Novel insights in SHBG regulation and clinical implications

Simó, Rafael; Sáez-López, Cristina; Barbosa-Desongles, Anna; Hernández, Cristina; Selva, David M.

doi:10.1016/j.tem.2015.05.001

Cited by 335Hormonal and reproductive studiesEstrogen and related hormone effectsGrowth Hormone and Insulin-like Growth Factors

Novel insights in SHBG regulation and clinical implications

Simó, Rafael, Sáez-López, Cristina, Barbosa-Desongles, Anna, Hernández, Cristina, Selva, David M.·2015·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2015.05.001

Open this paper in CoChat — free account

Abstract

Sex hormone-binding globulin (SHBG) is produced and secreted by the liver into the bloodstream where it binds sex steroids and regulates their bioavailability. Traditionally, body mass index (BMI) was thought to be the major determinant of SHBG concentrations and hyperinsulinemia the main cause for low SHBG levels found in obesity. However, no mechanisms have ever been described. Emerging evidence now shows that liver fat content rather than BMI is a strong determinant of circulating SHBG. In this review we discuss evidence demonstrating that insulin might not regulate SHBG production, describe putative molecular mechanisms by which proinflammatory cytokines downregulate SHBG, and comment on recent findings suggesting dietary SHBG regulation. Finally, clinical implications of all of these findings and future perspectives are discussed.

Integrity signals

Registry

Crossref · 10.1016/j.tem.2015.05.001

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The direct inverse link between insulin and SHBG has proven to be invalid.
“This direct inverse link between insulin and SHBG has proven to be invalid [130].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [130]
Adiponectin increases the production of SHBG by activating AMPK and reducing the activity of enzymes involved in liver lipogenesis.
“It was recently found that adiponectin increases the production of SHBG by activating AMPK and reducing the activity of enzymes involved in liver lipogenesis.”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [71]

