Cited by 303Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchTraumatic Brain Injury and Neurovascular Disturbances

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Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

Liu, W., Tang, Y., Feng, J.·2011·Life Sciences

DOI 10.1016/j.lfs.2011.05.011

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Abstract

Microglia and astrocytes in the central nervous system are now recognized as active participants in various pathological conditions such as trauma, stroke, or chronic neurodegenerative disorders. Their activation is closely related with the development and severity of diseases. Interestingly, activation of microglia and astrocytes occurs with a spatially and temporarily distinct pattern. The present review explores the cross talk in the process of their activation. Microglia, activated earlier than astrocytes, promote astrocytic activation. On the other hand, activated astrocytes not only facilitate activation of distant microglia, but also inhibit microglial activities. Molecules contributing to their intercommunication include interleukin-1 (IL-1), adenosine triphosphate (ATP), and transforming growth factor beta (TGF-β). A better understanding about the cross talk between activation of microglia and astrocytes would be helpful to elucidate the role of glial cells in pathological conditions, which could accelerate the development of treatment for various diseases.

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Eugenín, J. L., Vecchiola, A., Murgas, P., Arroyo, P., Cornejo, F., & Rommy von Bernhardi, M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160083 · Cited by 35
“In the context of an injury, microglia are activated earlier and move more easily to the lesion site than do astrocytes [94].”
Post-Exposure Administration of Diazepam Combined with Soluble Epoxide Hydrolase Inhibition Stops Seizures and Modulates Neuroinflammation in a Murine Model of Acute TETS Intoxication
Vito, S. T., Austin, A. T., Banks, C. N., Inceoğlu, B., Bruun, D. A., Żółkowska, D., Tancredi, D., Rogawski, M., Hammock, B., & Lein, P. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.10.001 · Cited by 32
“Similarly, there is evidence that activated astrocytes can cause or exacerbate neuronal injury (Davalos et al., 2005; Liu et al., 2011) or play a neuroprotective role following brain and spinal cord injury via secretion of anti-inflammatory factors that suppress the activation of microglia (Faulkner et al.”
Astrocyte–Oligodendrocyte–Microglia Crosstalk in Astrocytopathies
de Waard, D. M., & Bugiani, M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.608073 · Cited by 38
Loss of the Extracellular Matrix Molecule Tenascin-C Leads to Absence of Reactive Gliosis and Promotes Anti-inflammatory Cytokine Expression in an Autoimmune Glaucoma Mouse Model
Wiemann, S., Reinhard, J., Reinehr, S., Cibir, Z., Joachim, S. C., & Faissner, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.566279 · Cited by 33
Female sex steroids and glia cells: Impact on multiple sclerosis lesion formation and fine tuning of the local neurodegenerative cellular network
Kipp, M., Hochstrasser, T., Schmitz, C., & Beyer, C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.016 · Cited by 32
Activation of neonatal microglia can be influenced by other neural cells
Turano, A., Lawrence, J. H., & Schwarz, J. M. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.052 · Cited by 29
“Stimulated microglia can directly activate astrocytes, which go on to generate a calcium wave that spreads to local and distant microglia to further excite or inhibit microglial activity [14].”
Background
Mechanisms and Therapeutic Prospects of Microglia-Astrocyte Interactions in Neuropathic Pain Following Spinal Cord Injury
Liu, Y., Cai, X., Shi, B., Mo, Y., Zhang, J., Luo, W., Yu, B., & Li, X. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04562-1 · Cited by 31
“Given that microglia are ramified and dynamic, they are capable of surveilling the microenvironment of CNS [27].”
Microglial distribution, branching, and clearance activity in aged rat hippocampus are affected by astrocyte meshwork integrity: evidence of a novel cell‐cell interglial interaction
Lana, D., Ugolini, F., Wenk, G. L., Giovannini, M. G., Zecchi‐Orlandini, S., & Nosi, D. (2018) · The FASEB Journal · doi:10.1096/fj.201801539r · Cited by 32
A Dual‐Layered Microfluidic System for Long‐Term Controlled In Situ Delivery of Multiple Anti‐Inflammatory Factors for Chronic Neural Applications
Frey, L., Bandaru, P., Zhang, Y. S., O'Kelly, K., Khademhosseini, A., & Shin, S. R. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201702009 · Cited by 33
An efficient method to limit microglia-dependent effects in astroglial cultures
Losciuto, S., Dorban, G., Gabel, S., Gustin, A., Hoenen, C., Grandbarbe, L., Heuschling, P., & Heurtaux, T. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.03.010 · Cited by 28
Addiction: A dysregulation of satiety and inflammatory processes
Harricharan, R., Abboussi, O., & Daniels, W. M. U. (2017) · Progress in brain research · doi:10.1016/bs.pbr.2017.07.012 · Cited by 35
“In the event of injury or disease, microglia and astrocytes undergo a process known as activation (Liu et al., 2011).”
