Cited by 126Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceAntioxidants, Aging, Portulaca oleracea

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Mouse models of ageing and their relevance to disease

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Kõks, Sulev, Dogan, Soner, Tuna, Bilge Guvenc, González-Navarro, Herminia, Potter, Paul, Vandenbroucke, Roosmarijn E.·2016·Mechanisms of Ageing and Development

DOI 10.1016/j.mad.2016.10.001

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Abstract

Ageing is a process that gradually increases the organism's vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction.

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RETRACTED: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice
Safdar, A., Bourgeois, J. M., Ogborn, D. I., Little, J. P., Hettinga, B. P., Akhtar, M., Thompson, J. E., Melov, S., Mocellin, N. J., Kujoth, G. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019581108 · Cited by 320
Retracted
RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
Safdar, A., Khrapko, K., Flynn, J. M., Saleem, A., Lisio, M. D., Johnston, A. P. W., Kratysberg, Y., Samjoo, I. A., Kitaoka, Y., Ogborn, D. I., et al. (2015) · Skeletal Muscle · doi:10.1186/s13395-016-0075-9 · Cited by 68
Retracted
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J., Scott, L., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003) · Nature · doi:10.1038/nature01629 · Cited by 1,990
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
Fiorentino, D. F., Zlotnik, A., Vieira, P., Mosmann, T. R., Howard, M., Moore, K. W., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.10.3444 · Cited by 1,866
The mitochondrial basis of aging
Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441
Lamin a truncation in Hutchinson-Gilford progeria
De Sandre-Giovannoli, A., Bernard, R., Cau, P., Navarro, C., Amiel, J., Boccaccio, I., Lyonnet, S., Stewart, C. L., Munnich, A., Le Merrer, M., et al. (2003) · Science · doi:10.1126/science.1084125 · Cited by 1,346
Essential role of mouse telomerase in highly proliferative organs
Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270 · cited 1×
“However, late-generation Terc−/− mice did show a shortened lifespan, overall frailty, decreased fertility and tissue atrophy with impaired organ function (Lee et al., 1998).”
Background
Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
Li, S., Crenshaw, E. B., Rawson, E. J., Simmons, D. M., Swanson, L. W., & Rosenfeld, M. G. (1990) · Nature · doi:10.1038/347528a0 · Cited by 1,196
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
Berg, D., Davidson, N. M., Kühn, R., Müller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M. W., & Rennick, D. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118861 · Cited by 1,125
Dwarf mice and the ageing process
Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091
Biochemical Adaptations to Endurance Exercise in Muscle
Holloszy, J. O., & Booth, F. W. (1976) · Annual Review of Physiology · doi:10.1146/annurev.ph.38.030176.001421 · Cited by 1,053 · cited 1×
“Among the many benefits endurance exercise brings (reviewed n Mendonca et al. (2016)) is an increased mitochondrial biogeneis (Holloszy and Booth, 1976).”
Background
The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake
Weindruch, R. H., Walford, R. L., Fligiel, S., & Guthrie, D. (1986) · Journal of Nutrition · doi:10.1093/jn/116.4.641 · Cited by 992
Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges
Chaix, A., Zarrinpar, A., Miu, P., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.001 · Cited by 956 · cited 3×
“The effects of CR on age-related metabolic diseases Dietary effects on age-related metabolic disorders have been shown in different mouse studies (Chaix et al., 2014; Hatori et al., 2012).”
Background
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
Zhang, G., Li, J., Purkayastha, S., Tang, Y., Zhang, H., Yin, Y., Li, B., Liu, G., & Cai, D. (2013) · Nature · doi:10.1038/nature12143 · Cited by 834 · cited 4×
“Mouse models of HGPS are models of laminopathies based on modification of the Lamna gene or its processing enzyme (Zhang et al., 2013a).”
Influential
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5172 · Cited by 819
Caloric restriction
Speakman, J. R., & Mitchell, S. E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.07.001 · Cited by 797
Detection of a specific mitochondrial DNA deletion in tissues of older humans
Cortopassi, G. A., & Arnheim, N. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.23.6927 · Cited by 788
Linking functional decline of telomeres, mitochondria and stem cells during ageing
Sahin, E., & DePinho, R. A. (2010) · Nature · doi:10.1038/nature08982 · Cited by 759
Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for Replication
Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G., & Attardi, G. M. (1999) · Science · doi:10.1126/science.286.5440.774 · Cited by 724
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711
Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program
Turturro, A., Witt, W. W., Lewis, S. M., Hass, B. S., Lipman, R. D., & Hart, R. W. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.11.b492 · Cited by 675
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.
