Neural Responsivity to Food Cues in Fasted and Fed States Pre and Post Gastric Bypass Surgery
Open accessAbstract
Reductions in mesolimbic responsivity have been noted following Roux-en-Y gastric bypass (RYGB; Ochner et al., 2011a). Given potential for postoperative increases in postprandial gut (satiety) peptides to affect mesolimbic neural responsivity, we hypothesized that: (1) post RYGB changes in mesolimbic responsivity would be greater in the fed relative to the fasted state and; (2) fasted vs. fed state differences in mesolimbic responsivity would be greater post-relative to pre-surgery. fMRI was used to asses neural responsivity to high- and low-calorie food cues in five women 1 mo pre- and 1 mo post-RYGB. Scans were repeated in fasted and fed states. Significant post RYGB decreases in the insula, ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) responsivity were found in the fasted state. These changes were larger than neural changes in the fed state, which were non-significant. Preoperatively, fasted vs. fed differences in neural responsivity were greater in the precuneus, with large but nonsignificant clusters in the vmPFC and dlPFC. Postoperatively, however, no fasted vs. fed differences in neural responsivity were noted. Results were opposite to that predicted and appear inconsistent with the initial hypothesis that postoperative increases in postprandial gut peptides are the primary driver of postoperative changes in neural responsivity.
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After bariatric surgery, foods that are highly palatable and energy dense are most impacted by these neurobiological changes, which, in turn, decrease food intake.
“After having bariatric surgery, foods that are highly palatable and energy dense are most impacted by these neurobiological changes, which, in turn, decrease food intake (56–59).”
From Behavioral Interventions to Attenuate Driven Overeating and Weight Regain After Bariatric Surgery (2022) · cites this paper as [57]
The Results (fasted-state pre- to post-operative change; page not provided) report greater postoperative reductions in neural responses to high- versus low-calorie food cues. The Introduction describes a possible link between neural responses and food intake, but this study does not establish that the neural changes decreased food intake. (LLM, conf=0.86)
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- Authors
- Ochner, C. N., Laferrère, B., Afifi, L., Atalayer, D., Geliebter, A., & Teixeira, J.
- Affiliations
- St. Luke's-Roosevelt Hospital Center (US)
- Corresponding author
- Ochner, Christopher N.
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 74
- Issue
- 2
- Pages
- 138-143
- ISSN
- 0168-0102 (ISSN-L)
- PMC
- PMC3626459
- OpenAlex
- W2062512115
- Cited by
- 80
- References
- 27
- Citations by year
- 2024: 2 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 4 · 2015: 10 · 2014: 8 · 2013: 9
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK080153, R01DK080153, P30DK026687)
- National Center for Research Resources (KL2RR024157)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- Roux-en-Y gastric bypass, food cues, satiety peptides, insula, ventromedial prefrontal cortex, dorsolateral prefrontal cortex, precuneus, bariatric surgery, obesity
- MeSH terms
- Acoustic Stimulation, Adult, Appetite, Energy Intake, Cerebral Cortex, Corpus Striatum, Cues, Fasting, Feeding Behavior, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Models, Neurological, Models, Psychological, Obesity, Morbid, Peptide Fragments, Photic Stimulation, Postoperative Period, Reward, Satiety Response, Gastric Bypass, Prefrontal Cortex, Postprandial Period, Peptide YY, Glucagon-Like Peptide 1, Young Adult
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