Astrocyte senescence promotes glutamate toxicity in cortical neurons
Open accessAbstract
Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of patients with Alzheimer's and related dementias and cancer patients after chemo- or radio-therapies. A recently emerged driver of these and other age-related pathologies is cellular senescence, a cell fate that entails a permanent cell cycle arrest and pro-inflammatory senescence-associated secretory phenotype (SASP). Although there is a link between inflammation and neurodegenerative diseases, there are many open questions regarding how cellular senescence affects neurodegenerative pathologies. Among the various cell types in the brain, astrocytes are the most abundant. Astrocytes have proliferative capacity and are essential for neuron survival. Here, we investigated the phenotype of primary human astrocytes made senescent by X-irradiation, and identified genes encoding glutamate and potassium transporters as specifically downregulated upon senescence. This down regulation led to neuronal cell death in co-culture assays. Unbiased RNA sequencing of transcripts expressed by non-senescent and senescent astrocytes confirmed that glutamate homeostasis pathway declines upon senescence. Our results suggest a key role for cellular senescence, particularly in astrocytes, in excitotoxicity, which may lead to neurodegeneration including Alzheimer's disease and related dementias.
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Primary human astrocytes exposed to X-rays exhibit increased expression of senescence-associated proteins (p16INK4a and Hp1γ) and cytokines associated with SASP, such as IL-1β and IL-6.
“Furthermore, primary human astrocytes exposed to X-rays exhibit increased expression of senescence-associated proteins (p16INK4a and Hp1γ) and cytokines associated with SASP, such as IL-1β and IL-6.294–296”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [295]
The Results section, “Irradiation induces senescence and a SASP in human primary astrocytes” (page unavailable), reports increased p16INK4a mRNA and IL-6 expression and secretion after X-irradiation. It does not report increased p16INK4a protein or identify increased HP1γ or IL-1β in these astrocytes. (LLM, conf=0.90)
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Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668 · see citing works
Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 11,930 · see citing works
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Self-citationAstrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works
Self-citationStrittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · cited 4× · see citing works
“For example, p16INK4a mRNA was significantly increased in SEN samples (Fig 3B, left panel), while LMNB1 mRNA was significantly decreased (Fig 3B, center panel), and mRNAs encoding SASP factors IL-6, IL-8 and CXCL-1 increased (Fig 3B, right panel).”
BackgroundInfluentialSelf-citationClearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819 · see citing works
Self-citationAstrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,763 · see citing works
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730 · see citing works
Self-citationDose-ranging study of riluzole in amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis/Riluzole Study Group II, Lacomblez, L., Bensimon, G., Meininger, V., Leigh, P. N., & Guillet, P. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91680-3 · Cited by 1,303 · see citing works
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018) · Nature · doi:10.1038/s41586-018-0543-y · Cited by 1,289 · see citing works
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.011 · Cited by 1,275 · see citing works
Self-citationAstrocyte glutamate transport: Review of properties, regulation, and physiological functions
Anderson, C. M., & Swanson, R. A. (2000) · Glia · doi:10.1002/1098-1136(200010)32:1 · Cited by 1,218 · see citing works
Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation · doi:10.1161/01.cir.0000013836.85741.17 · Cited by 1,061 · see citing works
Lamin B1 loss is a senescence-associated biomarker
Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046 · see citing works
Self-citationGlutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease
HYND, M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.03.007 · Cited by 938 · see citing works
Glia and epilepsy: excitability and inflammation
Devinsky, O., Vezzani, A., Najjar, S., de Lanerolle, N. C., & Rogawski, M. A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.11.008 · Cited by 868 · see citing works
Mechanisms of Disease: astrocytes in neurodegenerative disease
Maragakis, N., & Rothstein, J. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 834 · see citing works
Astrocyte dysfunction in neurological disorders: a molecular perspective
Seifert, G., Schilling, K., & Steinhäuser, C. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1870 · Cited by 798 · see citing works
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723 · see citing works
Tong, X., Ao, Y., Faas, G. C., Nwaobi, S. E., Xu, J., Haustein, M. D., Anderson, M. A., Mody, I., Olsen, M. L., Sofroniew, M. V., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3691 · Cited by 592 · see citing works
Astrocyte Senescence as a Component of Alzheimer’s Disease
Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045069 · Cited by 586 · see citing works
Chinta, S. J., Woods, G., Demaria, M., Rane, A., Zou, Y., McQuade, A., Rajagopalan, S., Limbad, C., Madden, D. T., Campisi, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.092 · Cited by 530 · see citing works
Self-citationGlial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation
Jäkel, S., & Dimou, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00024 · Cited by 501 · see citing works
The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
Bosch, L. V. D., Damme, P. V., Bogaert, E., & Robberecht, W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.05.002 · Cited by 491 · see citing works
Morales, I., Guzmán-MartÃnez, L., Cerda-Troncoso, C., FarÃas, G. A., & Maccioni, R. B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00112 · Cited by 490 · see citing works
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
Davalos, A. R., Kawahara, M., Malhotra, G. K., Schaum, N., Huang, J., Ved, U., Beausejour, C. M., Coppe, J.-P., Rodier, F., & Campisi, J. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201206006 · Cited by 439 · see citing works
Self-citationFunctions of Astrocytes and their Potential As Therapeutic Targets
Kimelberg, H. K., & Nedergaard, M. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.006 · Cited by 409 · see citing works
The importance of inflammatory mechanisms in alzheimer disease
McGeer, E. G., & McGeer, P. L. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00013-8 · Cited by 335 · see citing works
New roles for astrocytes (stars at last)
Ransom, B. R., Behar, T. N., & Nedergaard, M. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.006 · Cited by 335 · see citing works
Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M., & Soininen, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07738.x · Cited by 333 · see citing works
Behrens, P. F. (2002) · Brain · doi:10.1093/brain/awf180 · Cited by 322 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · cited 3× · see citing works
“Cellular senescence is a pleiotropic cell fate that prevents cancer in early life, but can also promote age-related diseases, including cancer, during aging, largely by producing pro-inflammatory SASP factors [20, 30].”
BackgroundResultRevett, T. J., Baker, G. B., Jhamandas, J. H., & Kar, S. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110190 · Cited by 294 · see citing works
Cellular senescence and the aging brain
Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.018 · Cited by 282 · see citing works
Self-citationKucheryavykh, Y. V., Kucheryavykh, L. Y., Nichols, C. G., Maldonado, H. M., Baksi, K., Reichenbach, A., Skatchkov, S. N., & Eaton, M. J. (2006) · Glia · doi:10.1002/glia.20455 · Cited by 242 · see citing works
Schnabl, B., Purbeck, C. A., Choi, Y. H., Hagedorn, C. H., & Brenner, D. (2003) · Hepatology · doi:10.1053/jhep.2003.50097 · Cited by 224 · see citing works
Excitotoxic Neuronal Death and the Pathogenesis of Huntington's Disease
Estrada‐Sánchez, A. M., Mejía-Toiber, J., & Massieu, L. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.11.011 · Cited by 213 · see citing works
Ras Induces Vascular Smooth Muscle Cell Senescence and Inflammation in Human Atherosclerosis
Minamino, T., Yoshida, T., Tateno, K., Miyauchi, H., Zou, Y., Toko, H., & Komuro, I. (2003) · Circulation · doi:10.1161/01.cir.0000093274.82929.22 · Cited by 208 · see citing works
Stress-induced senescence in human and rodent astrocytes
Bitto, A., Sell, C., Crowe, E., Lorenzini, A., Malaguti, M., Hrelia, S., & Torres, C. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.06.021 · Cited by 204 · see citing works
Context-dependent effects of cellular senescence in cancer development.
Lecot, P., Alimirah, F., Desprez, P.-Y., Campisi, J., & Wiley, C. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.115 · Cited by 183 · see citing works
Self-citationElevated connexin43 immunoreactivity at sites of amyloid plaques in alzheimer's disease
Nagy, J. I., Li, W., Hertzberg, E. L., & Marotta, C. A. (1996) · Brain Research · doi:10.1016/0006-8993(95)01526-4 · Cited by 180 · see citing works
Howard, R. J., McShane, R. H., Lindesay, J. E. B., Ritchie, C. W., Baldwin, A., Barber, R., Burns, A. S., Dening, T., Findlay, D. M., Holmes, C., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00258-6 · Cited by 164 · see citing works
Zumkehr, J., Rodríguez‐Ortiz, C. J., Cheng, D., Kieu, Z., Wai, T., Hawkins, C., Kilian, J., Lim, S., Medeiros, R., & Kitazawa, M. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.005 · Cited by 152 · see citing works
Kulijewicz‐Nawrot, M., Syková, E., Chvátal, A., Verkhratsky, A., & Rodriguez, J. J. (2013) · ASN NEURO · doi:10.1042/an20130017 · Cited by 138 · see citing works
Dráberová, E., Valle, L. D., Gordon, J., Marková, V., Šmejkalová, B., Bertrand, L., de Chadarévian, J., Agamanolis, D. P., Legido, A., Khalili, K., et al. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31816a686d · Cited by 125 · see citing works
Riluzole and amyotrophic lateral sclerosis survival: a population‐based study in southern Italy
Zoccolella, S., Beghi, E., Palagano, G., Fraddosio, A., Guerra, V., Samarelli, V., Lepore, V. L., Simone, I. L., Lamberti, P., Serlenga, L., et al. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01575.x · Cited by 120 · see citing works
Are there roles for brain cell senescence in aging and neurodegenerative disorders?
