Cited by 392DNA Repair MechanismsNuclear Structure and FunctionGenetic factors in colorectal cancer

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Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

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Ogi, Tomoo, Limsirichaikul, Siripan, Overmeer, René M., Volker, Marcel, Takenaka, Katsuya, Cloney, Ross, Nakazawa, Yuka, Niimi, Atsuko, Miki, Yoshio, Jaspers, Nicolaas G., Mullenders, Leon H.F., Yamashita, Shunichi, Fousteri, Maria I., Lehmann, Alan R.·2010·Molecular Cell

DOI 10.1016/j.molcel.2010.02.009

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Abstract

Nucleotide excision repair (NER) is the most versatile DNA repair system that deals with the major UV photoproducts in DNA, as well as many other DNA adducts. The early steps of NER are well understood, whereas the later steps of repair synthesis and ligation are not. In particular, which polymerases are definitely involved in repair synthesis and how they are recruited to the damaged sites has not yet been established. We report that, in human fibroblasts, approximately half of the repair synthesis requires both pol kappa and pol delta, and both polymerases can be recovered in the same repair complexes. Pol kappa is recruited to repair sites by ubiquitinated PCNA and XRCC1 and pol delta by the classical replication factor complex RFC1-RFC, together with a polymerase accessory factor, p66, and unmodified PCNA. The remaining repair synthesis is dependent on pol epsilon, recruitment of which is dependent on the alternative clamp loader CTF18-RFC.

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RETRACTED: Sealing of Chromosomal DNA Nicks during Nucleotide Excision Repair Requires XRCC1 and DNA Ligase IIIα in a Cell-Cycle-Specific Manner
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Self-citation

Authors: Ogi, T., Limsirichaikul, S., Overmeer, R. M., Volker, M., Takenaka, K., Cloney, R., Nakazawa, Y., Niimi, A., Miki, Y., Jaspers, N. G., Mullenders, L. H. F., Yamashita, S., Fousteri, M. I., & Lehmann, A. R.
Affiliations: Nagasaki University (JP)
Leiden University Medical Center (NL)
University of Sussex (GB)
Tokyo Medical and Dental University (JP)
Erasmus MC (NL)
Corresponding author: Ogi, Tomoo
Lehmann, Alan R.
ORCID: Ogi, Tomoo
Overmeer, René M.
Cloney, Ross
Nakazawa, Yuka
Miki, Yoshio
Yamashita, Shunichi
Fousteri, Maria I.
Lehmann, Alan R.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2010-03
Volume: 37
Issue: 5
Pages: 714-727
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2010.02.009
OpenAlex: W2037936898
Cited by: 392
References: 55
Citations by year: 2026: 18 · 2025: 13 · 2024: 23 · 2023: 25 · 2022: 16 · 2021: 22 · 2020: 19 · 2019: 15 · 2018: 20 · 2017: 31 · 2016: 21 · 2015: 20 · 2014: 33 · 2013: 26 · 2012: 40
FWCI: 15.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1270 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Institutional Repositories DataBase (IRDB) (acceptedVersion)
Sussex Research Online (University of Sussex) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Figshare (submittedVersion, cc-by)
Nagasaki University's Academic Output SITE (Nagasaki University) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: nucleotide excision repair, DNA repair synthesis, DNA polymerase kappa, DNA polymerase delta, DNA polymerase epsilon, PCNA ubiquitination, XRCC1, replication factor C, p66, UV photoproducts, human fibroblasts
MeSH terms: ATPases Associated with Diverse Cellular Activities, Poly-ADP-Ribose Binding Proteins, X-ray Repair Cross Complementing Protein 1, Y-Family DNA Polymerases, Carrier Proteins, Cell Line, DNA Damage, DNA Polymerase II, DNA Polymerase III, DNA-Directed DNA Polymerase, DNA Repair, DNA-Binding Proteins, Fibroblasts, Humans, Nuclear Proteins, Protein Processing, Post-Translational, Recombinant Fusion Proteins, Time Factors, Transfection, Ultraviolet Rays, Cellular Senescence, Proliferating Cell Nuclear Antigen, Protein Transport, RNA Interference, Ubiquitin-Protein Ligases, Replication Protein C, Ubiquitination

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Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

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