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
Adiponectin and Adiponectin Receptors
Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634 · see citing works
Polycystic ovary syndrome
Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61345-2 · Cited by 1,360 · see citing works
Sex differences in autoimmune disease
Whitacre, C. C. (2001) · Nature Immunology · doi:10.1038/ni0901-777 · Cited by 1,271 · see citing works
Sex‐hormone binding-globulin
ANDERSON, D. C. (1974) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1974.tb03298.x · Cited by 1,127 · see citing works
Impaired Glucose Tolerance, Type 2 Diabetes and Metabolic Syndrome in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Moran, L. J., Misso, M. L., Wild, R. A., & Norman, R. J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq001 · Cited by 1,108 · see citing works
Polycystic ovary syndrome
Lawrence, J., Douglas, P., & Gandy, J. (2016) · doi:10.1002/9781119163411.ch73 · Cited by 1,014 · see citing works
Testosterone and Sex Hormone–Binding Globulin Predict the Metabolic Syndrome and Diabetes in Middle-Aged Men
Laaksonen, D. E., Niskanen, L., Punnonen, K., Nyyssönen, K., Tuomainen, T.-P., Valkonen, V.-P., Salonen, R., & Salonen, J. T. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1036 · Cited by 920 · see citing works
Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2734 · Cited by 837 · see citing works
A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome*
NESTLER, J. E., POWERS, L. P., MATT, D. W., STEINGOLD, K. A., PLYMATE, S. R., RITTMASTER, R. S., CLORE, J. N., & BLACKARD, W. G. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-1-83 · Cited by 815 · see citing works
The Effect of Testosterone Replacement on Endogenous Inflammatory Cytokines and Lipid Profiles in Hypogonadal Men
Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731 · see citing works
Sex hormone-binding globulin and risk of type 2 diabetes in women and men
Ding, E. L., Song, Y., Manson, J. E., Hunter, D. J., Lee, C. C., Rifai, N., Buring, J. E., Gaziano, J. M., & Liu, S. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804381 · Cited by 726 · see citing works
Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.
PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-460 · Cited by 693 · see citing works
Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008
López-Miranda, J., Pérez-Jiménez, F., Ros, E., De Caterina, R., Badimón, L., Covas, M. I., Escrich, E., Ordovás, J. M., Soriguer, F., Abiá, R., et al. (2010) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.12.007 · Cited by 520 · see citing works
The role of hepatokines in metabolism
Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500 · see citing works
AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives
Viollet, B., Guigas, B., Leclerc, J., Hébrard, S., Lantier, L., Mounier, R., Andréelli, F., & Foretz, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01970.x · Cited by 486 · see citing works
Low serum testosterone and sex-hormone-binding-globulin in massively obese men
GLASS, A. R., SWERDLOFF, R. S., BRAY, G. A., DAHMS, W. T., & ATKINSON, R. L. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-6-1211 · Cited by 430 · see citing works
Sex Hormone–Binding Globulin and the Free Androgen Index Are Related to Cardiovascular Risk Factors in Multiethnic Premenopausal and Perimenopausal Women Enrolled in the Study of Women Across the Nation (SWAN)
Sutton-Tyrrell, K., Wildman, R. P., Matthews, K. A., Chae, C. U., Lasley, B. L., Brockwell, S. E., Pasternak, R. C., Lloyd‐Jones, D. M., Sowers, M. F., & Torréns, J. I. (2005) · Circulation · doi:10.1161/01.cir.0000157697.54255.ce · Cited by 401 · see citing works
Diverse Roles for Sex Hormone-Binding Globulin in Reproduction
Hammond, G. L. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.092593 · Cited by 317 · see citing works
Changes in sex hormone‐binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome
Niskanen, L., Laaksonen, D. E., Punnonen, K., Mustajoki, P., Kaukua, J., & Rissanen, A. (2004) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00335.x · Cited by 275 · see citing works
Sex hormone binding globulin and insulin resistance
Wallace, I. R., McKinley, M. C., Bell, P. M., & Hunter, S. J. (2013) · Clinical Endocrinology · doi:10.1111/cen.12086 · Cited by 268 · see citing works
Low Sex-Hormone-Binding Globulin Concentration as Independent Risk Factor for Development of NIDDM: 12-Yr Follow-Up of Population Study of Women in Gothenburg, Sweden
Lindstedt, G., Lundberg, P.-A., Lapidus, L., Lundgren, H., Bengtsson, C., & Björntorp, P. (1991) · Diabetes · doi:10.2337/diab.40.1.123 · Cited by 252 · see citing works
Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone–binding globulin gene
Selva, D. M., Hogeveen, K. N., Innis, S. M., & Hammond, G. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32249 · Cited by 232 · see citing works
Self-citation
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