Tan, F. C. C., Hutchison, E. R., Eitan, E., & Mattson, M. P. (2014) · Biogerontology · doi:10.1007/s10522-014-9532-1 · Cited by 116 · see citing works
Age and Alzheimer’s disease gene expression profiles reversed by the glutamate modulator riluzole
Pereira, A. C., Gray, J. D., Kogan, J. F., Davidson, R. L., Rubin, T. G., Okamoto, M., Morrison, J. H., & McEwen, B. S. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.33 · Cited by 116 · see citing works
Glutamate, excitotoxicity, and programmed cell death in parkinson disease
Caudle, W. M., & Zhang, J. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.09.027 · Cited by 110 · see citing works
Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
Crowe, E. P., Tuzer, F., Gregory, B. D., Donahue, G., Gosai, S. J., Cohen, J., Leung, Y. Y., Yetkin, E., Nativio, R., Wang, L.-S., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00208 · Cited by 110 · see citing works
Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
Zhou, F. J., Onizawa, S., Nagai, A., & Aoshiba, K. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-78 · Cited by 108 · see citing works
Kobayashi, E., Nakano, M., Kubota, K., Himuro, N., Mizoguchi, S., Chikenji, T., Otani, M., Mizue, Y., Nagaishi, K., & Fujimiya, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-19442-7 · Cited by 98 · see citing works
Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype
Jeon, H.-Y., Kim, J.-K., Ham, S. W., Oh, S.-Y., Kim, J., Park, J.-B., Lee, J.-Y., Kim, S.-C., & Kim, H. (2016) · Tumor Biology · doi:10.1007/s13277-015-4439-2 · Cited by 73 · see citing works
The Interaction of Amyloid-β with ApoE
Carter, D. B. (2005) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/0-387-23226-5_13 · Cited by 65 · see citing works
Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation
Zou, Y., Zhang, N., Ellerby, L. M., Davalos, A. R., Zeng, X., Campisi, J., & Desprez, P.-Y. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.08.043 · Cited by 41 · see citing works
Self-citationA Model for p38MAPK-Induced Astrocyte Senescence
Mombach, J. C. M., Vendrusculo, B., & Bugs, C. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125217 · Cited by 39 · see citing works
Riemenschneider, M. J., & Reifenberger, G. (2009) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-540-31206-2_1 · Cited by 27 · see citing works
Flagged first, then by citations
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Sorted by citations
Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works
Hu, Y., Fryatt, G. L., Ghorbani, M., Obst, J., Menassa, D. A., Martin-Estebane, M., Muntslag, T. A. O., Olmos-Alonso, A., Guerrero-Carrasco, M., Thomas, D., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109228 · Cited by 298 · see citing works
Tauopathies: new perspectives and challenges
Zhang, Y., Wu, K.-M., Yang, L., Dong, Q., & Yu, J.-T. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00533-z · Cited by 323 · see citing works
Cellular senescence in brain aging
Sikora, E., Bielak-Zmijewska, A., Dudkowska, M., Krzystyniak, A., Mosieniak, G., Wesierska, M., & Wlodarczyk, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646924 · Cited by 304 · see citing works
“This downregulation led to neuronal cell death in co-culture assays, suggesting a pivotal role of cellular senescence, particularly in astrocytes, in excitotoxicity, which may lead to neurodegeneration and pathologies such as Alzheimer’s disease and related dementias (Limbad et al., 2020).”
