Not only cardiovascular, but also coordinative exercise increases hippocampal volume in older adults.
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Cardiovascular activity has been shown to be positively associated with gray and white matter volume of, amongst others, frontal and temporal brain regions in older adults. This is particularly true for the hippocampus, a brain structure that plays an important role in learning and memory, and whose decline has been related to the development of Alzheimer's disease. In the current study, we were interested in whether not only cardiovascular activity but also other types of physical activity, i.e., coordination training, were also positively associated with the volume of the hippocampus in older adults. For this purpose we first collected cross-sectional data on "metabolic fitness" (cardiovascular fitness and muscular strength) and "motor fitness" (e.g., balance, movement speed, fine coordination). Second, we performed a 12-month randomized controlled trial. Results revealed that motor fitness but not metabolic fitness was associated with hippocampal volume. After the 12-month intervention period, both, cardiovascular and coordination training led to increases in hippocampal volume. Our findings suggest that a high motor fitness level as well as different types of physical activity were beneficial to diminish age-related hippocampal volume shrinkage or even increase hippocampal volume.
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Randomized controlled trials in healthy samples have demonstrated that aerobic exercise interventions were associated with increases in hippocampal volume in older adults.
“RCTs in healthy samples have demonstrated that AE interventions were associated with increases in hippocampal volume in young and middle aged (Thomas et al., 2016) and older adults (Colcombe et al., 2006; Erickson et al., 2011; Niemann et al., 2014; Kleemeyer et al., 2015; Maass et al., 2015; Sexton et al., 2015a).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Niemann et al., 2014
Discrepancies in aerobic exercise effects on hippocampal volume may be caused by a lack of consistency in aerobic exercise protocols used or in methods of calculating hippocampal volume.
“While some RCTs have found that AE did not have an impact on hippocampal volume (Ruscheweyh et al., 2011; Scheewe et al., 2013; Krogh et al., 2014; Rosenbaum et al., 2015; Malchow et al., 2016), it is possible that such discrepancies are caused by a lack of consistency in AE protocols used (Prakash et al., 2015) or in the methods of calculating hippocampal volume (Niemann et al., 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Niemann et al., 2014
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- Authors
- Niemann, C., Godde, B., & Voelcker-Rehage, C.
- Affiliations
- Constructor University (DE)
- ORCID
- Godde, Ben
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-08-04
- Volume
- 6
- Pages
- 170-170
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC4131191
- OpenAlex
- W2153307757
- Cited by
- 190
- References
- 76
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 14 · 2023: 16 · 2022: 15 · 2021: 21 · 2020: 19 · 2019: 19 · 2018: 17 · 2017: 24 · 2016: 18 · 2015: 13
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Robert Bosch Stiftung (12.5.1366.0005.0)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampal volume, older adults, coordination training, cardiorespiratory fitness, motor fitness, physical activity, brain aging, Alzheimer's disease, cognitive aging, balance, muscle strength
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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