Disrupted reward circuits is associated with cognitive deficits and depression severity in major depressive disorder
Abstract
Neuroimaging studies have demonstrated that major depressive disorder (MDD) patients show blunted activity responses to reward-related tasks. However, whether abnormal reward circuits affect cognition and depression in MDD patients remains unclear. Seventy-five drug-naive MDD patients and 42 cognitively normal (CN) subjects underwent a resting-state functional magnetic resonance imaging scan. The bilateral nucleus accumbens (NAc) were selected as seeds to construct reward circuits across all subjects. A multivariate linear regression analysis was employed to investigate the neural substrates of cognitive function and depression severity on the reward circuits in MDD patients. The common pathway underlying cognitive deficits and depression was identified with conjunction analysis. Compared with CN subjects, MDD patients showed decreased reward network connectivity that was primarily located in the prefrontal-striatal regions. Importantly, distinct and common neural pathways underlying cognition and depression were identified, implying the independent and synergistic effects of cognitive deficits and depression severity on reward circuits. This study demonstrated that disrupted topological organization within reward circuits was significantly associated with cognitive deficits and depression severity in MDD patients. These findings suggest that in addition to antidepressant treatment, normalized reward circuits should be a focus and a target for improving depression and cognitive deficits in MDD patients.
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In unmedicated MDD, disrupted functional connectivity of NAc with caudate, medial OFC, rostral ACC, superior temporal gyrus, insular lobe, dmPFC, dorsal ACC.
“In a resting-state fMRI study in 75 unmedicated MDD patients and 42 HCs, disrupted functional connectivity was reported for the NAc with the caudate, medial OFC, rostral ACC, superior temporal gyrus (left), insular lobe, dorsomedial PFC (dmPFC), and dorsal ACC (Gong et al., 2017).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Gong et al., 2017
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- Authors
- Gong, L., Yin, Y., He, C., Ye, Q., Bai, F., Yuan, Y., Zhang, H., Lv, L., Zhang, H., Xie, C., & Zhang, Z.
- Affiliations
- Zhongda Hospital Southeast University (CN)
- Henan Medical University (CN)
- Corresponding author
- Zhang, Hongxing
- Xie, Chunming
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 84
- Pages
- 9-17
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2520786489
- Cited by
- 82
- References
- 49
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 8 · 2023: 5 · 2022: 12 · 2021: 10 · 2020: 14 · 2019: 8 · 2018: 4 · 2017: 8
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- major depressive disorder, reward systems, cognitive impairment, depression severity, nucleus accumbens, resting-state functional connectivity, network topology, drug-naive patients
- MeSH terms
- Adult, Brain, Brain Mapping, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Mental Status Schedule, Neural Pathways, Neuropsychological Tests, Psychiatric Status Rating Scales, Reward, Severity of Illness Index, Multivariate Analysis, Linear Models
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