BackgroundGaikwad, S., Puangmalai, N., Bittar, A., Montalbano, M., Garcia, S., McAllen, S., Bhatt, N., Sonawane, M., Sengupta, U., & Kayed, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109419 · Cited by 234 · see citing works
Cellular senescence at the crossroads of inflammation and Alzheimer's disease
Guerrero, A., De Strooper, B., & Arancibia-Cárcamo, I. L. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.06.007 · Cited by 236 · see citing works
Häussinger, D., Dhiman, R. K., Felipo, V., Görg, B., Jalan, R., KIRCHEIS, G., Merli, M., Montagnese, S., Romero‐Gómez, M., Schnitzler, A., et al. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00366-6 · Cited by 220 · see citing works
Herdy, J. R., Traxler, L., Agarwal, R. K., Karbacher, L., Schlachetzki, J. C. M., Boehnke, L., Zangwill, D., Galasko, D., Glass, C. K., Mertens, J., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.11.010 · Cited by 208 · see citing works
Matias, I., Diniz, L. P., Damico, I. V., Araujo, A. P. B., Neves, L. D. S., Vargas, G., Leite, R. E. P., Suemoto, C. K., Nitrini, R., Jacob‐Filho, W., et al. (2022) · Aging Cell · doi:10.1111/acel.13521 · Cited by 183 · see citing works
Lau, V. Z., Ramer, L. M., & Tremblay, M. (2023) · Nature Communications · doi:10.1038/s41467-023-37304-3 · Cited by 168 · see citing works
The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Liu, Y., Tan, Y., Zhang, Z., Yi, M., Zhu, L., & Peng, W. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00397-x · Cited by 144 · see citing works
Emerging Evidence for the Widespread Role of Glutamatergic Dysfunction in Neuropsychiatric Diseases
McGrath, T., Baskerville, R., Rogero, M. M., & Castell, L. M. (2022) · Nutrients · doi:10.3390/nu14050917 · Cited by 120 · see citing works
Gaikwad, S., Senapati, S., Haque, M. A., & Kayed, R. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13490 · Cited by 117 · see citing works
The role of cellular senescence in neurodegenerative diseases
Wang, Y., Kuča, K., Li, Y., Nepovimová, E., Heger, Z., Valko, M., Adam, V., Wu, Q., & Jomová, K. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03768-5 · Cited by 118 · see citing works
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
Fontana, L., Ghezzi, L., Cross, A. H., & Piccio, L. M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190086 · Cited by 116 · see citing works
Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms
Beck, J. A., Turnquist, C., Horikawa, I., & Harris, C. C. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa071 · Cited by 94 · see citing works
Glucose metabolism, neural cell senescence and Alzheimer's disease
Wang, Q., Duan, L., Li, X., Wang, Y., Guo, W., Guan, F., & Ma, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084351 · Cited by 90 · see citing works
Wong-Guerra, M., Calfío, C., Maccioni, R. B., & Rojo, L. E. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1161850 · Cited by 92 · see citing works
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson’s Disease Models
Verma, D., Seo, B. A., Ghosh, A., Ma, S.-X., Hernandez-Quijada, K., Andersen, J. K., Ko, H. S., & Kim, Y. (2021) · Cells · doi:10.3390/cells10071694 · Cited by 85 · see citing works
ATF3 drives senescence by reconstructing accessible chromatin profiles
Zhang, C., Zhang, X., Huang, L., Guan, Y., Huang, X., Tian, X., Zhang, L., & Tao, W. (2021) · Aging Cell · doi:10.1111/acel.13315 · Cited by 84 · see citing works
“…2019; Hernandez-Segura et al., 2017; Komseli et al., 2018; Lau, Porciuncula, Yu, Iwakura, & David, 2019; Leveque et al., 2019; Q. Li et al., 2013; Limbad et al., 2020; Lowe & Raj, 2014; Nagano et al., 2016; Pan et al., 2019; Pantazi et al., 2019; Suwan et al., 2009; Wu, Pepowski, Takahashi, &…”
ResultPreininger, M. K., & Kaufer, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116217 · Cited by 83 · see citing works
Reactive gliosis in traumatic brain injury: a comprehensive review
