NAD(+) in aging: molecular mechanisms and translational implications

The Hallmarks of Aging

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study

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Multiple Sclerosis

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Mitochondria and cancer

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Self-consumption: the interplay of autophagy and apoptosis

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Autophagy and Aging

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Autophagy in infection, inflammation and immunity

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Glycotoxins: Dietary and Metabolic Origins; Possible Amelioration of Neurotoxicity by Carnosine, with Special Reference to Parkinson’s Disease

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Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death

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Normal ageing of the brain: Histological and biological aspects

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NAD+ Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease

Chanvillard, L., Tammaro, A., & Sorrentino, V. (2022) · Cells · doi:10.3390/cells12010021 · Cited by 28

From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Adapted Mitochondria

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The evolution of small molecule enzyme activators

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Microfluidic models of the neurovascular unit: a translational view

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Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions

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Progresses in both basic research and clinical trials of NAD+ in Parkinson’s disease

Maria Jose Perez, J., Baden, P., & Deleidi, M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111499 · Cited by 26

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Kim, C.-K., Sachdev, P. S., & Braidy, N. (2022) · Aging and Disease · doi:10.14336/ad.2021.0705 · Cited by 27

The Role of Calorie Restriction in the Prevention of Cardiovascular Disease

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Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target

Sun, W.-D., Zhu, X., Li, J., Mei, Y.-Z., Li, W.-S., & Li, J.-H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113208 · Cited by 24

Antiaging Therapies, Cognitive Impairment, and Dementia

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Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6

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C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration

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Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions

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Establishment of a direct 2.5D organoid culture model using companion animal cancer tissues

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Emerging Role of Nicotinamide Riboside in Health and Diseases

Sharma, C., Donu, D., & Cen, Y. (2022) · Nutrients · doi:10.3390/nu14193889 · Cited by 24

Harnessing enzyme cofactors and plant metabolism: an essential partnership

da Fonseca‐Pereira, P., Batista, R. D. C. M., Araújo, W. L., & Nunes‐Nesi, A. (2023) · The Plant Journal · doi:10.1111/tpj.16167 · Cited by 25

Niacin – a scoping review for Nordic Nutrition Recommendations 2023

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Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility

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Metabolic Rewiring in the Face of Genomic Assault: Integrating DNA Damage Response and Cellular Metabolism

Ma, W., & Zhou, S. (2025) · Biomolecules · doi:10.3390/biom15020168 · Cited by 31

N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin?

Nejabati, H. R., Schmeißer, K., Shahnazi, V., Samimifar, D., Faridvand, Y., Bahrami‐Asl, Z., Maroufi, N. F., Nikanfar, S., & Nouri, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101131 · Cited by 23

The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential

Zhang, X., Zhang, Y., Sun, A., & Ge, J. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.04.001 · Cited by 24

Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Midlife and Older Adults

Freeberg, K. A., Craighead, D. H., Martens, C. R., You, Z., Chonchol, M., & Seals, D. R. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.881703 · Cited by 23

NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs

Zong, L., Tanaka-Yano, M., Park, B., Yanai, H., Turhan, F. T., Croteau, D. L., Tian, J., Fang, E. F., Bohr, V. A., & Beerman, I. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00078-3 · Cited by 22

The Role of NAD+ in Regenerative Medicine

Conlon, N. J. (2021) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000009673 · Cited by 24

Metabolic impact of pathogenic variants in the mitochondrial glutamyl‐tRNA synthetase EARS2

Ni, M., Black, L. F., Pan, C., Vu, H., Pei, J., Ko, B., Cai, L., Solmonson, A., Yang, C., Nugent, K. M., et al. (2021) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12387 · Cited by 23

Activation of cardiac Nmnat/NAD+/SIR2 pathways mediates endurance exercise resistance to lipotoxic cardiomyopathy in aging Drosophila

Wen, D., Zheng, L., Lǚ, K., & Hou, W.-Q. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.242425 · Cited by 21

