NAD(+) in aging: molecular mechanisms and translational implications

The Hallmarks of Aging

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study

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Multiple Sclerosis

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Mitochondria and cancer

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Self-consumption: the interplay of autophagy and apoptosis

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Autophagy and Aging

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Autophagy in infection, inflammation and immunity

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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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NAD+ and sirtuins in aging and disease

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Fasting: molecular mechanisms and clinical applications

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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NAD + in aging, metabolism, and neurodegeneration

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PARP inhibition: PARP1 and beyond

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NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

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Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

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CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

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Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

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Compromised autophagy and neurodegenerative diseases

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

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Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

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Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

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Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L., & Bohr, V. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.026 · Cited by 711

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD + Precursor Vitamins in Human Nutrition

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DNA repair mechanisms in dividing and non-dividing cells

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Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

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Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

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NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

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Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

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The multifaceted functions of sirtuins in cancer

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Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

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Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

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Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

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In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

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Environmental Noise Pollution in the United States: Developing an Effective Public Health Response

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DNA Damage, DNA Repair, Aging, and NeurodegenerationPreprint

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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

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SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

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Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

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Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

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Biosensor reveals multiple sources for mitochondrial NAD +

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Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

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Parkin and PINK1: much more than mitophagy

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Nuclear DNA damage signalling to mitochondria in ageing

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Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

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Regulation of intracellular levels of NAD: A novel role for CD38

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A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in Cockayne syndrome

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Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

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NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

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Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38

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Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

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Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice

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Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

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AMPK activation protects cells from oxidative stress‐induced senescence via autophagic flux restoration and intracellular NAD + elevation

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Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

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Sirtuins at a glance

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Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

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Activation of SIRT3 by the NAD(+) precursor nicotinamide riboside protects from noise-induced hearing loss

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NAD + as a metabolic link between DNA damage and cell death

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Nicotinamide-induced Mitophagy

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Cockayne syndrome: Clinical features, model systems and pathways

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PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

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NAD + repletion improves muscle function in muscular dystrophy and counters global PARylation

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The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet‐induced obesity

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The importance of NAMPT / NAD / SIRT1 in the systemic regulation of metabolism and ageing

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Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

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A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

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Do DNA Double-Strand Breaks Drive Aging?

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Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

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Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model

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Three complementation groups in Cockayne syndrome

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