Amlerova, Z., Chmelová, M., Anděrová, M., & Vargová, L. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1335849 · Cited by 86 · see citing works
Chowen, J. A., & García‐Segura, L. M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111473 · Cited by 89 · see citing works
Jurcău, M. C., Jurcău, A., Cristian, A., Hogea, V. O., Diaconu, R. G., & Nunkoo, V. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910535 · Cited by 90 · see citing works
Aging, Cellular Senescence, and Progressive Multiple Sclerosis
Papadopoulos, D., Magliozzi, R., Mitsikostas, D. D., Gorgoulis, V. G., & Nicholas, R. S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00178 · Cited by 83 · see citing works
Evidence of sex differences in cellular senescence
Ng, M., & Hazrati, L. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.08.014 · Cited by 80 · see citing works
HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress
Thangaraj, A., Chivero, E. T., Tripathi, A., Singh, S., Niu, F., Guo, M.-L., Pillai, P., Periyasamy, P., & Buch, S. (2021) · Redox Biology · doi:10.1016/j.redox.2020.101843 · Cited by 76 · see citing works
Cellular Senescence: Mechanisms, Morphology, and Mouse Models
Beck, J. A., Horikawa, I., & Harris, C. C. (2020) · Veterinary Pathology · doi:10.1177/0300985820943841 · Cited by 72 · see citing works
Astrocyte senescence and SASP in neurodegeneration: tau joins the loop
Ungerleider, K., Beck, J. A., Lissa, D., Turnquist, C., Horikawa, I., Harris, B. T., & Harris, C. C. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1909260 · Cited by 71 · see citing works
Cellular senescence in brain aging and cognitive decline
Shafqat, A., Khan, S., Omer, M. H., Niaz, M., Albalkhi, I., AlKattan, K. M., Yaqinuddin, A., Tchkonia, T., Kirkland, J. L., & Hashmi, S. K. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1281581 · Cited by 75 · see citing works
Ring, N., Valdivieso, K., Grillari, J., Redl, H. R., & Ogrodnik, M. B. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.04.005 · Cited by 57 · see citing works
The Role of Glial Cell Senescence in Alzheimer's Disease
Alshaebi, F., Sciortino, A., & Kayed, R. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70051 · Cited by 60 · see citing works
Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies
Lazic, A., Balint, V., Ninković, D. S., Perić, M., & Stevanović, M. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094995 · Cited by 58 · see citing works
Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Gillispie, G. J., Milligan, C., & Orr, M. E. (2021) · Life · doi:10.3390/life11030229 · Cited by 54 · see citing works
Astrocytic modulation of neuronal signalling
Purushotham, S. S., & Buskila, Y. (2023) · Frontiers in Network Physiology · doi:10.3389/fnetp.2023.1205544 · Cited by 54 · see citing works
Schwab, N., Taskina, D., Leung, E., Innes, B. T., Bader, G. D., & Hazrati, L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1027116 · Cited by 52 · see citing works
Klotho inhibits neuronal senescence in human brain organoids
Shaker, M. R., Aguado, J., Chaggar, H. K., & Wolvetang, E. J. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00070-x · Cited by 51 · see citing works
The role of the complement system in Multiple Sclerosis: A review
Saez-Calveras, N., & Stüve, O. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.970486 · Cited by 49 · see citing works
Review of Design Considerations for Brain-on-a-Chip Models
Cameron, T., Bennet, T. J., Rowe, E. M., Anwer, M., Wellington, C. L., & Cheung, K. C. (2021) · Micromachines · doi:10.3390/mi12040441 · Cited by 48 · see citing works
Aging, Senescence, and Dementia
Behfar, Q., Zuniga, A. R., & Adami, P. V. M. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.42 · Cited by 49 · see citing works
Inflammaging, cellular senescence, and cognitive aging after traumatic brain injury