Background
The Role of Oxytocin in Abnormal Brain Development: Effect on Glial Cells and Neuroinflammation
Knoop, M. S., Possovre, M.-L., Jacquens, A., Charlet, A., Baud, O., & Darbon, P. (2022) · Cells · doi:10.3390/cells11233899 · Cited by 35
“Reactive astrocytes also amplify the inflammatory response [115].”
BackgroundInfluential
The Role of Glial Mitochondria in α-Synuclein Toxicity
Jeon, Y., Kwon, Y., Jo, M., Lee, S., Kim, S., & Kim, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.548283 · Cited by 31
Mouse Astrocytes Promote Microglial Ramification by Releasing TGF-β and Forming Glial Fibers
Zhang, J., Zhang, L., Yi, S., Jiang, X., Qiao, Y., Zhang, Y., Xiao, C., & Zhou, T. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00195 · Cited by 34
“Previous studies showed that TGF-β secreted by astrocytes contributes to microglial ramification (Schilling et al., 2001; Liu et al., 2011).”
Result
The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death
Merlo, S., Spampinato, S. F., Beneventano, M., & Sortino, M. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-25453-1 · Cited by 29
“Aβ(1-42) peptide from Innovagen (Lund, Sweden) was dissolved in dimethylsulfoxide (DMSO) as a 5 mM stock, subsequently diluted to 100 μM in culture medium and enriched in oligomers by aggregation at RT for 24 h followed by at least 2 freeze-thaw cycles prior to use.”
The Important Double-Edged Role of Astrocytes in Neurovascular Unit After Ischemic Stroke
Han, G., Song, L., Ding, Z., Wang, Q., Yan, Y., Huang, J., & Ma, C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.833431 · Cited by 32
Vasopressin Impairment During Sepsis Is Associated with Hypothalamic Intrinsic Apoptotic Pathway and Microglial Activation
da Costa, L. H. A., Santos-Júnior, N. N., Catalão, C. H. R., Sharshar, T., Chrétien, F., & Rocha, M. J. A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0094-x · Cited by 27
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.
Squarcialupi, L., Colotta, V., Catarzi, D., Varano, F., Filacchioni, G., Varani, K., Corciulo, C., Vincenzi, F., Borea, P., Ghelardini, C., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400068e · Cited by 27
The crucial role of Erk2 in demyelinating inflammation in the central nervous system
Okazaki, R., Doi, T., Hayakawa, K., Morioka, K., Imamura, O., Takishima, K., Hamanoue, M., Sawada, Y., Nagao, M., Tanaka, S., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0690-8 · Cited by 31
“Several studies have reported interaction between microglia and astrocytes in the progression of inflammation [29, 30].”
Glia-based biomarkers and their functional role in the CNS
Jha, M. K., & Suk, K. (2013) · Expert Review of Proteomics · doi:10.1586/epr.12.70 · Cited by 28
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation.
Varano, F., Catarzi, D., Squarcialupi, L., Betti, M., Vincenzi, F., Ravani, A., Varani, K., Ben, D. D., Thomas, A., Volpini, R., et al. (2015) · European journal of medicinal chemistry · doi:10.1016/j.ejmech.2015.04.010 · Cited by 25
Melatonin regulates microglial polarization and protects against ischemic stroke-induced brain injury in mice.
Li, D., He, T.-P., Zhang, Y., Liu, J.-R., Zhao, H.-Y., Wang, D.-L., Wang, Q., Yuan, Y., & Zhang, S.-X. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114464 · Cited by 24
Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and Its Implications
Sharon, A., Jankowski, M. M., Shmoel, N., Erez, H., & Spira, M. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.646914 · Cited by 21
Directed glia‐assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood‐barrier function
Farahani, R. H., Sarrafpour, B., Simonian, M. R., Li, Q., & Hunter, N. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23162 · Cited by 25
Fatty Acid-Derived N-acylethanolamines Dietary Supplementation Attenuates Neuroinflammation and Cognitive Impairment in LPS Murine Model
Tyrtyshnaia, A. A., Konovalova, S. P., Ponomarenko, A. I., Egoraeva, A. A., & Manzhulo, I. (2022) · Nutrients · doi:10.3390/nu14183879 · Cited by 25
“Astrocyte activation occurs as a response to pathological conditions during neuroinflammation and, as a rule, takes place followed by microglia activation, although it can also develop through independent mechanisms [48].”
