Cited by 62Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesTreatment of Major Depression

The roles of the orbitofrontal cortex via the habenula in non-reward and depression, and in the responses of serotonin and dopamine neurons

Rolls, Edmund T.·2017·Neuroscience & Biobehavioral Reviews

Abstract

Cortical regions such as the orbitofrontal cortex involved in reward and in non-reward and which are implicated in depression, and the amygdala, are connected to the habenula via the striatum and pallidum, and via subcortical limbic structures. The habenula in turn projects to the raphe nuclei, the source of the serotonin-containing neurons that project to the forebrain. It is proposed that this provides a route for cortical signals related to reward, and to not obtaining expected rewards, to influence the serotonin-containing neuronal system that is influenced by many antidepressant treatments. This helps to provide a more circuit-based understanding of the brain mechanisms related to depression, and how some treatments influence this system. The habenula also projects via the rostromedial tegmental nucleus to the dopamine-containing neurons, and this, it is proposed, provides a route for reward prediction error signals and other reward- and punishment-related signals of cortical and striatal origin to influence the dopamine system.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2017.02.013

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The OFC projects reward-related information to the ventral striatum, providing a route, in part via the habenula, for reward-related information to reach dopamine neurons, which respond to positive reward prediction error.

    “The OFC projects reward-related information to the ventral striatum (Williams et al., 1993), and this provides a route, in part via the habenula, for reward-related information to reach the dopamine neurons (Rolls, 2017), which respond inter alia to positive reward prediction error (Bromberg-Martin et al., 2010; Schultz, 2016a, 2017).”

    From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Rolls, 2017

  • The orbitofrontal cortex is a source of reward-related information that reaches the dopamine neurons in the brainstem.

    “the OFC is a source of reward-related information that reaches the dopamine neurons in the brainstem (Rolls, 2017; Namboodiri et al., 2019) (Fig. 2)”

    From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Rolls, 2017

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Rolls, E. T.
Affiliations
University of Warwick (GB)
Corresponding author
Rolls, Edmund T.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2017-04
Volume
75
Pages
331-334
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2587817646
Cited by
62
References
30
Citations by year
2026: 1 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 5
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
orbitofrontal cortex, habenula, depression, serotonergic neurons, dopaminergic neurons, reward prediction error, rostromedial tegmental nucleus, raphe nuclei, striatum, globus pallidus, amygdala, antidepressant mechanism, limbic system
MeSH terms
Depression, Dopamine, Humans, Reward, Serotonin, Prefrontal Cortex, Habenula, Dopaminergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review