NAD(+) in aging: molecular mechanisms and translational implications

The Hallmarks of Aging

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study

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Multiple Sclerosis

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Mitochondria and cancer

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Self-consumption: the interplay of autophagy and apoptosis

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Autophagy and Aging

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Autophagy in infection, inflammation and immunity

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Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Saito, Y., Sato, K., Jinno, S., Nakamura, Y., Nobukuni, T., Ogishima, S., Mizuno, S., Koshiba, S., Kuriyama, S., Ohneda, K., et al. (2023) · Nutrients · doi:10.3390/nu16010145 · Cited by 10

Effects of lifelong exercise and aging on the blood metabolic fingerprint of rats

Tzimou, A., Benaki, D. C., Nikolaidis, S., Mikros, E., Taitzoglou, I., & Mougios, V. (2020) · Biogerontology · doi:10.1007/s10522-020-09871-1 · Cited by 12

DNA Methylation Ageing Atlas Across 17 Human TissuesPreprint

Jacques, M., Seale, K., Voisin, S. A. C., Lysenko, A., Grolaux, R., Jones, B., Lamon, S., Levinger, I., Bauer, C., Sharples, A. P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.21.665830 · Cited by 12

Exercise to Mitigate Cerebrovascular Aging: A Geroscience Perspective

Norling, A. M., & Lipsitz, L. A. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae083 · Cited by 12

The enigmatic role of SIRT2 in the cardiovascular system: Deciphering its protective and detrimental actions to unlock new avenues for therapeutic intervention

Alhasaniah, A. H., Alissa, M., Elsaid, F. G., Alsugoor, M. H., Alqahtani, M. S., Alessa, A., Jambi, K., Albakri, G. S., Albaqami, F. M. K., & Bennett, E. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102929 · Cited by 10

OAB-14 alleviates mitochondrial impairment through the SIRT3-dependent mechanism in APP/PS1 transgenic mice and N2a/APP cells

Zheng, N., Cao, R.-L., Liu, D., Liu, P., Zhao, X., Zhang, S.-X., Huang, M., Zheng, Z., Chen, G., & Zou, L. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.01.014 · Cited by 10

Cardiac Damage in Hypertension: From Molecular Mechanisms to Novel Therapeutic Approaches

Gallo, G., & Rubattu, S. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125610 · Cited by 12

Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance associated with neurodegeneration

Kaluski-Kopatch, S., Stein, D., García-Venzor, A., Campos, A. M. F., Planque, M., Goldstein, B., Allende-Becerra, E. D., Smirnov, D., Zaretsky, A., Eremenko, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67021-y · Cited by 12

Comparison of protective effects of nicotinamide mononucleotide and nicotinamide riboside on DNA damage induced by cisplatin in HeLa cells

Qiu, S., Zhang, Y., 邵诗涵, Zhang, Y., Yin, J., Xu, X., Yang, J. J., Hong, Y., Yang, J., Tan, X., et al. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101655 · Cited by 12

Innovations and Emerging Therapies to Combat Renal Cell Damage: NAD + As a Drug Target

Manrique‐Caballero, C. L., Kellum, J. A., Gómez, H., Franco, F., Giacchè, N., & Pellicciari, R. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8066 · Cited by 10

Chronological and reproductive aging-associated changes in resistance to oxidative stress in post-reproductive female mice

King, T. L., Underwood, K. B., Hansen, K. K., Kinter, M. T., Schneider, A., Masternak, M. M., & Mason, J. B. (2023) · GeroScience · doi:10.1007/s11357-023-00865-8 · Cited by 9

High-efficient preparation of β-nicotinamide mononucleotides by crude enzymes cascade catalytic reaction

Liu, J., Huo, R., Fu, H., Chen, S., Qiao, X., Xu, B., Zhang, Z., Wu, J., & Su, L. (2024) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2024.110482 · Cited by 9

Supplementation with NAD+ Precursors for Treating Alzheimer’s Disease: A Metabolic Approach

Alghamdi, M. A., & Braidy, N. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231277 · Cited by 13

Harnessing Metabolism to Combat Neurodegeneration: Strategies for Reversing Age-Related Cognitive Decline

Jain, S., Acharya, R., Verma, L., & Chauhan, A. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00077 · Cited by 9

Reproductive Effects of Nicotinamide on Testicular Function and Structure in Old Male Rats: Oxidative, Apoptotic, Hormonal, and Morphological Analyses

