A Randomized Controlled Trial Examining the Effects of Intranasal Oxytocin on Alcohol Craving and Intimate Partner Aggression among Couples

Flanagan, Julianne C.; Nietert, Paul J.; Sippel, Lauren; Jarnecke, Amber M.; Kirby, Charli; Hogan, Jasara N.; Massa, Andrea A.; Brower, Jessica; Back, Sudie E.; Parrott, Dominic

doi:10.1016/j.jpsychires.2022.06.011

Cited by 17Neuroendocrine regulation and behaviorSubstance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

A Randomized Controlled Trial Examining the Effects of Intranasal Oxytocin on Alcohol Craving and Intimate Partner Aggression among Couples

Open access

Flanagan, Julianne C., Nietert, Paul J., Sippel, Lauren, Jarnecke, Amber M., Kirby, Charli, Hogan, Jasara N., Massa, Andrea A., Brower, Jessica +2 more·2022·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2022.06.011PMC PMC9308670

Open this paper in CoChat — free account

Abstract

Background While alcohol use disorder (AUD) is a well-established risk factor for intimate partner aggression (IPA), effective treatments for co-occurring AUD and IPA (AUD/IPA) are lacking. Oxytocin is one promising pharmacological candidate for AUD/IPA given its potential to modulate social behavior and attenuate alcohol use. However, emerging data suggests that oxytocin's prosocial effects are inconsistent, and a small number of studies have also found that oxytocin might have the potential to be aggressogenic. No studies have directly examined the impact of oxytocin on alcohol- or IPA-related outcomes in a dyadic context. Methods The goal of this double-blind, randomized, and placebo-controlled trial was to examine the effects of a single dose of intranasal oxytocin (40 international units) on cue-induced alcohol craving, subjective aggression, laboratory task-based IPA, and cortisol reactivity in a sample of 100 couples (N = 200 individuals) with AUD and physical IPA in their current relationship. Results There were no statistically significant differences between the oxytocin and placebo conditions for any of the primary outcomes. Conclusions Findings suggest that a single dose of intranasal oxytocin was not efficacious in mitigating alcohol craving or aggression in this sample. Although hypotheses were not supported, the findings provide important evidence that oxytocin was not aggressogenic in this high-risk sample. Future research investigating dispositional and contextual moderators of oxytocin response in addition to the therapeutic effects of more intensive oxytocin dosing or administration strategies on alcohol craving and aggression is warranted.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jpsychires.2022.06.011

