Cited by 190Cancer Immunotherapy and BiomarkersLung Cancer Treatments and MutationsFerroptosis and cancer prognosis

Immune Checkpoint Inhibitors in EGFR-Mutated NSCLC: Dusk or Dawn?

Open access
Qiao, Meng, Jiang, Tao, Liu, Xinyu, Mao, Shiqi, Zhou, Fei, Li, Xuefei, Zhao, Chao, Chen, Xiaoxia +3 more·2021·Journal of Thoracic Oncology

Abstract

Although immune checkpoint inhibitors (ICIs) that target programmed cell death protein-1/programmed cell death ligand-1 axis have significantly shifted the treatment paradigm in advanced NSCLC, clinical benefits of these agents are limited in patients with EGFR-mutated NSCLC. Several predictive biomarkers (e.g., programmed cell death ligand-1 expression, tumor mutation burden), which have been validated in EGFR-wild type NSCLC, however, are not efficacious in EGFR-mutated tumors, suggesting the unique characteristics of tumor microenvironment of EGFR-mutated NSCLC. Here, we first summarized the clinical evidence on the efficacy of ICIs in patients with EGFR-mutated NSCLC. Then, the cancer immunogram features of EGFR-mutated NSCLC was depicted to visualize the state of cancer-immune system interactions, including tumor foreignness, tumor sensitivity to immune effectors, metabolism, general immune status, immune cell infiltration, cytokines, and soluble molecules. We further discussed the potential subpopulations with EGFR mutations that could benefit from ICI treatment. Lastly, we put forward future strategies to adequately maximize the efficacy of ICI treatment in patients with EGFR-mutated NSCLC in the upcoming era of combination immunotherapies.

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Crossref · 10.1016/j.jtho.2021.04.003

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Authors
Qiao, M., Jiang, T., Liu, X., Mao, S., Zhou, F., Li, X., Zhao, C., Chen, X., Su, C., Ren, S., & Zhou, C.
Affiliations
Tongji University (CN)
Corresponding author
Zhou, Caicun
Venue
Journal of Thoracic Oncology
Publisher
Elsevier BV
Published
2021-08
Volume
16
Issue
8
Pages
1267-1288
ISSN
1556-0864 (ISSN-L)
OpenAlex
W3159640891
Cited by
186
References
184
Citations by year
2026: 24 · 2025: 39 · 2024: 39 · 2023: 35 · 2022: 35 · 2021: 14
FWCI
3.85
Type
journal article
Language
en
Open access
Locations
  • Journal of Thoracic Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81871865, 81972167)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords
immune checkpoint inhibitors, EGFR-mutant non-small cell lung cancer, PD-1/PD-L1 axis, predictive biomarkers, tumor mutational burden, PD-L1 expression, tumor microenvironment, immune cell infiltration, cytokines, combination immunotherapy, treatment response
MeSH terms
Immune Checkpoint Inhibitors, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Mutation, Biomarkers, Tumor, Tumor Microenvironment, B7-H1 Antigen, ErbB Receptors

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