The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
NAD(+) in aging: molecular mechanisms and translational implications
Open accessAbstract
The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of NAD+ levels is important for cells with high energy demands and for proficient neuronal function. NAD+ depletion is detected in major neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cardiovascular disease and muscle atrophy. Emerging evidence suggests that NAD+ decrements occur in various tissues during aging, and that physiological and pharmacological interventions bolstering cellular NAD+ levels might retard aspects of aging and forestall some age-related diseases. Here, we discuss aspects of NAD+ biosynthesis, together with putative mechanisms of NAD+ action against aging, including recent preclinical and clinical trials.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“NAD+ is a vital redox cofactor for metabolism and ATP production, and a key substrate for at least four families of enzymes involved in healthspan and longevity (Fang et al., 2017; Gomes et al., 2013; Verdin, 2015).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Fang et al., 2017
In the citing paper
“SIRTS, PARPs, CD38/CD157, and SARM1 compete with each other to consume cellular NAD+; thus, the hyperactivation of one enzyme can impair the activities of other NAD+-dependent enzymes.”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Fang et al., 2017
In the citing paper
“Emerging findings are revealing linkages by which age-related NAD+ depletion is positively related to the 10 hallmarks of brain aging.”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Fang et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083
Noseworthy, J. H., Lucchinetti, C. F., Rodriguez, M., & Weinshenker, B. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431307 · Cited by 3,016
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600
Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404
Self-consumption: the interplay of autophagy and apoptosis
Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107
Autophagy in infection, inflammation and immunity
Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3532 · Cited by 1,919
Research works printed but not linked: 5
- Verdin, 2015, NAD(+) in aging, metabolism, and neurodegeneration, Science, 350, 1208, 10.1126/science.aac4854 · DOI · Paper page
- Kerr, 2017, Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms, Trends Neurosci., 40, 151, 10.1016/j.tins.2017.01.002 · DOI · Paper page
- Scheibye-Knudsen, 2014, A high fat diet and NAD+ rescue premature aging in cockayne syndrome, Cell Metab., 20, 840, 10.1016/j.cmet.2014.10.005 · DOI · Paper page
- Fang, 2016, Nuclear DNA damage signalling to mitochondria in ageing, Nat. Rev. Mol. Cell Biol., 17, 308, 10.1038/nrm.2016.14 · DOI · Paper page
- Fang, 2016, NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair, Cell Metab., 24, 566, 10.1016/j.cmet.2016.09.004 · DOI · Paper page
Cited by
Sorted by citations
Items 401–500 of 501
Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging
Wang, F., Pei, Z., Wang, K., & Wang, L. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220304121917 · Cited by 2
Novel Approaches to Address the Dual Challenges of Neurodegeneration and Aging
Zeng, C. (2023) · Trends journal of sciences research · doi:10.31586/jcn.2023.649 · Cited by 2
Untargeted metabolomic profiling on the effect of ginger on rat hepatic changes during ageing
Ekeuku, S. O., Shahzalli, A. B. A., Tan, J. K., & Makpol, S. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106054 · Cited by 2
Evaluation of the Role of PnuC Gene in Enhancing Nicotinamide Mononucleotide Synthesis
Vo, G. T. T., Nguyen, K. K. H., & Kim, B. S. (2025) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2713 · Cited by 2
Autophagy and bioenergetics in aging
Zhang, J., Wang, H., & Fang, E. F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91617-2.00002-x · Cited by 2
Self-citationDalmasso, M. C., Arán, M., Galeano, P., Perin, S., Giavalisco, P., Adami, P. V. M., Castaño, E. M., Cuello, A. C., Scherer, M., Maier, W., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-518284/v1 · Cited by 2
Dou, X., Long, Q., Liu, S., Zou, Y., Fu, D., Chen, X., Xu, Q., Wang, C., Ren, X., Zhang, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.21203/rs.3.rs-1966019/v1 · Cited by 2
SIRT6 regulates protein synthesis and folding through nucleolar remodelingPreprint
Toiber, D., Stein, D., Portillo, M., Kaluski-Kopatch, S., Stein, D., Lachberg, Y., Eremenko, E., Smirnov, D., Einav, M., Khrameeva, E. E., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4215918/v1 · Cited by 2