Cites

106 of 107 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Literature on oxytocin's effects on social cognition and behavior among romantic couples has yielded mixed findings.
“A smaller literature has examined oxytocin's effects on social cognition and behavior among romantic couples, however, this literature has yielded mixed findings3–6.”
From Results of a Randomized Controlled Trial Examining the Efficacy of Intranasal Oxytocin to Enhance Alcohol Behavioral Couple Therapy (2025) · cites this paper as [5]
The Introduction (Oxytocin: Modulator of Social Behavior and Aggression; page unavailable) describes differing findings on oxytocin and aggression, and the Discussion (page unavailable) calls the broader literature inconsistent. The paper studies romantic couples, but it does not establish that a body of studies specifically on social cognition and behavior among romantic couples has yielded mixed findings. (LLM, conf=0.83)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption‐II
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,482 · see citing works
Untitled work
(1998) · PubMed · Cited by 10,216 · see citing works
Measuring Dyadic Adjustment: New Scales for Assessing the Quality of Marriage and Similar Dyads
Spanier, G. B. (1976) · Journal of Marriage and the Family · doi:10.2307/350547 · Cited by 7,095 · see citing works
The Revised Conflict Tactics Scales (CTS2): Development and Preliminary Psychometric Data
STRAUS, M. A., HAMBY, S. L., BONEY-McCOY, S., & SUGARMAN, D. B. (1996) · Journal of Family Issues · doi:10.1177/019251396017003001 · Cited by 6,923 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Assessment of Alcohol Withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA‐Ar)
SULLIVAN, J. T., SYKORA, K., SCHNEIDERMAN, J., NARANJO, C. A., & SELLERS, E. M. (1989) · British Journal of Addiction · doi:10.1111/j.1360-0443.1989.tb00737.x · Cited by 1,988 · see citing works
Intimate partner violence and women's physical and mental health in the WHO multi-country study on women's health and domestic violence: an observational study
Ellsberg, M., Jansen, H. A., Heise, L., Watts, C. H., & Garcia-Moreno, C. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60522-x · Cited by 1,820 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Davey, G. (2013) · Encyclopedia of Women in Today's World · doi:10.4135/9781412995962.n207 · Cited by 1,485 · see citing works
The Social Salience Hypothesis of Oxytocin
Shamay-Tsoory, S. G., & Abu-Akel, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.020 · Cited by 904 · see citing works
Aggressive behavior and physiological arousal as a function of provocation and the tendency to inhibit aggression1
Taylor, S. P. (1967) · Journal of Personality · doi:10.1111/j.1467-6494.1967.tb01430.x · Cited by 870 · see citing works
Oxytocin increases generosity in humans
Zak, P. J., Stanton, A. A., & Ahmadi, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001128 · Cited by 831 · see citing works
Intimate Partner Violence and Women’s Physical, Mental, and Social Functioning
Bonomi, A. E., Thompson, R. S., Anderson, M., Reid, R. J., Carrell, D., Dimer, J. A., & Rivara, F. P. (2006) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2006.01.015 · Cited by 686 · see citing works
Dominance and symmetry in partner violence by male and female university students in 32 nations
Straus, M. A. (2007) · Children and Youth Services Review · doi:10.1016/j.childyouth.2007.10.004 · Cited by 646 · see citing works
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · see citing works
The Peptide That Binds: A Systematic Review of Oxytocin and its Prosocial Effects in Humans
MacDonald, K., & MacDonald, T. M. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673220903523615 · Cited by 585 · see citing works
Lifetime Economic Burden of Intimate Partner Violence Among U.S. Adults
Peterson, C., Kearns, M. C., McIntosh, W. L., Estefan, L. F., Nicolaidis, C., McCollister, K. E., Gordon, A. L., & Florence, C. (2018) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2018.04.049 · Cited by 474 · see citing works
Prevalence and risk factors of intimate partner violence in eighteen U.S. states/territories, 2005.
Breiding, M., Black, M. C., & Ryan, G. (2008) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2007.10.001 · Cited by 398 · see citing works
Addiction is a Reward Deficit and Stress Surfeit Disorder
Koob, G. F. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00072 · Cited by 397 · see citing works
Barriers to Help Seeking for Lesbian, Gay, Bisexual, Transgender, and Queer Survivors of Intimate Partner Violence
Calton, J. M., Cattaneo, L. B., & Gebhard, K. T. (2016) · Trauma, Violence, & Abuse · doi:10.1177/1524838015585318 · Cited by 370 · see citing works
Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research
Guastella, A. J., Hickie, I. B., McGuinness, M. M., Otis, M., Woods, E. A., Disinger, H. M., Chan, H.-K., Chen, T. F., & Banati, R. B. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.019 · Cited by 357 · see citing works
Anger, hostility, and male perpetrators of intimate partner violence: A meta-analytic review
Norlander, B., & Eckhardt, C. I. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.10.001 · Cited by 351 · see citing works
Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies
Walum, H., Waldman, I. D., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.016 · Cited by 345 · see citing works
Patterns of Intimate Partner Violence and Their Associations with Physical Health, Psychological Distress, and Substance Use
Carbone‐Lopez, K., Kruttschnitt, C., & Macmillan, R. (2006) · Public Health Reports · doi:10.1177/003335490612100406 · Cited by 314 · see citing works
Mental health correlates of intimate partner violence in marital relationships in a nationally representative sample of males and females
Afifi, T. O., MacMillan, H., Cox, B. J., Asmundson, G. J. G., Stein, M. B., & Sareen, J. (2009) · Journal of Interpersonal Violence · doi:10.1177/0886260508322192 · Cited by 305 · see citing works
Intimate partner violence and specific substance use disorders: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions.
Smith, P. H., Homish, G. G., Leonard, K. E., & Cornelius, J. R. (2012) · Psychology of Addictive Behaviors · doi:10.1037/a0024855 · Cited by 279 · see citing works
Reactivity of alcoholics and nonalcoholics to drinking cues.
Monti, P. M., Binkoff, J. A., Abrams, D. B., Zwick, W. R., Nirenberg, T. D., & Liepman, M. R. (1987) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.96.2.122 · Cited by 268 · see citing works
Breaking the loop: Oxytocin as a potential treatment for drug addiction
McGregor, I. S., & Bowen, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.001 · Cited by 268 · see citing works
The differential association of intimate partner physical, sexual, psychological, and stalking violence and posttraumatic stress symptoms in a nationally representative sample of women
Basile, K. C., Arias, I., Desai, S., & Thompson, M. P. (2004) · Journal of Traumatic Stress · doi:10.1023/b:jots.0000048954.50232.d8 · Cited by 264 · see citing works
Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research
Quintana, D. S., Lischke, A., Grace, S., Scheele, D., Ma, Y., & Becker, B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00864-7 · Cited by 263 · see citing works
Abstinent Opiate Abusers Exhibit Conditioned Craving, Conditioned Withdrawal and Reductions in both through Extinction
Childress, A. R., McLellan, A. T., & O’Brien, C. P. (1986) · British Journal of Addiction · doi:10.1111/j.1360-0443.1986.tb00385.x · Cited by 258 · see citing works
Predictors of Dropout Among Men Who Batter: A Review of Studies With Implications for Research and Practice
Daly, J. E., & Pelowski, S. R. (2000) · Violence and Victims · doi:10.1891/0886-6708.15.2.137 · Cited by 247 · see citing works
Alcohol May Not Cause Partner Violence But It Seems to Make It Worse: A Cross National Comparison of the Relationship Between Alcohol and Severity of Partner Violence
Graham, K., Bernards, S., Wilsnack, S. C., & Gmel, G. (2011) · Journal of Interpersonal Violence · doi:10.1177/0886260510370596 · Cited by 220 · see citing works
Further evidence for the validity of the Taylor Aggression Paradigm
Giancola, P. R., & Parrott, D. J. (2008) · Aggressive Behavior · doi:10.1002/ab.20235 · Cited by 218 · see citing works
Self-citation
Thirty years of research show alcohol to be a cause of intimate partner violence: Future research needs to identify who to treat and how to treat them
Leonard, K. E., & Quigley, B. M. (2016) · Drug and Alcohol Review · doi:10.1111/dar.12434 · Cited by 213 · see citing works
Alcohol, drugs, and violence: A meta-meta-analysis.
Duke, A. A., Smith, K. M. Z., Oberleitner, L., Westphal, A., & McKee, S. A. (2017) · Psychology of Violence · doi:10.1037/vio0000106 · Cited by 211 · see citing works
Process and treatment adherence factors in group cognitive-behavioral therapy for partner violent men
Taft, C. T., Murphy, C. M., King, D. W., Musser, P. H., & DeDeyn, J. M. (2003) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.71.4.812 · Cited by 197 · see citing works
Intranasal oxytocin blocks alcohol withdrawal in human subjects
Pedersen, C. A., Smedley, K. L., Leserman, J., Jarskog, L. F., Rau, S. W., Kampov‐Polevoi, A., Casey, R. L., Fender, T., & Garbutt, J. C. (2013) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01958.x · Cited by 196 · see citing works
Partner violence before and after individually based alcoholism treatment for male alcoholic patients.
O’Farrell, T. J., Fals-Stewart, W. S., Murphy, M., & Murphy, C. M. (2003) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.71.1.92 · Cited by 195 · see citing works
A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health
Cardoso, C., Kingdon, D., & Ellenbogen, M. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.014 · Cited by 171 · see citing works
Alcohol Consumption and Intimate Partner Violence by Alcoholic Men: Comparing Violent and Nonviolent Conflicts.
Murphy, C. M., Winters, J. J., O’Farrell, T. J., Fals-Stewart, W. S., & Murphy, M. (2005) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.19.1.35 · Cited by 147 · see citing works
The Proximal Effects of Acute Alcohol Consumption on Male-to-Female Aggression
Crane, C. A., Godleski, S. A., Przybyla, S., Schlauch, R. C., & Testa, M. (2015) · Trauma Violence & Abuse · doi:10.1177/1524838015584374 · Cited by 147 · see citing works
Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats
Bowen, M. T., Carson, D. S., Spiro, A., Arnold, J. C., & McGregor, I. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027237 · Cited by 143 · see citing works