Cortopassi, G. A., Shibata, D. K., Soong, N.-W., & Arnheim, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7370 · Cited by 639
Genetic variability in adult bone density among inbred strains of mice
Beamer, W. G., Donahue, L. R., Rosen, C. J., & Baylink, D. J. (1996) · Bone · doi:10.1016/8756-3282(96)00047-6 · Cited by 630
Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
Miller, R. A., Harrison, D. E., Astle, C. M., Fernández, E., Flurkey, K., Han, M. L., Javors, M. A., Li, X., Nadon, N. L., Nelson, J. F., et al. (2013) · Aging Cell · doi:10.1111/acel.12194 · Cited by 625
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
Halagappa, V. K. M., Guo, Z., Pearson, M., Matsuoka, Y., Cutler, R. G., LaFerla, F. M., & Mattson, M. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.019 · Cited by 580
Mutations in PROP1 cause familial combined pituitary hormone deficiency
Wu, W., Cogan, J. D., Pfäffle, R. W., Dasen, J. S., Frisch, H., O’Connell, S. M., Flynn, S. E., Brown, M. R., Mullis, P. E., Parks, J. S., et al. (1998) · Nature Genetics · doi:10.1038/ng0298-147 · Cited by 562
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice
Pendás, A. M., Zhou, Z., Cadiñanos, J., Freije, J. M. P., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodríguez, F., Tryggvason, K., et al. (2002) · Nature Genetics · doi:10.1038/ng871 · Cited by 554
Premature Aging in Mice Deficient in DNA Repair and Transcription
de Boer, J., Andressoo, J. O., de Wit, J., Huijmans, J., Beems, R. B., van Steeg, H., Weeda, G., van der Horst, G. T. J., van Leeuwen, W., Themmen, A. P. N., et al. (2002) · Science · doi:10.1126/science.1070174 · Cited by 545
Aging, adiposity, and calorie restriction
Fontana, L. (2007) · JAMA · doi:10.1001/jama.297.9.986 · Cited by 526
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.
White, J. K., Gerdin, A.-K., Karp, N. A., Ryder, E., Buljan, M., Bussell, J. N., Salisbury, J., Clare, S., Ingham, N. J., Podrini, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.022 · Cited by 509
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
Simon, M. M., Greenaway, S., White, J. K., Fuchs, H., Gailus-Durner, V., Wells, S., Sorg, T., Wong, K., Bedu, E., Cartwright, E. J., et al. (2013) · Genome Biology · doi:10.1186/gb-2013-14-7-r82 · Cited by 507
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening
Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501
Association of human aging with a functional variant of klotho
Arking, D. E., Krebsová, A., Maçek, M., Maçek, M., Arking, A., Mian, S. I., Fried, L. F., Hamosh, A., Dey, S., McIntosh, I., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022484299 · Cited by 491
High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population
Svenson, K. L., Gatti, D. M., Valdar, W. S. J., Welsh, C. E., Cheng, R., Chesler, E. J., Palmer, A. A., McMillan, L., & Churchill, G. A. (2012) · Genetics · doi:10.1534/genetics.111.132597 · Cited by 474
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
Chang, S., Multani, A. S., Cabrera, N. G., Naylor, M. L., Laud, P., Lombard, D., Pathak, S., Guarente, L., & DePinho, R. A. (2004) · Nature Genetics · doi:10.1038/ng1389 · Cited by 462
The Diversity Outbred Mouse Population
Churchill, G., Gatti, D. M., Munger, S. C., & Svenson, K. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9414-2 · Cited by 451
A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice
Toye, A. A., Lippiat, J. D., Proks, P., Shimomura, K., Bentley, L., Hugill, A., Mijat, V., Goldsworthy, M. E., Moir, L., Haynes, A. R., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1680-z · Cited by 450
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
Bergö, M. O., Gavino, B. J., Ross, J., Schmidt, W. K., Hong, C., Kendall, L. V., Mohr, A., Meta, M. D., Genant, H. K., Jiang, Y., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192460799 · Cited by 443
Splicing-directed therapy in a new mouse model of human accelerated aging
Osorio, F. G., Navarro, C. L., Cadiñanos, J., López-Mejía, I. C., Quirós, P. M., Bartoli, C., Rivera, J., Tazi, J., Guzmán, G., Varela, I., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002847 · Cited by 432
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.-J., & Mattson, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536856100 · Cited by 428 · cited 2×
“…diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases and stroke (Van Cauwenberghe et al., 2016; Bondolfi et al., 2004; Patel et al., 2005; Wang et al., 2005; Park et al., 2013; Wu et al., 2008; Halagappa et al., 2007; Hornsby et al., 2016; Duan et al., 2003; Mattson et al., 2003).”
Background
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 422
Animal Models of Alzheimer Disease
LaFerla, F. M., & Green, K. N. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006320 · Cited by 419
Mitochondrial point mutations do not limit the natural lifespan of mice
Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2007) · Nature Genetics · doi:10.1038/ng1988 · Cited by 404
Progeria syndromes and ageing: what is the connection?
Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386
Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
Weeda, G., Donker, I., de Wit, J., Morreau, H., Janssens, R. C., Vissers, C. J., Nigg, A. L., STEEG, H. V., Bootsma, D., & Hoeijmakers, J. H. J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00190-4 · Cited by 386
Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage
Kennedy, S. R., Salk, J. J., Schmitt, M. W., & Loeb, L. A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003794 · Cited by 363
DIABETES MELLITUS AND SIMPLE OPTIC ATROPHY AMONG SIBLINGS: REPORT OF FOUR CASES
Wolfram, D. J. (1938) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(26)04711-7 · Cited by 344
Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models
Patel, N. V., Gordon, M. N., Connor, K. E., Good, R. A., Engelman, R. W., Mason, J., Morgan, D. G., Morgan, T. E., & Finch, C. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.014 · Cited by 329
Deletion of Nicotinamide Nucleotide Transhydrogenase
Freeman, H. C., Hugill, A., Dear, N. T., Ashcroft, F. M., & Cox, R. (2006) · Diabetes · doi:10.2337/db06-0358 · Cited by 325
Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease
Wang, J., Ho, L., Qin, W., Rocher, A. B., Seror, I., Humala, N., Maniar, K. P., Dolios, G., Wang, R., Hof, P. R., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3182fje · Cited by 324
Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson–Gilford progeria syndrome mutation
Yang, S. H., Bergö, M. O., Toth, J. I., Qiao, X., Hu, Y., Sandoval, S., Meta, M. D., Bendale, P. M., Gelb, M. H., Young, S. G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504641102 · Cited by 311
Metabolic reprogramming, caloric restriction and aging
Anderson, R. M., & Weindruch, R. H. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.11.005 · Cited by 309
T Cell–specific Inactivation of the Interleukin 10 Gene in Mice Results in Enhanced T Cell Responses but Normal Innate Responses to Lipopolysaccharide or Skin Irritation
Roers, A., Siewe, L., Strittmatter, E., Deckert, M., Schlüter, D., Stenzel, W., Gruber, A. D., Krieg, T. M., Rajewsky, K., & Müller, W. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041789 · Cited by 309
Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in micePreprint
Chen, Y., Kao, C., Chen, Y.-T., Wang, C., Wu, C.-Y., Tsai, C., Liu, F.-C., Yang, C.-W., Wei, Y., Hsu, M., et al. (2009) · Genes & Development · doi:10.1101/gad.1779509 · Cited by 306
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
Lebel, M., & Leder, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13097 · Cited by 304
Calorie restriction and prevention of age‐associated chronic disease
Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293
Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms
Mattson, M. P., Duan, W., & Guo, Z. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01586.x · Cited by 289
Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.
Paigen, B., Mitchell, D., Reue, K., Morrow, A. L., Lusis, A. J., & LeBoeuf, R. C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3763 · Cited by 288
A Homozygous Mutation in a Novel Zinc-Finger Protein, ERIS, Is Responsible for Wolfram Syndrome 2
Amr, S. S., Heisey, C., Zhang, M., Xia, X.-J., Shows, K. H., Ajlouni, K. M., Pandya, A., Satin, L. S., El‐Shanti, H., & Shiang, R. (2007) · The American Journal of Human Genetics · doi:10.1086/520961 · Cited by 287
The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping
Brown, S. D. M., & Moore, M. W. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9427-x · Cited by 282
Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria
Dai, D., Chen, T., Wanagat, J., Laflamme, M., Marcinek, D. J., Emond, M. J., Ngo, C. P., Prolla, T. A., & Rabinovitch, P. S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00581.x · Cited by 280
Genotypic Differences in Behavioral, Physiological and Anatomical Expressions of Age-Related Hearing Loss in the Laboratory Mouse: Original Papers Travaux originaux
Henry, K. R., & Chole, R. A. (1980) · International Journal of Audiology · doi:10.3109/00206098009070071 · Cited by 280
Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice
Bondolfi, L., Ermini, F., Long, J. M., Ingram, D. K., & Jucker, M. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00083-6 · Cited by 277
Disruption of the WFS1 gene in mice causes progressive -cell loss and impaired stimulus-secretion coupling in insulin secretion
Ishihara, H. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh125 · Cited by 259
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice
Hiona, A., Sanz, A., Kujoth, G. C., Pamplona, R., Seo, A. Y., Hofer, T., Someya, S., Miyakawa, T., Nakayama, C., Samhan-Arias, A. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011468 · Cited by 250
Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging
Norddahl, G. L., Pronk, C. J., Wahlestedt, M., Sten, G., Nygren, J. M., Ugale, A., Sigvardsson, M., & Bryder, D. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.03.009 · Cited by 249
Genotype and age influence the effect of caloric intake on mortality in mice
Forster, M. J., Morris, P., & Sohal, R. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0533fje · Cited by 236
Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment
Villa‐Bellosta, R., Rivera, J., Osorio, F. G., Acín‐Pérez, R., Enrı́quez, J. A., López-Otı́n, C., & Andrés, V. (2013) · Circulation · doi:10.1161/circulationaha.112.000571 · Cited by 229
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
Riggs, A. C., Bernal‐Mizrachi, E., Ohsugi, M., Wasson, J., Fátrai, S., Welling, C. M., Murray, J., Schmidt, R. E., Herrera, P. L., & Permutt, M. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1947-4 · Cited by 228
The Snell dwarf mutation Pit1dw can increase life span in mice
Flurkey, K., Papaconstantinou, J., & Harrison, D. E. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00339-6 · Cited by 218
Mitochondria and Aging
Lee, H., & Wei, Y. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_14 · Cited by 207
Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings
Trepanowski, J. F., Canale, R. E., Marshall, K. E., Kabir, M. M., & Bloomer, R. J. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-107 · Cited by 204
Caloric restriction: powerful protection for the aging heart and vasculature
Weiss, E. P., & Fontana, L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00685.2011 · Cited by 198
An aging Interventions Testing Program: study design and interim report
Miller, R. A., Harrison, D. E., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00311.x · Cited by 197
The Physical and Biological Characterization of a Frail Mouse Model
Walston, J. D., Fedarko, N. S., Yang, H., Leng, S. X., Beamer, B. A., Espinoza, S. E., Lipton, A., Zheng, H., & Becker, K. G. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.4.391 · Cited by 192
The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities
Vanhooren, V., & Libert, C. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.010 · Cited by 190
Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background
Lombard, D. B., Beard, C., Johnson, B., Marciniak, R. A., Dausman, J., Bronson, R., Buhlmann, J. E., Lipman, R., Curry, R., Sharpe, A., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.3286-3291.2000 · Cited by 187
Mitochondria and Ageing
Leeuwenburgh, C., Pamplona, R., & Sanz, A. (2011) · Journal of Aging Research · doi:10.4061/2011/782946 · Cited by 186
Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice
Bygrave, A. E., Rose, K. L., Cortés-Hernández, J., Warren, J. A., Rigby, R. J., Cook, H. T., Walport, M. J., Vyse, T. J., & Botto, M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020243 · Cited by 186
Dyskeratosis congenita, stem cells and telomeres
Kirwan, M., & Dokal, I. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.01.010 · Cited by 180
Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes
Kasahara, T., Kubota, M., Miyauchi, T., Noda, Y., Mouri, A., Nabeshima, T., & Kato, T. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001824 · Cited by 178
Characterization of the Native and Recombinant Catalytic Subunit of Human DNA Polymerase γ: Identification of Residues Critical for Exonuclease Activity and Dideoxynucleotide Sensitivity
Longley, M. J., Ropp, P. A., Lim, S. E., & Copeland, W. C. (1998) · Biochemistry · doi:10.1021/bi980772w · Cited by 174
Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice
Donato, A. J., Walker, A. E., Magerko, K. A., Bramwell, R. C., Black, A. D., Henson, G. D., Lawson, B. R., Lesniewski, L. A., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12103 · Cited by 170
Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice
Berghe, T. V., Hulpiau, P., Martens, L., Vandenbroucke, R. E., Wonterghem, E. V., Perry, S. W., Bruggeman, I., Divert, T., Choi, S. M., Vuylsteke, M., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.011 · Cited by 168
Self-citation
Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress
Rippe, C., Lesniewski, L. A., Connell, M. L., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 160
EMPReSS: standardized phenotype screens for functional annotation of the mouse genome
Brown, S. D. M., Chambon, P., & de Angelis, M. H. (2005) · Nature Genetics · doi:10.1038/ng1105-1155 · Cited by 159
Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated
Yang, S. H., Andres, D., Spielmann, H. P., Young, S. G., & Fong, L. G. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35876 · Cited by 159
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project
Ayadi, A., Birling, M., BOTTOMLEY, J. R., Bussell, J., Fuchs, H., Fray, M., Gailus‐Durner, V., Greenaway, S., Houghton, R., Karp, N. A., et al. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9418-y · Cited by 158
Mitochondrial genome maintenance in health and disease
Copeland, W. C., & Longley, M. J. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.010 · Cited by 147
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
de Angelis, M. H., Nicholson, G., Selloum, M., White, J. K., Morgan, H., Ramírez‐Solis, R., Sorg, T., Wells, S., Fuchs, H., Fray, M., et al. (2015) · Nature Genetics · doi:10.1038/ng.3360 · Cited by 147
Ionizing radiation and aging: rejuvenating an old idea
Richardson, R. B. (2009) · Aging · doi:10.18632/aging.100081 · Cited by 146
Genetic Effects on Aging
Harrison, D. E. (1990) · Cited by 146
Strain background effects and genetic modifiers of hearing in mice
Johnson, K. R., Zheng, Q. Y., & Noben‐Trauth, K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.021 · Cited by 145
Design of aging intervention studies: the NIA interventions testing program