Hacıoğlu, C., Kar, F., & Kanbak, G. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00647-7 · Cited by 9

NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction

Stock, A. J., & Liu, Y. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.785171 · Cited by 10

The Extracellular Matrix Vitalizer RATM Increased Skin Elasticity by Modulating Mitochondrial Function in Aged Animal Skin

Byun, K.-A., Oh, S., Batsukh, S., Kim, M., Lee, J. H., Park, H. J., Chung, M. S., Son, K. H., & Byun, K. (2023) · Antioxidants · doi:10.3390/antiox12030694 · Cited by 9

Potential Therapeutic Interventions Targeting NAD+ Metabolism for ALS

Lundt, S., & Ding, S. (2024) · Cells · doi:10.3390/cells13171509 · Cited by 12

Insuffisance rénale aiguë en soins intensifs-réanimation et ses conséquences : mise au point

Orieux, A., Boyer, A., Dewitte, A., Combe, C., & Rubin, S. (2021) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2021.07.324 · Cited by 12

Combined Metabolic Activators with Different NAD+ Precursors Improve Metabolic Functions in the Animal Models of Neurodegenerative Diseases

Altay, Ö., Yang, H., Yıldırım, S., Bayram, C., Bolat, İ., Öner, S., Tozlu, Ö. Ö., Arslan, M. E., Hacımüftüoğlu, A., Shoaie, S., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12040927 · Cited by 9

Omega‐3 fatty acids increase OXPHOS energy for immune therapy of Alzheimer disease patients

Lau, Y. C. C., Ding, J., Simental, A., Mirzoyan, H., Lee, W. E., Diamante, G., Cely, I., Tran, M., Morselli, M., Dang, J., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000669rr · Cited by 9

Autophagy promotes cell and organismal survival by maintaining NAD(H) poolsPreprint

Sedlackova, L., Otten, E. G., Scialò, F., Shapira, D., Kataura, T., Carroll, B., Seranova, E., Rabanal‐Ruiz, Y., Kelly, G., Stefanatos, R. K. A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.31.928424 · Cited by 9

Mechanisms and early efficacy data of caloric restriction and caloric restriction mimetics in neurodegenerative disease

Trisal, A., & Singh, A. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.004 · Cited by 9

Mitochondrial homeostasis in stem cell senescence

Peng, B., & Zhang, H. (2025) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2025.9610006 · Cited by 8

Mitochondrial Damage and Autophagy Dysregulation in Alzheimer’s Disease: Mechanisms and Therapeutic Opportunities

Yu, Q., Li, L., Yu, S., Han, J., Cheng, Q., Cui, Z., Chen, H., Li, M., & Lu, Z. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04490-z · Cited by 9

Telomere-targeted medicine: Bridging molecular mechanisms and clinical applications in age-related diseases

Niazi, S. K. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123904 · Cited by 8

Nicotinamide riboside supplementation to improve skeletal muscle mitochondrial health and whole‐body glucose homeostasis: does it actually work in humans?

Leduc‐Gaudet, J., Dulac, M., Reynaud, O., Ayoub, M., & Gouspillou, G. (2019) · The Journal of Physiology · doi:10.1113/jp279280 · Cited by 8

A Lactobacilli diet that confers MRSA resistance causes amino acid depletion and increased antioxidant levels in the C. elegans host

Møller, K. V., Nguyen, H. T. T., Mørch, M. G. M., Hesselager, M. O., Mulder, F. A. A., Fuursted, K., & Olsen, A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.886206 · Cited by 8

NAD+ Precursors Reverse Experimental Diabetic Neuropathy in Mice

Chandrasekaran, K., Najimi, N., Sagi, A. R., Yarlagadda, S., Salimian, M., Arvas, M. I., Hedayat, A. F., Kevas, Y., Kadakia, A., Kristián, T., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021102 · Cited by 7

Intestinal lysozyme1 deficiency alters microbiota composition and impacts host metabolism through the emergence of NAD + -secreting ASTB Qing110 bacteria

Zhang, C. L., Chen, X., Zhou, K., Liu, X., Qiao, G., Zhao, Y., Dong, K., Sun, K., & Liu, Z. (2024) · mSystems · doi:10.1128/msystems.01214-23 · Cited by 7

