SLC19A1 is an importer of the immunotransmitter cGAMP.

NIH Image to ImageJ: 25 years of image analysis

Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638

Improved vectors and genome-wide libraries for CRISPR screening

Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239

Genome-scale CRISPR-Cas9 knockout screening in human cells

Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science · doi:10.1126/science.1247005 · Cited by 5,234

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996

Regulation of Adaptive Immunity by the Innate Immune System

Iwasaki, A., & Medzhitov, R. M. (2010) · Science · doi:10.1126/science.1183021 · Cited by 2,220

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.-D., Mauceri, H., Beckett, M., Darga, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.019 · Cited by 2,182

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

Woo, S.-R., Fuertes, M. B., Corrales, L., Spranger, S., Furdyna, M. J., Leung, M. Y. K., Duggan, R., Wang, Y., Barber, G. N., Fitzgerald, K. A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.017 · Cited by 1,917

cGAS surveillance of micronuclei links genome instability to innate immunity

Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature · doi:10.1038/nature23449 · Cited by 1,752

Chromosomal instability drives metastasis through a cytosolic DNA response

Bakhoum, S. F., Ngo, B., Laughney, A. M., Cavallo, J.-A., Murphy, C. J., Ly, P., Shah, P., Sriram, R. K., Watkins, T. B. K., Taunk, N. K., et al. (2018) · Nature · doi:10.1038/nature25432 · Cited by 1,593

STING is a direct innate immune sensor of cyclic di-GMP

Burdette, D. L., Monroe, K. M., Sotelo-Troha, K., Iwig, J. S., Eckert, B., Hyodo, M., Hayakawa, Y., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10429 · Cited by 1,570

The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Decout, A., Katz, J. D., Venkatraman, S., & Ablasser, A. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00524-z · Cited by 2,309

Molecular mechanisms and cellular functions of cGAS–STING signalling

Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0244-x · Cited by 2,052

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

Kwon, J., & Bakhoum, S. F. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0761 · Cited by 1,293

Inflammatory microenvironment remodelling by tumour cells after radiotherapy

McLaughlin, M., Patin, E. C., Pedersen, M., Wilkins, A. C., Dillon, M. T., Melcher, A. A., & Harrington, K. J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0246-1 · Cited by 921

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

Zhang, X., Bai, X., & Chen, Z. J. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.013 · Cited by 859

Cold and hot tumors: from molecular mechanisms to targeted therapy

Wu, B., Zhang, B., Li, B., Wu, H., & Jiang, M. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01979-x · Cited by 811

The cGAS–STING pathway and cancer

Samson, N., & Ablasser, A. (2022) · Nature Cancer · doi:10.1038/s43018-022-00468-w · Cited by 740

Improving cancer immunotherapy through nanotechnology

Goldberg, M. S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0186-9 · Cited by 628

Roles of natural killer cells in immunity to cancer, and applications to immunotherapy

Wolf, N. K., Kissiov, D. U., & Raulet, D. H. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00732-1 · Cited by 622

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway

Kim, J., Kim, H., & Chung, J. H. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00965-7 · Cited by 594

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

Zhou, Y., Fei, M., Zhang, G., Liang, W., Lin, W., Wu, Y., Piskol, R., Ridgway, J. B., McNamara, E., Huang, H., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.014 · Cited by 406

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion

Wu, J., Dobbs, N., Yang, K., & Yan, N. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.009 · Cited by 373

Extracellular cGAMP is a cancer-cell-produced immunotransmitter involved in radiation-induced anticancer immunity

Carozza, J. A., Böhnert, V., Nguyen, K. C., Skariah, G. M., Shaw, K. E., Brown, J. A., Rafat, M., von Eyben, R., Graves, E. E., Glenn, J. S., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0028-4 · Cited by 375

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy

Garland, K. M., Sheehy, T. L., & Wilson, J. T. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00750 · Cited by 372

New frontiers in the cGAS-STING intracellular DNA-sensing pathway

Dvorkin, S., Cambier, S., Volkman, H. E., & Stetson, D. B. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.019 · Cited by 390

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Ablasser, A., & Hur, S. (2019) · Nature Immunology · doi:10.1038/s41590-019-0556-1 · Cited by 339

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

Zheng, J., Mo, J., Zhu, T., Zhuo, W., Yi, Y., Hu, S., Yin, J., Zhang, W., Zhou, H., & Liu, Z. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01250-1 · Cited by 344

