The DOI matches its Crossref record; 181 of the 182 references it cites were found in a registry or an index.
Mouse models of ageing and their relevance to disease
Open accessAbstract
Ageing is a process that gradually increases the organism's vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction.
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“aging biology differs between rodents and humans, and findings from a mouse model may not fully translate to human liver [5,51,52].”
From Fluorescence-Guided Spatial Mapping of p21-Expressing Senescent Cells in Aged Liver at Single-Cell Resolution (2026) · cites this paper as [52]
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“The identification of specific mutations causing these syndromes has enabled the development of mouse models that simulate premature aging.304”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [304]
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2 retracted
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Metadata
- Authors
- Kõks, S., Dogan, S., Tuna, B. G., González-Navarro, H., Potter, P., & Vandenbroucke, R. E.
- Affiliations
- Estonian University of Life Sciences (EE)
- Mary Lyon Centre at MRC Harwell (GB)
- Ghent University (BE)
- Corresponding author
- Vandenbroucke, Roosmarijn E.
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 160
- Pages
- 41-53
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2529858651
- Cited by
- 125
- References
- 182
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 15 · 2020: 6 · 2019: 18 · 2018: 12 · 2017: 4
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Mechanisms of Ageing and Development (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
- Murdoch University Research Portal (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- aging, accelerated aging, caloric restriction, disease susceptibility, phenotypic characterization
- MeSH terms
- Aging, Animals, Humans, Models, Biological, Mice
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