Cited by 90Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

Quantitative structural MRI for early detection of Alzheimer's disease

Open access
McEvoy, Linda K, Brewer, James B·2010·Expert Review of Neurotherapeutics

Abstract

Alzheimer's disease (AD) is a common progressive neurodegenerative disorder that is not currently diagnosed until a patient reaches the stage of dementia. There is a pressing need to identify AD at an earlier stage, so that treatment, when available, can begin early. Quantitative structural MRI is sensitive to the neurodegeneration that occurs in mild and preclinical AD, and is predictive of decline to dementia in individuals with mild cognitive impairment. Objective evidence of ongoing brain atrophy will be critical for risk/benefit decisions once potentially aggressive, disease-modifying treatments become available. Recent advances have paved the way for the use of quantitative structural MRI in clinical practice, and initial clinical use has been promising. However, further experience with these measures in the relatively unselected patient populations seen in clinical practice is needed to complete translation of the recent enormous advances in scientific knowledge of AD into the clinical realm.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1586/ern.10.162

Cites

141 of 142 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
McEvoy, L. K., & Brewer, J. B.
Affiliations
  • University of California San Diego (US)
  • University of California System (US)
Venue
Expert Review of Neurotherapeutics
Published
2010-11
Volume
10
Issue
11
Pages
1675-1688
ISSN
  • 1473-7175 (ISSN-L)
  • 1744-8360
OpenAlex
W2002277005
Cited by
90
References
138
Citations by year
2026: 8 · 2025: 15 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 2 · 2019: 10 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 5
FWCI
0.54
Type
journal article
Language
en
Open access
Locations
  • Expert Review of Neurotherapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (K01AG029218)
  • National Institute of Neurological Disorders and Stroke (K02NS067427)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
Alzheimer's disease, early detection, preclinical Alzheimer's disease, mild cognitive impairment, brain atrophy, neurodegeneration, disease-modifying therapy, clinical translation
MeSH terms
Alzheimer Disease, Brain, Cognition Disorders, Humans, Magnetic Resonance Imaging, Disease Progression, Early Diagnosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review