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Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing
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Cells transiently adapt to hypoxia by globally decreasing protein translation. However, specific proteins needed to respond to hypoxia evade this translational repression. The mechanisms of this phenomenon remain unclear. We screened for and identified small molecules that selectively decrease HIF-2a translation in an mTOR-independent manner, by enhancing the binding of Iron-Regulatory Protein 1 (IRP1) to a recently reported iron-responsive element (IRE) within the 5'-untranslated region (UTR) of the HIF-2a message. Knocking down the expression of IRP1 by shRNA abolished the effect of the compounds. Hypoxia derepresses HIF-2a translation by disrupting the IRP1-HIF-2a IRE interaction. Thus, this chemical genetic analysis describes a molecular mechanism by which translation of the HIF-2a message is maintained during conditions of cellular hypoxia through inhibition of IRP-1-dependent repression. It also provides the chemical tools for studying this phenomenon.
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“Consistent with the central role of HIF-2α in the regulation of iron homeostasis, HIF-2α (but not HIF-1α) is also regulated by iron due to the presence of an RNA stem-loop element known as an iron-responsive element (IRE), in the 5’ untranslated region (UTR) of the HIF-2α transcript [22].”
From The HIF Axes in Cancer - Angiogenesis, Metabolism and Immune-Modulation (2025) · cites this paper as [22]
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., et al. (1999) · Science · doi:10.1126/science.286.5439.531 · Cited by 11,516
Self-citationMootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Self-citationJaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Lamb, J., Crawford, E. D., Peck, D., Modell, J. W., Blat, I. C., Wrobel, M. J., Lerner, J., Brunet, J.-P., Subramanian, A., Ross, K. N., et al. (2006) · Science · doi:10.1126/science.1132939 · Cited by 5,257
Self-citationThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
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Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791
Self-citationHIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693
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Zhong, L., D'Urso, A., Toiber, D., Sebastian, C., Henry, R. E., Vadysirisack, D. D., Guimaraes, A., Marinelli, B., Wikstrom, J. D., Nir, T., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.041 · Cited by 1,001
Self-citationRegulation of cellular iron metabolism
Wang, J., & Pantopoulos, K. (2011) · Biochemical Journal · doi:10.1042/bj20101825 · Cited by 986
Self-citationHeddleston, J. M., Li, Z., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9701 · Cited by 813
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Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787
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Gossage, L., Eisen, T. G., & Maher, E. R. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3844 · Cited by 800
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Linehan, W. M., Srinivasan, R., & Schmidt, L. S. (2010) · Nature Reviews Urology · doi:10.1038/nrurol.2010.47 · Cited by 754
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Kerins, M. J., & Ooi, A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7176 · Cited by 755
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687
“…2003 Cardiac glycosides unknown Zhang et al., 2008b FM19G11 unknown Moreno-Manzano et al., 2010 HIF-2α translational inhibitors IRP1/IRE interaction Zimmer et al., 2008 HIF-α/HIF-1β dimerization Acriflavine HIF-1α/2α PAS-B domain Lee et al., 2009 PT2385 HIF-2α PAS-B domain Scheuermann et al.,…”
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Fleming, R. E., & Ponka, P. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1004967 · Cited by 607
Mammalian iron metabolism and its control by iron regulatory proteins
Anderson, C. P., Shen, M., Eisenstein, R. S., & Leibold, E. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.010 · Cited by 493
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Wilkinson, N., & Pantopoulos, K. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00176 · Cited by 366