Lu, Y., Jarrahi, A., Moore, N. D., Bartoli, M., Brann, D. W., Baban, B., & Dhandapani, K. M. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106090 · Cited by 49 · see citing works
Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner
Warde, K. M., Smith, L., Liu, L., Stubben, C., Lohman, B. K., Willett, P. W., Ammer, J. L., Castaneda-Hernandez, G., Imodoye, S. O., Zhang, C., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00420-2 · Cited by 47 · see citing works
Muwanigwa, M. N., Modamio, J., Antony, P. M. A., Gomez‐Giro, G., Krüger, R., Bolognin, S., & Schwamborn, J. C. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103919 · Cited by 50 · see citing works
Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM‐HET3 mice
Jayarathne, H. S. M., Debarba, L. K., Jaboro, J. J., Ginsburg, B. C., Miller, R. A., & Sadagurski, M. (2022) · Aging Cell · doi:10.1111/acel.13653 · Cited by 45 · see citing works
Kwiatkowska, K. M., Mavrogonatou, E., Papadopoulou, A., Sala, C., Calzari, L., Gentilini, D., Bacalini, M. G., Dall’Olio, D., Castellani, G., Ravaioli, F., et al. (2023) · Cells · doi:10.3390/cells12060927 · Cited by 52 · see citing works
Li, H., Zeng, F., Huang, C., Pu, Q., Thomas, E. R., Chen, Y., & Li, X. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14411 · Cited by 45 · see citing works
Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types
Limbad, C., Doi, R., McGirr, J., Ciotlos, S., Pérez, K., Clayton, Z. S., Daya, R., Seals, D. R., Campisi, J., & Melov, S. (2022) · iScience · doi:10.1016/j.isci.2022.103848 · Cited by 46 · see citing works
Self-citationSandau, U. S., McFarland, T. J., Smith, S. J., Galasko, D. R., Quinn, J. F., & Saugstad, J. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.864022 · Cited by 46 · see citing works
Maternal immune activation primes deficiencies in adult hippocampal neurogenesis
Couch, A. C. M., Berger, T., Hanger, B., Matulevičiūtė, R., Srivastava, D. P., Thuret, S., & Vernon, A. C. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.021 · Cited by 44 · see citing works
Potential neurotoxic activity of diverse molecules released by astrocytes
Murray, T. E., Richards, C. M., Robert-Gostlin, V. N., Bernath, A. K., Lindhout, I. A., & Klegeris, A. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.08.015 · Cited by 42 · see citing works
Bouvier, D., Fixemer, S., Heurtaux, T., Jeannelle, F., Frauenknecht, K., & Mittelbronn, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.814889 · Cited by 36 · see citing works
Wong, G. C., & Chow, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220203 · Cited by 40 · see citing works
Sex Differences in Astrocyte Activity
Gozlan, E., Lewit-Cohen, Y., & Frenkel, D. (2024) · Cells · doi:10.3390/cells13201724 · Cited by 39 · see citing works
Residual Disease in Glioma Recurrence: A Dangerous Liaison with Senescence
Putavet, D. A., & de Keizer, P. L. J. (2021) · Cancers · doi:10.3390/cancers13071560 · Cited by 39 · see citing works
Wünnemann, F., Tadjo, T. F., Beaudoin, M., Lalonde, S., Lo, K. S., Kleinstiver, B. P., & Lettre, G. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010680 · Cited by 39 · see citing works
Old Stars and New Players in the Brain Tumor Microenvironment
Parmigiani, E., Scalera, M., Mori, E., Tantillo, E., & Vannini, E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.709917 · Cited by 33 · see citing works
Matias, I. C. P., Diniz, L. P., Araújo, A. P. B., Damico, I. V., de Moura, P., Cabral‐Miranda, F., Diniz, F., Parmeggiani, B., Coelho, V. D. M., Leite, R. E. P., et al. (2023) · ASN NEURO · doi:10.1177/17590914231157974 · Cited by 33 · see citing works
Wang, J., Lu, Y., Carr, C., Dhandapani, K. M., & Brann, D. W. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1227705 · Cited by 34 · see citing works
Cellular senescence and failure of myelin repair in multiple sclerosis
Koutsoudaki, P. N., Papadopoulos, D., Passias, P.-G., Koutsoudaki, P., & Gorgoulis, V. G. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111366 · Cited by 32 · see citing works