Signaling by cGAS–STING in Neurodegeneration, Neuroinflammation, and Aging

Paul, B. D., Snyder, S. H., & Bohr, V. A. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.008 · Cited by 336

Role of the cGAS–STING pathway in systemic and organ-specific diseases

Skopelja‐Gardner, S., An, J., & Elkon, K. B. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00589-6 · Cited by 318

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

Zhou, C., Chen, X., Planells‐Cases, R., Chu, J., Wang, L., Cao, L., Li, Z., López‐Cayuqueo, K. I., Xie, Y., Ye, S., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.016 · Cited by 295

Regulation of cGAS–STING signalling and its diversity of cellular outcomes

Zhang, Z., & Zhang, C. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01112-7 · Cited by 287

Cytosolic DNA sensing by cGAS: regulation, function, and human diseases

Yu, L., & Liu, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00554-y · Cited by 295

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

Pulido, Á. D. M., Hänggi, K., Celias, D. P., Gardner, A., Li, J., Bittencourt, B. M. B., Mohamed, E. T., Trillo-Tinoco, J., Osunmakinde, O., Peña, R. J., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.019 · Cited by 282

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

Wan, D., Jiang, W., & Hao, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00615 · Cited by 270

NK cells mediate clearance of CD8 + T cell–resistant tumors in response to STING agonists

Nicolai, C. J., Wolf, N., Chang, I.-C., Kirn, G., Marcus, A., Ndubaku, C. O., McWhirter, S. M., & Raulet, D. H. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz2738 · Cited by 268

Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy

Aval, L. M., Pease, J. E., Sharma, R., & Pinato, D. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103323 · Cited by 253

The STING1 network regulates autophagy and cell death

Zhang, R., Kang, R., & Tang, D. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00613-4 · Cited by 266

Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer

Loo, T. M., Miyata, K., Tanaka, Y., & Takahashi, A. (2020) · Cancer Science · doi:10.1111/cas.14266 · Cited by 232

Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles

Li, X., Khorsandi, S., Wang, Y., Santelli, J., Huntoon, K. M., Nguyen, N., Yang, M., Lee, D., Lü, Y., Gao, R., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01134-z · Cited by 217

Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy

Zhang, Z., Zhou, H., Ouyang, X., Dong, Y., Sarapultsev, A., Luo, S., & Hu, D. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01252-z · Cited by 222

The interactions between cGAS-STING pathway and pathogens

Cheng, Z., Dai, T., He, X., Zhang, Z., Xie, F., Wang, S., Zhang, L., & Zhou, F. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0198-7 · Cited by 216

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

Lahey, L. J., Mardjuki, R. E., Wen, X., Hess, G. T., Ritchie, C., Carozza, J. A., Böhnert, V., Maduke, M. C., Bassik, M. C., & Li, L. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.10.021 · Cited by 201

Mitochondria-Striking a balance between host and endosymbiont

Youle, R. J. (2019) · Science · doi:10.1126/science.aaw9855 · Cited by 199

The cGAS/STING Pathway: A Novel Target for Cancer Therapy

Gan, Y., Li, X., Han, S., Liang, Q., Ma, X., Rong, P., Wang, W., & Li, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.795401 · Cited by 194

Old dogs, new trick: classic cancer therapies activate cGAS

Yum, S., Li, M., & Chen, Z. J. (2020) · Cell Research · doi:10.1038/s41422-020-0346-1 · Cited by 184

The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications

Shen, M., Jiang, X., Qiu, P., Oyang, L., Ren, Z., Wang, J., Peng, M., Zhou, Y., Deng, X., & Liao, Q. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01691-5 · Cited by 210

Targeting STING to promote antitumor immunity

Chin, E. N., Sulpizio, A., & Lairson, L. L. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.06.010 · Cited by 170

The balance of STING signaling orchestrates immunity in cancer

Lanng, K. R. B., Lauridsen, E. L., & Jakobsen, M. R. (2024) · Nature Immunology · doi:10.1038/s41590-024-01872-3 · Cited by 179

Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes

Cordova, A. F., Ritchie, C., Böhnert, V., & Li, L. (2021) · ACS Central Science · doi:10.1021/acscentsci.1c00440 · Cited by 157

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

Gentili, M., Liu, B., Papanastasiou, M., Dele-Oni, D. O., Schwartz, M. A., Carlson, R. J., Al’Khafaji, A. M., Krug, K., Brown, A., Doench, J. G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36132-9 · Cited by 151

Regulation of the cGAS-STING Pathway

Zhang, B., Xu, P., & Ablasser, A. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101721-032910 · Cited by 164

