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Sleep Duration and Cardiovascular Disease Risk
Open accessAbstract
Inadequate sleep is increasingly pervasive, and the impact on health remains to be fully understood. The cardiovascular consequences alone appear to be substantial. This review summarizes epidemiologic evidence regarding the association between extremes of sleep duration and the prevalence and incidence of cardiovascular diseases. The adverse effects of experimental sleep loss on physiological functions are discussed, along with cardiovascular risk factors that may underlie the association with increased morbidity and mortality. Current data support the concept that inadequate sleep duration confers heightened cardiovascular risk. Thus implementation of preventative strategies may reduce the potential disease burden associated with this high-risk behavior.
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“The relationship between self-reported sleep duration and prevalent hypertension follows a U-shaped association with the nadir of the U being between 7 and 8 hours of uninterrupted sleep per night.256,264,265”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [264]
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“Both short and long self-reported sleep durations are associated with higher CVD risk.(18) Sensitivity analyses concerning age categories or and preexisting conditions did not impact the overall association.”
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“Nevertheless, there were scarcely 50% of adults in the US reported a habitual sleep time falling within the recommended sleeping hour (Covassin and Singh, 2016), and this trend was also found in other developed countries (Bin et al.”
BackgroundAssociation between sleep duration and depression: A Mendelian randomization analysis
Liu, H. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.05.020 · Cited by 47
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“ficient sleep to increased morbidity and mortality, as recently reviewed elsewhere.(50,51) Sleep deficiency enhances vulnerability to weight gain and obesity, mostly abdominal obesity.”
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“However, millions of Americans suffer from sleeprelated disorders each year, with only 48% of adults reporting a habitual sleep duration within this range [6].”
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“Sleep-related problems—To assess sleep-related problems, we asked three questions: (1) During the past month, how often have you taken medicine to help you sleep? (2) During the past month, how often have you had trouble staying awake while driving, eating meals, or engaging in your daily activities? (3) During the pa…”
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“, 2006), cardiovascular diseases (Covassin and Singh, 2016; Li et al., 2020), renal disease (Geng et al.”
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“, exercise, nutrition and sleep) has been widely acknowledged to have a large influence on BP [2], [3].”
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“Although studies substantiate relationship between sleep duration and CVD risk (e.g., Covassin and Singh 2016; Kwok et al. 2018; Tao et al. 2021), ones linking it specifically to subclinical atherosclerosis are relatively sparse.”
BackgroundClinical outcomes of light therapy in hospitalized patients – A systematic review
Lindskov, F. O., Iversen, H. K., & West, A. S. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1993240 · Cited by 20
“2018), cardiovascular disease (Covassin and Singh 2016) and mortality (Cappuccio et al.”
BackgroundGiménez, M. C., Luxwolda, M., van Stipriaan, E., Bollen, P. P., Hoekman, R. L., Koopmans, M. A., Arany, P. R., Krames, M. R., Berends, A. C., Hut, R. A., et al. (2022) · Biology · doi:10.3390/biology12010060 · Cited by 27
Sleep disorders related to index and comorbid mental disorders and psychotropic drugs
Merrill, R. M., Ashton, M. K., & Angell, E. (2023) · Annals of General Psychiatry · doi:10.1186/s12991-023-00452-3 · Cited by 27
Deriving Accurate Nocturnal Heart Rate, rMSSD and Frequency HRV from the Oura Ring
Liang, T., Yılmaz, G., & Soon, C. S. (2024) · Sensors · doi:10.3390/s24237475 · Cited by 19
Patel, A. R., Hsu, A., Perez, I. A., Wren, T. A. L., & Edison, B. R. (2020) · Research in Sports Medicine · doi:10.1080/15438627.2020.1716229 · Cited by 21
The Relationship between Sleep Duration and Metabolic Syndrome Severity Scores in Emerging Adults
Chaudhry, B. A., Brian, M. S., & Morrell, J. S. (2023) · Nutrients · doi:10.3390/nu15041046 · Cited by 20
Liu, M., Yadong, W., Song, J., & He, W. W. (2023) · Sleep And Breathing · doi:10.1007/s11325-023-02966-2 · Cited by 19
“Significantly, only 48% of respondents in the United States reported a usual sleep time within this range [11].”
fu, X., Wilson, P., & Chung, W. S. F. (2020) · BMC Emergency Medicine · doi:10.1186/s12873-020-00356-5 · Cited by 19
Koçak, A. T., & Arslan, S. (2020) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0000000000000562 · Cited by 19
Evbayekha, E. O., Aiwuyo, H. O., Dilibe, A., Nriagu, B. N., Idowu, A. B., Eletta, R. Y., & Ohikhuai, E. E. (2022) · Cureus · doi:10.7759/cureus.33005 · Cited by 18
“Some studies have found increased rates of major adverse cardiovascular outcomes among patients with sleep deprivation [16,30].”