Emerging roles of Sirtuin 2 in cardiovascular diseases

Taneja, A., Ravi, V., Hong, J. Y., Lin, H., & Sundaresan, N. R. (2021) · The FASEB Journal · doi:10.1096/fj.202100490r · Cited by 23

miR‐125a‐5p increases cellular DNA damage of aging males and perturbs stage‐specific embryo development via Rbm38‐p53 signaling

Liang, K., Yao, L., Wang, S., Zheng, L., Zhang, Q., Ge, Y., Chen, L., Cheng, X., Ma, R., Li, C., et al. (2021) · Aging Cell · doi:10.1111/acel.13508 · Cited by 23

Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells

Kolotyeva, N. A., Groshkov, A. A., Rozanova, N. A., Berdnikov, A. K., Novikova, S. V., Komleva, Y. K., Salmina, A. B., Illarioshkin, S. N., & Пирадов, М. А. (2024) · Biomolecules · doi:10.3390/biom14121556 · Cited by 24

Inhibition of the cGAS–STING pathway via an endogenous copper ion-responsive covalent organic framework nanozyme for Alzheimer's disease treatment

Zhang, H., Ya, J., Sun, M., Du, X., Ren, J., & Qu, X. (2025) · Chemical Science · doi:10.1039/d4sc07963a · Cited by 21

A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects

Ito, T. K., Sato, T., Takanashi, Y., Tamannaa, Z., Kitamoto, T., Odagiri, K., & Setou, M. (2021) · Translational Medicine of Aging · doi:10.1016/j.tma.2021.09.001 · Cited by 23

NAD + , Axonal Maintenance, and Neurological Disease

Alexandris, A. S., & Koliatsos, V. E. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0350 · Cited by 20

Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease

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Nicotinamide riboside—A missing piece in the puzzle of exercise therapy for older adults?

Custodero, C., Saini, S. K., Shin, M., Jeon, Y. K., Christou, D. D., McDermott, M. M., Leeuwenburgh, C., Anton, S. D., & Mankowski, R. T. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110972 · Cited by 21

SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience

Islam, M. A., Sehar, U., Sultana, O. F., Mukherjee, U., Brownell, M., Kshirsagar, S., & Reddy, P. H. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111936 · Cited by 21

Nicotinamide riboside supplementation ameliorated post-ovulatory oocyte quality decline

Li, H., Wang, H., Xu, J., Zeng, X., Sun, Y., & Yang, Q. (2022) · Reproduction · doi:10.1530/rep-22-0095 · Cited by 21

Caffeine and NAD+ Improve Motor Neural Integrity of Dissociated Wobbler Cells In Vitro

Zwilling, M., Theiß, C., & Matschke, V. (2020) · Antioxidants · doi:10.3390/antiox9060460 · Cited by 20

Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma

Cosio, T., Prete, M. D., & Campione, E. (2020) · Biomedicines · doi:10.3390/biomedicines8060156 · Cited by 20

A Glimmer of Hope: Maintain Mitochondrial Homeostasis to Mitigate Alzheimer’s Disease

Li, W., Kui, L., Tsirukis, D. I., Gong, X., & Tang, M. (2020) · Aging and Disease · doi:10.14336/ad.2020.0105 · Cited by 21

Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry

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Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid

Feng, S., Guo, L., Wang, H., Yang, S., & Liu, H. (2023) · Communications Biology · doi:10.1038/s42003-023-04613-8 · Cited by 20

Nucleotide‐binding domain and leucine‐rich‐repeat‐containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung‐like changes

Shin, H. J., Kim, S., Park, H., Shin, M., Kang, I., & Kang, M. (2021) · Aging Cell · doi:10.1111/acel.13410 · Cited by 18

NAD+: An old but promising therapeutic agent for skeletal muscle ageing

Xu, Y., & Xiao, W. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102106 · Cited by 20

Breakdown and repair of metabolism in the aging brain

Shichkova, P., Coggan, J. S., Kanari, L., Boci, E., Favreau, C., Antonel, S., Keller, D. X., & Markram, H. (2025) · Frontiers in Science · doi:10.3389/fsci.2025.1441297 · Cited by 22

Quantitation of NAD+: Why do we need to measure it?

