Fission and proliferation of peroxisomes

Schrader, M.; Bonekamp, N.A.; Islinger, M.

doi:10.1016/j.bbadis.2011.12.014

Cited by 189Cellular transport and secretionAutophagy in Disease and TherapyRedox biology and oxidative stress

Fission and proliferation of peroxisomes

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Schrader, M., Bonekamp, N.A., Islinger, M.·2012·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2011.12.014

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Abstract

Peroxisomes are remarkably dynamic, multifunctional organelles, which react to physiological changes in their cellular environment and adopt their morphology, number, enzyme content and metabolic functions accordingly. At the organelle level, the key molecular machinery controlling peroxisomal membrane elongation and remodeling as well as membrane fission is becoming increasingly established and defined. Key players in peroxisome division are conserved in animals, plants and fungi, and key fission components are shared with mitochondria. However, the physiological stimuli and corresponding signal transduction pathways regulating and modulating peroxisome maintenance and proliferation are, despite a few exceptions, largely unexplored. There is emerging evidence that peroxisomal dynamics and proper regulation of peroxisome number and morphology are crucial for the physiology of the cell, as well as for the pathology of the organism. Here, we discuss several key aspects of peroxisomal fission and proliferation and highlight their association with certain diseases. We address signaling and transcriptional events resulting in peroxisome proliferation, and focus on novel findings concerning the key division components and their interplay. Finally, we present an updated model of peroxisomal growth and division. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of Peroxisomes in Health and Disease.

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Peroxisome biogenesis occurs by two distinct mechanisms: de novo synthesis or self-replication through growth and fission.
“Peroxisome biogenesis occurs by two distinct mechanisms, de novo synthesis (Ma et al., 2011; Agrawal and Subramani, 2016) or, self-replication through growth and fission (Schrader et al., 2012).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Schrader et al., 2012

