The roles of the orbitofrontal cortex via the habenula in non-reward and depression, and in the responses of serotonin and dopamine neurons
Abstract
Cortical regions such as the orbitofrontal cortex involved in reward and in non-reward and which are implicated in depression, and the amygdala, are connected to the habenula via the striatum and pallidum, and via subcortical limbic structures. The habenula in turn projects to the raphe nuclei, the source of the serotonin-containing neurons that project to the forebrain. It is proposed that this provides a route for cortical signals related to reward, and to not obtaining expected rewards, to influence the serotonin-containing neuronal system that is influenced by many antidepressant treatments. This helps to provide a more circuit-based understanding of the brain mechanisms related to depression, and how some treatments influence this system. The habenula also projects via the rostromedial tegmental nucleus to the dopamine-containing neurons, and this, it is proposed, provides a route for reward prediction error signals and other reward- and punishment-related signals of cortical and striatal origin to influence the dopamine system.
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The OFC projects reward-related information to the ventral striatum, providing a route, in part via the habenula, for reward-related information to reach dopamine neurons, which respond to positive reward prediction error.
“The OFC projects reward-related information to the ventral striatum (Williams et al., 1993), and this provides a route, in part via the habenula, for reward-related information to reach the dopamine neurons (Rolls, 2017), which respond inter alia to positive reward prediction error (Bromberg-Martin et al., 2010; Schultz, 2016a, 2017).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Rolls, 2017
The orbitofrontal cortex is a source of reward-related information that reaches the dopamine neurons in the brainstem.
“the OFC is a source of reward-related information that reaches the dopamine neurons in the brainstem (Rolls, 2017; Namboodiri et al., 2019) (Fig. 2)”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Rolls, 2017
Cites
The reward circuit: linking primate anatomy and human imaging
Haber, S. N., & Knutson, B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.129 · Cited by 3,718 · see citing works
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396 · see citing works
Dopamine reward prediction-error signalling: A two-component response
Schultz, W. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.26 · Cited by 1,036 · see citing works
The orbitofrontal cortex: Neuronal activity in the behaving monkey
Thorpe, S. J., Rolls, E. T., & Maddison, S. (1983) · Experimental Brain Research · doi:10.1007/bf00235545 · Cited by 836 · see citing works
The orbitofrontal cortex and beyond: From affect to decision-making
Rolls, E. T., & Fabian Grabenhorst, B. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.001 · Cited by 808 · see citing works
Value, pleasure and choice in the ventral prefrontal cortex
Grabenhorst, F., & Rolls, E. T. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.12.004 · Cited by 766 · see citing works
Haber, S. N., Kim, K.-S., Mailly, P., & Calzavara, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0271-06.2006 · Cited by 686 · see citing works
Updating dopamine reward signals
Schultz, W. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.11.012 · Cited by 651 · see citing works
Hornak, J., O'Doherty, J., Bramham, J., Rolls, E. T., Morris, R. G., Bullock, P. R., & Polkey, C. E. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/089892904322926791 · Cited by 603 · see citing works
Self-citationRepresentation of negative motivational value in the primate lateral habenula
Matsumoto, M., & Hikosaka, O. (2009) · Nature Neuroscience · doi:10.1038/nn.2233 · Cited by 547 · see citing works
Reward processing by the lateral habenula in normal and depressive behaviors
Proulx, C. D., Hikosaka, O., & Malinow, R. (2014) · Nature Neuroscience · doi:10.1038/nn.3779 · Cited by 461 · see citing works
Emotion and Decision-making Explained
Rolls, E. T. (2013) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199659890.001.0001 · Cited by 445 · see citing works
Limbic systems for emotion and for memory, but no single limbic system
