Cited by 250Posttraumatic Stress Disorder ResearchNeurotransmitter Receptor Influence on BehaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Reward functioning in PTSD: A systematic review exploring the mechanisms underlying anhedonia

Nawijn, Laura, van Zuiden, Mirjam, Frijling, Jessie L., Koch, Saskia B.J., Veltman, Dick J., Olff, Miranda·2015·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2015.01.019

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Abstract

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder. An important diagnostic feature of PTSD is anhedonia, which may result from deficits in reward functioning. This has however never been studied systematically in PTSD. To determine if PTSD is associated with reward impairments, we conducted a systematic review of studies in which reward functioning was compared between PTSD patients and healthy control participants, or investigated in relation to PTSD symptom severity. A total of 29 studies were included, covering reward anticipation and approach ('wanting'), and hedonic responses to reward ('liking'). Overall, results were mixed, although decreased reward anticipation and approach and reduced hedonic responses were repeatedly observed in PTSD patients compared to healthy controls. Decreased reward functioning was seen more often in female than in male PTSD samples and most often in response to social positive stimuli. Though more research is needed, these findings are a first step in understanding the possible mechanisms underlying anhedonia in PTSD.

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Diagnostic and Statistical Manual of Mental Disorders(DSM)
Leong, F. T. L. (2008) · Sage eBooks · doi:10.4135/9781412963978.n182 · Cited by 10,861
Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS scales
Carver, C. S., & White, T. L. (1994) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.67.2.319 · Cited by 7,306
Précis of The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system
Gray, J. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00013066 · Cited by 4,477
Twelve‐month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States
Kessler, R. C., Petukhova, M., Sampson, N. A., Zaslavsky, A. M., & Wittchen, H. (2012) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1359 · Cited by 2,947
Masked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205
Sex differences in trauma and posttraumatic stress disorder: A quantitative review of 25 years of research.
Tolin, D. F., & Foa, E. B. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.6.959 · Cited by 2,197
Dissecting components of reward: ‘liking’, ‘wanting’, and learning
Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942
A scale for the assessment of hedonic tone the Snaith-Hamilton pleasure scale
Snaith, R. P., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., & Trigwell, P. (1995) · British Journal of Psychiatry · doi:10.1192/bjp.167.1.99 · Cited by 1,778
Behavioral Theories and the Neurophysiology of Reward
Schultz, W. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070229 · Cited by 1,637
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579

Show all 101 references

Research works printed but not linked: 1

Killgore, 2013, Cortico-limbic responses to masked affective faces across PTSD, panic disorder, and specific phobia, Depress. Anxiety, 159, 150

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Authors: Nawijn, L., van Zuiden, M., Frijling, J. L., Koch, S. B. J., Veltman, D. J., & Olff, M.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author: Nawijn, Laura
ORCID: Nawijn, Laura
Frijling, Jessie L.
Koch, Saskia B.J.
Veltman, Dick J.
Olff, Miranda
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2015-04
Volume: 51
Pages: 189-204
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2015.01.019
OpenAlex: W2016541117
Semantic Scholar: 64b3d956bb37a28b619fb4c589c5d80de9f5effb
Cited by: 250
References: 101
Citations by year: 2026: 12 · 2025: 20 · 2024: 25 · 2023: 23 · 2022: 23 · 2021: 34 · 2020: 35 · 2019: 21 · 2018: 23 · 2017: 16 · 2016: 13 · 2015: 5
FWCI: 2.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: ZonMw (91210041)
Academic Medical Center Research Council (110614)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: post-traumatic stress disorder, anhedonia, reward processing, reward anticipation, approach behavior, hedonic response, sex differences, social reward, symptom severity
MeSH terms: Brain, Humans, Reward, Stress Disorders, Post-Traumatic, Anhedonia

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Reward functioning in PTSD: A systematic review exploring the mechanisms underlying anhedonia

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