquier, P. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-17 · Cited by 77
Nourbakhsh, B., Julian, L. J., & Waubant, E. L. (2016) · European Journal of Neurology · doi:10.1111/ene.13102 · Cited by 79
Personality traits in multiple sclerosis: association with mood and anxiety disorders.
Bruce, J. M., & Lynch, S. (2011) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.12.010 · Cited by 94
Sandroff, B. M., Hillman, C. H., Benedict, R. H. B., & Motl, R. W. (2015) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2014.1001723 · Cited by 79
Self-citationMotl, R. W., Sandroff, B. M., & Benedict, R. H. B. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511409612 · Cited by 78
Self-citationExercise Training and Cognitive Rehabilitation
Motl, R. W., Sandroff, B. M., & DeLuca, J. (2015) · Neurorehabilitation and neural repair · doi:10.1177/1545968315606993 · Cited by 81
Gottberg, K., Einarsson, U., Fredrikson, S., von Koch, L., & Holmqvist, L. W. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.090654 · Cited by 78
Sweetland, J., Howse, E., & Playford, E. D. (2012) · Disability and Rehabilitation · doi:10.3109/09638288.2012.669019 · Cited by 77
Pucak, M. L., Carroll, K. A. L., Kerr, D. A., & Kaplin, A. L. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.2/mpucak · Cited by 82
Fatigue, Sleep Quality, and Disability in Relation to Quality of Life in Multiple Sclerosis
Tabrizi, F. M., & Radfar, M. (2015) · International Journal of MS Care · doi:10.7224/1537-2073.2014-046 · Cited by 75
The impact of fatigue on cognitive functioning in patients with multiple sclerosis
Bol, Y., Duits, A., Hupperts, R., Verlinden, I., & Verhey, F. R. J. (2010) · Clinical Rehabilitation · doi:10.1177/0269215510367540 · Cited by 75
Rainone, N., Chiodi, A., Lanzillo, R., Magri, V., Napolitano, A., Morra, V. B., Valerio, P., & Freda, M. F. (2016) · Quality of Life Research · doi:10.1007/s11136-016-1466-4 · Cited by 70
Regional brain atrophy in primary fatigued patients with multiple sclerosis
Andreasen, A. K., Jakobsen, J., Sørensen, L. M., Andersen, H., Petersen, T., Bjarkam, C. R., & Ahdidan, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.118 · Cited by 68
Contribution of symptom clusters to multiple sclerosis consequences
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Benedict, R. H. B., & Zivadinov, R. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.05.020 · Cited by 73
Self-citationTwork, S., Wiesmeth, S., Spindler, M., Wirtz, M. A., Schipper, S., Pöhlau, D., Klewer, J., & Kügler, J. (2010) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-8-55 · Cited by 66
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Metadata
- Authors
- Benedict, R. H. B., Wahlig, E., Bakshi, R., Fishman, I., Munschauer, F., Zivadinov, R., & Weinstock-Guttman, B.
- Affiliations
- State University of New York (US)
- Brigham and Women's Hospital (US)
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 231
- Issue
- 1-2
- Pages
- 29-34
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2005390537
- Cited by
- 528
- References
- 51
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 19 · 2023: 17 · 2022: 21 · 2021: 33 · 2020: 24 · 2019: 32 · 2018: 32 · 2017: 34 · 2016: 42 · 2015: 41 · 2014: 24 · 2013: 24 · 2012: 32
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- multiple sclerosis, health-related quality of life, physical disability, fatigue, depression, cognitive function, vocational status, employability, personality, conscientiousness, disease duration, MSQOL-54
- MeSH terms
- Adult, Analysis of Variance, Cognition, Fatigue, Female, Persons with Disabilities, Humans, Male, Middle Aged, Multiple Sclerosis, Neuropsychological Tests, Personality, Predictive Value of Tests, Quality of Life, Linear Models, Mood Disorders
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