Does Alcohol Make a Difference?
Testa, M., Quigley, B. M., & Leonard, K. E. (2003) · Journal of Interpersonal Violence · doi:10.1177/0886260503253232 · Cited by 137 · see citing works
Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
Lee, M. R., Shnitko, T. A., Blue, S. W., Kaucher, A. V., Winchell, A. J., Erikson, D. W., Grant, K. A., & Leggio, L. (2020) · Nature Communications · doi:10.1038/s41467-020-15942-1 · Cited by 132 · see citing works
Experiences of Intimate Partner Violence Among Lesbian, Gay, Bisexual, and Transgender College Students: The Intersection of Gender, Race, and Sexual Orientation
Whitfield, D. L., Coulter, R. W. S., Langenderfer‐Magruder, L., & López, D. J. (2018) · Journal of Interpersonal Violence · doi:10.1177/0886260518812071 · Cited by 129 · see citing works
Stages and processes of change in Batterers' treatment
Daniels, J. W., & Murphy, C. M. (1997) · Cognitive and Behavioral Practice · doi:10.1016/s1077-7229(97)80015-6 · Cited by 122 · see citing works
Intranasal administration of oxytocin increases human aggressive behavior
Ne'eman, R., Perach-Barzilay, N., Fischer-Shofty, M., Atias, A., & Shamay-Tsoory, S. G. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.01.015 · Cited by 121 · see citing works
Attendance-enhancing procedures in group counseling for domestic abusers.
Taft, C. T., Murphy, C. M., Elliott, J. D., & Morrel, T. M. (2001) · Journal of Counseling Psychology · doi:10.1037/0022-0167.48.1.51 · Cited by 116 · see citing works
A daily process examination of the temporal association between alcohol use and verbal and physical aggression in community couples.
Testa, M., & Derrick, J. L. (2013) · Psychology of Addictive Behaviors · doi:10.1037/a0032988 · Cited by 114 · see citing works
Mechanisms of Alcohol-Facilitated Intimate Partner Violence
Eckhardt, C. I., Parrott, D. J., & Sprunger, J. G. (2015) · Violence Against Women · doi:10.1177/1077801215589376 · Cited by 110 · see citing works
Self-citation
Alcohol Dose and Aggression: Another Reason Why Drinking More Is a Bad Idea
Duke, A. A., Giancola, P. R., Morris, D. H., Holt, J. C. D., & Gunn, R. L. (2011) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2011.72.34 · Cited by 110 · see citing works
Oxytocin for the treatment of drug and alcohol use disorders
Lee, M. R., & Weerts, E. M. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000258 · Cited by 105 · see citing works
Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala
Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., et al. (2019) · PLOS Biology · doi:10.1371/journal.pbio.2006421 · Cited by 104 · see citing works
Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99 · see citing works
Self-citation
Targeting the Oxytocin System to Treat Addictive Disorders: Rationale and Progress to Date
Lee, M. R., Rohn, M. C. H., Tanda, G., & Leggio, L. (2016) · CNS Drugs · doi:10.1007/s40263-016-0313-z · Cited by 97 · see citing works
Intranasal oxytocin effects on social cognition: A critique
Evans, S. L., Dal Monte, O., Noble, P., & Averbeck, B. B. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.008 · Cited by 97 · see citing works
When the Love Hormone Leads to Violence: Oxytocin Increases Intimate Partner Violence Inclinations Among High Trait Aggressive People
DeWall, C. N., Gillath, O., Pressman, S. D., Black, L. L., Bartz, J. A., Moskovitz, J., & Stetler, D. A. (2014) · Social Psychological and Personality Science · doi:10.1177/1948550613516876 · Cited by 96 · see citing works
Evidence for Intranasal Oxytocin Delivery to the brain: Recent Advances and Future Perspectives
Quintana, D. S., Smerud, K. T., Andreassen, O. A., & Djupesland, P. G. (2018) · Therapeutic Delivery · doi:10.4155/tde-2018-0002 · Cited by 94 · see citing works
Violence among men and women in substance use disorder treatment: A multi-level event-based analysis
Chermack, S. T., Grogan‐Kaylor, A. C., Perron, B. E., Murray, R. L., Chavez, P. D. D., & Walton, M. A. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.06.005 · Cited by 94 · see citing works
Oxytocin reduces ethanol self-administration in mice
King, C. E., Griffin, W. C., Luderman, L. N., Kates, M. M., McGinty, J. F., & Becker, H. C. (2017) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13359 · Cited by 89 · see citing works
Intranasal oxytocin selectively modulates social perception, craving, and approach behavior in subjects with alcohol use disorder
Mitchell, J. M., Arcuni, P. A., Weinstein, D., & Woolley, J. D. (2016) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000213 · Cited by 82 · see citing works
Randomized clinical trial examining the incremental efficacy of a 90-minute motivational alcohol intervention as an adjunct to standard batterer intervention for men
Stuart, G. L., Shorey, R. C., Moore, T. M., Ramsey, S. E., Kahler, C. W., O’Farrell, T. J., Strong, D. R., Temple, J. R., & Monti, P. M. (2013) · Addiction · doi:10.1111/add.12142 · Cited by 78 · see citing works
The Working Alliance in Intervention for Partner Violence Perpetrators: Recent Research and Theory
Taft, C. T., & Murphy, C. M. (2007) · Journal of Family Violence · doi:10.1007/s10896-006-9053-z · Cited by 77 · see citing works
Peripheral oxytocin administration reduces ethanol consumption in rats