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Ligation-Based qPCR-Amplification Assay for Radiolabel-Free Detection of ATP and NAD+ with High Selectivity and Sensitivity

Zhang, X., Wang, Y., & Zhou, X. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05663 · Cited by 19

Advantages of formate dehydrogenase reaction for efficient NAD+ quantification in biological samples

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Metabolomic and transcriptional profiling reveals bioenergetic stress and activation of cell death and inflammatory pathways in vivo after neuronal deletion of NAMPT

Lundt, S., Zhang, N., Li, J.-L., Zhang, Z., Zhang, L., Wang, X., Bao, R., Cai, F., Sun, W., Ge, W., et al. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x21992625 · Cited by 19

Exploring NNMT: from metabolic pathways to therapeutic targets

Park, J., Shin, E. J., Kim, T. H., Yang, J. H., Ki, S. H., Kang, K. W., & Kim, K. M. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01519-9 · Cited by 19

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease

Asimakidou, E., Pluchino, S., Silva, B. A., & Peruzzotti‐Jametti, L. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01409-4 · Cited by 24

Safety Evaluation for Restorin® NMN, a NAD+ Precursor

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Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE2 Pathway

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Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo

Stock, A. J., Ayyar, S., Kashyap, A., Wang, Y., Yanai, H., Starost, M. F., Tanaka-Yano, M., Bodogai, M., Sun, C., Wang, Y., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00752-2 · Cited by 25

Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments

Peng, Y. S., Shi, Z., Satyanarayanan, S. K., He, C., Li, P., Wan, J., & Su, H. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.005 · Cited by 18

Potential Efficacy of Nutrient Supplements for Treatment or Prevention of COVID-19

Bogan-Brown, K. L., Nkrumah-Elie, Y. M., Ishtiaq, Y., Redpath, P., & Shao, A. E. (2021) · Journal of Dietary Supplements · doi:10.1080/19390211.2021.1881686 · Cited by 20

The liquid crystal monomer EtCBN induced neurotoxicity by activating the NOD-like receptor signaling pathway through the Muribaculum-epigallocatechin axis

Duan, L., Liang, J., Zhang, W., Liu, Z., Kang, H., Huang, D., Wang, Z., Jiang, G., & Gao, A. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.139206 · Cited by 17

Understanding and improving vaccine efficacy in older adults

Hofer, S. J., Rapp, S., Klenerman, P., & Simon, A. K. (2025) · Nature Aging · doi:10.1038/s43587-025-00939-6 · Cited by 23

Utilizing pathophysiological concepts of ischemia-reperfusion injury to design renoprotective strategies and therapeutic interventions for normothermic ex vivo kidney perfusion

Ogurlu, B., Hamelink, T. L., Tricht, I. M. V., Leuvenink, H. G. D., de Borst, M. H., Moers, C., & Pool, M. B. F. (2024) · American Journal of Transplantation · doi:10.1016/j.ajt.2024.01.001 · Cited by 17

The significance of caloric restriction mimetics as anti-aging drugs

Nassar, K., El-mekawey, D., Elmasry, A. E., Refaey, M. S., El-Sayed Ghoneim, M., & Elshaier, Y. A. M. M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149354 · Cited by 16

Dietary restriction in aging and longevity

Schmauck‐Medina, T., Lautrup, S., Francesco, A. D., Mitchell, S. J., Clemmensen, C., Partridge, L., Roth, G. S., Anderson, R. M., Mattison, J. A., de Cabo, R., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01091-5 · Cited by 18

Emissive Synthetic Cofactors: A Highly Responsive NAD + Analogue Reveals Biomolecular Recognition Features

Feldmann, J., Li, Y., & Tor, Y. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201805520 · Cited by 16

Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1

Bloom, C. R., & North, B. J. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00589-2 · Cited by 16

How Does Fusarium oxysporum Sense and Respond to Nicotinaldehyde, an Inhibitor of the NAD+ Salvage Biosynthesis Pathway?

Anand, G., Waiger, D., Vital, N. Y., Maman, J., Ma, L., & Covo, S. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00329 · Cited by 16

Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells

Reed, M. R., Maddukuri, L., Ketkar, A. D., Byrum, S. D., Zafar, M. K., Bostian, A. C. L., Tackett, A. J., & Eoff, R. L. (2021) · NAR Cancer · doi:10.1093/narcan/zcab014 · Cited by 16

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Zhou, S., Xiong, X., Hou, J., Duan, Q., Zheng, Y., Jiang, T., Huang, J., He, H., Xu, J., Chen, K., et al. (2025) · Advanced Science · doi:10.1002/advs.202408503 · Cited by 15

A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

Ito, T. K., Sato, T., Hakamata, A., Onoda, Y., Sato, S., Yamazaki, F., Horikawa, M., Takahashi, Y., Kitamoto, T., Suzuki, M., et al. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.04.002 · Cited by 16

Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem Cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner Syndrome

Gudmundsrud, R., Skjånes, T. H., Gilmour, B. C., Caponio, D., Lautrup, S., & Fang, E. F. (2021) · Cytogenetic and Genome Research · doi:10.1159/000516386 · Cited by 17

Nicotinamide as potential biomarker for Alzheimer’s disease: A translational study based on metabolomics

Dalmasso, M. C., Arán, M., Galeano, P., Perin, S., Giavalisco, P., Adami, P. V. M., Novack, G. V., Castaño, E. M., Cuello, A. C., Scherer, M., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1067296 · Cited by 16

ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging

Kapitansky, O., & Gozes, I. (2019) · GeroScience · doi:10.1007/s11357-019-00079-x · Cited by 15

In vivo X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging

Zhu, X.-H., & Chen, W. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00394 · Cited by 15

The role of gut microbiota–mitochondria crosstalk in neurodegeneration: Underlying mechanisms and potential therapies

Ju, T., Zhang, Y., Liu, L., Zhao, X., Li, X., Liu, C., Sun, S., & Wu, L. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01419 · Cited by 16

The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD+ Level Is Lower than the Sirtuin-Saturating Concentrations

Yang, N.-C., Cho, Y.-H., & Lee, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010142 · Cited by 16

Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging

Chao, C., Shen, P.-W., Tzeng, T., Kung, H., Tsai, T., & Wong, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9111635 · Cited by 13

NADH Intraperitoneal Injection Prevents Lung Inflammation in a BALB/C Mice Model of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

Slama, N., Abdellatif, A., Bahria, K., Gasmi, S. N., Khames, M., Hadji, A., Birkmayer, G. D., Oumouna, M., Amrani, Y., & Benachour, K. (2024) · Cells · doi:10.3390/cells13100881 · Cited by 14

Mitonuclear Communication in Stem Cell Function

Peng, B., Wang, Y., & Zhang, H. (2024) · Cell Proliferation · doi:10.1111/cpr.13796 · Cited by 14

Pharmaceutical Intervention of Aging

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Metabolic Regulation: A Potential Strategy for Rescuing Stem Cell Senescence

Zhang, W., Li, J., Duan, Y., Li, Y., Sun, Y., Sun, H., Yu, X., Gao, X., Zhang, C., Zhang, H., et al. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10348-6 · Cited by 14

Mitophagy Modulators

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Mitochondria and Epigenetic Regulation: Bidirectional Crosstalk and Emerging Mitochondria-Targeted Degron Tools

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Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation

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Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease

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Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes

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Increased radioprotection attained by DNA repair enhancement

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Role of NADþ in regulating cellular andmetabolic signaling pathways

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NAD + in aging, metabolism, and neurodegeneration

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