Rolls, E. T. (2013) · Cortex · doi:10.1016/j.cortex.2013.12.005 · Cited by 428 · see citing works
Linking context with reward: a functional circuit from hippocampal CA3 to ventral tegmental area
Luo, A. H., Tahsili-Fahadan, P., Wise, R. A., Lupica, C. R., & Aston-Jones, G. (2011) · Science · doi:10.1126/science.1204622 · Cited by 425 · see citing works
Cheng, W., Rolls, E. T., Qiu, J., Liu, W., Tang, Y., Huang, C.-C., Wang, X., Zhang, J., Lin, W., Zheng, L., et al. (2016) · Brain · doi:10.1093/brain/aww255 · Cited by 294 · see citing works
Lateral habenula neurons signal errors in the prediction of reward information
Bromberg-Martin, E. S., & Hikosaka, O. (2011) · Nature Neuroscience · doi:10.1038/nn.2902 · Cited by 275 · see citing works
Neuropsychological mechanism underlying antidepressant effect: a systematic meta-analysis
Ma, Y. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.24 · Cited by 270 · see citing works
LOONEN, A. J. M., & Ivanova, S. А. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00394 · Cited by 250 · see citing works
Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders
Fakhoury, M. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9152-z · Cited by 248 · see citing works
A basal ganglia circuit for evaluating action outcomes
Stephenson‐Jones, M., Yu, K., Ahrens, S., Tucciarone, J., van Huijstee, A. N., Mejia, L. A., Penzo, M. A., Tai, L.-H., Wilbrecht, L., & Li, B. (2016) · Nature · doi:10.1038/nature19845 · Cited by 217 · see citing works
Cerebral cortex : principles of operation
Rolls, E. T. (2016) · doi:10.82444/warw.33712699 · Cited by 187 · see citing works
Harmer, C. J., & Cowen, P. J. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0407 · Cited by 183 · see citing works
A non-reward attractor theory of depression
Rolls, E. T. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.007 · Cited by 180 · see citing works
Neuronal responses in the ventral striatum of the behaving macaque
WILLIAMS, G., ROLLS, E., LEONARD, C., & STERN, C. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90120-f · Cited by 146 · see citing works
Self-citationThe habenula in psychiatric disorders: More than three decades of translational investigation
Fakhoury, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.010 · Cited by 90 · see citing works
Circuits regulating pleasure and happiness in major depression
Loonen, A. J. M., & Ivanova, S. A. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2015.12.013 · Cited by 69 · see citing works
LOONEN, A. J. M., & Ivanova, S. А. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00539 · Cited by 67 · see citing works
Hong, S., & Hikosaka, O. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00778 · Cited by 63 · see citing works
Non-reward neural mechanisms in the orbitofrontal cortex
Rolls, E. T., & Deco, G. (2016) · Cortex · doi:10.1016/j.cortex.2016.06.023 · Cited by 25 · see citing works
LOONEN, A. J. M., & Ivanova, S. А. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.007 · Cited by 9 · see citing works
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Bueno, D., Lima, L. B., Souza, R., Gonçalves, L., Leite, F., Souza, S., Furigo, I. C., Donato, J., & Metzger, M. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24729 · Cited by 38 · see citing works
Han, S., Cui, Q., Wang, X., Chen, Y., Li, D., Li, L., Guo, X., Fan, Y., Guo, J., Sheng, W., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109865 · Cited by 34 · see citing works
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Lages, Y., & McNaughton, N. (2022) · Personality Neuroscience · doi:10.1017/pen.2022.4 · Cited by 28 · see citing works
Xu, T., Zhou, X., Kanen, J. W., Wang, L., Li, J., Chen, Z., Zhang, R., Jiao, G., Zhou, F., Zhao, W., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02001-6 · Cited by 26 · see citing works
Sheth, C. S., Furlong, T. M., Keefe, K. A., & Taha, S. A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.029 · Cited by 25 · see citing works
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Oh, H., Lee, J., Gosnell, S. N., Patriquin, M. A., Kosten, T. R., & Salas, R. (2020) · Addictive Behaviors · doi:10.1016/j.addbeh.2020.106457 · Cited by 18 · see citing works
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Yu, W., Lü, Y., Chen, T., Xia, Y., Tang, J., Hussein, N. M., Meng, S., Liu, X., Liu, P., & Yan, Z. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.051 · Cited by 13 · see citing works
