Circadian rhythm sleep-wake phase disorders
Abstract
This article reviews delayed and advanced sleep-wake phase disorders. Diagnostic procedures include a clinical interview to verify the misalignment of the major nocturnal sleep episode relative to the desired and social-normed timing of sleep, a 3-month or greater duration of the sleep-wake disturbance, and at least a week of sleep diary data consistent with the sleep timing complaint. Treatment options include gradual, daily shifting of the sleep schedule (chronotherapy); shifting circadian phase with properly timed light exposure (phototherapy); or melatonin administration. Future directions are discussed to conclude the article.
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In healthy individuals, melatonin levels usually rise about 2 h before bedtime.
“In healthy individuals, melatonin levels usually rise about 2 h before bedtime (33)”
From Interplay of Dinner Timing and <i>MTNR1B</i> Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial (2022) · cites this paper as [33]
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- Authors
- Culnan, E., McCullough, L. M., & Wyatt, J. K.
- Affiliations
- Rush University Medical Center (US)
- Corresponding author
- Wyatt, James K.
- ORCID
- Wyatt, James K.
- Venue
- Neurologic Clinics
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 37
- Issue
- 3
- Pages
- 527-543
- ISSN
- 0733-8619 (ISSN-L)
- OpenAlex
- W2946939898
- Cited by
- 42
- References
- 91
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 2 · 2019: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurologic Clinics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- delayed sleep phase syndrome, chronotherapy, phototherapy, melatonin, sleep timing, sleep diary
- MeSH terms
- Circadian Rhythm, Humans, Melatonin, Phototherapy, Sleep Disorders, Circadian Rhythm
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