Weight Gain Is Associated with Reduced Striatal Response to Palatable Food
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Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors and show less striatal response to palatable food intake. Low striatal response to food intake predicts future weight gain in those at genetic risk for reduced signaling of dopamine-based reward circuitry. Yet animal studies indicate that intake of palatable food results in downregulation of D2 receptors, reduced D2 sensitivity, and decreased reward sensitivity, implying that overeating may contribute to reduced striatal responsivity. Thus, we tested whether overeating leads to reduced striatal responsivity to palatable food intake in humans using repeated-measures functional magnetic resonance imaging. Results indicated that women who gained weight over a 6 month period showed a reduction in striatal response to palatable food consumption relative to weight-stable women. Collectively, results suggest that low sensitivity of reward circuitry increases risk for overeating and that this overeating may further attenuate responsivity of reward circuitry in a feedforward process.
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In humans, weight gain over six months is predicted by a reduction in striatal response to palatable food consumption over the same period.
“In humans, weight gain over a six-month period is predicted by a reduction in striatal response to palatable food consumption over this same time period.182”
From Early life adversity and health-risk behaviors: Proposed psychological and neural mechanisms (2018) · cites this paper as [182]
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- Authors
- Stice, E., Yokum, S., Blum, K., & Bohon, C.
- Affiliations
- The University of Texas at Austin (US)
- University of Florida (US)
- University of California, Los Angeles (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-09-29
- Volume
- 30
- Issue
- 39
- Pages
- 13105-13109
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2967483
- OpenAlex
- W1967830372
- Cited by
- 401
- References
- 35
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 9 · 2023: 13 · 2022: 17 · 2021: 25 · 2020: 22 · 2019: 22 · 2018: 30 · 2017: 33 · 2016: 27 · 2015: 37 · 2014: 35 · 2013: 31 · 2012: 39
- FWCI
- 13.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R1MH64560A, R01MH064560)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK080760, R01DK080760)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- weight gain, striatum, dopamine D2 receptor, reward systems, palatable food, overeating, obesity, dopamine sensitivity, food reward, women
- MeSH terms
- Appetite Regulation, Appetitive Behavior, Brain Mapping, Corpus Striatum, Female, Humans, Hyperphagia, Magnetic Resonance Imaging, Neural Inhibition, Neuropsychological Tests, Obesity, Prospective Studies, Reward, Weight Gain, Young Adult
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