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Donaire, R., Morón, I., Blanco, S., Villatoro, A., Gámiz, F., Papini, M. R., & Torres, C. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.044 · Cited by 12 · see citing works
Risk and aversion coding in human habenula high gamma activity
Manssuer, L. R., Ding, Q., Zhang, Y., Gong, H., Liu, W., Yang, R., Zhang, C., Zhao, Y., Pan, Y., Zhan, S., et al. (2022) · Brain · doi:10.1093/brain/awac456 · Cited by 12 · see citing works
Liu, J., Shu, Y., Wu, G., Hu, L., & Cui, H. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1321660 · Cited by 12 · see citing works
Li, Y., Yu, Y., Yin, Y., Hu, X., & Wu, S. (2023) · ALPHA PSYCHIATRY · doi:10.5152/alphapsychiatry.2023.231191 · Cited by 8 · see citing works
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Hu, Y., Shi, J.-Y., Xia, G., Liu, L.-F., Li, P., Shan, Q., & Wang, Y. (2024) · Sleep And Breathing · doi:10.1007/s11325-024-03064-7 · Cited by 9 · see citing works
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Yang, J., Hellerstein, D. J., Chen, Y., McGrath, P. J., Stewart, J. W., Liu, Z., Peterson, B. S., & Wang, Z. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.12.009 · Cited by 6 · see citing works
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Habenula contributions to negative self-cognitions
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Lin, W., Yu, L., Xu, H., Xiao, X., Xia, Z., Dou, Z., Hu, D., He, Y., Yang, L., Yang, J., et al. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01236-5 · Cited by 3 · see citing works
Wu, D., Yu, Y., Wang, H., Zhang, J., You, J., Kai, Y., Zhao, Y., Wu, Y., Wang, K., & Tian, Y. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.01.066 · Cited by 3 · see citing works
Neurobiological Approach to Stress
Tafet, G. E. (2022) · Springer eBooks · doi:10.1007/978-3-031-00864-1_2 · Cited by 3 · see citing works
Jeong, Y., & Noh, J. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114983 · Cited by 3 · see citing works
Herrera, M. L., Rubio, N. G., Quintanilla, J. P., Huerta, V. M., Osorio-Forero, A., Molano, M. A. C., Corredor, K., Valderrama, M. A., & Cárdenas, F. P. (2018) · Acta Colombiana de Psicología · doi:10.14718/acp.2017.21.2.10 · Cited by 2 · see citing works
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Rolls, E. T. (2024) · Springer eBooks · doi:10.1007/978-3-031-38391-5_11 · Cited by 2 · see citing works
Hagen, C. W., Ogállar, P. M., Guarino, S., & Papini, M. R. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114114 · Cited by 2 · see citing works
Wilkie, L., Fisher, Z., Kemp, A. H., Charles, S., & Fletcher, J. (2025) · International Journal of Science Education Part B · doi:10.1080/21548455.2025.2556047 · Cited by 1 · see citing works
The Habenula in Mood Disorders: A Scoping Review of Human StudiesPreprint
Fortin, J., Lafleur, M., Parisien, C., & Hétu, S. (2024) · doi:10.31234/osf.io/2jgvx
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Tafet, G. E. (2024) · Springer eBooks · doi:10.1007/978-3-031-58285-1_2
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Jones, R. E., Sands, L. P., Trattner, J. D., Jiang, A., Johnson, C. K., Gligorovic, P. V., Douglas, H. E., Ramos, R., & Kishida, K. T. (2024) · medRxiv · doi:10.1101/2024.10.02.24314373
Multisystem regulation of reward and addiction: beyond the dopaminergic system
Arias-Carrión, Ó., Ortega‐Robles, E., Treviño, M., Guerra‐Crespo, M., Manjarrez, E., & Pöppel, E. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1840096
- Authors
- Rolls, E. T.
- Affiliations
- University of Warwick (GB)
- Corresponding author
- Rolls, Edmund T.
- ORCID
- Rolls, Edmund T.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 75
- Pages
- 331-334
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2587817646
- Cited by
- 62
- References
- 30
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 5
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- orbitofrontal cortex, habenula, depression, serotonergic neurons, dopaminergic neurons, reward prediction error, rostromedial tegmental nucleus, raphe nuclei, striatum, globus pallidus, amygdala, antidepressant mechanism, limbic system
- MeSH terms
- Depression, Dopamine, Humans, Reward, Serotonin, Prefrontal Cortex, Habenula, Dopaminergic Neurons
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