1 retracted

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Peroxisome Biogenesis: End of the Debate
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Redox Homeostasis and Mitochondrial Dynamics
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Plant Peroxisomes: Biogenesis and Function
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Human disorders of peroxisome metabolism and biogenesis
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Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
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Adaptor Proteins MiD49 and MiD51 Can Act Independently of Mff and Fis1 in Drp1 Recruitment and Are Specific for Mitochondrial Fission
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The peroxisome: an update on mysteries
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The Impact of Peroxisomes on Cellular Aging and Death
Manivannan, S., Scheckhuber, C. Q., Marten Veenhuis, A., & van der Klei, I. J. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00050 · Cited by 273 · see citing works
The physiological functions of human peroxisomes
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Peroxisome‐mitochondria interplay and disease
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Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes
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Hypoxia signaling pathways: modulators of oxygen-related organelles
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Peroxisomal metabolism and oxidative stress
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Phosphorylation of Pex11p does not regulate peroxisomal fission in the yeast Hansenula polymorpha
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Hif-2α Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy
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A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission
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Proliferation and fission of peroxisomes — An update
Schrader, M., Costello, J. L., Godinho, L. F., Azadi, A. S., & Islinger, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.09.024 · Cited by 157 · see citing works
No peroxisome is an island — Peroxisome contact sites
Shai, N., Schuldiner, M., & Zalckvar, E. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.09.016 · Cited by 155 · see citing works
Organelle interplay-peroxisome interactions in health and disease.
Schrader, M., Kamoshita, M., & Islinger, M. (2020) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12083 · Cited by 149 · see citing works
Self-citation
Redox Regulation of Homeostasis and Proteostasis in Peroxisomes
Walker, C. L., Pomatto, L. C. D., Tripathi, D. N., & Davies, K. J. A. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2016 · Cited by 145 · see citing works
Peroxisomes Extend Peroxules in a Fast Response to Stress via a Reactive Oxygen Species-Mediated Induction of the Peroxin PEX11a
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Making connections: interorganelle contacts orchestrate mitochondrial behavior
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A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11β gene
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Peroxisomes in Immune Response and Inflammation
Cara, F. D., Andreoletti, P., Trompier, D., Véjux, A., Bülow, M. H., Sellin, J., Lizard, G., Cherkaoui‐Malki, M., & Savary, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163877 · Cited by 127 · see citing works
Yeast peroxisomes: structure, functions and biotechnological opportunities
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Mitochondrial Morphofunction in Mammalian Cells
Bulthuis, E. P., Adjobo-Hermans, M. J. W., Willems, P. H. G. M., & Koopman, W. J. H. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7534 · Cited by 128 · see citing works
Getting around the cell: physical transport in the intracellular world
Mogre, S. S., Brown, A. I., & Koslover, E. F. (2020) · Physical Biology · doi:10.1088/1478-3975/aba5e5 · Cited by 123 · see citing works
Crosstalk between mitochondria and peroxisomes
Demarquoy, J. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i4.301 · Cited by 123 · see citing works
The dynamin GTPase OPA1: More than mitochondria?
Belenguer, P., & Pellegrini, L. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.08.004 · Cited by 119 · see citing works
Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage
Defourny, J., Aghaie, A., Perfettini, I., Avan, P., Delmaghani, S., & Petit, C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821844116 · Cited by 118 · see citing works
Dynamin Assembly Strategies and Adaptor Proteins in Mitochondrial Fission
Bui, H., & Shaw, J. M. (2013) · Current Biology · doi:10.1016/j.cub.2013.08.040 · Cited by 112 · see citing works
Spectrum of combined respiratory chain defects
Mayr, J., Haack, T., Freisinger, P., Karall, D., Makowski, C., Koch, J., Feichtinger, R., Zimmermann, F., Rolinski, B., Ahting, U., et al. (2015) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-015-9831-y · Cited by 114 · see citing works
Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy
Nazarko, T. Y., Ozeki, K., Till, A., Ramakrishnan, G., Lotfi, P., Yan, M., & Subramani, S. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201307050 · Cited by 99 · see citing works
Overexpression of PGC-1α increases peroxisomal activity and mitochondrial fatty acid oxidation in human primary myotubes
Huang, T., Zheng, D., Houmard, J. A., Brault, J. J., Hickner, R. C., & Cortright, R. N. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00331.2016 · Cited by 90 · see citing works
Optimal Compartmentalization Strategies for Metabolic Microcompartments
Hinzpeter, F., Gerland, U., & Tostevin, F. (2017) · Biophysical Journal · doi:10.1016/j.bpj.2016.11.3194 · Cited by 81 · see citing works
Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent apoptosis pathway
Tanaka, H., Okazaki, T., Aoyama-Ishiwatari, S., Yokota, M., Koike, M., Okada, Y., Fujiki, Y., & Gotoh, Y. (2019) · Journal of Cell Science · doi:10.1242/jcs.224766 · Cited by 81 · see citing works