Background
Intense Acute Swimming Induces Delayed-Onset Muscle Soreness Dependent on Spinal Cord Neuroinflammation
Borghi, S. M., Bussulo, S. K. D., Pinho-Ribeiro, F. A., Fattori, V., Carvalho, T. T., Rasquel-Oliveira, F., Zaninelli, T. H., Ferraz, C. R., Casella, A. M., Cunha, F., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.734091 · Cited by 23
“Activated astrocytic networks may as well facilitate microglial activation via calcium wave-related adenosine triphosphate (ATP) release, which interacts with its purinergic receptor in microglia and activates these cells (Liu et al., 2011).”
Background
Indirubin-3′-monoxime prevents aberrant activation of GSK-3β/NF-κB and alleviates high fat-high fructose induced Aβ-aggregation, gliosis and apoptosis in mice brain
Priya, C. S., Vidhya, R., Kalpana, K., & Anuradha, C. V. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.02.053 · Cited by 25
Carotid body contribution to the physio‐pathological consequences of intermittent hypoxia: role of nitro‐oxidative stress and inflammation
Iturriaga, R. (2023) · Journal of Physiology · doi:10.1113/jp284112 · Cited by 22
“…of microglia and astroglia by severe CIH produces deleterious effects (neuronal injury, apoptosis) in different areas of the brain, the effects on hippocampal CA1, frontal cortical neurons and cerebellar Purkinje and fastigial neurons being more severe (Kiernan et al., 2016; Liu et al., 2011).”
Background
Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication
Fernández-Calle, R., Galán-Llario, M., Gramage, E., Zapatería, B., Vicente-Rodríguez, M., Zapico, J., de Pascual-Teresa, B., Ramos, A., Ramos-Álvarez, M., Uríbarri, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76415-5 · Cited by 22
Molecular Basis of the Brain Renin Angiotensin System in Cardiovascular and Neurologic Disorders: Uncovering a Key Role for the Astroglial Angiotensin Type 1 Receptor AT1R
Haspula, D., & Clark, M. A. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.248831 · Cited by 25
“Ang II–mediated ROS elevation and proinflammatory conditions are associated with neurodegeneration and also astrocyte senescence (Lanz et al., 2010; Liu et al., 2011a; Min et al., 2011).”
Background
SB-334867 (an Orexin-1 Receptor Antagonist) Effects on Morphine-Induced Sensitization in Mice—a View on Receptor Mechanisms
Łupina, M., Tarnowski, M., Baranowska‐Bosiacka, I., Talarek, S., Listos, P., Kotlinska, J. H., Gutowska, I., & Listos, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0993-0 · Cited by 23
“They maintain homeostasis in non-infected regions and promote inflammation in infected or damaged tissues [93].”
Background
A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice.
Martín-Álvarez, R., Paúl-Fernández, N., Palomo, V., Gil, C., Martínez, A., & Mengod, G. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.12.001 · Cited by 22
Wild Bitter Melon Exerts Anti-Inflammatory Effects by Upregulating Injury-Attenuated CISD2 Expression following Spinal Cord Injury
Kung, W.-M., Lin, C.-C., Kuo, C.-Y., Juin, Y.-C., Wu, P.-C., Lin, M.-S., & Klivényi, P. (2020) · Behavioural Neurology · doi:10.1155/2020/1080521 · Cited by 21
NLRP3 inflammasome activation is involved in trimethyltin-induced neuroinflammation
Long, J., Wang, Q., He, H., Sui, X. Y., Lin, G.-D., Wang, S., Yang, J., You, P., Luo, Y., & Wang, Y. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.003 · Cited by 20
Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson’s disease
Kostuk, E. W., Cai, J., & Iacovitti, L. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1181-x · Cited by 26
Do Microglia default on network maintenance in Alzheimer's disease?
Southam, K. A., Vincent, A. J., & Small, D. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151075 · Cited by 20
Understanding the influence of TLR-mediated immune system on necroptosis-induced neurodegeneration in Parkinson’s disease
Jadhav, V. S., & Khatri, D. K. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102872 · Cited by 22
VEGFD/VEGFR3 signaling contributes to the dysfunction of the astrocyte IL-3/microglia IL-3Rα cross-talk and drives neuroinflammation in mouse ischemic stroke
Wang, S., Guo, Y., Cao, R.-Q., Zhu, Y., Qiao, S., Du, H., Liu, Y., Xu, Y., Zhou, X.-Y., Sun, L., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01405-6 · Cited by 19
“The exchange of information and the interactions between astrocytes and microglia jointly affect the development and prognosis of the disease [17, 18].”
NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates
Boghdadi, A. G., Spurrier, J. M., Teo, L., Li, M., Škarica, M., Cao, B., Kwan, W. C., Merson, T. D., Nilsson, S. K., Šestan, N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27245-0 · Cited by 25
Astroglial cells as neuroendocrine targets in forebrain development: Implications for sex differences in psychiatric disease
Rurak, G. M., Woodside, B. C., Aguilar‐Valles, A., & Salmaso, N. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100897 · Cited by 24
Involvement of Testosterone Signaling in the Integrity of the Neurovascular Unit in the Male: Review of Evidence, Contradictions, and Hypothesis
Ahmadpour, D., & Grange‐Messent, V. (2020) · Neuroendocrinology · doi:10.1159/000509218 · Cited by 22
Astrocytes in the spinal dorsal horn and chronic itch
Tsuda, M. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.08.010 · Cited by 20
A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation
Plog, B. A., Moll, K., Kang, H.-Y., Iliff, J. J., Dashnaw, M. L., Nedergaard, M., & Vates, G. E. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.04.001 · Cited by 19
“There is some evidence that SAH can cause activation of microglia (Liu et al., 2011; Murakami et al., 2011; Ransohoff and Cardona, 2010), but the time course and degree of microglial activation after SAH remains poorly described, in part because the quantification of microglial activation has…”
Background
Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes
Nam, S., Kim, Y. N., Yoo, D., Yi, S.-S., Choi, J.-H., Hwang, I., Seong, J., & Yoon, Y. (2013) · Neural Regeneration Research · doi:10.3969/j.issn.1673-5374.2013.26.007 · Cited by 19
“Researches about the microglia and astrocytes in pathological states were conducted in plentiful studies [17-22] .”
Background
Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia
Avalos, M. P., Guzman, A. S., Rigoni, D., Gorostiza, E. A., Sanchez, M. A., Mongi‐Bragato, B., García‐Keller, C., Perassi, E. M., Virgolini, M. B., Ramos, J. M. P., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.01.014 · Cited by 20
25C-NBF, a new psychoactive substance, has addictive and neurotoxic potential in rodents
Hur, K., Kim, S., Lee, B., Ko, Y., Seo, J., Kim, S., Ma, S., Kim, Y., Jeong, Y., Pham, D. T., et al. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02740-3 · Cited by 19
Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeutic Targets
Ahremenko, E. A., Andreev, A., Apushkin, D., & Korkotian, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411995 · Cited by 20
“This self-perpetuating interaction drives chronic astrogliosis and microglial activation within the CNS, culminating in neuronal damage [3,12,37,71–74].”
Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury
Zheng, X., Mi, T., Wang, R., Zhang, Z., Li, W., Zhao, J., Yang, P., Xia, H., & Mao, Q. (2022) · Glia · doi:10.1002/glia.24175 · Cited by 29
“Ample evidence has confirmed the significance of the crosstalk between these two cell types in different neuropathologic conditions (Abudara et al., 2015; W. Liu et al., 2011; Norden et al., 2014).”
Background
Combination of Scalp Acupuncture with Exercise Therapy Effectively Counteracts Ischemic Brain Injury in Rats.
Li, Z., Meng, X.-Z., Ren, M., & Shao, M.-L. (2020) · Journal of Stroke & Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105286 · Cited by 17
TLR2 deficiency attenuated chronic intermittent hypoxia-induced neurocognitive deficits
Li, W., Yu, Y., Li, D., Xu, N., Fang, J., Sun, Y., Xu, M., Wang, X., Han, X., Zhang, X., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106284 · Cited by 14
Osteopontin is indispensable for activation of astrocytes in injured mouse brain and primary culture
Ikeshima‐Kataoka, H., Matsui, Y., & Uede, T. (2018) · Neurological Research · doi:10.1080/01616412.2018.1517995 · Cited by 16
“astrocytes is not yet fully understood [35].”
Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex
Adedayo, A. D., Stephen, A. O., Adekilekun, T. A., & Daniel, A. T. (2017) · doi:10.2399/ana.17.015 · Cited by 16
“According to the descriptions of Liu et al.[17] and Liu et al.,[18] tastrocytes and microglia are two of the four types of glial cells in the brain that are involved in the activation and regulation of the brain immunity in response to pathological conditions.”