Palikhe, S., & Nakagawa, T. (2022) · Springer eBooks · doi:10.1007/978-981-16-7977-3_8 · Cited by 1
Cellular Senescence and Stem Cell Exhaustion: Implications for Aging and Regeneration
Kumar, N., & Walia, H. K. (2025) · Cellular Senescence, Age-Related Disorders, and Emerging Treatments · doi:10.1007/978-981-96-1041-9_6 · Cited by 1
Nicotinamide Adenine Dinucleotide and Aging
Jiang, Z., Luo, L., Qin, Y., Huang, Y., & Yan, S. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_28 · Cited by 1
Farina, S., Cattabiani, A., Mandge, D., Shichkova, P., Isbister, J. B., Jacquemier, J., King, J. G., Markram, H., & Keller, D. X. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013070 · Cited by 1
Bakaleinikova, E. (2025) · Biogerontology · doi:10.1007/s10522-025-10286-z · Cited by 1
Zhang, H., Ya, J., Liao, X., Du, X., Zhao, C., Ren, J., & Qu, X. (2025) · Small · doi:10.1002/smll.202509547 · Cited by 1
Wang, Q., Sun, X., Han, X., Zhang, X., Wang, W., Wang, H., Ren, H., & Gu, L. (2026) · MedComm – Oncology · doi:10.1002/mog2.70054 · Cited by 1
Swain, A., Soni, N. D., Gaspar, R. B., Davis, J. G., Liu, F., Juul, H. M., Nanga, R. P. R., Baur, J. A., & Reddy, R. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-01958-0 · Cited by 1
Yi, Z., Juvvadi, N., Zhai, R. G., Moraes, C. T., & Pinto, M. (2026) · Mitochondrial Communications · doi:10.1016/j.mitoco.2026.01.001 · Cited by 2
NAD+ and Its Precursors for Health and Longevity
Yi, L. (2026) · Healthy ageing and longevity · doi:10.1007/978-3-032-11608-6_5 · Cited by 1
Rui, S., Yueyang, W., Zezhou, H., Yunlong, C., & Jianguo, L. (2026) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2026.117778 · Cited by 1
Targeting NAD Homeostasis: Compartmentalization, Quantification, and Modulation
Nobile, M., Fontanini, V., Serrao, S., Burtscher, J., Re, F., & Paglia, G. (2026) · Metabolites · doi:10.3390/metabo16050338 · Cited by 1
Liu, A., Zhu, X., Sun, W.-D., Bi, S.-Z., Zhang, C., & Li, J. N. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112688 · Cited by 1
Hong, W., Kim, J., Noh, S., Shim, J., Park, S.-K., & Kim, M.-H. (2026) · Cosmetics · doi:10.3390/cosmetics13040172 · Cited by 1
Medoro, A., Davinelli, S., Mazzotta, C. G., Agnifili, L., & Scapagnini, G. (2026) · Pharmaceuticals · doi:10.3390/ph19081268 · Cited by 1
Oxidative stress and inflammation in neurodegenerative disorders
Jomová, K., Alomar, S. Y., Valko, R., Nepovimová, E., Kuča, K., & Valko, M. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04518-5 · Cited by 1
A specialized role played by a redox cofactor
Xie, S., & Zhang, L. (2022) · Engineering Microbiology · doi:10.1016/j.engmic.2022.100010 · Cited by 1
Mitophagy Impairments as Culprit of Alzheimer’s Disease
Mani, S., Swargiary, G., Singh, M., & Rawal, M. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_5 · Cited by 1
Targeting mitochondrial dysfunction with nutrients: challenges and opportunities
Frantz, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00010-2 · Cited by 1
The role of phagocytic cells in aging: insights from vertebrate and invertebrate models
Driesschaert, B., Mergan, L., Lucci, C., Simon, C., Santos, D., Groef, L. D., & Temmerman, L. (2024) · Biogerontology · doi:10.1007/s10522-024-10131-9 · Cited by 1
Aging Biomarkers in Assessing the Efficacy of Geroprotective Therapy: Problems and Prospects
Rybina, O. Y., & PASYUKOVA, E. G. (2024) · Nanobiotechnology Reports · doi:10.1134/s2635167624601104 · Cited by 2
Gredilla, R., Lopez‐Torres, M., & Sánchez-Román, I. (2025) · Biomolecules · doi:10.3390/biom15070969 · Cited by 1
Guimera, A. M., & Shanley, D. P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/753566 · Cited by 1
Ji, H., Sapar, M. L., Sarkar, A., Wang, B., & Han, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.26.173245 · Cited by 1
Igarashi, M., Miura, M., Nakagawa-Nagahama, Y., Yaku, K., Kashiwabara, K., Sawada, M., Sekine, R., Fukamizu, Y., Sato, T., Sakurai, T., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-455083/v1 · Cited by 1
PncA from bacteria improves diet-induced NAFLD by enabling the transition from NAM to NA in micePreprint
Feng, S., Guo, L., & Liu, H. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.04.471202 · Cited by 1
Palikaras, K., & Tavernarakis, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-21573-6_10027-1 · Cited by 1
Zhang, X., Liu, X., Qiao, Y., Rabata, A., Liu, N., Yao, C., Parimon, T., Chen, D., Chen, P., Stripp, B. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.30.662456 · Cited by 1
Electrochemical Characterization of Nicotinamide Riboside
Goines, S., & Dick, J. E. (2019) · ChemElectroChem · doi:10.1002/celc.201901435
The Microbiome of ALS – Does It Start from the Gut?
