CoChat
Sign Up
Cited by 41

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging

Sepe, Sara, Nardacci, Roberta, Fanelli, Francesca, Rosso, Pamela, Bernardi, Cinzia, Cecconi, Francesco, Mastroberardino, Pier G., Piacentini, Mauro, Moreno, Sandra·2014·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2013.07.001
Open this paper in CoChat — free account

Abstract

Autophagy is a major protein degradation pathway, essential for stress-induced and constitutive protein turnover. In nervous tissue, autophagy is constitutively active and crucial to neuronal survival. The efficiency of the autophagic pathway reportedly undergoes age-related decline, and autophagy defects are observed in neurodegenerative diseases. Since Ambra1 plays a fundamental role in regulating the autophagic process in developing nervous tissue, we investigated the expression of this protein in mature mouse brain and during physiological and Alzheimer type aging. The present study accomplished the first complete map of Ambra1 protein distribution in the various brain areas, and highlights differential expression in neuronal/glial cell populations. Differences in Ambra1 content are possibly related to specific neuronal features and properties, particularly concerning susceptibility to neurodegeneration. Furthermore, the analysis of Ambra1 expression in physiological and pathological brain aging supports important, though conflicting, functions of autophagy in neurodegenerative processes. Thus, novel therapeutic approaches, based on autophagy modulation, should also take into account the age-dependent roles of this mechanism in establishing, promoting, or counteracting neurodegeneration.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.neurobiolaging.2013.07.001

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 7 references

Research works printed but not linked: 61

  1. Aggleton, 2011, Unraveling the contributions of the diencephalon to recognition memory: a review, Learn. Mem., 18, 384, 10.1101/lm.1884611 · DOI
  2. Baltanás, 2011, Nucleolar disruption and Cajal body disassembly are nuclear hallmarks of DNA damage-induced neurodegeneration in purkinje cells, Brain Pathol., 21, 374, 10.1111/j.1750-3639.2010.00461.x · DOI
  3. Bolland, 2006, Neuronal macroautophagy: from development to degeneration, Mol. Aspects Med., 27, 503, 10.1016/j.mam.2006.08.009 · DOI
  4. Bonfanti, 2011, Adult neurogenesis in mammals—a theme with many variations, Eur. J. Neurosci., 34, 930, 10.1111/j.1460-9568.2011.07832.x · DOI
  5. Caballero, 2012, An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain, Histol. Histopathol., 27, 263
  6. Cecconi, 2008, The involvement of cell death and survival in neural tube defects: a distinct role for apoptosis and autophagy?, Cell Death Differ., 15, 1170, 10.1038/cdd.2008.64 · DOI
  7. Cepeda, 2007, The corticostriatal pathway in Huntington's disease, Prog. Neurobiol., 81, 253, 10.1016/j.pneurobio.2006.11.001 · DOI
  8. Cheng, 2011, Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy, J. Neurosci., 31, 2125, 10.1523/JNEUROSCI.5519-10.2011 · DOI
  9. Cheung, 2009, The emerging role of autophagy in Parkinson's disease, Mol. Brain, 2, 29, 10.1186/1756-6606-2-29 · DOI
  10. Cheung, 2011, Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives, J. Neurochem., 118, 317, 10.1111/j.1471-4159.2011.07314.x · DOI
  11. Choi, 2013, Autophagy in human health and disease, N. Engl. J. Med., 368, 651, 10.1056/NEJMra1205406 · DOI · Paper page
  12. Cimini, 2009, Early biochemical and morphological modifications in the brain of a transgenic mouse model of Alzheimer's disease: a role for peroxisomes, J. Alzheimers Dis., 18, 935, 10.3233/JAD-2009-1199 · DOI
  13. D'Amelio, 2011, Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease, Nat. Neurosci., 14, 69, 10.1038/nn.2709 · DOI · Paper page
  14. Di Bartolomeo, 2010, The dynamic interaction of Ambra1 with the dynein motor complex regulates mammalian autophagy, J. Cell Biol., 191, 155, 10.1083/jcb.201002100 · DOI
  15. Dringen, 1999, The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells, J. Neurochem., 72, 2523, 10.1046/j.1471-4159.1999.0722523.x · DOI
  16. Fernandez-Gonzalez, 2002, Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1, Science, 295, 1904, 10.1126/science.1068912 · DOI
  17. Fimia, 2007, Ambra1 regulates autophagy and development of the nervous system, Nature, 447, 1121, 10.1038/nature05925 · DOI
  18. Giannakopoulos, 2009, Pathological substrates of cognitive decline in Alzheimer's disease, Front. Neurol. Neurosci., 24, 20, 10.1159/000197881 · DOI · Paper page
  19. Ginet, 2009, Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms, Am. J. Pathol., 175, 1962, 10.2353/ajpath.2009.090463 · DOI
  20. Hamasaki, 2013, Autophagosomes form at ER-mitochondria contact sites, Nature, 495, 389, 10.1038/nature11910 · DOI · Paper page
  21. Hara, 2006, Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice, Nature, 441, 885, 10.1038/nature04724 · DOI · Paper page
  22. He, 2010, The Beclin 1 interactome, Curr. Opin. Cell Biol., 22, 140, 10.1016/j.ceb.2010.01.001 · DOI
  23. Hernandez, 2012, Regulation of presynaptic neurotransmission by macroautophagy, Neuron, 74, 277, 10.1016/j.neuron.2012.02.020 · DOI
  24. Hsiao, 1996, Correlative memory deficits, Abeta elevation and amyloid plaques in transgenic mice, Science, 274, 99, 10.1126/science.274.5284.99 · DOI · Paper page
  25. Ishibashi, 2009, Association of autophagy with cholesterol-accumulated compartments in Niemann-Pick disease type C cells, J. Clin. Neurosci., 16, 954, 10.1016/j.jocn.2008.09.020 · DOI
  26. Jacobsen, 2006, Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease, Proc. Natl. Acad. Sci. U.S.A, 103, 5161, 10.1073/pnas.0600948103 · DOI · Paper page
  27. Jaeger, 2009, All-you-can-eat: autophagy in neurodegeneration and neuroprotection, Mol. Neurodegener., 4, 16, 10.1186/1750-1326-4-16 · DOI
  28. Johnson, 2012, Modulating macroautophagy: a neuronal perspective, Future Med. Chem., 4, 1715, 10.4155/fmc.12.112 · DOI
  29. Lipinski, 2010, Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease, Proc. Natl. Acad. Sci. U.S.A, 107, 14164, 10.1073/pnas.1009485107 · DOI · Paper page
  30. Ma, 2011, Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice, Exp. Gerontol., 46, 533, 10.1016/j.exger.2011.02.006 · DOI
  31. Madeo, 2010, Can autophagy promote longevity?, Nat. Cell Biol., 12, 842, 10.1038/ncb0910-842 · DOI
  32. Majumder, 2011, Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits, PLoS One, 6, e25416, 10.1371/journal.pone.0025416 · DOI · Paper page
  33. Martone, 2000, Alterations of hippocampal postsynaptic densities following transient ischemia, Hippocampus, 10, 610, 10.1002/1098-1063(2000)10:5<610::AID-HIPO12>3.0.CO;2-E · DOI
  34. McCray, 2008, The role of autophagy in age-related neurodegeneration, Neurosignals, 16, 75, 10.1159/000109761 · DOI
  35. Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639 · DOI · Paper page
  36. Mizushima, 2011, The role of Atg proteins in autophagosome formation, Annu. Rev. Cell Dev. Biol., 27, 107, 10.1146/annurev-cellbio-092910-154005 · DOI · Paper page
  37. Niewiadomska, 2009, The septo-hippocampal system, learning and recovery of function, Prog. Neuropsychopharmacol. Biol. Psychiatry, 33, 791, 10.1016/j.pnpbp.2009.03.039 · DOI · Paper page
  38. Nixon, 2007, Autophagy, amyloidogenesis and Alzheimer disease, J. Cell Sci., 120, 4081, 10.1242/jcs.019265 · DOI · Paper page
  39. Nixon, 2011, Autophagy failure in Alzheimer's disease–locating the primary defect, Neurobiol. Dis., 43, 38, 10.1016/j.nbd.2011.01.021 · DOI · Paper page
  40. Pickford, 2008, The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice, J. Clin. Invest., 118, 2190
  41. Rubinsztein, 2011, Autophagy and aging, Cell, 146, 682, 10.1016/j.cell.2011.07.030 · DOI · Paper page
  42. Santos, 2011, Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease, J. Neurochem., 117, 927, 10.1111/j.1471-4159.2011.07262.x · DOI
  43. Sarkar, 2008, Huntington's disease: degradation of mutant huntingtin by autophagy, FEBS J., 275, 4263, 10.1111/j.1742-4658.2008.06562.x · DOI
  44. Sarna, 2003, Patterned Purkinje cell degeneration in mouse models of Niemann-Pick type C disease, J. Comp. Neurol., 456, 279, 10.1002/cne.10522 · DOI
  45. Schliebs, 2011, The cholinergic system in aging and neuronal degeneration, Behav. Brain Res., 221, 555, 10.1016/j.bbr.2010.11.058 · DOI · Paper page
  46. Shehata, 2012, Neuronal stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical long-term depression, J. Neurosci., 32, 10413, 10.1523/JNEUROSCI.4533-11.2012 · DOI · Paper page
  47. Small, 2011, A pathophysiological framework of hippocampal dysfunction in ageing and disease, Nat. Rev. Neurosci., 12, 585, 10.1038/nrn3085 · DOI
  48. Smith, 2011, Autophagy in acute brain injury: feast, famine, or folly?, Neurobiol. Dis., 43, 52, 10.1016/j.nbd.2010.09.014 · DOI
  49. Son, 2012, Neuronal autophagy and neurodegenerative diseases, Exp. Mol. Med., 44, 89, 10.3858/emm.2012.44.2.031 · DOI
  50. Strappazzon, 2011, Mitochondrial BCL-2 inhibits Ambra1-induced autophagy, EMBO J., 30, 1195, 10.1038/emboj.2011.49 · DOI
  51. Tamura, 2010, Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains, J. Histochem. Cytochem., 58, 443, 10.1369/jhc.2010.955690 · DOI · Paper page
  52. Tung, 2012, Autophagy: a double-edged sword in Alzheimer's disease, J. Biosci., 37, 157, 10.1007/s12038-011-9176-0 · DOI
  53. Uchiyama, 2008, Autophagic neuron death in neonatal brain ischemia/hypoxia, Autophagy, 4, 404, 10.4161/auto.5598 · DOI
  54. Uchiyama, 2009, Autophagic neuron death, Methods Enzymol., 453, 33, 10.1016/S0076-6879(08)04003-2 · DOI
  55. Valero, 2007, Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse, Dev. Neurobiol., 67, 839, 10.1002/dneu.20352 · DOI
  56. Viscomi, 2012, Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage, Autophagy, 8, 222, 10.4161/auto.8.2.18599 · DOI
  57. Welberg, 2012, Neurotransmission: autophagy regulates transmission, Nat. Rev. Neurosci., 13, 362, 10.1038/nrn3266 · DOI
  58. Yang, 2011, Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits, Brain, 134, 258, 10.1093/brain/awq341 · DOI · Paper page
  59. Yu, 2005, Macroautophagy–a novel beta-amyloid peptide-generating pathway activated in Alzheimer's disease, J. Cell Biol., 171, 87, 10.1083/jcb.200505082 · DOI · Paper page
  60. Yuste, 2004, Genesis of dendritic spines: insights from ultrastructural and imaging studies, Nat. Rev. Neurosci., 5, 24, 10.1038/nrn1300 · DOI
  61. Zukor, 2009, HO-1-mediated macroautophagy: mechanism for unregulated deposition in aging and degenerating neural tissue, J. Neurochem., 109, 776, 10.1111/j.1471-4159.2009.06007.x · DOI

Cited by

Sorted by citations

Metadata

Authors
Sepe, S., Nardacci, R., Fanelli, F., Rosso, P., Bernardi, C., Cecconi, F., Mastroberardino, P. G., Piacentini, M., & Moreno, S.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2014-01
Volume
35
Issue
1
Pages
96-108
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2013.07.001
Cited by
41
References
7
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Telethon Foundation (GGP10225)
  • Italian Ministry of University and Research
  • Italian Ministry of Health
  • AIRC

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review