Ablation of NAMPT in dopaminergic neurons leads to neurodegeneration and induces Parkinson’s disease in mouse

Chen, C., Wang, T., Gao, T., Chen, Y.-L., Lu, Y., & Zhang, W. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111114 · Cited by 7

α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence

Wang, Y., Zheng, Y., Liang, X., Chang, Y., Liu, Y., Cheng, X. W., Zhang, M., Gao, W., & Li, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-92328-7 · Cited by 7

Multi-omics analysis of canine aging markers and evaluation of stem cell intervention

Li, B., Ding, Y., Han, M., Zhang, Z., Ling, Z., Zhu, W., Xian-jun, Z., Zhang, Y., Lv, C., Li, N., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08333-z · Cited by 7

NAD+ glycohydrolases-CD38 as a therapeutic target in aging: physiological roles, molecular mechanisms, and future opportunities in anti-aging research

Sun, J.-Y., Wang, Z., Xu, W., & Zhao, J. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117050 · Cited by 8

Is NAD+ a key factor in ovarian aging and dysfunction? Insights and uncertainties from current research

Cordone, V., Vergara, T., Falone, S., Tatone, C., & Emidio, G. D. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf140 · Cited by 8

Targeting glial dysfunction in Alzheimer’s disease: insights into pathogenesis and emerging therapeutics

Zhu, Q., Song, Y., Qian, Y., Zhang, R., Xue, J., & Hou, Y. (2025) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2025.25 · Cited by 6

The Influence of Sirtuin 6 on Chondrocyte Senescence in Osteoarthritis Under Aging: Focusing on Mitochondrial Dysfunction and Oxidative Stress

Zhao, H., & Wu, W. (2025) · Antioxidants · doi:10.3390/antiox14101228 · Cited by 8

Reproductive Ageing: Current insights and a potential role of NAD in the reproductive health of aging fathers and their children

Feuz, M. B., Nelson, D., Miller, L. B., Zwerdling, A. E., Meyer, R. G., & Meyer‐Ficca, M. L. (2024) · Reproduction · doi:10.1530/rep-23-0486 · Cited by 8

NAD+ supplement relieved chronic sleep restriction (CSR)-induced microglial proinflammation in vivo and in vitro

Chen, Q., Xiao, J., Lin, Z., Xu, X., & Chen, J. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578469 · Cited by 11

The role of α-tocopherol in the prevention and treatment of Alzheimer's disease

Pelczarski, M., Wolaniuk, S., Zaborska, M., Sadowski, J., Sztangreciak-Lehun, A., & Bułdak, R. J. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05214-1 · Cited by 10

Impact of nicotinamide mononucleotide on transplanted mouse ovarian tissue

Bertoldo, M. J., Paris, V. R., Gook, D. A., Edwards, M. C., Wu, K., Liang, C. J. J., Marinova, M. B., Wu, L. E., Walters, K. A., & Gilchrist, R. B. (2020) · Reproduction · doi:10.1530/rep-20-0539 · Cited by 7

Nicotinamide effects on the metabolism of human fibroblasts and keratinocytes assessed by quantitative, label-free fluorescence imaging

Liu, Z., Chiang, C. ‐., Nip, J., Feng, L., Zhang, Y., Rocha, S., & Georgakoudi, I. (2021) · Biomedical Optics Express · doi:10.1364/boe.432561 · Cited by 7

Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen®+ IV and NAD+ IV in healthy adultsPreprint

Hawkins, J., Idoine, R., Kwon, J., Shao, A. E., Dunne, E., Hawkins, E. M., Dawson, K., & Nkrumah-Elie, Y. M. (2024) · medRxiv · doi:10.1101/2024.06.06.24308565 · Cited by 9

Nampt: a new therapeutic target for modulating NAD+ levels in metabolic, cardiovascular, and neurodegenerative diseases

Manickam, R., Santhana, S., Xuan, W., Bisht, K. S., & Tipparaju, S. M. (2025) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2024-0400 · Cited by 9

High Concentrations of Circulating 2PY and 4PY—Potential Risk Factor of Cardiovascular Disease in Patients with Chronic Kidney Disease

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Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment

Jara, C., Venegas-Zamora, L., Park-Kang, H. S., Lira, M., Ricca, M., Valenzuela, S., & Tapia‐Rojas, C. (2026) · npj Aging · doi:10.1038/s41514-026-00351-3 · Cited by 7