Labarre, A., & Parker, J. A. (2021) · Wiley eBooks · doi:10.1002/9781119745532.ch5
Entstehung und Prävention altersassoziierter neurodegenerativer Erkrankungen
Calabrese, P. (2022) · Springer eBooks · doi:10.1007/978-3-662-61417-4_16 · Cited by 1
Palikaras, K., & Tavernarakis, N. (2021) · Springer eBooks · doi:10.1007/978-3-030-57401-7_10027
Damschroder, D., Perez, R. Z., Houtkooper, R. H., & Wessells, R. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.06.475267
Nöral Yaşlanma ile İlişkili Süreçlerin Nöroplastisite Üzerine Etkisi
ALBAYRAK, İ. G., & Mutlu, E. (2022) · Black Sea Journal of Health Science · doi:10.19127/bshealthscience.1021574
Dalmasso, M. C., Arán, M., Galeano, P., Perin, S., Giavalisco, P., Adami, P. V. M., Castaño, E. M., Cuello, A. C., Scherer, M., Maier, W., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-518284/v2
Morgan, B. P. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733535967.793564738
Impact of aging on the central nervous system: Approaches for antiaging
Yavaş, G., & Mut, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98804-9.00023-2
Metabolic mapping of high-fit and low-fit individuals for human physiological health
Janssen, J. J. E. (2022) · doi:10.18174/573397
Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins
TABIBZADEH, S. S. (2022) · Aging and Disease · doi:10.14336/ad.2022.0414
Abd-alzahraa, Z. T., & Al-Abady, Z. N. (2022) · Military Medical Science Letters · doi:10.31482/mmsl.2022.030
Qiu, S., Zhang, Y., Shao, S., Zhang, Y., Yin, J., Xu, X., Yang, L., Hong, Y., Yang, J. J., Tan, X., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3177159/v1
Impact of the NAD+ salvage pathway on the motor system and bioenergetics
Lundt, S. (2023) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/96990
Metabolic control of oocyte development
YiQiu, W. U., Shuai, Z. H. U., & Qiang, W. A. N. G. (2023) · Scientia Sinica Vitae · doi:10.1360/ssv-2023-0152
Aslam, R. M. N., Noor‐ul‐Ain, Ali, H., Muzammil, A., & Iqbal, A. (2024) · Asian Journal of Medicine and Health · doi:10.9734/ajmah/2024/v22i1977
NAMPT deficiency triggers dopaminergic neurodegeneration in the substantia nigra of mousePreprint
Chen, C., Gao, T., Wang, T., Chen, Y.-L., Lu, Y., & Zhang, W. (2024) · Research Square · doi:10.21203/rs.3.rs-3993436/v1
Phytochemicals as Protective Agents for Brain Aging
Zaky, M. Y., Morsy, H. M., & Ahmed, O. M. (2024) · Springer eBooks · doi:10.1007/978-981-99-7269-2_1
Dong, Y. J., & Lu, J. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0039
Kundu, S., Kumar, V., Arora, S., Prasad, S., Singh, C., & Singh, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00026-9
Mitochondrial Autophagy in Brain
Watzlawik, J. O., Hou, X., Fiesel, F. C., & Springer, W. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_9
Potential roles of LMNA in promoting longevity for larger Argopecten scallops
Zhao, Y., Ning, J., Wang, Q., Liu, G., Xu, X. S., Chen, R., Wang, C., & Lu, X. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.742254
Methods for Coenzyme I Assessment
Koju, N., & Sheng, R. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_7
Alsuhaibani, A. M., Shakya, S., & Refat, M. S. E.-D. (2025) · ChemistrySelect · doi:10.1002/slct.202405747
Alzheimer’s Disease: Link to Aging and Epigenetics
Zala, D. K., Banerjee, S., & Tiwari, A. K. (2025) · RNA technologies · doi:10.1007/978-3-031-91072-2_15
Olatomide, O. D., Musa, S. A., Bauchi, Z. M., Sambo, S. J., Agbon, A. N., Omoniyi, A. A., & Abolaji, A. O. (2025) · Research Square · doi:10.21203/rs.3.rs-7474241/v1
