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NAD(+) in aging: molecular mechanisms and translational implications
Open accessAbstract
The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of NAD+ levels is important for cells with high energy demands and for proficient neuronal function. NAD+ depletion is detected in major neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cardiovascular disease and muscle atrophy. Emerging evidence suggests that NAD+ decrements occur in various tissues during aging, and that physiological and pharmacological interventions bolstering cellular NAD+ levels might retard aspects of aging and forestall some age-related diseases. Here, we discuss aspects of NAD+ biosynthesis, together with putative mechanisms of NAD+ action against aging, including recent preclinical and clinical trials.
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“NAD+ is a vital redox cofactor for metabolism and ATP production, and a key substrate for at least four families of enzymes involved in healthspan and longevity (Fang et al., 2017; Gomes et al., 2013; Verdin, 2015).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Fang et al., 2017
In the citing paper
“SIRTS, PARPs, CD38/CD157, and SARM1 compete with each other to consume cellular NAD+; thus, the hyperactivation of one enzyme can impair the activities of other NAD+-dependent enzymes.”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Fang et al., 2017
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“Emerging findings are revealing linkages by which age-related NAD+ depletion is positively related to the 10 hallmarks of brain aging.”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Fang et al., 2017
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Metadata
- Authors
- Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A.
- Affiliations
- National Institutes of Health (US)
- University of Copenhagen (DK)
- Corresponding author
- Bohr, Vilhelm A.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 23
- Issue
- 10
- Pages
- 899-916
- ISSN
- 1471-4914 (ISSN-L)
- PMC
- PMC7494058
- OpenAlex
- W2751352835
- Cited by
- 501
- References
- 119
- Citations by year
- 2026: 42 · 2025: 75 · 2024: 69 · 2023: 45 · 2022: 64 · 2021: 74 · 2020: 53 · 2019: 48 · 2018: 29 · 2017: 2
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Scopus (Elsevier) (submittedVersion)
- Funders
- Intramural Research Program of the National Institute on Aging (2015-2016, 2016-2017)
- The Oticon Foundation
- Ib Henriksen’s Foundation
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- NAD+, aging, NAD+ depletion, NAD biosynthesis, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, cardiovascular disease, muscle atrophy, age-related diseases, NAD+ supplementation, cellular bioenergetics, stress response
- MeSH terms
- Aging, Alzheimer Disease, Animals, Cardiovascular Diseases, Energy Metabolism, Humans, Muscular Atrophy, NAD, Parkinson Disease
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