Small but mighty: the causes and consequences of micronucleus rupture

Kwon, M., Leibowitz, M. L., & Lee, J. H. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00529-z · Cited by 149

ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP

Maltbaek, J. H., Cambier, S., Snyder, J. M., & Stetson, D. B. (2022) · Immunity · doi:10.1016/j.immuni.2022.08.006 · Cited by 132

ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling

Carozza, J. A., Cordova, A. F., Brown, J. A., AlSaif, Y., Böhnert, V., Cao, X., Mardjuki, R. E., Skariah, G. M., Fernández, D., & Li, L. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119189119 · Cited by 131

Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS–cGAMP–STING Pathway

Ritchie, C., Carozza, J. A., & Li, L. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-040320-101629 · Cited by 123

Mitochondrial Quality Control and Restraining Innate Immunity

Moehlman, A. T., & Youle, R. J. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-021820-101354 · Cited by 125

Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP

Carozza, J. A., Brown, J. A., Böhnert, V., Fernández, D., AlSaif, Y., Mardjuki, R. E., Smith, M. A., & Li, L. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.07.007 · Cited by 116

Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells

Flynn, P. J., Koch, P. D., & Mitchison, T. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2103585118 · Cited by 118

TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer

Lv, H., Zong, Q., Chen, C., Lv, G., Xiang, W., Xing, F., Jiang, G., Yan, B., Sun, X., Ma, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-43743-9 · Cited by 117

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Sullivan, M. R., Darnell, A. M., Reilly, M. F., Kunchok, T., Joesch-Cohen, L. M., Rosenberg, D. W., Ali, A., Rees, M. G., Roth, J. A., Lewis, C. A., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00486-5 · Cited by 120

MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

Kitajima, S., Tani, T., Springer, B. F., Campisi, M., Osaki, T., Haratani, K., Chen, M., Knelson, E. H., Mahadevan, N. R., Ritter, J., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.08.015 · Cited by 107

The Druggability of Solute Carriers

Wang, W., Gallo, L. H., Jadhav, A. M., Hawkins, R., & Parker, C. G. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01237 · Cited by 113

Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases

Okude, H., Ori, D., & Kawai, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.625833 · Cited by 104

Non-Small-Cell Lung Cancer Signaling Pathways, Metabolism, and PD-1/PD-L1 Antibodies

Santarpía, M., Aguilar, A., CHAIB-OUKADOUR, I., Cardona, A. F., Fancelli, S., Laguía, F., Bracht, J. W. P., Cao, P., Molina‐Vila, M. Á., Karachaliou, N., et al. (2020) · Cancers · doi:10.3390/cancers12061475 · Cited by 102

LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

Wei, X., Zhang, L., Yang, Y., Hou, Y., Xu, Y., Wang, Z., Su, H., Han, F., Han, J., Liu, P., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110880 · Cited by 103

cGAS-STING pathway in oncogenesis and cancer therapeutics

Hoong, B. Y. D., Gan, Y., Liu, H., & Chen, E. S. (2020) · Oncotarget · doi:10.18632/oncotarget.27673 · Cited by 106

The Relationship between Reactive Oxygen Species and the cGAS/STING Signaling Pathway in the Inflammaging Process

Andrade, B., Jara‐Gutiérrez, C., Paz-Araos, M., Vázquez, M. C., Díaz, P., & Murgas, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315182 · Cited by 96

Nucleic Acid Sensors as Therapeutic Targets for Human Disease

McWhirter, S. M., & Jefferies, C. A. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.004 · Cited by 91

ENPP1 is an innate immune checkpoint of the anticancer cGAMP–STING pathway in breast cancer

Wang, S., Böhnert, V., Joseph, A. J., Sudaryo, V., Skariah, G. M., Swinderman, J. T., Yu, F. B., Subramanyam, V., Wolf, D. M., Lyu, X., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313693120 · Cited by 102

Mitochondrial dysfunction in astrocytes: A role in Parkinson’s disease?