A sensory and motor neuropathy caused by a genetic variant of NAMPT
Zhang, Z., Pilch, J., Lundt, S., Zhang, N., Chang, Y., Singer, T., Śladowski, D., Hu, X.-L., Zheng, L., Ge, W., et al. (2025) · Science Advances · doi:10.1126/sciadv.adx2407
Harikrishna, A. S., & Kesavan, V. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.144827
Genetic influences on aging and neurodegenerative diseases
Rajalakshmi, D., Nisha, K., Hassan, S., Kumar, V. R., Faya, M., Mehdi, M. M., & Singh, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36295-8.00002-x
Mitochondrial health and longevity: intermittent fasting’s impact on cellular energy production
Ghosh, S., Singh, D. K. K., Mishra, P. K., Sinha, J. K., & Mitra, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30060-8.00021-2 · Cited by 1
Mechanistic basis of NMN and rapamycin in aging biology: Independent and intersecting pathways
Sasidhar, C., Chitra, V., & Kumar, V. N. (2025) · Gene Reports · doi:10.1016/j.genrep.2025.102401
Venkateshvaran, A., Pundlik, S. S., Suresh, Y., Hegde, A., Venkatesh, B., Rajalakshmi, S., Dowari, S., Barik, A., Lal, H., Lakkaraju, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.11.28.690663
Xu, C., Mei, Y., Yang, R., Luo, Q., Zhang, J., Kou, X., Hu, J., Wang, Y., Li, Y., Chen, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25708927
Knapskog, A.-B., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Giil, L. M., Saltvedt, I. T., Watne, L. O., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26388855
Self-citationGopinath, V., Nair, V. P., & Raghavamenon, A. C. (2025) · Journal of advanced health research & clinical medicine. · doi:10.4103/jhcr.jhcr_19_25
Liu, Q., Li, H., Chen, H., Wang, X., Li, G., Tang, Z., Wang, W., Hou, Y., Zhao, P., & Xia, Q. (2026) · Insect Science · doi:10.1111/1744-7917.70191 · Cited by 1
Self-citationÚj biológiai és klinikai öregedéstudományi eredmények az egészséges életkor meghosszabbítására
Holczbauer, A., Kalmár, A., Valcz, G., Takács, I., & Molnar, B. A. (2026) · Magyar Belorvosi Archívum · doi:10.59063/mba.2026.79.1.4
Pyrimidine and NAD salvage pathways : unexpected allies in the maintenance of genome stability
Silveira, S. C. (2018) · theses.fr (ABES) · doi:10.70675/d8951764z7ae2z4d5eza2e1z0b24bea9f901
MOSAIC: a longitudinal phenotypic clock to dissect organismal aging trajectories in C. elegansPreprint
Vaudano, A. P., Pierron, M., Stojkovic, L., Membrez, M., Bourgeois, M., Neal, C., Chimen, M., Verbakel, L., Cornaglia, M., Solari, F., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.23.720365
Function, Regeneration, and Proliferation of Pancreatic β-Cells Centered on NAD
Nata, K. (2026) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.25-00172
Nkrumah-Elie, Y. M., Kwon, J., Simpson, S., Idoine, R., Mavoyan, J. S., Russ, A., Cavanaugh, J., Hawkins, L., Fuller, K., Jaeger, J., et al. (2026) · medRxiv · doi:10.64898/2026.04.28.26352007 · Cited by 1
Yu, B., Lin, Y., Liu, X., Li, J., Sun, Z., Xu, K., Ping, S., Jiang, Y., Miao, Y., Yang, X., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103214
Venkateshvaran, A., Pundlik, S. S., Suresh, Y., Hegde, A., Venkatesh, B., Dowari, S., Gogia, D., Rajalakshmi, S., Saha, P., Barik, A., et al. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c02051
Tbx20 and Sirt1 synergize to ameliorate cardiac aging through enhanced autophagy
