Cited by 264Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsFunctional Brain Connectivity Studies

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Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans

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Hua, Xue, Hibar, Derrek P., Lee, Suh, Toga, Arthur W., Jack, Clifford R., Weiner, Michael W., Thompson, Paul M.·2010·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2010.04.033PMC PMC2927200

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Abstract

We set out to determine factors that influence the rate of brain atrophy in 1-year longitudinal magnetic resonance imaging (MRI) data. With tensor-based morphometry (TBM), we mapped the 3-dimensional profile of progressive atrophy in 144 subjects with probable Alzheimer's disease (AD) (age: 76.5 +/- 7.4 years), 338 with amnestic mild cognitive impairment (MCI; 76.0 +/- 7.2), and 202 healthy controls (77.0 +/- 5.1), scanned twice, 1 year apart. Statistical maps revealed significant age and sex differences in atrophic rates. Brain atrophic rates were about 1%-1.5% faster in women than men. Atrophy was faster in younger than older subjects, most prominently in mild cognitive impairment, with a 1% increase in the rates of atrophy and 2% in ventricular expansion, for every 10-year decrease in age. TBM-derived atrophic rates correlated with reduced beta-amyloid and elevated tau levels (n = 363) at baseline, baseline and progressive deterioration in clinical measures, and increasing numbers of risk alleles for the ApoE4 gene. TBM is a sensitive, high-throughput biomarker for tracking disease progression in large imaging studies; sub-analyses focusing on women or younger subjects gave improved sample size requirements for clinical trials.

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Authors: Hua, X., Hibar, D. P., Lee, S., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M.
Affiliations: University of California, Los Angeles (US)
Mayo Clinic (US)
San Francisco VA Medical Center (US)
Corresponding author: Thompson, Paul M.
ORCID: Hua, Xue
Lee, Suh
Toga, Arthur W.
Jack, Clifford R.
Weiner, Michael W.
Thompson, Paul M.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2010-08
Volume: 31
Issue: 8
Pages: 1463-1480
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2010.04.033
PMC: PMC2927200
OpenAlex: W2103030628
Cited by: 234
References: 153
Citations by year: 2026: 13 · 2025: 12 · 2024: 40 · 2023: 21 · 2022: 20 · 2021: 23 · 2020: 15 · 2019: 12 · 2018: 19 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 3 · 2013: 12 · 2012: 3
FWCI: 5.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Dana Foundation
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD050735)
National Institutes of Health (K01 AG030514, P30 AG010129, U54-RR021813)
National Institute of Biomedical Imaging and Bioengineering (R01 EB007813, R01 EB008281, R01 EB008432)
National Institute on Aging (R01 AG020098)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: brain atrophy rate, sex differences, age differences, Alzheimer's disease, amnestic mild cognitive impairment, ventriculomegaly, amyloid-beta, tau protein, APOE ε4, disease progression biomarkers
MeSH terms: Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cognition Disorders, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Sex Characteristics, Disease Progression

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Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans

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