Nadon, N. L., Strong, R., Miller, R. A., Nelson, J., Javors, M., Sharp, Z. D., Peralba, J. M., & Harrison, D. E. (2008) · AGE · doi:10.1007/s11357-008-9048-1 · Cited by 142
Commercially Available Outbred Mice for Genome-Wide Association Studies
Yalcin, B., Nicod, J., Bhomra, A., Davidson, S. I., Cleak, J., Farinelli, L., Østerås, M., Whitley, A., Wei, Y., Gan, X., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001085 · Cited by 139
Adding fuel to the fire: the impact of stress on the ageing brain
Prenderville, J. A., Kennedy, P. J., Dinan, T. G., & Cryan, J. F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.001 · Cited by 136
Aging research using mouse models
Ackert‐Bicknell, C. L., Anderson, L. C., Sheehan, S., Hill, W. G., Chang, B., Churchill, G. A., Chesler, E. J., Korstanje, R., & Peters, L. L. (2015) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo140195 · Cited by 135
Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis
Zhang, D., Mott, J. L., Chang, S.-W., Denniger, G., Feng, Z., & Zassenhaus, H. P. (2000) · Genomics · doi:10.1006/geno.2000.6333 · Cited by 124
Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner
Hornsby, A. K. E., Redhead, Y. T., Rees, D. J., Ratcliff, M., Reichenbach, A., Wells, T., Francis, L. W., Amstalden, K. A. Z., Andrews, Z. B., & Davies, J. S. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.023 · Cited by 123
Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice
Sharp, Z. D., & Bartke, A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.293 · Cited by 122
Dietary Restriction Reduces Atherosclerosis and Oxidative Stress in the Aorta of Apolipoprotein E-Deficient Mice
Guo, Z., Mitchell-Raymundo, F., Yang, H., Ikeno, Y., Nelson, J., Diaz, V., Richardson, A., & Reddick, R. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00008-8 · Cited by 121 · cited 1×
“…cardiovascular diseases CVD) The prevalence of cardiomyopathies such as hypertension, therosclerosis, myocardial fibrosis and stroke increases with ageng (Omodei and Fontana, 2011; Lakatta and Levy, 2003; Donato t al., 2013; Guo et al., 2002; Wielinga et al., 2011; McMillen et al., 013).”
Background
The Collaborative Cross, a community resource for the genetic analysis of complex traits
T. Consortium (2004) · Nature Genetics · doi:10.1038/ng1104-1133 · Cited by 121
Caloric restriction: Beneficial effects on brain aging and Alzheimer’s disease
Van Cauwenberghe, C., Vandendriessche, C., Libert, C., & Vandenbroucke, R. E. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9647-6 · Cited by 121
Self-citation
Cooperative Interactions of p53 Mutation, Telomere Dysfunction, and Chronic Liver Damage in Hepatocellular Carcinoma Progression
Farazi, P. A., Glickman, J. N., Horner, J. W., & DePinho, R. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4608 · Cited by 119
Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice
Wu, P., Shen, Q., Dong, S., Xu, Z., Tsien, J. Z., & Hu, Y. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.028 · Cited by 118
The Different Roles of Glucocorticoids in the Hippocampus and Hypothalamus in Chronic Stress-Induced HPA Axis Hyperactivity
Zhu, L.-J., Liu, M.-Y., Li, H., Liu, X., Chen, C., Han, Z., Wu, H.-Y., Jing, X., Zhou, H.-H., Suh, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097689 · Cited by 114
Long-term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers
Sherman, H., Frumin, I., Gutman, R., Chapnik, N., Lorentz, A., Meylan, J., le Coutre, J., & Froy, O. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01160.x · Cited by 109
Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age
Sikka, G., Miller, K. L., Steppan, J., Pandey, D., Jung, S. M., Fraser, C. D., Ellis, C. L., Ross, D., Vandegaer, K. M., Bedja, D., et al. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.001 · Cited by 101
Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis
Williams, R. W., Bennett, B., Lu, L., Gu, J., DeFries, J. C., Carosone‐Link, P., Rikke, B. A., Belknap, J. K., & Johnson, T. E. (2004) · Mammalian Genome · doi:10.1007/s00335-004-2380-6 · Cited by 100
Loss of Nfkb1 leads to early onset aging
Bernal, G. M., Wahlstrom, J. S., Crawley, C. D., Cahill, K. E., Pytel, P., Liang, H., Kang, S., Weichselbaum, R. R., & Yamini, B. (2014) · Aging · doi:10.18632/aging.100702 · Cited by 97
The mtDNA mutation spectrum of the progeroid polg mutator mouse includes abundant control region multimers
Williams, S. L., Huang, J., Edwards, Y. J. K., Ulloa, R. H., Dillon, L. M., Prolla, T. A., Vance, J. M., Moraes, C. T., & Züchner, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.012 · Cited by 96
In vivo levels of mitochondrial hydrogen peroxide increase with age in mt DNA mutator mice
Logan, A., Shabalina, I. G., Prime, T. A., Rogatti, S., Kalinovich, A., Hartley, R. C., Budd, R. C., Cannon, B., & Murphy, M. P. (2014) · Aging Cell · doi:10.1111/acel.12212 · Cited by 93
Calorie Restriction in Mammals and Simple Model Organisms
Taormina, G., & Mirisola, M. G. (2014) · BioMed Research International · doi:10.1155/2014/308690 · Cited by 93
Understanding Mammalian Genetic Systems: The Challenge of Phenotyping in the Mouse
Brown, S. D. M., Hancock, J. M., & Gates, H. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020118 · Cited by 88
Mouse models of laminopathies
Zhang, H., Kieckhaefer, J. E., & Cao, K. (2012) · Aging Cell · doi:10.1111/acel.12021 · Cited by 88
‘Accelerated aging’: a primrose path to insight?