New Concepts in the Manipulation of the Aging Process

Hollands, P., & Ovokaitys, T. (2023) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x18666230208102635 · Cited by 6

Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature

Tung, P. W., Thaker, V., Gallagher, D., & Kupsco, A. J. (2024) · Current Obesity Reports · doi:10.1007/s13679-024-00588-7 · Cited by 6

Advances in pharmacological interventions of aging in mice

Qian, M., & Liu, B. (2019) · Translational Medicine of Aging · doi:10.1016/j.tma.2019.11.002 · Cited by 6

Metabolic Fingerprinting of Murine L929 Fibroblasts as a Cell-Based Tumour Suppressor Model System for Methionine Restriction

Schmitz, W., Koderer, C., El‐Mesery, M., Gubik, S., Sampers, R., Straub, A., Kübler, A. C., & Seher, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063039 · Cited by 6

New Crystalline Salts of Nicotinamide Riboside as Food Additives

Schabert, G., Haase, R. G., Parris, J., Pala, L., Hery-Barranco, A., Spingler, B., & Spitz, U. P. (2021) · Molecules · doi:10.3390/molecules26092729 · Cited by 6

Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications

Li, P., Xia, C., Kong, X., & Zhang, J. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106963 · Cited by 6

Distinct effects of thermal treatments after lengthening contraction on mechanical hyperalgesia and exercise-induced physiological changes in rat muscle

Tsuboshima, K., Urakawa, S., Takamoto, K., Taguchi, T., Matsuda, T., Sakai, S., Mizumura, K., Ono, T., & Nishijo, H. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00355.2019 · Cited by 6

Metabolic control of oocyte development

Zhu, S., & Wang, Q. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac082 · Cited by 7

Discovery of Potent, Selective, and Brain-Penetrant Small Molecule CD38 Inhibitors

Stott, A. J., Bürli, R. W., Doyle, K. J., Dickson, L., Hewer, R. C., Pickford, P., Roberts, M. J., Waters-Hall, R., Wu, Y., Zebisch, M., et al. (2026) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5c00727 · Cited by 5

Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions

Yang, S., Sun, D., Wu, Y., Chen, S., Guo, Y., Li, J., Dong, G., & Sheng, C. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02370 · Cited by 5

NAD+ homeostasis and its role in exercise adaptation: A comprehensive review

Jiang, Z., Luo, X., Han, C., Qin, Y.-Y., Pan, S.-Y., Qin, Z.-H., Bao, J., & Luo, L. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.09.036 · Cited by 6

The General Principle of the Warburg Effect as a Possible Approach for Cancer Immunotherapy: The Regulatory Effect of Plant Extracts Could Change the Game

Ivanova, D., Semkova, S., Grigorov, B., Tzanova, M. T., Georgieva, A., Danchev, D., Nikolova, B., & Yaneva, Z. L. (2025) · Molecules · doi:10.3390/molecules30020393 · Cited by 5

Combination of Stem Cells with Chinese Herbs for Secondary Depression in Neurodegenerative Diseases Based on Traditional Chinese Medicine Theories

Feng, J., Liao, L., Xu, F., Zhang, L., & Zhang, J. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6847917 · Cited by 6

Small Molecule Detection with Ligation-Dependent Light-Up Aptamer Transcriptional Amplification

Lee, D.-G., Min, Y. H., Byun, J., & Shin, Y. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00987 · Cited by 5

Reduction of halocarbons to hydrocarbons by NADH models and NADH

Denk, M. K., Milutinović, N. S., & Dereviankin, M. Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.05.169 · Cited by 5

Editorial: Cellular Senescence and Cellular Communications Within Tissue Microenvironments During Aging

Wei, Z., Ma, H., Fang, E. F., & Chen, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.890577 · Cited by 5

Nicotinamide mononucleotide rescues Di-n-butyl phthalate induced blood-brain barrier damage via NAD+/Sirt1/FOXO1a pathway activation

Liu, R., Feng, J., Song, Y., Yin, H., Yang, Z., Zhao, Y., Ma, J., Chen, X., & Gao, H. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119290 · Cited by 6

Yoga for Neurodegenerative Disorders: Therapeutic Effects, Mechanisms, and Applications in Alzheimer’s and Parkinson’s Disease