Perry, J. R. B., Weedon, M. N., Langenberg, C., Jackson, A. U., Lyssenko, V., Sparsø, T., Thorleifsson, G., Grallert, H., Ferrucci, L., Maggio, M., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddp522 · Cited by 217 · see citing works
Structure, Function, and Regulation of Androgen-Binding Protein/Sex Hormone-Binding Globulin
JOSEPH, D. R. (1994) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61148-6 · Cited by 212 · see citing works
Association of Testosterone and Sex Hormone–Binding Globulin With Metabolic Syndrome and Insulin Resistance in Men
Li, C., Ford, E. S., Li, B., Giles, W. H., & Liu, S. (2010) · Diabetes Care · doi:10.2337/dc09-1788 · Cited by 194 · see citing works
Sex hormone-binding globulin and type 2 diabetes mellitus
Le, T. N., Nestler, J. E., Strauss, J. F., & Wickham, E. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.09.005 · Cited by 191 · see citing works
Minireview: Neuro-Immuno-Endocrine Modulation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis by gp130 Signaling Molecules
Chesnokova, V., & Melmed, S. K. (2002) · Endocrinology · doi:10.1210/endo.143.5.8861 · Cited by 188 · see citing works
Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men
Haffner, S. M., Valdez, R. A., Morales, P. A., Hazuda, H. P., & D, M. P. S. M. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.1.8325960 · Cited by 178 · see citing works
Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
Peter, A., Kantartzis, K., Machann, J., Schick, F., Staiger, H., Machicao, F. E., Schleicher, E. D., Fritsche, A., Häring, H., & Stefan, N. (2010) · Diabetes · doi:10.2337/db10-0179 · Cited by 156 · see citing works
Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome
PUGEAT, M. M., Nader, N., Hogeveen, K. N., Raverot, G., Déchaud, H., & Grenot, C. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.020 · Cited by 149 · see citing works
Sex Hormone-Binding Globulin and Insulin-Like Growth Factor-Binding Protein-1 as Indicators of Metabolic Syndrome, Cardiovascular Risk, and Mortality in Elderly Men
Kalme, T., Seppälä, M. T., Qiao, Q., Koistinen, R. A., Nissinen, A. M., Harrela, M., Loukovaara, M. J., Leinonen, P. J., & Tuomilehto, J. O. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0762 · Cited by 141 · see citing works
Male Hypogonadism in Systemic Disease
Kalyani, R. R., Gavini, S., & Dobs, A. S. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.014 · Cited by 137 · see citing works
Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men
Gannagé‐Yared, M., Khalifé, S., Semaan, M., Fares, F., Jambart, S., & Halaby, G. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02175 · Cited by 134 · see citing works
Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma- derived (Hep G2) cells
Crave, J. C., Lejeune, H., Brébant, C., Baret, C., & Pugeat, M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7536204 · Cited by 133 · see citing works
Concentrations of sex-hormone binding globulin and corticosteroid binding globulin in serum in relation to cardiovascular risk factors and to 12-year incidence of cardiovascular disease and overall mortality in postmenopausal women.
Lapidus, L., Lindstedt, G., Lundberg, P. A., Bengtsson, C., & Gredmark, T. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.1.146 · Cited by 130 · see citing works
Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4α
Selva, D. M., & Hammond, G. L. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0025 · Cited by 128 · see citing works
Self-citation
Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone–Binding Globulin
Simó, R., Barbosa-Desongles, A., Lecube, A., Hernández, C., & Selva, D. M. (2011) · Diabetes · doi:10.2337/db11-0727 · Cited by 127 · see citing works
Self-citation
Clinical Utility of Sex Hormone-Binding Globulin Measurement
PUGEAT, M. M., Crave, J. C., TOURNIAIRE, J., & Forest, M. G. (2008) · Hormone Research · doi:10.1159/000184778 · Cited by 120 · see citing works
Effects of tumor necrosis factor blockade on cardiovascular risk factors in psoriatic arthritis: A double‐blind, placebo‐controlled study
Sattar, N. A., Crompton, P., Cherry, L., Kane, D., Lowe, G. D. O., & McInnes, I. B. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22447 · Cited by 118 · see citing works
Five-Day Pulsatile Gonadotropin-Releasing Hormone Administration Unveils Combined Hypothalamic-Pituitary-Gonadal Defects Underlying Profound Hypoandrogenism in Men with Prolonged Critical Illness1
den Berghe, G. V., Weekers, F., Baxter, R. C., Wouters, P. J., Iranmanesh, A., Bouillon, R., & Veldhuis, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7680 · Cited by 116 · see citing works
Human Sex Hormone-Binding Globulin Gene Expression in Transgenic Mice
Jänne, M., Deol, H. K., Power, S. G. A., Yee, S.-P., & Hammond, G. L. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.1.0050 · Cited by 113 · see citing works
Association of decreased sex hormone binding globulin and cardiovascular risk factors.
Haffner, S. M., Katz, M. S., D, M. P. S. M., & Dunn, J. F. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.1.136 · Cited by 104 · see citing works