BackgroundGao, Y., Tang, W., Mao, D., Chen, L.-L., & Ding, X. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04601-6 · Cited by 20
Relationship between sleep disorders and female infertility among US reproductive-aged women
Zhao, J., Chen, Q., & Xue, X. (2023) · Sleep And Breathing · doi:10.1007/s11325-023-02802-7 · Cited by 19
Disparities in Hypertension Among African-Americans: Implications of Insufficient Sleep
Covassin, N., Greene, E. L., Singh, P., & Somers, V. K. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0855-1 · Cited by 19
Self-citationAcute Ramelteon Treatment Maintains the Cardiac Rhythms of Rats during Non-REM Sleep
Yoshimoto, A., Yamashiro, K., Ikegaya, Y., & Matsumoto, N. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b20-00932 · Cited by 18
Du, J., Chen, Y., Zhou, N., Song, Y., Wang, W., & Hong, X. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.04.004 · Cited by 16
Sleep quality and anxiety levels among university students
Silva, D. N., Lima, A. O., dos Santos, L. A., Barreto, D. M., & Pithon, K. R. (2022) · O Mundo da Saúde · doi:10.15343/0104-7809.202246247254 · Cited by 19
The Benefits of Physical Activity for Older People
Koster, A., Stenholm, S., & Schrack, J. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-71291-8_3 · Cited by 17
Devine, J. K., Collen, J. F., Choynowski, J. J., & Capaldi, V. F. (2020) · Military Medical Research · doi:10.1186/s40779-020-00239-7 · Cited by 17
Health-Risk Behaviors and Dietary Patterns Among Jordanian College Students: A Pilot Study
Alkhalidy, H., Orabi, A., Alzboun, T., Alnaser, K., Al-Shami, I. K., & Al-Bayyari, N. S. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.632035 · Cited by 23
Chappel-Farley, M. G., Mander, B. A., Neikrug, A. B., Stehli, A., Nan, B., Grill, J. D., Yassa, M. A., & Benca, R. M. (2021) · SLEEP · doi:10.1093/sleep/zsab240 · Cited by 16
Reconstruction of Pulse Wave and Respiration From Wrist Accelerometer During Sleep
Zschocke, J., Leube, J., Glos, M., Semyachkina-Glushkovskaya, O., Penzel, T., Bartsch, R. P., & Kantelhardt, J. W. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3107978 · Cited by 16
Possible association between oral health and sleep duration
Han, S., Jee, D., Kang, Y.-J., Park, Y. J., & Cho, J. (2021) · Medicine · doi:10.1097/md.0000000000028035 · Cited by 15
“Both short and long sleepers are more likely to be in poorer overall health and to have been diagnosed with more medical conditions than normal sleepers.([14,15,17]) Appropriate sleep is important in terms of both general health and quality of life.”
Background
Metadata
- Authors
- Covassin, N., & Singh, P.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Covassin, Naima
- Venue
- Sleep Medicine Clinics
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 11
- Issue
- 1
- Pages
- 81-89
- ISSN
- 1556-407X (ISSN-L)
- PMC
- PMC4791534
- OpenAlex
- W2293620633
- Cited by
- 314
- References
- 94
- Citations by year
- 2026: 19 · 2025: 48 · 2024: 49 · 2023: 57 · 2022: 41 · 2021: 29 · 2020: 28 · 2019: 15 · 2018: 17 · 2017: 7 · 2016: 4
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Sleep Medicine Clinics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association (11SDG7260046)
- National Heart, Lung, and Blood Institute (R01HL114676)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Keywords
- sleep duration, cardiovascular disease, insufficient sleep, sleep deprivation, cardiovascular risk factors, cardiovascular mortality, cardiovascular disease incidence, disease prevention
- MeSH terms
- Cardiovascular Diseases, Humans, Sleep
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