Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: A possible role in homeostatic synaptic plasticity

Takács, Eszter; Nyilas, Rita; Szepesi, Zsuzsanna; Baracskay, Péter; Karlsen, Bente; Røsvold, Tina; Bjørkum, Alvhild A.; Czurkó, András; Kovács, Zsolt; Kékesi, Adrienna K.; Juhász, Gábor

doi:10.1016/j.neuint.2010.03.003

Cited by 63Epilepsy research and treatmentProtease and Inhibitor MechanismsNeuroscience and Neuropharmacology Research

Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: A possible role in homeostatic synaptic plasticity

Takács, Eszter, Nyilas, Rita, Szepesi, Zsuzsanna, Baracskay, Péter, Karlsen, Bente, Røsvold, Tina, Bjørkum, Alvhild A., Czurkó, András +3 more·2010·Neurochemistry International

DOI 10.1016/j.neuint.2010.03.003

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Abstract

Matrix metalloproteases (MMPs) degrade or modify extracellular matrix or membrane-bound proteins in the brain. MMP-2 and MMP-9 are activated by treatments that result in a sustained neuronal depolarization and are thought to contribute to neuronal death and structural remodeling. At the synapse, MMP actions on extracellular proteins contribute to changes in synaptic efficacy during learning paradigms. They are also activated during epileptic seizures, and MMP-9 has been associated with the establishment of aberrant synaptic connections after neuronal death induced by kainate treatment. It remains unclear whether MMPs are activated by epileptic activities that do not induce cell death. Here we examine this point in two animal models of epilepsy that do not involve extensive cell damage. We detected an elevation of MMP-9 enzymatic activity in cortical regions of secondary generalization after focal seizures induced by 4-aminopyridine (4-AP) application in rats. Pro-MMP-9 levels were also higher in Wistar Glaxo Rijswijk (WAG/Rij) rats, a genetic model of generalized absence epilepsy, than they were in Sprague-Dawley rats, and this elevation was correlated with diurnally occurring spike-wave-discharges in WAG/Rij rats. The increased enzymatic activity of MMP-9 in these two different epilepsy models is associated with synchronized neuronal activity that does not induce widespread cell death. In these epilepsy models MMP-9 induction may therefore be associated with functions such as homeostatic synaptic plasticity rather than neuronal death.

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Heightened MMP activity has been reported in other models of epilepsy, with elevated MMP level associated with epileptiform activity.
“While we suggest a pivotal role for the MMP activity in glioma-associated epilepsy, heightened MMP activity has also been reported in other models of epilepsy46 with elevated MMP level being associated with epileptiform activity47–50.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [50]

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Authors: Takács, E., Nyilas, R., Szepesi, Z., Baracskay, P., Karlsen, B., Røsvold, T., Bjørkum, A. A., Czurkó, A., Kovács, Z., Kékesi, A. K., & Juhász, G.
Affiliations: Eötvös Loránd University (HU)
Høgskolen i Bergen (NO)
University of Sopron (HU)
Corresponding author: Takács, Eszter
ORCID: Nyilas, Rita
Bjørkum, Alvhild A.
Czurkó, András
Kovács, Zsolt
Juhász, Gábor
Venue: Neurochemistry International
Publisher: Elsevier BV
Published: 2010-05
Volume: 56
Issue: 6-7
Pages: 799-809
ISSN: 0197-0186 (ISSN-L)
DOI: 10.1016/j.neuint.2010.03.003
OpenAlex: W1964178903
Cited by: 63
References: 103
Citations by year: 2026: 2 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 3 · 2012: 8
FWCI: 5.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurochemistry International (publishedVersion)
PubMed (publishedVersion)
Funders: Nemzeti Kutatási és Technológiai Hivatal
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: MMP-9, epileptic seizures, homeostatic plasticity, 4-aminopyridine-induced seizures, WAG/Rij rats, spike-wave discharges, secondary generalization, focal seizures, extracellular matrix remodeling, neuronal depolarization
MeSH terms: Animals, Behavior, Animal, Disease Models, Animal, Electroencephalography, Epilepsy, Frontal Lobe, Homeostasis, Male, Neuronal Plasticity, Neurons, Parietal Lobe, Synapses, Thalamus, 4-Aminopyridine, Cell Death, Rats, Sprague-Dawley, Rats, Wistar, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Potassium Channel Blockers, Rats

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Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: A possible role in homeostatic synaptic plasticity

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