Hepatocyte Nuclear Factor-4 Controls Transcription from a TATA-less Human Sex Hormone-binding Globulin Gene Promoter
Jänne, M., & Hammond, G. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34105 · Cited by 94 · see citing works
Sex Hormone-Binding Globulin in the Diagnosis of Peripheral Tissue Resistance to Thyroid Hormone: The Value of Changes after Short Term Triiodothyronine Administration*
SARNE, D. H., Refetoff, S., Rosenfield, R. L., & FARRIAUX, J. P. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-4-740 · Cited by 94 · see citing works
Adiponectin Upregulates SHBG Production: Molecular Mechanisms and Potential Implications
Simó, R., Sáez‐López, C., Lecube, A., Hernández, C., Fort, J. M., & Selva, D. M. (2014) · Endocrinology · doi:10.1210/en.2014-1072 · Cited by 86 · see citing works
Self-citation
IL1β Down-regulation of Sex Hormone-Binding Globulin Production by Decreasing HNF-4α Via MEK-1/2 and JNK MAPK Pathways
Simó, R., Barbosa-Desongles, A., Hernández, C., & Selva, D. M. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1152 · Cited by 84 · see citing works
Self-citation
Opening of microglial KATP channels inhibits rotenone‐induced neuroinflammation
Zhou, F., Yao, H., Wu, J., Ding, J., Sun, T., & Hu, G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00144.x · Cited by 84 · see citing works
Effects of acute hyperinsulinemia on testosterone serum concentrations in adult obese and normal-weight men
Pasquali, R., Macor, C., Vicennati, V., Iasio, F. R. D., Mesini, P., Boschi, S., Casimirri, F., & Vettor, R. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90189-x · Cited by 81 · see citing works
Regulation of production and secretion of sex hormone-binding globulin in HepG2 cell cultures by hormones and growth factors
Loukovaara, M. J., Carson, M., & Adlercreutz, H. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829605 · Cited by 80 · see citing works
Sex Hormone-Binding Globulin Gene Expression and Insulin Resistance
Winters, S. J., Gogineni, J., Karegar, M., Scoggins, C., Wunderlich, C. A., Baumgartner, R., & Ghooray, D. T. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2640 · Cited by 79 · see citing works
Inverse Relationship between Serum Levels of Interleukin-1β and Testosterone in Men with Stable Coronary Artery Disease
Nettleship, J., Pugh, P., Channer, K., Jones, T., & Jones, R. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-976543 · Cited by 73 · see citing works
Gonadal Hormones in Men with Rheumatoid Arthritis — From Onset Through 2 Years
Tengstrand, B., Carlström, K., & Hafström, I. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.080558 · Cited by 73 · see citing works
Nonalcoholic Fatty Liver Disease and Low-Carbohydrate Diets
York, L. W., Puthalapattu, S., & Wu, G. Y. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-070208-114232 · Cited by 68 · see citing works
Molecular Mechanism of TNFα-Induced Down-Regulation of SHBG Expression
Simó, R., Barbosa-Desongles, A., Sáez‐López, C., Lecube, A., Hernández, C., & Selva, D. M. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1321 · Cited by 68 · see citing works
Self-citation
Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes
Stefan, N., Schick, F., & Häring, H.-U. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0910143 · Cited by 66 · see citing works
Serum sex hormone-binding globulin levels are independently associated with nonalcoholic fatty liver disease in people with type 2 diabetes
Shin, J. Y., Kim, S., Lee, M. Y., Kim, H. S., Ye, B. I., Shin, Y. G., Baik, S. K., & Chung, C. H. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.07.029 · Cited by 59 · see citing works
Rosiglitazone increases bioactive testosterone and reduces waist circumference in hypogonadal men with type 2 diabetes
Kapoor, D., Channer, K. S., & Jones, T. H. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.022 · Cited by 58 · see citing works
Inter‐relations between growth hormone, insulin, insulin‐like growth factor‐l (IGF‐I), IGF‐binding protein‐1 (IGFBP‐1) and sex hormone‐binding globulin in acromegaly
Holly, J. M. P., Cotterlll, A. M., Jemmott, R. C., et al. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb03766.x · Cited by 57 · see citing works
Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations
Yasui, T., Tomita, J., Miyatani, Y., Yamada, M., Uemura, H., Irahara, M., Arai, M., Kojimahara, N., Okabe, R., Ishii, Y., et al. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.08.001 · Cited by 55 · see citing works
Prepregnancy SHBG Concentrations and Risk for Subsequently Developing Gestational Diabetes Mellitus
Hedderson, M. M., Xu, F., Darbinian, J. A., Quesenberry, C. P., Sridhar, S. B., Kim, C., Gunderson, E. P., & Ferrara, A. M. (2014) · Diabetes Care · doi:10.2337/dc13-1965 · Cited by 54 · see citing works
Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis: suppressive effect of interleukin-1 on the secretion of GnRH
Öktenli, Ç. (2004) · Human Reproduction · doi:10.1093/humrep/deh161 · Cited by 50 · see citing works