Cellular Senescence in Traumatic Brain Injury: Evidence and Perspectives
Schwab, N., Leung, E., & Hazrati, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.742632 · Cited by 33 · see citing works
Molecular hallmarks of ageing in amyotrophic lateral sclerosis
Jagaraj, C. J., Shadfar, S., Kashani, S. A., Saravanabavan, S., Farzana, F., & Atkin, J. D. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05164-9 · Cited by 33 · see citing works
Contribution of senescent and reactive astrocytes on central nervous system inflammaging
López‐Teros, M., Alarcón‐Aguilar, A., López‐Díazguerrero, N. E., Luna‐López, A., & Königsberg, M. (2022) · Biogerontology · doi:10.1007/s10522-022-09952-3 · Cited by 34 · see citing works
Miller, S., Campbell, C. E., Jimenez-Corea, H. A., Wu, G., & Logan, R. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.824191 · Cited by 32 · see citing works
Chojak, R., Fares, J., Petrosyan, E., & Lesniak, M. S. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04387-3 · Cited by 30 · see citing works
Diniz, L. P., Araújo, A. P. B., Carvalho, C. F., Matias, I. C. P., Hayashide, L. D. S., Marques, M., Pessoa, B., de Andrade, C. B. V., Vargas, G., Queiroz, D. D., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167470 · Cited by 31 · see citing works
Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion
Fazio, E. D., Pittarello, M., Gans, A., Ghosh, B., Slika, H., Alimonti, P., & Tyler, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052563 · Cited by 31 · see citing works
王学文, Kang, J., Li, X., Wu, P., Huang, Y., Huang, Y., Feng, J., & Feng, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118016 · Cited by 30 · see citing works
Nanoparticles-based anti-aging treatment of Alzheimer’s disease
Chu, J., Ji, W., Zhuang, J., Gong, B., Chen, X., Cheng, W., Liang, W., Li, G., Gao, J., & Yin, Y. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2094501 · Cited by 29 · see citing works
Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29 · see citing works
Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering their Influences in Aging
Rouillard, M. E., Sutter, P. A., Durham, O. R., Willis, C. M., & Crocker, S. J. (2021) · Aging and Disease · doi:10.14336/ad.2021.0608 · Cited by 27 · see citing works
Thorin‐Trescases, N., Labbé, P., Mury, P., Lambert, M., & Thorin, É. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212232 · Cited by 28 · see citing works
Astrocytes: News about Brain Health and Diseases
Meldolesi, J. (2020) · Biomedicines · doi:10.3390/biomedicines8100394 · Cited by 27 · see citing works
Kristiani, L., & Kim, Y. (2023) · Cells · doi:10.3390/cells12091234 · Cited by 26 · see citing works
The key roles of organelles and ferroptosis in Alzheimerʼs disease
Long, H., Cheng, Y., Zhou, Z., Luo, H., Wen, D., & Gao, L. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25033 · Cited by 27 · see citing works
Role of Senescent Astrocytes in Health and Disease
Meldolesi, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108498 · Cited by 26 · see citing works
Wear, D., Vegh, C., Sandhu, J. K., Sikorska, M., Cohen, J. S., & Pandey, S. (2021) · Antioxidants · doi:10.3390/antiox10050764 · Cited by 25 · see citing works
Kabiraj, P., Grund, E. M., Clarkson, B. D. S., Johnson, R. K., LaFrance‐Corey, R. G., Lucchinetti, C. F., & Howe, C. L. (2022) · Scientific Reports · doi:10.1038/s41598-022-07024-7 · Cited by 25 · see citing works
Gale, J. R., Hartnett, K. A., Ross, M. M., Rosenberg, P. A., & Aizenman, E. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15961 · Cited by 25 · see citing works
Han, X., Lei, Q., Liu, H., Zhang, T., & Gou, X. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad278 · Cited by 22 · see citing works
Tangavelou, K., & Bhaskar, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212335 · Cited by 24 · see citing works
Senolytics: A Novel Strategy for Neuroprotection in ALS?