BackgroundMethodInfluential
Correlation between astrocyte activity and recovery from blood–brain barrier breakdown caused by brain injury
Ikeshima‐Kataoka, H., & Yasui, M. (2016) · NeuroReport · doi:10.1097/wnr.0000000000000619 · Cited by 16
Intra-amygdala microinfusion of neuropeptide S attenuates neuropathic pain and suppresses the response of spinal microglia and astrocytes after spinal nerve ligation in rats
Yang, F., Peng, L., Luo, J., Yi, H., & Hu, X. (2016) · Peptides · doi:10.1016/j.peptides.2016.05.005 · Cited by 17
Urolithin-A Derivative UAS03 Improves Cognitive Deficits and Memory by Activating Nrf2 Pathways to Alleviate Oxidative Stress and Neuroinflammation.
Maity, D., Rahi, V., Dorai, S. T., Chandrashekharappa, S., & Kaundal, R. K. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00886 · Cited by 15
Microglial Dynamics Modulate Vestibular Compensation in a Rodent Model of Vestibulopathy and Condition the Expression of Plasticity Mechanisms in the Deafferented Vestibular Nuclei
Mahmoudi, N. E., Marouane, E., Rastoldo, G., Péricat, D., Watabe, I., Lapôtre, A., Tonetto, A., Chabbert, C., & Tighilet, B. (2022) · Cells · doi:10.3390/cells11172693 · Cited by 16
“In particular, reactive microglial cells are known to beactivated first under pathological conditions, and to initiate astrocyte reaction [99].”
Background
The effects of retinol oral supplementation in 6-hydroxydopamine dopaminergic denervation model in Wistar rats
Kunzler, A., Ribeiro, C. T., Gasparotto, J., Petiz, L. L., da Rosa, H. T., da Silva, J. D., Bortolin, R. C., de Souza, P. O., Barreto, F., Espitia-Pérez, P., et al. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.02.002 · Cited by 20
“Depending on the degree of inflammation and the duration of stimuli, astrocytes are capable to exert an inhibitory effect on microglia, limiting neuroinflammation (Liu et al., 2011).”
Rapid plasticity of intact axons following a lesion to the visual pathways during early brain development is triggered by microglial activation
Chagas, L. D. S., Trindade, P., Gomes, A. L. T., Mendonça, H. R., Campello‐Costa, P., Faria‐Melibeu, A. D. C., Linden, R., & Serfaty, C. A. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.10.002 · Cited by 17
“infection, trauma, ischemia, neurodegenerative diseases or altered neuronal activity) evokes, in microglial population, a rapid morphological shift to an amoeboid phenotype associated to changes in gene expression, leading to an activation state, secreting inflammatory cytokines and chemokines, followed by an astrocyt…”
Neurotoxicity of the Cyanotoxin BMAA Through Axonal Degeneration and Intercellular Spreading
Tan, V. X., Lassus, B., Lim, C. K., Tixador, P., Courte, J., Bessede, A., Guillemin, G. J., & Peyrin, J. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9790-1 · Cited by 19
“The role of astroglial cells in neurodegenerative disease is well known (Liu et al. 2011; Maragakis and Rothstein 2006; Nagai et al. 2007; Rossi and Volterra 2009), and the presence of BMAA in astrocytes may be attributed to its role in regulation of amino acids and neurotransmitters, thus,…”
Background
Targeting Inflammation in Alzheimer’s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review
Topalis, V., Voros, C., & Ziaka, M. (2025) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/08919887251361578 · Cited by 14
SIRPα deficiency accelerates the pathologic process in models of Parkinson disease
Wang, J., Ding, X., Wu, X., Liu, J., Zhou, R., Wei, P., Zhang, Q., Zhang, C., Zen, K., & Li, L. (2019) · Glia · doi:10.1002/glia.23689 · Cited by 20
Molecular mechanisms of microglia- and astrocyte-driven neurorestoration triggered by application of electromagnetic fields
Isaković, J., Gorup, D., & Mitrečić, D. (2019) · Croatian Medical Journal · doi:10.3325/cmj.2019.60.127 · Cited by 14
Refining the interactions between microglia and astrocytes in Alzheimer’s disease pathology
Chen, J., Xu, S., Wang, L., Liu, X., Liu, G., Tan, Q., Li, W., Zhang, S., & Du, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.033 · Cited by 17
Intranasal delivery of extracellular vesicles derived from human bone marrow mesenchymal stem cells dampens neuroinflammation and ameliorates motor deficits in a mouse model of cortical stroke
Barbati, S. A., D’Amelio, C., Feroleto, C., Morotti, M., Sarrapochiello, I. N., Natale, F., Puma, D. D. L., Gómez‐Gálvez, Y., Blanco‐Suárez, E., Iacovitti, L., et al. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115540 · Cited by 11
Astrocytes and Microglia in Alzheimer's Disease: Friends, Foes, or Both?