Zoila, F., de Stefano, M. I., Sgobbio, A., Panaro, M. A., Maffione, A. B., Antonucci, L., Benameur, T., Massaro, M., Gaban, S. V. F., Filannino, F. M., et al. (2025) · Sports · doi:10.3390/sports13120458 · Cited by 6

Sirt6 deficiency in mast cells promotes adipose fibroinflammation in obesity through galectin-3 signaling

Song, M.-Y., Jeon, Y. G., Yang, J. D., Moon, Y. J., Kim, J. B., Bae, E. J., & Park, B. C. (2026) · Nature Communications · doi:10.1038/s41467-025-66040-z · Cited by 4

The interplay between STING and metabolic reprogramming: From mechanisms to therapeutic strategies

Zhou, L., Wang, Y., & Zhang, L. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114987 · Cited by 4

Aging and anti-aging strategies: A review of past and future therapeutics

Wei, Y., Xiong, B., Song, Z., Zhong, S., Zheng, N., Zhang, A., Chen, Y., & Sun, H. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118340 · Cited by 4

Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives

Garay, R. P. (2024) · Exploration of Drug Science · doi:10.37349/eds.2024.00040 · Cited by 4

Potential application of traditional Chinese medicine in age-related macular degeneration—focusing on mitophagy

Yu, Y., Wang, G., Liu, Y., & Meng, Z. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1410998 · Cited by 4

Impact of nicotinamide riboside supplementation on skeletal muscle mitochondria and whole‐body glucose homeostasis: challenging the current hypothesis

Moore, M. P., & Mucinski, J. M. (2020) · The Journal of Physiology · doi:10.1113/jp279749 · Cited by 4

Interventions in Nicotinamide Adenine Dinucleotide Metabolism, the Intestinal Microbiota and Microcin Peptide Antimicrobials

Baquero, F., del Campo, R., & Martínez, J. L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.861603 · Cited by 4

One-step synthesis of molecularly imprinted fluorescent sensors for highly selective detection of nicotinamide mononucleotide

Xie, L., Zhang, M., Wu, Y., Xiong, H., & hao, L. (2024) · Journal of Materials Science Materials in Electronics · doi:10.1007/s10854-024-12058-w · Cited by 4

Stem cell derived astrocytes with POLG mutations and mitochondrial dysfunction including abnormal NAD+ metabolism is toxic for neuronsPreprint

Liang, K. X., Kianian, A., Chen, A., Kristiansen, C. K., Hong, Y., Furriol, J., Høyland, L. E., Ziegler, M., Kråkenes, T., Tzoulis, C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.20.423652 · Cited by 4

Role of Nicotinamide in the Pathogenesis of Actinic Keratosis: Implications for NAD+/SIRT1 Pathway

Belardi, R., Pacifici, F., Cosio, T., Lambiase, S., Shumak, R. G., Artosi, F., Rivieccio, A., Cavalloro, D., Dellambra, E., Bianchi, L., et al. (2024) · Biomolecules · doi:10.3390/biom14121512 · Cited by 3

Identification of novel Piperazine based bisubstrate inhibitors of human nicotinamide N-methyltransferase (hNNMT) with potential anticancer activities

Harikrishna, A. S., & Kesavan, V. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118368 · Cited by 3

Genetic convergence in brain aging and neurodegeneration: from cellular mechanisms to therapeutic targets

Polu, P. R., & Mishra, S. (2025) · Journal of Neurogenetics · doi:10.1080/01677063.2025.2571127 · Cited by 3

The case for space as a model of accelerated aging

Manwaring-Mueller, M., Du, H., Valentino, T. R., Fuentealba, M., Chebykin, A., Wu, F., Furman, D., & Winer, D. A. (2026) · Nature Aging · doi:10.1038/s43587-026-01105-2 · Cited by 3

The Roles of Caloric Restriction Mimetics in Central Nervous System Demyelination and Remyelination

Kaffe, D., Kaplanis, S. I., & Karagogeos, D. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45120596 · Cited by 4

Age-related disease: Immune system

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[Therapeutic potential of NADH: in neurodegenerative diseases characterizde by mitochondrial dysfunction].

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Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice

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Nicotinamide mononucleotide enhances the efficacy and persistence of CD19 CAR-T cells via NAD + –Sirt1 axisPreprint

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Increased radioprotection attained by DNA repair enhancement

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The Role of NAD+ in Rejuvenating Human Body

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Role of NADþ in regulating cellular andmetabolic signaling pathways

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