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Synaptic logistics: Competing over shared resources

Hafner, Anne-Sophie, Triesch, Jochen·2023·Molecular and Cellular Neuroscience
DOI 10.1016/j.mcn.2023.103858
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  • Disruption in cargo selection can significantly impact synaptic function because synaptic receptors undergo rapid turnover via endocytosis.

    “Given the rapid turnover of synaptic receptors via endocytosis, any disruption in cargo selection can significantly impact synaptic function [13].”

    From Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer’s disease mouse model (2025) · cites this paper as [13]

    Section 4, “Resource bottlenecks for synaptic function” (page not provided), says glutamate receptors have among the fastest turnover rates of postsynaptic proteins and that disruptions to their supply could significantly affect responses to neurotransmitter release. It does not say that this turnover occurs via endocytosis or specifically link disrupted cargo selection to impaired synaptic function. (LLM, conf=0.86)

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Metadata

Authors
Hafner, A.-S., & Triesch, J.
Venue
Molecular and Cellular Neuroscience
Publisher
Elsevier BV
Published
2023-06
Volume
125
Pages
103858
ISSN
1044-7431
DOI
10.1016/j.mcn.2023.103858
Cited by
2
References
6
Language
en
Licence
Funders
  • Horizon 2020
  • European Research Council (101076961)
  • Deutsche Forschungsgemeinschaft (TR881/8-1, SPP-2041)
  • Johanna Quandt Stiftung

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