Miller, R. A. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00081.x · Cited by 87
Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension
Rikke, B. A., Liao, C.-Y., McQueen, M. B., Nelson, J. F., & Johnson, T. E. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.04.008 · Cited by 84
Rapamycin extends life- and health span because it slows aging
Blagosklonny, M. V. (2013) · Aging · doi:10.18632/aging.100591 · Cited by 82
Chronic Stress Induces a Hyporeactivity of the Autonomic Nervous System in Response to Acute Mental Stressor and Impairs Cognitive Performance in Business Executives
Teixeira, R. R., Díaz, M. M., Santos, T. V. D. S., Bernardes, J. T. M., Peixoto, L. G., Bocanegra, O., Neto, M. B., & Espíndola, F. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119025 · Cited by 79
Chronic Exercise Modifies Age-Related Telomere Dynamics in a Tissue-Specific Fashion
Ludlow, A. T., Witkowski, S., Marshall, M. R., Wang, Z. J., Lima, L., Pitchford, L. M., Spangenburg, E. E., & Roth, S. M. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls002 · Cited by 77
Inflammation and mortality in a frail mouse model
Ko, F., Yu, Q., Xue, Q., Yao, W., Brayton, C. F., Yang, H., Fedarko, N. S., & Walston, J. D. (2011) · AGE · doi:10.1007/s11357-011-9269-6 · Cited by 74
Wfs1-deficient mice display impaired behavioural adaptation in stressful environment
Luuk, H., Plaas, M., Raud, S., Innos, J., Sütt, S., Lasner, H., Abramov, U., Kurrikoff, K., Kõks, S., & Vasar, E. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.007 · Cited by 74
Self-citation
Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue
Massip, L., Garand, C., Turaga, R. V. N., Deschênes, F., Thorin, É., & Lebel, M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.011 · Cited by 73
Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages
Petkova, S. B., Yuan, R., Tsaih, S., Schott, W. H., Roopenian, D. C., & Paigen, B. J. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00185.2007 · Cited by 73
Linkage of Wolfram syndrome to chromosome 4p16.1 and evidence for heterogeneity.
Collier, D. A., Barrett, T. G., Curtis, D., Macleod, A. F., Arranz, M. J., Maassen, J. A., & Bundey, S. (1996) · PubMed Central · Cited by 72
Calorie restriction alleviates the age‐related decrease in neural progenitor cell division in the aging brain
Park, J., Glass, Z., Sayed, K., Michurina, T. V., Lazutkin, A. A., Mineyeva, O. A., Velmeshev, D., Ward, W. F., Richardson, A. G., & Enikolopov, G. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12249 · Cited by 72
Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse
Ko, F., Abadir, P. M., Marx, R., Westbrook, R., Cooke, C., Yang, H., & Walston, J. D. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.11.010 · Cited by 70
Connecting chronic and recurrent stress to vascular dysfunction: no relaxed role for the renin-angiotensin system
Groeschel, M., & Braam, B. G. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00208.2010 · Cited by 69
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress
McBurney, M. W., Clark-Knowles, K. V., Caron, A. Z., & Gray, D. A. (2013) · Genes & Cancer · doi:10.1177/1947601912474893 · Cited by 69
Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway
Kõks, S., Soomets, U., Paya-Cano, J. L., Fernandes, C., Luuk, H., Plaas, M., Terasmaa, A., Tillmann, V., Noormets, K., Vasar, E., et al. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.90407.2008 · Cited by 66
Self-citation
Articular Aging and Osteoarthrosis in Dwarf Mice
Silberberg, R. (2008) · Pathologia et Microbiologia · doi:10.1159/000162458 · Cited by 64
Impact of Exercise Training on Physiological Measures of Physical Fitness in the Elderly
Mendonça, G. V., Pezarat‐Correia, P., Vaz, J. R., Silva, L., de Almeida, I. D., & Heffernan, K. S. (2016) · Current Aging Science · doi:10.2174/1874609809666160426120600 · Cited by 64
Mitochondrial DNA Damage Patterns and Aging: Revising the Evidences for Humans and Mice
Kazachkova, N. (2013) · Aging and Disease · doi:10.14336/ad.2013.0400337 · Cited by 63
Mouse Models and Aging
Liao, C., & Kennedy, B. K. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-397920-9.00003-2 · Cited by 59
Circulating micro RNA signature of genotype‐by‐age interactions in the long‐lived A mes dwarf mouse
Victoria, B., Dhahbi, J. M., López, Y. O. N., Spinel, L., Atamna, H., Spindler, S. R., & Masternak, M. M. (2015) · Aging Cell · doi:10.1111/acel.12373 · Cited by 58
Genetic influence on electrocardiogram time intervals and heart rate in aging mice
