Cited by 154Axon Guidance and Neuronal SignalingNerve injury and regenerationProteoglycans and glycosaminoglycans research

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Semaphorin 3A displays a punctate distribution on the surface of neuronal cells and interacts with proteoglycans in the extracellular matrix

De Wit, Joris, De Winter, Fred, Klooster, Jan, Verhaagen, Joost·2005·Molecular and Cellular Neuroscience

DOI 10.1016/j.mcn.2004.12.009

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Abstract

Secreted semaphorins are essential for neural development and continue to be expressed in subpopulations of adult neurons, where they subserve as yet unknown functions. We employed functional myc- and GFP-tagged Sema3A proteins to obtain insight in the localization of Sema3A in neuronal cells. Sema3A localized to both axons and dendrites of cortical neurons. GFP-Sema3A exhibited a characteristic punctate distribution on the surface of Neuro-2a cells, localized to migratory pathways of cultured cells, and co-localized with and induced clustering of its receptor component neuropilin-1. Treatment with excess glycosaminoglycans and chondroitinase ABC resulted in the removal of cell surface Sema3A. Heparin enhanced Sema3A's binding to neuropilin-1-expressing cells and potentiated its growth cone collapsing activity. Together, these results indicate that association with proteoglycans in the extracellular matrix of neuronal cells plays an important role in the localization of the chemorepulsive guidance cue Sema3A, and that this interaction may enhance its biological activity.

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Authors: De Wit, J., De Winter, F., Klooster, J., & Verhaagen, J.
Corresponding author: Verhaagen, Joost
ORCID: Verhaagen, Joost
Venue: Molecular and Cellular Neuroscience
Publisher: Elsevier BV
Published: 2005-05
Volume: 29
Issue: 1
Pages: 40-55
ISSN: 1044-7431 (ISSN-L)
DOI: 10.1016/j.mcn.2004.12.009
OpenAlex: W2078936926
Cited by: 154
References: 92
Citations by year: 2026: 5 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 9 · 2015: 11 · 2014: 9 · 2013: 14 · 2012: 8
FWCI: 3.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Neuroscience (publishedVersion)
PubMed (publishedVersion)
KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Lirias (KU Leuven) (submittedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: semaphorin 3A, neuropilin-1, proteoglycans, extracellular matrix, glycosaminoglycans, chondroitinase ABC, cell surface localization, growth cone collapse, axons and dendrites, cortical neurons, N2a cells, heparin binding
MeSH terms: Animals, Anticoagulants, Epitopes, Cerebral Cortex, Heparin, Membrane Proteins, Neuroblastoma, Neurons, Protein Binding, Proteoglycans, Tumor Cells, Cultured, Proto-Oncogene Proteins c-myc, Extracellular Matrix Proteins, Rats, Wistar, Growth Cones, Neuropilin-1, Semaphorin-3A, Green Fluorescent Proteins, Mice, Rats

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Semaphorin 3A displays a punctate distribution on the surface of neuronal cells and interacts with proteoglycans in the extracellular matrix

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