Sharma, A., Parekh, B. K., Patil, V., Renuka Jyothi, S., Nayak, P. P., Janney, J. B., Singh, G., & Al-Hasnaawei, S. (2025) · Developmental Neurobiology · doi:10.1002/dneu.23015 · Cited by 17
“Once activated, reactive astrocytes reciprocate signals that further stimulate and maintain microglial activation, creating a feedback loop perpetuating chronic neuroinflammation (Liu et al. 2011).”
Microglia at the Centre of Brain Research: Accomplishments and Challenges for the Future
Soares, N. L., & Vieira, H. L. A. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03456-1 · Cited by 14
Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations
Said, E. S., Elsayed, A. M., Rashed, L. A., Nadwa, E. H., Alsuhaibani, N. A., Alfuraih, B. S., & Mahmoud, R. H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174511 · Cited by 14
Inhibition of PI3Kγ by AS605240 Protects tMCAO Mice by Attenuating Pro-Inflammatory Signaling and Cytokine Release in Reactive Astrocytes
Shang, S., Liu, L., Wu, X., Fan, F., Hu, E., Wang, L., Ding, Y. P., Zhang, Y., & Lu, X. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.06.001 · Cited by 13
Lipopolysaccharide-Induced Microglia Activation Promotes the Survival of Midbrain Dopaminergic Neurons In Vitro
Zhou, X., & Spittau, B. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9842-6 · Cited by 13
Pleiotrophin modulates acute and long-term LPS-induced neuroinflammatory responses and hippocampal neurogenesis
Rodríguez‐Zapata, M., López‐Rodríguez, R., Ramos, P., Herradón, G., Pérez‐García, C., & Gramage, E. (2024) · Toxicology · doi:10.1016/j.tox.2024.153947 · Cited by 12
Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease
Costas‐Ferreira, C., & Faro, L. R. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210421092725 · Cited by 14
A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury
Patil, V., O'Connell, E., Quinlan, L., Fearnhead, H., McMahon, S., & Pandit, A. (2020) · iScience · doi:10.1016/j.isci.2021.102182 · Cited by 11
Perspectives on neuroinflammation contributing to chronic cough
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“Accumulating evidence suggests that microglia are activated first, and via the release of ATP and inflammatory mediators, including IL-1, TNF-α or PGE 2 , they subsequently trigger astrocytic activation and enhanced production and secretion of stromal cell-derived factor 1, TNF-α and PGE 2 [64, 65].”
Background
Do glial cells play an anti-oxidative role in Huntington's disease?
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Authors: Liu, W., Tang, Y., & Feng, J.
Affiliations: Guangzhou University of Chinese Medicine (CN)
Sun Yat-sen University (CN)
Corresponding author: Liu, W.
Tang, Y.
ORCID: Tang, Y.
Venue: Life Sciences
Publisher: Elsevier BV
Published: 2011-08
Volume: 89
Issue: 5-6
Pages: 141-146
ISSN: 0024-3205 (ISSN-L)
DOI: 10.1016/j.lfs.2011.05.011
OpenAlex: W2036224773
Cited by: 303
References: 84
Citations by year: 2026: 11 · 2025: 21 · 2024: 15 · 2023: 11 · 2022: 18 · 2021: 20 · 2020: 35 · 2019: 20 · 2018: 20 · 2017: 24 · 2016: 29 · 2015: 20 · 2014: 15 · 2013: 22 · 2012: 18
FWCI: 1.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Life Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: Guangzhou University of Chinese Medicine
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: microglia, astrocytes, microglial activation, astrocyte activation, central nervous system pathology, neuroinflammation, stroke, traumatic brain injury, neurodegenerative diseases, interleukin-1, adenosine triphosphate, TGF-beta, glial communication
MeSH terms: Animals, Astrocytes, Cell Communication, Central Nervous System Diseases, Humans, Macrophage Activation, Microglia, Calcium Signaling, Receptor Cross-Talk

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Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

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