Bantle, C. M., Hirst, W. D., Weihofen, A., & Shlevkov, E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.608026 · Cited by 95

Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform ‘cold’ tumors into ‘hot’ tumors

Ying, X., Chen, Q., Yang, Y., Wu, Z., Zeng, W., Miao, C., Huang, Q., & Ai, K. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02186-6 · Cited by 87

Responsive Multivesicular Polymeric Nanovaccines that Codeliver STING Agonists and Neoantigens for Combination Tumor Immunotherapy

Su, T., Cheng, F., Qi, J., Zhang, Y. X., Zhou, S., Mei, L., Fu, S., Zhang, F., Lin, S., & Zhu, G. (2022) · Advanced Science · doi:10.1002/advs.202201895 · Cited by 78

CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling

Slavik, K. M., & Kranzusch, P. J. (2023) · Annual Review of Virology · doi:10.1146/annurev-virology-111821-115636 · Cited by 87

Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

Sun, W. Y., Liu, R., Gao, X., Lin, Z., Tang, H., Cui, H., & Zhao, E. (2023) · Biomarker Research · doi:10.1186/s40364-023-00487-4 · Cited by 83

Regulation of cGAS and STING signaling during inflammation and infection

Chauvin, S. D., Stinson, W. A., Platt, D. J., Poddar, S., & Miner, J. J. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104866 · Cited by 77

ENPP1 Immunobiology as a Therapeutic Target

de Córdoba, B. R., Martínez‐Monge, R., & Lecanda, F. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1681 · Cited by 79

STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

Lu, L., Yang, C., Zhou, X., Wu, L., Hong, X., Li, W., Wang, X., Yang, Y., Cao, D., Zhang, A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113108 · Cited by 81

Conserved strategies for pathogen evasion of cGAS–STING immunity

Eaglesham, J. B., & Kranzusch, P. J. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.04.002 · Cited by 75

cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans

Patel, D. J., Yu, Y., & Xie, W. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-00933-9 · Cited by 79

The Evolution of STING Signaling and Its Involvement in Cancer

Vashi, N., & Bakhoum, S. F. W. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.12.010 · Cited by 72

Double-edged effects of interferons on the regulation of cancer-immunity cycle

Zhang, X., Wang, S., Zhu, Y., Zhang, M., Zhao, Y., Yan, Z., Wang, Q., & Li, X. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1929005 · Cited by 80

The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases

Zhang, Y., Zou, M., Wu, H., Zhu, J., & Jin, T. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106710 · Cited by 75

Solute carrier transporters: emerging central players in tumour immunotherapy

Chen, R., & Chen, L. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.08.002 · Cited by 69

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Pépin, G., Nardo, D. D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., Li, H., Quinn, K. M., Moghaddas, F., Chappaz, S., et al. (2020) · mBio · doi:10.1128/mbio.03187-19 · Cited by 69

T Cell Co-stimulation and Functional Modulation by Innate Signals

Imanishi, T., & Saito, T. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.01.003 · Cited by 67

Methotrexate recognition by the human reduced folate carrier SLC19A1

Wright, N. A., Fedor, J. G., Zhang, H., Jeong, P., Suo, Y., Yoo, J., Hong, J., Im, W., & Lee, S. (2022) · Nature · doi:10.1038/s41586-022-05168-0 · Cited by 66

Self-DNA Sensing in Lung Inflammatory Diseases

Benmerzoug, S., Ryffel, B., Togbe, D., & Quesniaux, V. F. J. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.06.001 · Cited by 65

Considerations for Size, Surface Charge, Polymer Degradation, Co‐Delivery, and Manufacturability in the Development of Polymeric Particle Vaccines for Infectious Diseases

Genito, C. J., Batty, C. J., Bachelder, E. M., & Ainslie, K. M. (2020) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000041 · Cited by 66

STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges

Yang, K., Tang, Z., Xing, C., & Yan, N. (2023) · Neuron · doi:10.1016/j.neuron.2023.10.014 · Cited by 63

cGAS/STING signalling pathway in senescence and oncogenesis

Yu, L., & Liu, P. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.08.007 · Cited by 67

Regulation of cGAS‐Mediated Immune Responses and Immunotherapy

Saeed, A. F. U. H., Ruan, X., Guan, H., Su, J., & Ouyang, S. (2020) · Advanced Science · doi:10.1002/advs.201902599 · Cited by 60

Molecular and spatial mechanisms governing STING signalling

Balka, K. R., & Nardo, D. D. (2020) · FEBS Journal · doi:10.1111/febs.15640 · Cited by 60

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

Eaglesham, J. B., McCarty, K. L., & Kranzusch, P. J. (2020) · eLife · doi:10.7554/elife.59753 · Cited by 58

Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation

Yu, Y., Liu, J., Liu, C., Liu, R., Liu, L., Yu, Z., Zhuang, J., & Sun, C. (2022) · Cells · doi:10.3390/cells11193043 · Cited by 59

cGAS–STING signalling in cancer: striking a balance with chromosomal instability

Beernaert, B., & Parkes, E. E. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220838 · Cited by 60

STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments

Guerini, D. (2022) · Cells · doi:10.3390/cells11071159 · Cited by 57

Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS‐STING Signaling

An, Y., Zhu, J., Xie, Q., Feng, J., Gong, Y., Fan, Q., Cao, J., Huang, Z., Shi, W., Lin, Q., et al. (2024) · Advanced Science · doi:10.1002/advs.202308131 · Cited by 55

Supply and demand: Cellular nutrient uptake and exchange in cancer

Papalazarou, V., & Maddocks, O. D. K. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.026 · Cited by 53

The role of cGAS/STING in intestinal immunity

Wottawa, F., Bordoni, D., Baran, N., Rosenstiel, P. C., & Aden, K. (2021) · European Journal of Immunology · doi:10.1002/eji.202048777 · Cited by 55

The interplay between autophagy and cGAS-STING signaling and its implications for cancer

Schmid, M., Fischer, P., Engl, M., Widder, J., Gruber, S., & Slade, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1356369 · Cited by 61

Regulation and inhibition of the DNA sensor cGAS

Hertzog, J., & Rehwinkel, J. (2020) · EMBO Reports · doi:10.15252/embr.202051345 · Cited by 52

cGAS-STING signaling pathway in intestinal homeostasis and diseases

Yang, Y., Wang, L., Peugnet-González, I., Parada‐Venegas, D., Dijkstra, G. D. H., & Faber, K. N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1239142 · Cited by 51

Crystal structures of human ENPP1 in apo and bound forms

Dennis, M. L., Newman, J. M., Dolezal, O., Hattarki, M. K., Surjadi, R. N., Nuttall, S. D., Pham, T. M., Nebl, T., Camerino, M. A., Khoo, P. S., et al. (2020) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798320010505 · Cited by 49

Recognition of cyclic dinucleotides and folates by human SLC19A1

Zhang, Q., Zhang, X., Zhu, Y., Sun, P., Zhang, L., Ma, J., Zhang, Y., Zeng, L., Nie, X., Gao, Y., et al. (2022) · Nature · doi:10.1038/s41586-022-05452-z · Cited by 50

cGAMP the travelling messenger

Blest, H. T. W., & Chauveau, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1150705 · Cited by 57

Cyclic dinucleotides at the forefront of innate immunity

Zaver, S. A., & Woodward, J. J. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.12.004 · Cited by 50

TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy

Dayoub, A. S., & Brekken, R. A. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-0521-5 · Cited by 49

cGAS/cGAMP/STING signal propagation in the tumor microenvironment: Key role for myeloid cells in antitumor immunity

Mekers, V. E., Kho, V. M., Ansems, M., & Adema, G. J. (2022) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2022.07.014 · Cited by 47

Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity

Bharadwaj, R., Lusi, C. F., Mashayekh, S., Nagar, A., Subbarao, M., Kane, G. I., Wodzanowski, K. A., Brown, A. R., Okuda, K., Monahan, A., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.04.001 · Cited by 50

SLC19A1 is a cyclic dinucleotide transporterPreprint

Luteijn, R. D., Zaver, S. A., Gowen, B. G., Wyman, S. K., Garelis, N. E., Onia, L., McWhirter, S. M., Katibah, G. E., Corn, J. E., Woodward, J. J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/539767 · Cited by 1

Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes

Cordova, A. F., Ritchie, C., Böhnert, V., & Li, L. (2021) · ACS Central Science · doi:10.1021/acscentsci.1c00440 · Cited by 157

SLC19A1 transports immunoreactive cyclic dinucleotides.

Luteijn, R. D., Zaver, S. A., Gowen, B. G., Wyman, S. K., Garelis, N. E., Onia, L., McWhirter, S. M., Katibah, G. E., Corn, J. E., Woodward, J. J., et al. (2019) · Nature · doi:10.1038/s41586-019-1553-0 · Cited by 379

In response to Luteijn et al .: Concerns regarding cGAMP uptake assay and evidence that SLC19A1 is not the major cGAMP importer in human PBMCsPreprint

Ritchie, C., Cordova, A. F., & Li, L. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/798397 · Cited by 4

An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP

Li, X., Zhu, Y., Zhang, X., An, X., Weng, M., Shi, J., Wang, S., Liu, C., Luo, S., & Zheng, T. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144339 · Cited by 36