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Haase, V. H. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00174.2010 · Cited by 347
Gameiro, P. A., Yang, J., Metelo, A. M., Pérez-Carro, R., Baker, R., Wang, Z., Arreola, A., Rathmell, W. K., Olumi, A., López-Larrubia, P., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.002 · Cited by 325
Self-citationThe physiological functions of iron regulatory proteins in iron homeostasis - an update
Zhang, D., Ghosh, M. C., & Rouault, T. A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00124 · Cited by 310
Brain iron metabolism and its perturbation in neurological diseases
Crichton, R. R., Dexter, D. T., & Ward, R. J. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0470-z · Cited by 247
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Yuan, X., Ruan, W., Bobrow, B., Carmeliet, P., & Eltzschig, H. K. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00848-6 · Cited by 245
Iron regulatory proteins and their role in controlling iron metabolism
Kühn, L. C. (2015) · Metallomics · doi:10.1039/c4mt00164h · Cited by 242
Lawen, A., & Lane, D. J. R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4271 · Cited by 220
Tong, W.-H., Sourbier, C., Kovtunovych, G., Jeong, S. Y., Vira, M., Ghosh, M., Romero, V. V., Sougrat, R., Vaulont, S., Viollet, B., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.07.018 · Cited by 212
The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption
Anderson, S. A., Nizzi, C. P., Chang, Y.-I., Deck, K. M., Schmidt, P. J., Galy, B., Damnernsawad, A., Broman, A. T., Kendziorski, C., Hentze, M. W., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.007 · Cited by 211
Hypoxia-inducible factors: a central link between inflammation and cancer
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Cho, H.-H., Cahill, C. M., Vanderburg, C. R., Scherzer, C. R., Wang, B., Huang, X., & Rogers, J. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149161 · Cited by 188
Smith, I. C. P., Greenside, P., Natoli, T. E., Lahr, D. L., Wadden, D., Tirosh, I., Narayan, R., Root, D. E., Golub, T. R., Subramanian, A., et al. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2003213 · Cited by 197
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Dai, Z., Zhu, M. M., Peng, Y., Machireddy, N., Evans, C. E., Machado, R. F., Zhang, X., & Zhao, Y. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201710-2079oc · Cited by 164
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Greene, C. J., Attwood, K., Sharma, N. J., Gross, K. W., Smith, G. J., Xu, B., & Kauffman, E. C. (2017) · Oncotarget · doi:10.18632/oncotarget.22323 · Cited by 87
Zhong, L., & Mostoslavsky, R. (2010) · Transcription · doi:10.4161/trns.1.1.12143 · Cited by 86
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Davis, L., Recktenwald, M., Hutt, E., Fuller, S., Briggs, M., Goel, A., & Daringer, N. (2022) · Cancers · doi:10.3390/cancers14051259 · Cited by 83
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Yuen, C., Asuthkar, S., Guda, M. R., Tsung, A. J., & Velpula, K. K. (2016) · CNS Oncology · doi:10.2217/cns-2015-0006 · Cited by 85
Rogers, J. T., Mikkilineni, S., Cantuti‐Castelvetri, I., Smith, D. H., Huang, X., Bandyopadhyay, S., Cahill, C. M., Maccecchini, M. L., Lahiri, D. K., & Greig, N. H. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-010-0513-5 · Cited by 82
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Ryu, J., Chae, C.-S., Kwak, J.-S., Oh, H., Shin, Y., Huh, Y. H., Lee, C., Park, Y.-W., Chun, C. H., Kim, Y., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001881 · Cited by 84
Kinnaird, A. S., Dromparis, P., Saleme, B., Gurtu, V., Watson, K., Paulin, R., Zervopoulos, S. D., Stenson, T. H., Sutendra, G., Pink, D., et al. (2016) · European Urology · doi:10.1016/j.eururo.2015.09.014 · Cited by 78
RNA‐binding proteins implicated in the hypoxic response
Masuda, K., Abdelmohsen, K., & Gorospe, M. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00842.x · Cited by 80
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Begum, S., & Latunde-Dada, G. O. (2019) · Nutrients · doi:10.3390/nu11102424 · Cited by 79
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Green, Y. S., Ferreira dos Santos, M. C., Fuja, D. G., Reichert, E. C., Campos, A. R., Cowman, S. J., Acuña Pilarte, K., Kohan, J., Tripp, S. R., Leibold, E. A., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02460-1 · Cited by 69
