Cited by 501Sirtuins and Resveratrol in MedicineBiochemical and Molecular ResearchGenetics, Aging, and Longevity in Model Organisms

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NAD(+) in aging: molecular mechanisms and translational implications

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Fang, Evandro F., Lautrup, Sofie, Hou, Yujun, Demarest, Tyler G., Croteau, Deborah L., Mattson, Mark P., Bohr, Vilhelm A.·2017·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2017.08.001PMC PMC7494058

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Abstract

The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of NAD+ levels is important for cells with high energy demands and for proficient neuronal function. NAD+ depletion is detected in major neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cardiovascular disease and muscle atrophy. Emerging evidence suggests that NAD+ decrements occur in various tissues during aging, and that physiological and pharmacological interventions bolstering cellular NAD+ levels might retard aspects of aging and forestall some age-related diseases. Here, we discuss aspects of NAD+ biosynthesis, together with putative mechanisms of NAD+ action against aging, including recent preclinical and clinical trials.

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Authors: Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A.
Affiliations: National Institutes of Health (US)
University of Copenhagen (DK)
Corresponding author: Bohr, Vilhelm A.
ORCID: Fang, Evandro F.
Lautrup, Sofie
Hou, Yujun
Croteau, Deborah L.
Mattson, Mark P.
Bohr, Vilhelm A.
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2017-10
Volume: 23
Issue: 10
Pages: 899-916
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2017.08.001
PMC: PMC7494058
OpenAlex: W2751352835
Cited by: 501
References: 119
Citations by year: 2026: 42 · 2025: 75 · 2024: 69 · 2023: 45 · 2022: 64 · 2021: 74 · 2020: 53 · 2019: 48 · 2018: 29 · 2017: 2
FWCI: 4.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Scopus (Elsevier) (submittedVersion)
Funders: Intramural Research Program of the National Institute on Aging (2015-2016, 2016-2017)
The Oticon Foundation
Ib Henriksen’s Foundation
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: NAD+, aging, NAD+ depletion, NAD biosynthesis, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, cardiovascular disease, muscle atrophy, age-related diseases, NAD+ supplementation, cellular bioenergetics, stress response
MeSH terms: Aging, Alzheimer Disease, Animals, Cardiovascular Diseases, Energy Metabolism, Humans, Muscular Atrophy, NAD, Parkinson Disease

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NAD(+) in aging: molecular mechanisms and translational implications

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