Khanam, R., Mandal, P., Khamaru, M., Dutta, P., Ghosh, M., Mitra, D., Sengupta, A., & Chakraborty, S. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103654
Huang, Z., Lin, S., Liang, Y., Khan, M., Chen, W., Li, X., Liu, X., Wu, Y. C., & Ye, J. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1852654
The Role of Oxidative Stress in Heart Failure: Mechanisms and Therapeutic Targets
Hussain, T., Pandey, A., Karki, D., & Neupane, P. (2026) · Cureus · doi:10.7759/cureus.111384
Decoding aging clocks from a metabolomic perspective
Qu, X., You, Q., Fan, M., & Xu, S. (2026) · PeerJ · doi:10.7717/peerj.21508
Metabolic Signatures of Aging and Gametogenesis in Hydra oligactis
Marami-Zonouz, N., Arc, E., Roach, T., Jansen‐Dürr, P., Bader, W., Hobmayer, B., & Kranner, I. (2026) · Aging Cell · doi:10.1111/acel.70643
Alcaraz, M., Ramachandra, R., Arnold, R., Teneche, M. G., Rajesh, A., Haddadin, L., Taing, M., Lei, X., Gandhi, A., Tzaridis, T., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.06.743365 · Cited by 1
Nicotinamide Mononucleotide Adenylyltransferase 1 and NAD+ Homeostasis in Neuroprotection and Aging
Sun, Y., Li, B., & Qian, Z. (2026) · Metabolites · doi:10.3390/metabo16080597
Grycan, M., Zyśk, R., Grycan, G., Jakiel, G., Dudek, A., & Gromadzka, G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177521
Insights Into the Mechanisms of Biological Aging That Guide Translational and Clinical Research
Fang, E. F., Nilsen, H., Scheibye‐Knudsen, M., Bohr, V. A., & Kang, L. (2026) · Aging Medicine · doi:10.1002/agm2.70107
Self-citationMcDermott, C., Cole, M. H., Pearson, M. A., Winberg, P. C., & Fernandez, F. (2026) · Molecules · doi:10.3390/molecules31193528
Dietary supplements to support healthy aging
Evans, C., Gilbert, G., Schwarz, A. V., Pereira, F., Byers, P. H., Emerson, K., Vasenina, K., Barelli, V., Naddafha, S., & António, J. (2026) · Longevity · doi:10.1080/30653495.2026.2743481
Park, S. E., Roh, E., Park, J.-W., Kim, S. J., Jeong, S. Y., Park, C. B., Lim, H. S., Kim, J. S., Kim, M. G., Kim, M. J., et al. (2026) · Aging Cell · doi:10.1111/acel.70745
BindingDB (2025) · UC San Diego · doi:10.7270/q25x2fk7
BindingDB Entry 50020539: The evolution of small molecule enzyme activators.
BindingDB (2024) · UC San Diego · doi:10.7270/q2b56q63
Metadata
- Authors
- Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A.
- Affiliations
- National Institutes of Health (US)
- University of Copenhagen (DK)
- Corresponding author
- Bohr, Vilhelm A.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 23
- Issue
- 10
- Pages
- 899-916
- ISSN
- 1471-4914 (ISSN-L)
- PMC
- PMC7494058
- OpenAlex
- W2751352835
- Cited by
- 501
- References
- 119
- Citations by year
- 2026: 42 · 2025: 75 · 2024: 69 · 2023: 45 · 2022: 64 · 2021: 74 · 2020: 53 · 2019: 48 · 2018: 29 · 2017: 2
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Scopus (Elsevier) (submittedVersion)
- Funders
- Intramural Research Program of the National Institute on Aging (2015-2016, 2016-2017)
- The Oticon Foundation
- Ib Henriksen’s Foundation
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- NAD+, aging, NAD+ depletion, NAD biosynthesis, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, cardiovascular disease, muscle atrophy, age-related diseases, NAD+ supplementation, cellular bioenergetics, stress response
- MeSH terms
- Aging, Alzheimer Disease, Animals, Cardiovascular Diseases, Energy Metabolism, Humans, Muscular Atrophy, NAD, Parkinson Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
