Cited by 109Curcumin's Biomedical ApplicationsNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Curcumin Inhibits Aβ-Induced Microglial Inflammatory Responses In Vitro: Involvement of ERK1/2 and P38 Signaling Pathways

Shi, Xiaolei, Zheng, Zhenyang, Li, Jie, Xiao, Zijian, Qi, Weiwei, Zhang, Aiwu, Wu, Qi, Fang, Yannan·2015·Neuroscience Letters

Abstract

Amyloid β (Aβ) plays an important role in Alzheimer's disease (AD) by inducing microglia activation. Once activated, microglial cells promote the release of reactive species and cytokines that are known to enhance immune responses in AD brain. Thus, negative regulators of microglia activation are considered as potential therapeutic candidates for AD. Curcumin, the major yellow pigment in turmeric (Curcuma longa), is proposed for its anti-inflammatory properties. Several studies have indicated the suppressive effects of curcumin on LPS-induced microglia activation and MAPK activities. However, the effects of curcumin on Aβ-treated microglia and the possible mechanisms are still not fully understood. In the present study, we found that curcumin improved microglial viability against Aβ42 in a time- and dose-dependent manner and remarkably suppressed Aβ42-induced CD68 expression. Moreover, curcumin concentration-dependently abolished Aβ42-induced interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) production in mRNA and protein levels in microglia. Besides, curcumin exerted an inhibitory effect on phosphorylation of ERK1/2 and p38 in Aβ42-activated microglia. Further experiments indicated that blockage of ERK1/2 and p38 pathways reduced inflammatory cytokines production from microglia. These results show that curcumin suppresses ERK1/2 and p38 signaling, thus, attenuating inflammatory responses of brain microglia.

Integrity signals

Registry

Crossref · 10.1016/j.neulet.2015.03.045

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Shi, X., Zheng, Z., Li, J., Xiao, Z., Qi, W., Zhang, A., Wu, Q., & Fang, Y.
Affiliations
Sun Yat-sen University (CN)
Corresponding author
  • Wu, Qi
  • Fang, Yannan
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2015-05
Volume
594
Pages
105-110
ISSN
0304-3940 (ISSN-L)
OpenAlex
W2000667575
Cited by
108
References
24
Citations by year
2026: 3 · 2025: 11 · 2024: 7 · 2023: 11 · 2022: 14 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 12 · 2016: 9 · 2015: 3
FWCI
4.94
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Sun Yat-sen University
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
curcumin, amyloid-beta, amyloid-beta 42, microglial activation, neuroinflammation, Alzheimer's disease, ERK signaling, p38 MAPK, inflammatory cytokines, CD68, anti-inflammatory activity
MeSH terms
Animals, Animals, Newborn, Anti-Inflammatory Agents, Cells, Cultured, Curcumin, Mice, Inbred BALB C, Peptide Fragments, Phosphorylation, RNA, Messenger, Tumor Necrosis Factor-alpha, Interleukin-6, Amyloid beta-Peptides, Microglia, Mitogen-Activated Protein Kinase 1, MAP Kinase Signaling System, p38 Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review