Cited by 126Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceAntioxidants, Aging, Portulaca oleracea

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Mouse models of ageing and their relevance to disease

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Kõks, Sulev, Dogan, Soner, Tuna, Bilge Guvenc, González-Navarro, Herminia, Potter, Paul, Vandenbroucke, Roosmarijn E.·2016·Mechanisms of Ageing and Development

DOI 10.1016/j.mad.2016.10.001

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Abstract

Ageing is a process that gradually increases the organism's vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction.

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Authors: Kõks, S., Dogan, S., Tuna, B. G., González-Navarro, H., Potter, P., & Vandenbroucke, R. E.
Affiliations: Estonian University of Life Sciences (EE)
Mary Lyon Centre at MRC Harwell (GB)
Ghent University (BE)
Corresponding author: Vandenbroucke, Roosmarijn E.
ORCID: Kõks, Sulev
Tuna, Bilge Guvenc
Potter, Paul
Vandenbroucke, Roosmarijn E.
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 2016-12
Volume: 160
Pages: 41-53
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/j.mad.2016.10.001
OpenAlex: W2529858651
Cited by: 125
References: 182
Citations by year: 2026: 12 · 2025: 11 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 15 · 2020: 6 · 2019: 18 · 2018: 12 · 2017: 4
FWCI: 1.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Mechanisms of Ageing and Development (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
Murdoch University Research Portal (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords: aging, accelerated aging, caloric restriction, disease susceptibility, phenotypic characterization
MeSH terms: Aging, Animals, Humans, Models, Biological, Mice

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