MacFadyen, K., Loveless, R., DeLucca, B., Wardley, K., Deogan, S., Thomas, C., & Peris, J. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.10.014 · Cited by 76 · see citing works
Partner violence before and after couples-based alcoholism treatment for female alcoholic patients.
Schumm, J. A., O’Farrell, T. J., Murphy, C. M., & Fals-Stewart, W. S. (2009) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0017389 · Cited by 74 · see citing works
Oxytocin and Aggression
A, T. R. D. J., & Neumann, I. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_13 · Cited by 74 · see citing works
Concordant and discordant alcohol, tobacco, and marijuana use as predictors of marital dissolution.
Leonard, K. E., Smith, P. H., & Homish, G. G. (2013) · Psychology of Addictive Behaviors · doi:10.1037/a0034053 · Cited by 72 · see citing works
The role of oxytocin in alcohol and drug abuse
King, C. E., Gano, A., & Becker, H. C. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146761 · Cited by 66 · see citing works
Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 62 · see citing works
Oxytocin, Tolerance, and the Dark Side of Addiction
Pedersen, C. A. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.08.003 · Cited by 58 · see citing works
Nanoparticle formulations that allow for sustained delivery and brain targeting of the neuropeptide oxytocin
Zaman, R. U., Mulla, N. S., Gomes, K. B., D’Souza, C., Murnane, K. S., & D’Souza, M. J. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.07.043 · Cited by 55 · see citing works
Triple jeopardy: impact of partner violence perpetration, mental health and substance use on perceived unmet need for mental health care among men
Lipsky, S., Caetano, R., & Roy‐Byrne, P. (2010) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-010-0258-3 · Cited by 54 · see citing works
Fluoxetine Treatment of Alcoholic Perpetrators of Domestic Violence
George, D. T., Phillips, M. J., Lifshitz, M., Lionetti, T., Spero, D. E., Ghassemzedeh, N., Doty, L., Umhau, J. C., & Rawlings, R. R. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05256gry · Cited by 53 · see citing works
Oxytocin attenuates stress-induced reinstatement of alcohol seeking behavior in male and female mice
King, C. E., & Becker, H. C. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05233-z · Cited by 53 · see citing works
Improvements in Empathy and Cognitive Flexibility after Court-Mandated Intervention Program in Intimate Partner Violence Perpetrators: The Role of Alcohol Abuse
Romero‐Martínez, Á., Lila, M., Martı́nez, M., Pedrón, V., & Moya‐Albiol, L. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13040394 · Cited by 49 · see citing works
Nanoparticle encapsulation increases the brain penetrance and duration of action of intranasal oxytocin
Oppong‐Damoah, A., Zaman, R. U., D’Souza, M. J., & Murnane, K. S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.12.011 · Cited by 49 · see citing works
Effect of co-occurring disorders and intimate partner violence on substance abuse treatment outcomes
Lipsky, S., Krupski, A., Roy‐Byrne, P., Lucenko, B. A., Mancuso, D., & Huber, A. (2010) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2009.12.005 · Cited by 48 · see citing works
“Strength at Home” Group Intervention for Military Populations Engaging in Intimate Partner Violence: Pilot Findings
Taft, C. T., Macdonald, A., Monson, C. M., Walling, S. M., Resick, P. A., & Murphy, C. M. (2013) · Journal of Family Violence · doi:10.1007/s10896-013-9496-y · Cited by 48 · see citing works
Oxytocin reduces alcohol consumption in prairie voles
Stevenson, J. R., Wenner, S. M., Freestone, D. M., Romaine, C. C., Parian, M. C., Christian, S. M., Bohidar, A. E., Ndem‐Galbert, J. R., Vogel, I., & O'Kane, C. M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.07.021 · Cited by 47 · see citing works
Effects of intranasal oxytocin on distraction as emotion regulation strategy in patients with post-traumatic stress disorder
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.002 · Cited by 47 · see citing works
Resistance Among Domestic Violence Offenders
Levesque, D. A., Velicer, W. F., Castle, P. H., & Greene, R. T. (2008) · Violence Against Women · doi:10.1177/1077801207312397 · Cited by 44 · see citing works
A precision medicine approach to oxytocin trials
Andari, E., Hurlemann, R., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_29 · Cited by 40 · see citing works
Evaluation of aggressive interactions in interpersonal and intergroup contexts
Otten, S., Mummendey, A., & Wenzel, M. (1995) · Aggressive Behavior · doi:10.1002/1098-2337(1995)21:3 · Cited by 39 · see citing works
Temporal Effects of Perpetrating or Receiving Intimate Partner Aggression on Alcohol Consumption: A Daily Diary Study of Community Couples
Derrick, J. L., & Testa, M. (2017) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2017.78.213 · Cited by 39 · see citing works
Penetration of the blood-brain barrier by peripheral neuropeptides: new approaches to enhancing transport and endogenous expression
Lee, M. R., & Jayant, R. D. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2959-y · Cited by 38 · see citing works
A randomized clinical trial of motivational enhancement therapy for alcohol problems in partner violent men
Murphy, C. M., Ting, L. A., Jordan, L. C., Musser, P. H., Winters, J. J., Poole, G. M., & Pitts, S. C. (2018) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2018.03.004 · Cited by 37 · see citing works