A study of serum androgen and cortisol levels in female patients with rheumatoid arthritis. Correlation with disease activity
MIRONE, L., Altomonte, L., D’Agostino, P., Zoli, A., Barini, A., & Magarò, M. (1996) · Clinical Rheumatology · doi:10.1007/bf02231678 · Cited by 49 · see citing works
Sex hormone-binding globulin predicts the incidence of hyperglycemia in women: interactions with adiponectin levels
Bonnet, F., Balkau, B., Malécot, J.-M., Picard, P., Lange, C., Fumeron, F., Aubert, R., Raverot, V., Déchaud, H., Tichet, J., et al. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0202 · Cited by 47 · see citing works
Antihypertensive drugs clonidine, diazoxide, hydralazine and furosemide regulate the production of cytokines by placentas and peripheral blood mononuclear cells in normal pregnancy
Xu, B., Makris, A., Thornton, C. E., et al. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000222762.84605.03 · Cited by 46 · see citing works
Human Sex Hormone-binding Globulin is Expressed in Testicular Germ Cells and not in Sertoli Cells
Selva, D. M., & Hammond, G. L. (2006) · Hormone and Metabolic Research · doi:10.1055/s-2006-925336 · Cited by 45 · see citing works
Self-citation
Original Research Communications
Barbe, P., Bennet, A., Stebenet, M., Perret, B., & Louvet, J. (1993) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.3.319 · Cited by 44 · see citing works
Testosterone, SHBG and risk of type 2 diabetes in the second evaluation of the Pizarra cohort study
Soriguer, F., Rubio‐Martín, E., Fernández, D., Valdés, S., García‐Escobar, E., Martín‐Núñez, G. M., Esteva, I., Almaraz, M. C., & Rojo‐Martínez, G. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02559.x · Cited by 43 · see citing works
Sex Hormone–Binding Globulin and Testosterone in Individuals With Childhood Diabetes
Danielson, K. K., Drum, M. L., & Lipton, R. B. (2008) · Diabetes Care · doi:10.2337/dc07-2169 · Cited by 43 · see citing works
The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells
Liu, X., Wu, J., Zhou, F., Sun, X., Yao, H., Yang, Y., Ding, J., & Hu, G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.018 · Cited by 36 · see citing works
Activation of estrogen receptors with E2 downregulates peroxisome proliferator-activated receptor γ in hepatocellular carcinoma
Lin, Y.-M., Velmurugan, B. K., Yeh, Y., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2793 · Cited by 34 · see citing works
Effects of thyroid hormone on sex hormone-binding globulin gene expression in human cells
Raggatt, L. E., Blok, R., Hamblin, P. S., & Barlow, J. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.1.1618999 · Cited by 27 · see citing works
Endocrine effects of the podophyllotoxine derivative drug CPH 82 (Reumacon®) in patients with rheumatoid arthritis
Carlström, P.-J. H. K. (2000) · Scandinavian Journal of Rheumatology · doi:10.1080/030097400750001888 · Cited by 26 · see citing works
Oleic acid increases hepatic sex hormone binding globulin production in men
Sáez‐López, C., Soriguer, F., Hernández, C., Rojo‐Martínez, G., Rubio‐Martín, E., Simó, R., & Selva, D. M. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300304 · Cited by 24 · see citing works
Self-citation
Intensive insulin therapy increases sex hormone-binding globulin in newly diagnosed type 2 diabetic patients
Tong, G., Hua, X., Zhong, Y., Zhang, K., Gu, G., Feng, W., Huang, H., Wang, W., Li, L., Sun, Y., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0557 · Cited by 23 · see citing works
Beneficial effects of adenosine triphosphate-sensitive K+channel opener on liver ischemia/reperfusion injury
Nogueira, M. A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15319 · Cited by 22 · see citing works
IL-32γ overexpression accelerates streptozotocin (STZ)-induced type 1 diabetes
Jhun, H., Choi, J., Hong, J., et al. (2014) · Cytokine · doi:10.1016/j.cyto.2014.05.002 · Cited by 19 · see citing works
Immunological and mass spectrometric assays of SHBG: consistent and inconsistent metabolic associations in healthy men.
Veldhuis, J., Bondar, O., Dyer, R. B., Trushin, S., Klee, E., Singh, R. J., & Klee, G. (2014) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-2642 · Cited by 19 · see citing works
Identification, characterization and expression of novel Sex Hormone Binding Globulin alternative first exons in the human prostate
Pinós, T., Barbosa-Desongles, A., Hurtado, A., Santamaria‐Martínez, A., de Torres, I. M., Moróte, J., Reventós, J., & Munell, F. (2009) · BMC Molecular Biology · doi:10.1186/1471-2199-10-59 · Cited by 14 · see citing works
Self-citation
[Plasma level of testosterone-estradiol-binding globulin in women with Itsenko-Cushing disease].
Манушарова, Р. А. (1987) · PubMed · Cited by 3 · see citing works
[Changes in plasma levels of androgens and SHBG in patients with polycystic ovary syndrome (PCOs) treated with oral contraceptives containing desogestrel].
Negri, P., D'Errico, G., Minisci, N., et al. (1988) · PubMed · Cited by 2 · see citing works