Xing, S., Tsaih, S.-W., Yuan, R., Svenson, K. L., Jorgenson, L. M., So, M., Paigen, B. J., & Korstanje, R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00681.2008 · Cited by 58
Mouse Genome Informatics (MGI): reflecting on 25 years
Eppig, J. T., Richardson, J. E., Kadin, J. A., Ringwald, M., Blake, J. A., & Bult, C. J. (2015) · Mammalian Genome · doi:10.1007/s00335-015-9589-4 · Cited by 58
Mouse Loci Associated With Life Span Exhibit Sex-Specific and Epistatic Effects
Jackson, A., Gałecki, A. T., Burke, D., & Miller, R. A. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.1.b9 · Cited by 51
Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan
Tsaih, S., Pezzolesi, M. G., Yuan, R., Warram, J. H., Królewski, A. S., & Korstanje, R. (2009) · Kidney International · doi:10.1038/ki.2009.434 · Cited by 50
Age, experience and genetic background influence treadmill walking in mice
Wooley, C. M., Xing, S., Burgess, R. W., Cox, G. A., & Seburn, K. L. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.10.020 · Cited by 48
Long‐lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC 1 activity
Drake, J. C., Bruns, D. R., Peelor, F. F., Biela, L. M., Miller, R. A., Miller, B. F., & Hamilton, K. L. (2015) · Aging Cell · doi:10.1111/acel.12329 · Cited by 47
Calorie restriction can reverse, as well as prevent, aging cardiomyopathy
Yan, L., Gao, S., Ho, D. W. T., Park, M., Ge, H., Wang, C., Tian, Y., Lai, L., Lorenzo, M. S. D., Vatner, D. E., et al. (2013) · AGE · doi:10.1007/s11357-012-9508-5 · Cited by 47
Effects of chronic vs. intermittent calorie restriction on mammary tumor incidence and serum adiponectin and leptin levels in MMTV-TGF-α mice at different ages
Doğan, S., Rogozina, O. P., Lokshin, A. E., Grande, J. P., & Cleary, M. P. (2009) · Oncology Letters · doi:10.3892/ol_00000031 · Cited by 46
Multiple-Trait Quantitative Trait Loci Analysis Using a Large Mouse Sibship
Jackson, A., Fornés, A., Gałecki, A. T., Miller, R. A., & Burke, D. (1999) · Genetics · doi:10.1093/genetics/151.2.785 · Cited by 45
From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing
Cox, L. S., & Faragher, R. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7123-x · Cited by 44
Genetic Modulation of Hormone Levels and Life Span in Hybrids Between Laboratory and Wild-Derived Mice
Harper, J. M., Durkee, S. J., Dysko, R. C., Austad, S. N., & Miller, R. A. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.10.1019 · Cited by 44
Recent Progress in Metabolic Signaling Pathways Regulating Aging and Life Span
Newgard, C. B., & Pessin, J. E. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu058 · Cited by 44
Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain
Sanz, A., Bartke, A., & Barja, G. (2002) · AGE · doi:10.1007/s11357-002-0010-3 · Cited by 43
Antiaging, longevity and calorie restriction
Morley, J. E., Chahla, E. J., & AlKaade, S. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283331384 · Cited by 43
Genetic analysis of murine strains C57BL/6J and C3H/HeJ to confirm the map position ofAth-1, a gene determining atherosclerosis susceptibility
Paigen, B. J., Albee, D., Holmes, P. A., & Mitchell, D. (1987) · Biochemical Genetics · doi:10.1007/bf00554352 · Cited by 38
Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span
Bogue, M. A., Peters, L. L., Paigen, B. J., Korstanje, R., Yuan, R., Ackert‐Bicknell, C. L., Grubb, S. C., Churchill, G. A., & Chesler, E. J. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu223 · Cited by 38
Male mice with deleted Wolframin (Wfs1) gene have reduced fertility
Noormets, K., Kõks, S., Kavak, A., Arend, A., Aunapuu, M., Keldrimaa, A., Vasar, E., & Tillmann, V. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-82 · Cited by 35
Self-citation
Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries
Walker, A. E., Henson, G. D., Reihl, K. D., Nielson, E. I., Morgan, R. G., Lesniewski, L. A., & Donato, A. J. (2013) · AGE · doi:10.1007/s11357-013-9585-0 · Cited by 34
A neurological phenotype in mice with DNA repair gene Ercc1 deficiency
Lawrence, N. J., Sacco, J. J., Brownstein, D. G., Gillingwater, T. H., & Melton, D. W. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.10.005 · Cited by 33
Age‐associated changes in hippocampal‐dependent cognition in D iversity O utbred mice
Koh, M. T., Spiegel, A. M., & Gallagher, M. (2014) · Hippocampus · doi:10.1002/hipo.22311 · Cited by 32
Sex Differences in the Development of Diabetes in Mice with Deleted Wolframin (Wfs1) Gene