Effect of intranasal oxytocin on alcohol withdrawal syndrome: a randomized placebo-controlled double-blind clinical trial
Melby, K., Gråwe, R. W., Aamo, T. O., Salvesen, Ø., & Spigset, O. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.01.003 · Cited by 33 · see citing works
Intranasal oxytocin reduces reactive aggression in men but not in women: A computational approach
Zhu, R., Liu, C., Li, T., Xu, Z., Fung, B. J., Feng, C., Wu, H., Luo, Y., & Wang, L. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.06.016 · Cited by 30 · see citing works
Intranasal administration of oxytocin decreases task-related aggressive responses in healthy young males
Berends, Y. R., Tulen, J. H. M., Wierdsma, A. I., PELT, J. V., Feldman, R., Zagoory‐Sharon, O., de Rijke, Y. B., Kushner, S. A., & Marle, H. J. C. V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.027 · Cited by 27 · see citing works
Self-Defense, Retaliation, and Gender: Clarifying Motivations for Physical Partner Violence
Leisring, P. A., & Grigorian, H. L. (2016) · Journal of Family Violence · doi:10.1007/s10896-016-9874-3 · Cited by 25 · see citing works
Cognitive and Affective Mediators of Alcohol-Facilitated Intimate-Partner Aggression
Eckhardt, C. I., Parrott, D. J., Swartout, K. M., Leone, R. M., Purvis, D. M., Massa, A. A., & Sprunger, J. G. (2021) · Clinical Psychological Science · doi:10.1177/2167702620966293 · Cited by 24 · see citing works
Self-citation
Alcohol and oxytocin: Scrutinizing the relationship
Ryabinin, A. E., & Fulenwider, H. D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.009 · Cited by 23 · see citing works
Efficacy of Self-Administered Intranasal Oxytocin on Alcohol Use and Craving After Detoxification in Patients With Alcohol Dependence. A Double-Blind Placebo-Controlled Trial
Melby, K., Gråwe, R. W., Aamo, T. O., Skovlund, E., & Spigset, O. (2020) · Alcohol and Alcoholism · doi:10.1093/alcalc/agaa133 · Cited by 22 · see citing works
Oxytocin treatment for alcoholism: Potential neurocircuitry targets
Peris, J., Steck, M. R., & Krause, E. G. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108091 · Cited by 21 · see citing works
Where is the love? A double-blind, randomized study of the effects of intranasal oxytocin on stress regulation and aggression
Romney, C. E., Hahn‐Holbrook, J., Norman, G. J., Moore, A., & Holt‐Lunstad, J. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.08.010 · Cited by 20 · see citing works
Oxytocin strengthens the link between provocation and aggression among low anxiety people
Pfundmair, M., Reinelt, A., DeWall, C. N., & Feldmann, L. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.04.025 · Cited by 19 · see citing works
Effects of Oxytocin Administration on Cue‐Induced Craving in Co‐occurring Alcohol Use Disorder and PTSD: A Within‐Participant Randomized Clinical Trial
Stauffer, C. S., Meinzer, N. K., Morrison, T., Wen, J., Radanovich, L., Leung, D., Niles, A. N., O’Donovan, A., Batki, S. L., & Woolley, J. D. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14217 · Cited by 17 · see citing works
Immediate and short-term reactions to participation in laboratory aggression research.
Parrott, D. J., Miller, C. A., & Hudepohl, A. D. (2014) · Psychology of Violence · doi:10.1037/a0035922 · Cited by 16 · see citing works
Self-citation
Intranasal Oxytocin Does Not Modulate Responses to Alcohol in Social Drinkers
Vena, A. A., King, A. C., Lee, R., & de Wit, H. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13814 · Cited by 14 · see citing works
An empirically based power primer for laboratory aggression research
Hyatt, C. S., Crowe, M. L., West, S. J., Vize, C. E., Carter, N. T., Chester, D. S., & Miller, J. D. (2021) · Aggressive Behavior · doi:10.1002/ab.21996 · Cited by 14 · see citing works
Augmenting Treatment for Posttraumatic Stress Disorder and Co-Occurring Conditions with Oxytocin
Flanagan, J. C., & Mitchell, J. (2019) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-019-00171-1 · Cited by 10 · see citing works
Self-citation
Effects of oxytocin on stress-induced reinstatement of alcohol-seeking in mice with and without a history of stress
King, C. E., McGinty, J. F., & Becker, H. C. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.02.305 · Cited by 7 · see citing works
Oxytocin reduces alcohol self-administration and stress-induced alcohol relapse behavior in mice
Becker, H. C., King, C. E., & Griffin, W. C. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.02.250 · Cited by 4 · see citing works
The effects of intranasal oxytocin on social cognition, implicit preferences and craving in alcoholics
Mitchell, J., Weinstein, D., Arcuni, P. A., Laxamana, J., & Woolley, J. D. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.09.485 · Cited by 2 · see citing works
ALCOHOL SCREENING AND BRIEF INTERVENTION (SBI) APPLIED BY HEALTH PROFESSIONALS/SOCIAL WORKERS TRAINED BY A DISTANCE LEARNING COURSE: DOES IT WORK?
Carneiro, A. P. L., Formigoni, M. L. O. D. S., Ramos, M. P., de Moura, Y. G., & Duarte, P. D. C. A. V. (2013) · UNIFESP Institutional Repository (Universidade Federal de São Paulo) · doi:10.1111/acer.12162 · Cited by 1 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Sobell LC, Sobell MB, 1992. Timeline follow-back, Measuring alcohol consumption. Springer, pp. 41– 72.

