Cited by 217Tea Polyphenols and EffectsAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites

Open access
Pervin, Monira, Unno, Keiko, Takagaki, Akiko, Isemura, Mamoru, Nakamura, Yoriyuki·2019·International Journal of Molecular Sciences

Abstract

Over the last three decades, green tea has been studied for its beneficial effects, including anti-cancer, anti-obesity, anti-diabetes, anti-inflammatory, and neuroprotective effects. At present, a number of studies that have employed animal, human and cell cultures support the potential neuroprotective effects of green tea catechins against neurological disorders. However, the concentration of (-)-epigallocatechin gallate (EGCG) in systemic circulation is very low and EGCG disappears within several hours. EGCG undergoes microbial degradation in the small intestine and later in the large intestine, resulting in the formation of various microbial ring-fission metabolites which are detectable in the plasma and urine as free and conjugated forms. Recently, in vitro experiments suggested that EGCG and its metabolites could reach the brain parenchyma through the blood-brain barrier and induce neuritogenesis. These results suggest that metabolites of EGCG may play an important role, alongside the beneficial activities of EGCG, in reducing neurodegenerative diseases. In this review, we discuss the function of EGCG and its microbial ring-fission metabolites in the brain in suppressing brain dysfunction. Other possible actions of EGCG metabolites will also be discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/ijms20153630

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 74 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Pervin, M., Unno, K., Takagaki, A., Isemura, M., & Nakamura, Y.
Affiliations
  • Shizuoka University (JP)
  • Mitsui (Japan) (JP)
Corresponding author
  • Pervin, Monira
  • Unno, Keiko
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-07-25
Volume
20
Issue
15
Pages
3630
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2964240146
Cited by
216
References
74
Citations by year
2026: 21 · 2025: 27 · 2024: 30 · 2023: 28 · 2022: 43 · 2021: 33 · 2020: 31 · 2019: 3
FWCI
4.09
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
green tea catechins, epigallocatechin gallate, neuroprotection, neurodegenerative diseases, blood-brain barrier, neurite outgrowth, brain parenchyma, gut-brain axis, anti-inflammatory activity
MeSH terms
Animals, Blood-Brain Barrier, Brain, Catechin, Cognition, Humans, Permeability, Plant Extracts, Structure-Activity Relationship, Tea, Molecular Structure, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review