Noormets, K., Kõks, S., Muldmaa, M., Mauring, L., Vasar, E., & Tillmann, V. (2010) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0030-1265163 · Cited by 32
Self-citation
Effects of age and caloric restriction on mitochondrial protein oxidative damage in mice
Li, X., Rebrin, I., Forster, M. J., & Sohal, R. S. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.12.001 · Cited by 30
Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity
Yan, L., Park, J. Y., Dillinger, J., Lorenzo, M. S. D., Yuan, C., Lai, L., Wang, C., Ho, D. W. T., Tian, B., Stanley, W. C., et al. (2012) · Aging Cell · doi:10.1111/acel.12013 · Cited by 29
Lifelong Treatment with Oral DHEA Sulfate Does Not Preserve Immune Function, Prevent Disease, or Improve Survival in Genetically Heterogeneous Mice
Miller, R. A., & Chrisp, C. E. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01291.x · Cited by 29
Early life programming of obesity.
Martin‐Gronert, M. S., & Ozanne, S. E. (2013) · PubMed · Cited by 28
Beneficial Effects of Alternate Dietary Regimen on Liver Inflammation, Atherosclerosis and Renal Activation
Wielinga, P. Y., Yakala, G. K., Heeringa, P., Kleemann, R., & Kooistra, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018432 · Cited by 26
Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology?
Ikeno, Y., Hubbard, G. B., Lee, S., Dube, S., Flores, L. C., Roman, M. G., & Bartke, A. (2013) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v3i0.20833 · Cited by 25
Psychological stress-induced catecholamines accelerates cutaneous aging in mice
Romana‐Souza, B., Lima-Cezar, G. S., & Monte‐Alto‐Costa, A. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.10.004 · Cited by 24
Mitochondrial DNA deletions in mice in men: Substantia nigra is much less affected in the mouse
Guo, X., Kudryavtseva, E., Bodyak, N. D., Nicholas, A., Dombrovsky, I., Yang, D., Kraytsberg, Y., Simon, D. K., & Khrapko, K. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.005 · Cited by 23
IGF-1 mediated phosphorylation of specific IRS-1 serines inAmes dwarffibroblasts is associated with longevity
Papaconstantinou, J., & Hsieh, C.-C. (2015) · Oncotarget · doi:10.18632/oncotarget.6112 · Cited by 6
Atherosclerosis and cardiac function assessment in low-density lipoprotein receptor-deficient mice undergoing body weight cycling
McMillen, T. S., Minami, E., & LeBoeuf, R. C. (2013) · Nutrition and Diabetes · doi:10.1038/nutd.2013.19 · Cited by 5

Research works printed but not linked: 1

Liao, 2010, Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening, Aging Cell, 9, 92, 10.1111/j.1474-9726.2009.00533.x · DOI · Paper page

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“The identification of specific mutations causing these syndromes has enabled the development of mouse models that simulate premature aging.(304) For instance, mouse models of HGPS have been created by modifying the Lmna gene or its processing enzyme.”
Background
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Loss of epigenetic information as a cause of mammalian aging
Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.027 · Cited by 643
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Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Gude, N. A., Broughton, K. M., Firouzi, F., & Sussman, M. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0061-5 · Cited by 172

See all 126

Authors: Kõks, S., Dogan, S., Tuna, B. G., González-Navarro, H., Potter, P., & Vandenbroucke, R. E.
Affiliations: Estonian University of Life Sciences (EE)
Mary Lyon Centre at MRC Harwell (GB)
Ghent University (BE)
Corresponding author: Vandenbroucke, Roosmarijn E.
ORCID: Kõks, Sulev
Tuna, Bilge Guvenc
Potter, Paul
Vandenbroucke, Roosmarijn E.
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 2016-12
Volume: 160
Pages: 41-53
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/j.mad.2016.10.001
OpenAlex: W2529858651
Cited by: 125
References: 182
Citations by year: 2026: 12 · 2025: 11 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 15 · 2020: 6 · 2019: 18 · 2018: 12 · 2017: 4
FWCI: 1.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Mechanisms of Ageing and Development (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
Murdoch University Research Portal (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords: aging, accelerated aging, caloric restriction, disease susceptibility, phenotypic characterization
MeSH terms: Aging, Animals, Humans, Models, Biological, Mice

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