Maximova, A., Werry, E. L., & Kassiou, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112078 · Cited by 21 · see citing works
Sharma, R. (2021) · PharmaNutrition · doi:10.1016/j.phanu.2021.100281 · Cited by 20 · see citing works
Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review
Chen, P., Chen, F., & Zhou, B. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2104102 · Cited by 20 · see citing works
Tarallo, D., Martínez, J., Leyva, A., Mónaco, A., Perroni, C., Tassano, M. R., Gambini, J. P., Cappetta, M., Durán, R., Moreno, M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-51427-7 · Cited by 20 · see citing works
Niu, Q., Li, D., Zhang, J., Piao, Z., Xi, Y., Xi, Y., Kamal, N. N. S. N. M., Li, P., Li, P., & Yin, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102593 · Cited by 19 · see citing works
Hugo, C., Asante, I., Sadybekov, A., Katritch, V., & Yassine, H. N. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0794 · Cited by 18 · see citing works
Chen, Z., Mao, Z., Tang, W., Shi, Y., Liu, J., & You, Y. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00517-1 · Cited by 21 · see citing works
From Neuron‐Centric to Glia‐Centric: How Aging Glial Networks Drive Neurodegenerative Disease
Hayashide, L. D. S., Pessoa, B., Dias, G. R., Pontes, B., Pinto, R. S., & Diniz, L. P. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70361 · Cited by 19 · see citing works
Aberrant NLRP3 Inflammasome Activation Ignites the Fire of Inflammation in Neuromuscular Diseases
Péladeau, C. L., & Sandhu, J. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116068 · Cited by 20 · see citing works
Regulatory mechanism of cyclins and cyclin-dependent kinases in post-mitotic neuronal cell division
Gupta, R. V., Jha, A., Ambasta, R. K., & Kumar, P. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120006 · Cited by 19 · see citing works
Senescent cells in the brain and where to find them
Rachmian, N., & Krizhanovsky, V. (2022) · FEBS Journal · doi:10.1111/febs.16649 · Cited by 17 · see citing works
Exploration of novel biomarkers in Alzheimer’s disease based on four diagnostic models
Zou, C., Su, L., Pan, M., Chen, L., Li, H., Zou, C., Xie, J., Huang, X., Lu, M., & Zou, D. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1079433 · Cited by 19 · see citing works
Huang, Z., Xu, P., Hess, D. C., & Zhang, Q. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00457-2 · Cited by 18 · see citing works
Institóris, Á., Murphy‐Royal, C., Tarantini, S., Yabluchanskiy, A., Haidey, J. N., Csiszár, A., Ungvari, Z. I., & Gordon, G. R. (2020) · GeroScience · doi:10.1007/s11357-020-00289-8 · Cited by 18 · see citing works
Various facets of excitotoxicity
Glaser, T., Silva, J. B., Juvenal, G. D. A., Maiolini, P. N., Turrini, N., Petiz, L. L., Marques, L. B., Ribeiro, D. E., Ye, Q., Tang, Y., et al. (2022) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2022.00017 · Cited by 18 · see citing works
Are cytoskeleton changes observed in astrocytes functionally linked to aging?
Villablanca, C., Vidal, R. L., & González-Billault, C. E. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.03.007 · Cited by 18 · see citing works
Ryu, S., Jung, M., Kim, C., Kang, H., Han, S., Cha, S., Jeong, S. M., & Lee, E. K. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04792-y · Cited by 18 · see citing works
Muraleedharan, A., Rotem‐Dai, N., Strominger, I., Anto, N. P., Isakov, N., Monsonego, A., & Livneh, E. (2020) · Glia · doi:10.1002/glia.23921 · Cited by 16 · see citing works
Morales-Rosales, S. L., Santín-Márquez, R., Posadas-Rodriguez, P., Rincon-Heredia, R., Montiel, T., Librado-Osorio, R., Luna-López, A., Rivero-Segura, N. A., Torres, C., Cano-Martínez, A., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.766306 · Cited by 17 · see citing works
Toward refining Alzheimer's disease into overlapping subgroups
Hascup, E. R., & Hascup, K. N. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12070 · Cited by 16 · see citing works
- Authors
- Limbad, C., Oron, T. R., Alimirah, F., Davalos, A. R., Tracy, T. E., Gan, L., Desprez, P.-Y., & Campisi, J.
- Affiliations
- Buck Institute for Research on Aging (US)
- Gladstone Institutes (US)
- Corresponding author
- Campisi, Judith
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-01-16
- Volume
- 15
- Issue
- 1
- Pages
- e0227887
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6964973
- OpenAlex
- W2999084078
- Cited by
- 183
- References
- 63
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 30 · 2023: 26 · 2022: 36 · 2021: 36 · 2020: 11
- FWCI
- 16.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institute on Aging (AG009909, AG017242)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- astrocyte senescence, cellular senescence, glutamate excitotoxicity, excitotoxicity, glutamate transporters, potassium transporters, glutamate homeostasis, neurodegeneration, Alzheimer's disease, senescence-associated secretory phenotype, X-ray irradiation, cortical neurons, neuronal cell death
- MeSH terms
- Alzheimer Disease, Astrocytes, Brain, Gene Expression Regulation, Humans, Nerve Degeneration, Neurons, X-Rays, Cellular Senescence, Glutamic Acid, Amino Acid Transport System X-AG, Cell Cycle Checkpoints, Primary Cell Culture
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