Wu, D., Dasgupta, A., Read, A. D., Bentley, R. E. T., Motamed, M., Chen, K., Al‐Qazazi, R., Mewburn, J. D., Dunham‐Snary, K. J., Alizadeh, E., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.452 · Cited by 69
Koh, M. Y., Spivak-Kroizman, T. R., & Powis, G. (2009) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-540-78281-0_3 · Cited by 70
Maffettone, C., Chen, G., Drozdov, I. A., Ouzounis, C. A., & Pantopoulos, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010163 · Cited by 68
Self-citationJasiecki, J., Targońska, M., & Wasąg, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042033 · Cited by 67
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Ghosh, M. C., Zhang, D., & Rouault, T. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.026 · Cited by 63
Li, H., Liu, Y., Shang, L., Cai, J., Wu, J., Zhang, W., Pu, X., Dong, W., Qiao, T., & Li, K. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820051116 · Cited by 62
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Elks, P. M., Renshaw, S. A., Meijer, A. H., Walmsley, S. R., & van Eeden, F. J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.021865 · Cited by 64
Kerins, M. J., Vashisht, A. A., Liang, B. X.-T., Duckworth, S. J., Praslicka, B. J., Wohlschlegel, J. A., & Ooi, A. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00079-17 · Cited by 57
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Hajjo, R., Setola, V., Roth, B. L., & Tropsha, A. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm2011657 · Cited by 55
Ghosh, M. C., Zhang, D., Ollivierre, W. H., Noguchi, A. C., Springer, D., Linehan, W. M., & Rouault, T. A. (2020) · Blood · doi:10.1182/blood.2020009138 · Cited by 54
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Metelo, A. M., Noonan, H. R., Li, X., Jin, Y. N., Baker, R., Kamentsky, L. D., Zhang, Y., van Rooijen, E., Shin, J. T., Carpenter, A. E., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73665 · Cited by 49
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Laviolette, L. A., Mermoud, J., Calvo, I. A., Olson, N., Boukhali, M., Steinlein, O. K., Roider, E., Sattler, E., Huang, D., Teh, B. T., et al. (2017) · Nature Communications · doi:10.1038/ncomms15866 · Cited by 47
Self-citationMicrobiota-assisted iron uptake promotes immune tolerance in the intestine
Zhu, L., Li, G., Liang, Z., Qi, T., Deng, K., Yu, J., Peng, Y., Zheng, J., Song, Y., & Chang, X. (2023) · Nature Communications · doi:10.1038/s41467-023-38444-2 · Cited by 47
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Metadata
- Authors
- Zimmer, M., Ebert, B. L., Neil, C., Brenner, K., Papaioannou, I., Melas, A., Tolliday, N., Lamb, J., Pantopoulos, K., Golub, T., & Iliopoulos, O.
- Affiliations
- Massachusetts General Hospital (US)
- Broad Institute (US)
- Harvard University (US)
- Lady Davis Institute for Medical Research (CA)
- Corresponding author
- Iliopoulos, Othon
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 32
- Issue
- 6
- Pages
- 838-848
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC3978139
- OpenAlex
- W2034427729
- Cited by
- 191
- References
- 65
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 14 · 2015: 10 · 2014: 16 · 2013: 13 · 2012: 19
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1725 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Cancer Institute
- Dana-Farber/Harvard Cancer Center
- National Institutes of Health (5R01CA104574)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- iron-responsive element, iron regulatory protein 1, 5' untranslated region, hypoxia, protein synthesis inhibition, oxygen sensing, small molecule inhibitors, chemical genetics, mRNA translation
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Dose-Response Relationship, Drug, Gene Expression Regulation, Humans, Iron, Iron Chelating Agents, Oxygen, Protein Binding, Protein Kinases, Receptors, Transferrin, RNA, Messenger, Protein Biosynthesis, Cell Hypoxia, Culture Media, Conditioned, 5' Untranslated Regions, Response Elements, Gene Expression Profiling, RNA Stability, Iron-Regulatory Proteins, Endothelial Cells, Cell Proliferation, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Small Molecule Libraries, Protein Stability, TOR Serine-Threonine Kinases
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