Flagged first, then by citations

Sorted by citations

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works
Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis
Laurent, M. R., Hammond, G. L., Blokland, M., Jardí, F., Antonio, L., Dubois, V., Khalil, R., Sterk, S. S., Gielen, E., Decallonne, B., et al. (2016) · Scientific Reports · doi:10.1038/srep35539 · Cited by 174 · see citing works
Effect of Sex Hormone-Binding Globulin on Polycystic Ovary Syndrome: Mechanisms, Manifestations, Genetics, and Treatment
Xing, C., Zhang, J., Zhao, H., & He, B. (2022) · International Journal of Women's Health · doi:10.2147/ijwh.s344542 · Cited by 118 · see citing works
Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology
Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96 · see citing works
Exenatide, dapagliflozin, or Phentermine/Topiramate differentially affect metabolic profiles in polycystic ovary syndrome
Elkind-Hirsch, K. E., Chappell, N., Seidemann, E., Storment, J., & Bellanger, D. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab408 · Cited by 96 · see citing works
Role of exercise-induced hepatokines in metabolic disorders
Ennequin, G., Sirvent, P., & Whitham, M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00433.2018 · Cited by 54 · see citing works
Efficacy of Very Low-Calorie Ketogenic Diet with the Pronokal® Method in Obese Women with Polycystic Ovary Syndrome: A 16-Week Randomized Controlled Trial
Pandurevic, S., Mancini, I., Mitselman, D., Magagnoli, M., Teglia, R., Fazzeri, R., Dionese, P., Cecchetti, C., Caprio, M., Moretti, C., et al. (2023) · Endocrine Connections · doi:10.1530/ec-22-0536 · Cited by 36 · see citing works
Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men
Gyawali, P., Martin, S. A., Heilbronn, L. K., Vincent, A. D., Jenkins, A. J., Januszewski, A. S., Taylor, A. W., Adams, R. J. T., O’Loughlin, P. D., & Wittert, G. A. (2018) · PLOS ONE · doi:10.1371/journal.pone.0200078 · Cited by 35 · see citing works
Ageing male (part I): Pathophysiology and diagnosis of functional hypogonadism
Huhtaniemi, I. T., & Wu, F. C. W. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101622 · Cited by 31 · see citing works
Contribution of Liver Fat to Weight Loss–Induced Changes in Serum Hepatokines: A Randomized Controlled Trial
Telgenkamp, I., Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., Bons, J. A. P., Schaper, N. C., Joris, P. J., Plat, J., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02378 · Cited by 18 · see citing works

Hypertension and Hyperinsulinemia
Kaplan, N. M. (1991) · Primary Care Clinics in Office Practice · doi:10.1016/s0095-4543(21)00341-9 · Cited by 6 · see citing works
Body fat distribution and hyperinsulinemia as risk factors for diabetes and cardiovascular disease.
D, M. P. S. M., & Haffner, S. M. (1986) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.6.2.123 · Cited by 331 · see citing works
Hyperinsulinemia, Insulin Resistance, and Hypertension
Bönner, G. (1994) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199406242-00007 · Cited by 35 · see citing works
1286-P: Hyperinsulinemia Is Common in Individuals with Normoglycemia in a Nationwide Working-Age Population
Louie, J. Z., Shiffman, D., Meigs, J. B., et al. (2023) · Diabetes · doi:10.2337/db23-1286-p
Hyperinsulinemia: A Merging History with Idiopathic Tinnitus, Vertigo, and Hearing Loss.
Kraft, J. (1998) · PubMed · Cited by 23 · see citing works

Authors: Simó, R., Sáez-López, C., Barbosa-Desongles, A., Hernández, C., & Selva, D. M.
Affiliations: Universitat Autònoma de Barcelona (ES)
Corresponding author: Simó, Rafael
Selva, David M.
ORCID: Simó, Rafael
Hernández, Cristina
Selva, David M.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2015-07
Volume: 26
Issue: 7
Pages: 376-383
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2015.05.001
OpenAlex: W1764086527
Cited by: 335
References: 81
Citations by year: 2026: 24 · 2025: 37 · 2024: 55 · 2023: 42 · 2022: 45 · 2021: 37 · 2020: 17 · 2019: 22 · 2018: 19 · 2017: 17 · 2016: 16 · 2015: 3
FWCI: 2.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: sex hormone-binding globulin, liver fat, body mass index, hyperinsulinemia, obesity, insulin, inflammatory cytokines, dietary regulation, liver
MeSH terms: Humans, Insulin, Liver, Monosaccharides, Obesity, Palmitates, Sex Hormone-Binding Globulin, Biomarkers, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Novel insights in SHBG regulation and clinical implications

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks