Cited by 135Dementia and Cognitive Impairment ResearchAging and Gerontology ResearchNeurological Disease Mechanisms and Treatments

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A review of the structural alterations in the cerebral hemispheres of the aging rhesus monkey

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Peters, Alan, Kemper, Thomas·2012·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2011.11.015PMC PMC3337968

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Abstract

Like humans, rhesus monkeys show cognitive decline and this review considers what structural age-related changes underlie this decline. Some structural measures do not alter significantly with age. These include brain weight, overall cortical thickness; numbers of cortical neurons; and numbers of astrocytes and microglial cells. Other structural measures change with age, but the change does not correlate with cognitive decline. These changes include nerve fiber loss from some fiber tracts, degeneration, and regeneration of myelin sheaths, and increase in the frequency of oligodendrocytes. Among the structural measures that increase in frequency with age and also correlate with cognitive decline are the increased frequency of degenerating myelin sheaths and a loss of nerve fibers from some fiber tracts; and the loss of synapses and dendritic spines from upper layers of prefrontal cortex. Consequently, the existing data suggest that cognitive decline correlates with changes in myelinated nerve fibers and with disconnections between and within cortical areas, as reflected by the age-related loss of synapses and of dendritic spines from some cortical areas.

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Authors: Peters, A., & Kemper, T.
Affiliations: Boston University (US)
Corresponding author: Peters, Alan
ORCID: Peters, Alan
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2012-10
Volume: 33
Issue: 10
Pages: 2357-2372
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2011.11.015
PMC: PMC3337968
OpenAlex: W2083634530
Cited by: 135
References: 96
Citations by year: 2026: 6 · 2025: 7 · 2024: 10 · 2023: 14 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 6 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 15 · 2013: 10 · 2012: 9
FWCI: 1.42
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health/ National Aging Institute (5P01 AG 000001 2)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: aging, rhesus monkeys, cognitive decline, cerebral hemispheres, myelinated axons, myelin degeneration, synaptic loss, dendritic spines, prefrontal cortex, cortical disconnection, oligodendrocytes, astrocytes, microglia, cortical neurons, cortical thickness
MeSH terms: Aging, Animals, Cognition Disorders, Female, Macaca mulatta, Male, Monkey Diseases, Myelin Sheath, Nerve Degeneration, Neuroglia, Neurons, Cerebrum

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A review of the structural alterations in the cerebral hemispheres of the aging rhesus monkey

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