Inhibition of matrix metalloproteinases prevents the potentiation of nondeprived-eye responses after monocular deprivation in juvenile rats
Abstract
The ocular dominance (OD) shift induced by monocular deprivation (MD) during the critical period is mediated by an initial depression of deprived-eye responses followed by an increased responsiveness to the nondeprived eye. It is not fully clear to what extent these 2 events are correlated and which are their physiological and molecular mediators. The extracellular synaptic environment plays an important role in regulating visual cortical plasticity. Matrix metalloproteinases (MMPs) are a family of activity-dependent zinc-dependent extracellular endopeptidases mediating extracellular matrix remodeling. We investigated the effects of MMP inhibition on OD plasticity in juvenile monocularly deprived rats. By using electrophysiological recordings, we found that MMP inhibition selectively prevented the potentiation of neuronal responses to nondeprived-eye stimulation occurring after 7 days of MD and potentiation of deprived-eye responses occurring after eye reopening. Three days of MD only resulted in a depression of deprived-eye responses insensitive to MMP inhibition. MMP inhibition did not influence homeostatic plasticity tested in the monocular cortex but significantly prevented an increase in dendritic spine density present after 7 days MD in layer II-III pyramids.
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In Mmp9−/− mice, there is no increase in the strength of the non-deprived input following monocular deprivation.
“However, we did not observe an increase in the strength of the non-deprived input in Mmp9−/− mice, consistent with previous reports (Spolidoro et al., 2012; Kelly et al., 2015; Pielecka-Fortuna et al., 2015)”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Spolidoro et al., 2012
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- Authors
- Spolidoro, M., Putignano, E., Munafò, C., Maffei, L., & Pizzorusso, T.
- Affiliations
- Neuroscience Institute (IT)
- Scuola Normale Superiore (IT)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-17
- Volume
- 22
- Issue
- 3
- Pages
- 725-734
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2132531370
- Cited by
- 58
- References
- 65
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 9 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 8 · 2013: 1 · 2012: 2
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Scuola Normale Superiore di Pisa (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- matrix metalloproteinases, monocular deprivation, ocular dominance, critical period, visual cortical plasticity, dendritic spine density, extracellular matrix remodeling, homeostatic plasticity, young rats
- MeSH terms
- Animals, Dipeptides, Enzyme Inhibitors, Evoked Potentials, Visual, Neural Inhibition, Neuronal Plasticity, Photic Stimulation, Visual Cortex, Rats, Long-Evans, Amaurosis Fugax, Matrix Metalloproteinases, Rats, Matrix Metalloproteinase Inhibitors
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