Sorted by citations

Pharmacological treatment for substance use disorder: A systematic review
Mateu-Mollá, J., Pérez-Gálvez, B., & Villanueva-Blasco, V. J. (2025) · Addictive Behaviors · doi:10.1016/j.addbeh.2024.108242 · Cited by 10 · see citing works
Oxytocin in the Treatment of Psychiatric Disorders
Kagizman, S. C., & Hocaoğlu, Ç. (2023) · Medeniyet Medical Journal · doi:10.4274/mmj.galenos.2023.13707 · Cited by 8 · see citing works
Effects of alcohol problem discrepancy on relationship adjustment: The moderating role of conflict negotiation among couples with alcohol use disorder and intimate partner violence
Flanagan, J. C., Leone, R. M., Melkonian, A. J., Jarnecke, A. M., Hogan, J. N., & Massa, A. A. (2023) · Family Process · doi:10.1111/famp.12891 · Cited by 6 · see citing works
Self-citation
The Relationship Between Oxytocin and Alcohol Dependence
Schimmer, J., Patwell, R., Küppers, S., & Grinevich, V. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_444 · Cited by 5 · see citing works
Advancements in addressing drug dependence: A review of promising therapeutic strategies and interventions
Guida, C. R., Maia, J. M., Ferreira, L. F. R., Rahdar, A., Branco, L. G. S., & Soriano, R. N. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111070 · Cited by 6 · see citing works
Examining Relationships Among Alcohol Use Disorder, Child Caretaking, and Intimate Partner Violence in High-Risk Couples
Giff, S. T., Forkus, S. R., Massa, A. A., Brower, J. L., Jarnecke, A. M., & Flanagan, J. C. (2024) · Journal of Family Violence · doi:10.1007/s10896-024-00696-x · Cited by 4 · see citing works
Self-citation
Results of a Randomized Controlled Trial Examining the Efficacy of Intranasal Oxytocin to Enhance Alcohol Behavioral Couple Therapy
Flanagan, J. C., Nietert, P. J., McCrady, B. S., Sellers, S., Yates-Johnson, A., Giff, S. T., & Forkus, S. R. (2025) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.24m15627 · Cited by 3 · see citing works
Self-citation
Oxytocin Neuropeptide in the Control of Drug Dependence: A Review of Past Studies and Future Challenges
Esmaili‐Shahzade‐Ali‐Akbari, P., Bozorgnia, A., Shaterian, M., Jandaghian, S., & Shahri, S. M. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70197 · Cited by 3 · see citing works
Psychosocial Sequalae of Sexual Assault in a Sample of Partnered Adults Experiencing Alcohol Use Disorder and Intimate Partner Violence
Fleming, C. E., Giff, S. T., Forkus, S. R., & Flanagan, J. C. (2024) · Journal of Interpersonal Violence · doi:10.1177/08862605241243335 · Cited by 1 · see citing works
Self-citation
The Role of Oxytocin and Oxytocin Gene Receptor Methylation During Withdrawal Therapy in Males With Alcohol Use Disorder
Proskynitopoulos, P. J., Haarmeyer, A. F., Bleich, S., Frieling, H., Hillemacher, T., Glahn, A., & Rhein, M. (2025) · Addiction Biology · doi:10.1111/adb.70060 · Cited by 1 · see citing works
Do Cognitive Emotion Regulation Strategies Interact With Trauma Exposure to Influence Intimate Partner Violence? An Examination Among Couples With Alcohol Use Disorder
Flanagan, J. C., Giff, S. T., Forkus, S. R., Crasta, D. J., & Miles, S. R. (2025) · Journal of Interpersonal Violence · doi:10.1177/08862605251399682 · Cited by 1 · see citing works
Self-citation
Negative Urgency, Emotion Regulation, and Intimate Partner Violence Severity in High Risk Couples with Alcohol Use Disorders.
Boyd-Rogers, C. C., Crasta, D., Forkus, S. R., Hall, E. G., Noblejas Guloy, R. A., McCallus, R. S., & Flanagan, J. C. (2026) · Substance Use & Misuse · doi:10.1080/10826084.2026.2670612
“In the parent study, participants were enrolled in a randomized controlled trial (NCT03046836), and results, study procedures, full exclusion and inclusion criteria, and sample descriptives from this study have previously been reported (Flanagan et al., 2022).”
Self-citation
Examining the role of posttraumatic stress disorder symptoms in intimate partner violence among couples with alcohol use disorder
Flanagan, J. C., Hogan, J. N., Massa, A. A., & Jarnecke, A. M. (2024) · Aggressive Behavior · doi:10.1002/ab.22137
Self-citation
Oxytocin Levels in Response to Others’ Suffering According to the Type of Conviction for Intimate Partner Violence Against Women
Marín‐Morales, A., Comes‐Fayos, J., Riveros, M. E., Lila, M., Romero‐Martínez, Á., & Moya‐Albiol, L. (2025) · Journal of Interpersonal Violence · doi:10.1177/08862605251387722
Trauma Therapies for Posttraumatic Stress Disorder and Co-occurring Substance-Related and Addictive Disorders
Gette, J. A., Prakash, K., Saraiya, T. C., Blakey, S. M., & Hien, D. A. (2026) · Springer eBooks · doi:10.1007/978-3-031-57159-6_78-1
Intranasal oxytocin for alcohol use disorder: A systematic review and multilevel, bayesian, and variance meta-analyses of randomized clinical trial data
Santos, V. H., Paloyelis, Y., Morgado, M., Rodrigues, J. R., Tjeng, R., Fraga, M., Carriço, P., Fernandes, L. P. N. S., & Martins, D. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.107915
Single Versus Multiple Intimate Partner Violence Relationships: Current Severity of Psychological Distress Among Romantic Partners
Hurd, J. A., Giff, S. T., Hall, E., Thomas, M., Guloy, R. A. N., & Flanagan, J. C. (2026) · Journal of Clinical Psychology · doi:10.1002/jclp.70179
Self-citation

