When Mars Versus Venus is Not a Cliché: Gender Differences in the Neurobiology of Alzheimer’s Disease
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sex is a strong factor underlying phenotypic variability in AD.
“As sex is a strong factor underlying phenotypic variability in AD”
From Distinct sex-specific DNA methylation differences in Alzheimer’s disease (2022) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Alzheimer disease in the United States (2010–2050) estimated using the 2010 census
Hebert, L. E., Weuve, J., Scherr, P. A., & Evans, D. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31828726f5 · Cited by 2,642 · see citing works
Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies
Andersen, K., Launer, L. J., Dewey, M. E., Letenneur, L., Ott, A., Copeland, J. R. M., Dartigues, J.-F., Kragh–Sorensen, P., Baldereschi, M., Brayne, C., et al. (1999) · Neurology · doi:10.1212/wnl.53.9.1992 · Cited by 650 · see citing works
Is the Risk of Developing Alzheimer's Disease Greater for Women than for Men?
Hebert, L. E., Scherr, P. A., McCann, J. J., Beckett, L. A., & Evans, D. A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.2.132 · Cited by 331 · see citing works
Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans
Hua, X., Hibar, D. P., Lee, S., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, P. M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.033 · Cited by 234 · see citing works
Higher Rates of Decline for Women and <i>Apolipoprotein E</i> ε4 Carriers
Holland, D., Desikan, R. S., Dale, A. M., & McEvoy, L. K. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3601 · Cited by 219 · see citing works
Gender, cognitive decline, and risk of AD in older persons
Barnes, L. L., Wilson, R. S., Schneider, J. A., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2003) · Neurology · doi:10.1212/01.wnl.0000065892.67099.2a · Cited by 173 · see citing works
Flagged first, then by citations
Research works printed but not linked: 18
- [2]Alzheimer’s Association. 2014 Alzheimer’s disease facts and figures. Alzheimers Dement (2014) 10(2): e47– 92. 24818261
- [5]Farrer LA Cupples LA Haines JL Hyman B Kukull WA Mayeux R Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis: APOE and Alzheimer disease meta analysis consortium. JAMA (1997) 278: 16. 10.1001/jama.1997.03550160069041 9343467 · DOI · Paper page
- [6]Seshadri S Wolf PA Beiser A Au R McNulty K White R Lifetime risk of dementia and Alzheimer’s disease. The impact of mortality on risk estimates in the Framingham Study. Neurology (1997) 49: 6. 10.1212/WNL.49.6.1498 9409336 · DOI · Paper page
- [8]Plassman BL Langa KM McCammon RJ Fisher GG Potter GG Burke JR Incidence of dementia and cognitive impairment, not dementia in the United States. Ann Neurol (2011) 70: 3. 10.1002/ana.22362 21425187 PMC3139807 · DOI
- [9]Irvine K Laws KR Gale TM Kondel TK. Greater cognitive deterioration in women than men with Alzheimer’s disease: a meta analysis. J Clin Exp Neuropsychol (2012) 34: 9. 10.1080/13803395.2012.712676 22913619 · DOI · Paper page
- [12]Barnes LL Wilson RS Bienias JL Schneider JA Evans DA Bennett DA. Sex differences in the clinical manifestations of Alzheimer disease pathology. Arch Gen Psychiatry (2005) 62: 6. 10.1001/archpsyc.62.6.685 15939846 · DOI · Paper page
- [13]Mielke MM Vemuri P Rocca WA. Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences. Clin Epidemiol (2014) 6: 37– 48. 10.2147/CLEP.S37929 24470773 PMC3891487 · DOI · Paper page
- [14]Altmann A Tian L Henderson VW Greicius MD. Sex modifies the APOE-related risk of developing Alzheimer’s disease. Ann Neurol (2014) 75: 4. 10.1002/ana.24135 24623176 PMC4117990 · DOI · Paper page
- [15]Damolseaux JS Seeley WW Zhou J Shirer WR Coppola G Karydas A Gender modulates the APOE4 effect in healthy older adults: convergent evidence from functional brain connectivity and spinal fluid tau levels. J Neurosci (2012) 32: 24. 10.1523/JNEUROSCI.0305-12.2012 22699906 PMC3394933 · DOI · Paper page
- [16]Spremo-Potparevic B Zivkovic L Djelic N Bajic V. Analysis of premature centromere division (PCD) of the X chromosome in Alzheimer patients through the cell cycle. Exp Gerontol (2004) 39: 5. 10.1016/j.exger.2004.01.012 15130680 · DOI
- [17]Bajic V Spremo-Potparevic B Zivkovic L Siedlak SL Casadeus G Smith MA. The X-chromosome instability phenotype in Alzheimer’s disease: a clinical sign of accelerating aging? Med Hypotheses (2009) 73: 6. 10.1016/j.mehy.2009.06.046 19647374 PMC2787990 · DOI
- [18]Yurov YB Vorsanova SG Liehr T Kolotii AD Iourov IY. X chromosome aneuploidy in the Alzheimer’s disease brain. Mol Cytogenet (2014) 7: 20. 10.1186/1755-8166-7-20 24602248 PMC3995993 · DOI
- [19]Ferrari R Dawoodi S Raju M Thumma A Hynan LS Maasumi SH Androgen receptor gene and gender specific Alzheimer’s disease. Neurobiol Aging (2013) 34: 8. 10.1016/j.neurobiolaging.2013.02.017 23545426 PMC4012749 · DOI
- [20]Swingland JT Durrenberger PF Reynolds R Dexter DT Pombo A Deprez M Mean expression of the X-chromosome is associated with neuronal density. Front Neurosci (2012) 6: 161. 10.3389/fnins.2012.00161 23162423 PMC3495263 · DOI
- [21]Janicki SC Park N Cheng R Lee JH Schupf N Clark LN. Estrogen receptor variants modify risk for Alzheimer’s disease in a multiethnic female cohort. J Alzheimers Dis (2014) 40: 1. 10.3233/JAD-130551 24326520 · DOI · Paper page
- [22]Barron AM Pike CJ. Sex hormones, aging, and Alzheimer disease. Front Biosci (Elite Ed) (2013) 4: 976– 97. 22201929 PMC3511049
- [23]Shumaker SA Legault C Rapp SR Thal L Wallace RB Ockene JK Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women. The Women’s Health Initiative Memory Study: a randomized control trial. JAMA (2003) 289: 20 10.1001/jama.289.20.2651 12771112 · DOI · Paper page
- [24]Coker LH Espeland MA Hogan PE. Change in brain and lesion volumes after CEE therapies: the WHIMS-MRI studies. Neurology (2014) 82: 5. 10.1212/WNL.0000000000000079 24384646 PMC3917682 · DOI
Cited by
Sorted by citations
Distinct sex-specific DNA methylation differences in Alzheimer’s disease
C. Silva, T., Zhang, W., Young, J. I., Gomez, L., Schmidt, M. A., Varma, A., Chen, X. S., Martin, E. R., & Wang, L. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-01070-z · Cited by 33 · see citing works
- Authors
- Lin, K. A., & Doraiswamy, P. M.
- Affiliations
- Duke University (US)
- Corresponding author
- Lin, Katherine Amy
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2015-01-12
- Volume
- 5
- Pages
- 288-288
- ISSN
- 1664-2295 (ISSN-L)
- PMC
- PMC4290582
- OpenAlex
- W2065286189
- Cited by
- 42
- References
- 6
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 9 · 2015: 4
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Keywords
- Alzheimer's disease, sex differences, gender differences, neurobiology, neurodegeneration, sex hormones
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
