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Cited by 72Suicide and Self-Harm StudiesNeural and Behavioral Psychology StudiesSchizophrenia research and treatment

First-degree relatives of suicide completers may have impaired decision-making but functional cognitive control

Hoehne, A., Richard-Devantoy, S., Ding, Y., Turecki, G., Jollant, F.·2015·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2015.07.004
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Abstract

Background The heritability of suicide is well established. Transmission of risk appears to follow traits more than disorders like depression. In the present project, we aimed at investigating the potential for transmission of cognitive deficits previously observed in suicide attempters, specifically impaired decision-making and cognitive control.Methods Seventeen healthy first-degree relatives of suicide completers with no personal history of suicidal act were compared to 18 first-degree relatives of individuals with major depressive disorder but no family history of suicidal act, and 19 healthy controls. Decision-making was assessed with the Iowa Gambling Task, and cognitive control with the Stroop Task, the Hayling Sentence Completion Test, and the Trail-Making Test.Results Both suicide and depressed relatives showed lower gambling task net scores than healthy controls. However, there were trends toward lower learning abilities in suicide than depressed relatives (interaction: p = 0.07), with more risky choices at the end of the test. Suicide relatives also showed a higher number of self-corrected errors relative to the total number of errors in the Stroop colour test compared to both control groups, with no difference in interference scores. There was no group-difference for any other cognitive tests.Conclusion Our findings suggest that decision-making impairment may be found in healthy relatives of suicides and represent a cognitive endophenotype of suicidal behaviour. Normal cognitive control (or self-corrected deficits) may protect relatives against suicidal acts. Impairments in value-based and control processes may, therefore, be part of the suicide vulnerability and represent potential targets of preventative interventions.

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  • Impaired decision making and related brain circuit changes are observed in healthy relatives of suicide decedents, consistent with familial transmission of an endophenotype for suicide risk.

    “Impaired decision making (36) and related brain circuit changes (37) are also observed in healthy relatives of suicide decedents, consistent with familial transmission of an endophenotype for suicide risk.”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [36]

  • Suicide-specific heritability is associated with suicide diathesis-related traits.

    “This suicide-specific heritability is associated with suicide diathesis–related traits (36, 250).”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [36]

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Authors
Hoehne, A., Richard-Devantoy, S., Ding, Y., Turecki, G., & Jollant, F.
Affiliations
Douglas Mental Health University Institute (CA)
Corresponding author
Jollant, F.
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2015-09
Volume
68
Pages
192-197
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2015.07.004
OpenAlex
W2167555131
Cited by
72
References
39
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 12 · 2019: 6 · 2018: 24 · 2017: 2 · 2016: 6 · 2015: 3
FWCI
14.47
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
suicide, first-degree relatives, decision-making, cognitive control, endophenotypes, Iowa Gambling Task, Stroop task, Trail Making Test, decision making under risk, learning ability, major depressive disorder, suicide prevention
MeSH terms
Adult, Decision Making, Major Depressive Disorder, Family, Female, Humans, Male, Middle Aged, Suicide, Executive Function, Endophenotypes

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