Intranasal Oxytocin for Alcohol Use Disorder: A Randomized, Double‐Blind, Placebo‐Controlled Multisite Trial Assessing Efficacy and Safety
Tiouririne, N. A., Legan, J. M., Devine, E. G., Lee, K., Weerts, E. M., Ellis, J. D., Ray, L. A., SHOPTAW, S. J., Falk, D. E., Ryan, M. L., et al. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70326 · Cited by 1 · see citing works
Results of a Randomized Controlled Trial Examining the Efficacy of Intranasal Oxytocin to Enhance Alcohol Behavioral Couple Therapy
Flanagan, J. C., Nietert, P. J., McCrady, B. S., Sellers, S., Yates-Johnson, A., Giff, S. T., & Forkus, S. R. (2025) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.24m15627 · Cited by 3 · see citing works
Self-citation
Effects of Oxytocin Administration on Cue‐Induced Craving in Co‐occurring Alcohol Use Disorder and PTSD: A Within‐Participant Randomized Clinical Trial
Stauffer, C. S., Meinzer, N. K., Morrison, T., Wen, J., Radanovich, L., Leung, D., Niles, A. N., O’Donovan, A., Batki, S. L., & Woolley, J. D. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14217 · Cited by 17 · see citing works
Intranasal oxytocin selectively modulates social perception, craving, and approach behavior in subjects with alcohol use disorder
Mitchell, J. M., Arcuni, P. A., Weinstein, D., & Woolley, J. D. (2016) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000213 · Cited by 82 · see citing works
Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial
Vetter, S., Schnabel, S., Reichl, M., Sirignano, L., Grinevich, V., Koopmann, A., Spanagel, R., Kiefer, F., Sommer, W. H., & Bach, P. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06779-x · Cited by 3 · see citing works

Authors: Flanagan, J. C., Nietert, P. J., Sippel, L., Jarnecke, A. M., Kirby, C., Hogan, J. N., Massa, A. A., Brower, J., Back, S. E., & Parrott, D.
Affiliations: Medical University of South Carolina (US)
Dartmouth College (US)
Georgia State University (US)
Corresponding author: Flanagan, Julianne C.
ORCID: Flanagan, Julianne C.
Nietert, Paul J.
Sippel, Lauren
Jarnecke, Amber M.
Kirby, Charli
Hogan, Jasara N.
Massa, Andrea A.
Back, Sudie E.
Parrott, Dominic
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2022-08
Volume: 152
Pages: 14-24
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2022.06.011
PMC: PMC9308670
OpenAlex: W4281789738
Cited by: 16
References: 107
Citations by year: 2026: 4 · 2025: 5 · 2024: 4 · 2023: 3
FWCI: 2.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 317 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Journal of Psychiatric Research (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIAAA
US Department of Veterans Affairs Office of Academic Affiliations
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: intranasal oxytocin, alcohol craving, intimate partner aggression, alcoholism, couples, cortisol response, pharmacotherapy
MeSH terms: Administration, Intranasal, Aggression, Ethanol, Alcoholism, Double-Blind Method, Humans, Oxytocin, Craving

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Randomized Controlled Trial Examining the Effects of Intranasal Oxytocin on Alcohol Craving and Intimate Partner Aggression among Couples

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks