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Cited by 246Posttraumatic Stress Disorder ResearchFunctional Brain Connectivity StudiesTraumatic Brain Injury Research

Restoring large-scale brain networks in PTSD and related disorders: a proposal for neuroscientifically-informed treatment interventions

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Lanius, Ruth A., Frewen, Paul A., Tursich, Mischa, Jetly, Rakesh, McKinnon, Margaret C.·2015·European Journal of Psychotraumatology
DOI 10.3402/ejpt.v6.27313PMC PMC4390556
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Abstract

BACKGROUND: Three intrinsic connectivity networks in the brain, namely the central executive, salience, and default mode networks, have been identified as crucial to the understanding of higher cognitive functioning, and the functioning of these networks has been suggested to be impaired in psychopathology, including posttraumatic stress disorder (PTSD). OBJECTIVE: 1) To describe three main large-scale networks of the human brain; 2) to discuss the functioning of these neural networks in PTSD and related symptoms; and 3) to offer hypotheses for neuroscientifically-informed interventions based on treating the abnormalities observed in these neural networks in PTSD and related disorders. METHODS: Literature relevant to this commentary was reviewed. RESULTS: Increasing evidence for altered functioning of the central executive, salience, and default mode networks in PTSD has been demonstrated. We suggest that each network is associated with specific clinical symptoms observed in PTSD, including cognitive dysfunction (central executive network), increased and decreased arousal/interoception (salience network), and an altered sense of self (default mode network). Specific testable neuroscientifically-informed treatments aimed to restore each of these neural networks and related clinical dysfunction are proposed. CONCLUSIONS: Neuroscientifically-informed treatment interventions will be essential to future research agendas aimed at targeting specific PTSD and related symptoms.

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Authors
Lanius, R. A., Frewen, P. A., Tursich, M., Jetly, R., & McKinnon, M. C.
Affiliations
  • Western University (CA)
  • Canadian Armed Forces (CA)
  • Homewood Research Institute (CA)
Corresponding author
Lanius, Ruth A.
ORCID
Venue
European Journal of Psychotraumatology
Publisher
Informa UK Limited
Published
2015-03-31
Volume
6
Issue
1
Pages
27313-27313
ISSN
2000-8066 (ISSN-L)
DOI
10.3402/ejpt.v6.27313
PMC
PMC4390556
OpenAlex
W2015982946
Cited by
246
References
157
Citations by year
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FWCI
28.56
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Psychotraumatology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • Scholarship@Western (Western University) (submittedVersion, cc-by)
  • Scholarship@Western (Western University) (submittedVersion)
  • Figshare (cc-by)
Funders
Canadian Institute for Military and Veteran Health Research
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
post-traumatic stress disorder, large-scale brain networks, frontoparietal network, salience network, default mode network, resting-state networks, cognitive impairment, selfhood

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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