Evolving models for peroxisome biogenesis
Hettema, E. H., Erdmann, R., van der Klei, I. J., & Marten Veenhuis, A. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.02.002 · Cited by 80 · see citing works
Peroxisome Interactions and Cross-Talk with Other Subcellular Compartments in Animal Cells
Schrader, M., Grille, S., Fahimi, H. D., & Islinger, M. (2013) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-6889-5_1 · Cited by 79 · see citing works
Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission
O'Mealey, G. B., Berry, W. L., & Plafker, S. M. (2016) · Redox Biology · doi:10.1016/j.redox.2016.11.007 · Cited by 77 · see citing works
Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes
Mohanty, A., & McBride, H. M. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00268 · Cited by 76 · see citing works
The progression of peroxisomal degradation through autophagy requires peroxisomal division
Mao, K., Liu, X., Feng, Y., & Klionsky, D. J. (2014) · Autophagy · doi:10.4161/auto.27852 · Cited by 76 · see citing works
Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration
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Peroxisomes as redox-signaling nodes in intracellular communication and stress responses
Sandalio, L. M., Peláez‐Vico, M. Á., Molina‐Moya, E., & Romero‐Puertas, M. C. (2021) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiab060 · Cited by 72 · see citing works
Recent insights into peroxisome biogenesis and associated diseases
Fujiki, Y., Abe, Y., Imoto, Y., Tanaka, A. J., Okumoto, K., Honsho, M., Tamura, S., Miyata, N., Yamashita, T., Chung, W. K., et al. (2020) · Journal of Cell Science · doi:10.1242/jcs.236943 · Cited by 72 · see citing works
Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives
Nordgren, M., Wang, B., Apanasets, O., & Fransen, M. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00145 · Cited by 67 · see citing works
Dynamin-related Protein 1 (Drp1) Promotes Structural Intermediates of Membrane Division*
Ugarte-Uribe, B., Müller, H.-M., Otsuki, M., Nickel, W., & García-Sáez, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.575779 · Cited by 65 · see citing works
Peroxisomes and Kidney Injury
Vasko, R. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6666 · Cited by 66 · see citing works
TRIMming down to TRIM37: Relevance to Inflammation, Cardiovascular Disorders, and Cancer in MULIBREY Nanism
Brigant, B., Meuth, V. M., Rochette, J., & Metzinger, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010067 · Cited by 65 · see citing works
Proteome Analysis of Peroxisomes from Etiolated Arabidopsis Seedlings Identifies a Peroxisomal Protease Involved in β-Oxidation and Development
Quan, S., Yang, P., Cassin-Ross, G., Kaur, N., Switzenberg, R., Aung, K., Li, J., & Hu, J. (2013) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.223453 · Cited by 64 · see citing works
New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes
Camões, F., Islinger, M., Guimarães, S., Kilaru, S., Schuster, M., Godinho, L. F., Steinberg, G., & Schrader, M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.10.005 · Cited by 63 · see citing works
Peroxisomes and Oxidative Stress: Their Implications in the Modulation of Cellular Immunity During Mycobacterial Infection
Ganguli, G., Mukherjee, U., & Sonawane, A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01121 · Cited by 60 · see citing works
Glycosomal Targets for Anti-Trypanosomatid Drug Discovery
Barros-Álvarez, X., Gualdrón‐López, M., Acosta, H., Cáceres, A. J., Graminha, M. A. S., Michels, P. A. M., Concepción, J. L., & Quiñones, W. A. (2014) · Current Medicinal Chemistry · doi:10.2174/09298673113209990139 · Cited by 50 · see citing works
Sharing the cell's bounty – organelle inheritance in yeast
Knoblach, B., & Rachubinski, R. A. (2015) · Journal of Cell Science · doi:10.1242/jcs.151423 · Cited by 47 · see citing works
Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease
Boardman, N. T., Trani, G., Scalabrin, M., Romanello, V., & Wüst, R. C. I. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad004 · Cited by 49 · see citing works
Effect of Eicosapentaenoic Acid and Docosahexaenoic Acid on Myogenesis and Mitochondrial Biosynthesis during Murine Skeletal Muscle Cell Differentiation
Hsueh, T., Baum, J., & Huang, Y. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00015 · Cited by 48 · see citing works
Peroxisomes: role in cellular ageing and age related disorders
Deori, N. M., Kale, A., Maurya, P. K., & Nagotu, S. (2018) · Biogerontology · doi:10.1007/s10522-018-9761-9 · Cited by 47 · see citing works
Pexophagy in yeast and mammals: an update on mysteries
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Authors: Schrader, M., Bonekamp, N. A., & Islinger, M.
Affiliations: University of Aveiro (PT)
ORCID: Schrader, M.
Bonekamp, N.A.
Islinger, M.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2012-09
Volume: 1822
Issue: 9
Pages: 1343-1357
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2011.12.014
OpenAlex: W2054290330
Cited by: 189
References: 211
Citations by year: 2026: 5 · 2025: 3 · 2024: 9 · 2023: 11 · 2022: 11 · 2021: 8 · 2020: 16 · 2019: 12 · 2018: 14 · 2017: 13 · 2016: 16 · 2015: 25 · 2014: 19 · 2013: 18 · 2012: 9
FWCI: 1.25
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Funders: Portuguese Foundation for Science and Technology (FCT)
FEDER
CRUP/DAAD
University of Aveiro
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: peroxisomes, peroxisome division, peroxisome proliferation, membrane fission, peroxisome biogenesis, peroxisome morphology, signal transduction, transcriptional regulation
MeSH terms: Animals, Humans, Intracellular Membranes, Membrane Proteins, Microtubule-Associated Proteins, Signal Transduction, Peroxisomal Disorders, Protein Isoforms, GTP Phosphohydrolases, Peroxisomes, Mitochondrial Proteins, Dynamins, PPAR alpha, Mitochondrial Dynamics

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Fission and proliferation of peroxisomes

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